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    <front>
        <journal-meta>
            <journal-id journal-id-type="publisher-id">JMU</journal-id>
            <journal-id journal-id-type="nlm-ta">JMIR mHealth uHealth</journal-id>
            <journal-title>JMIR mHealth and uHealth</journal-title>
            <issn pub-type="epub">2291-5222</issn>
            <publisher>
                <publisher-name>JMIR Publications Inc.</publisher-name>
                <publisher-loc>Toronto, Canada</publisher-loc>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="publisher-id">v3i1e28</article-id>
            <article-id pub-id-type="pmid">25786060</article-id>
            <article-id pub-id-type="doi">10.2196/mhealth.4026</article-id>
            <article-categories>
                <subj-group subj-group-type="heading">
                    <subject>Original Paper</subject>
                </subj-group>
                <subj-group subj-group-type="article-type">
                    <subject>Original Paper</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>mHealthApps: A Repository and Database of Mobile Health Apps</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="editor">
                    <name>
                        <surname>Eysenbach</surname>
                        <given-names>Gunther</given-names>
                    </name>
                </contrib>
            </contrib-group>
            <contrib-group>
                <contrib contrib-type="reviewer">
                    <name>
                        <surname>Muessig</surname>
                        <given-names>Kathryn</given-names>
                    </name>
                </contrib>
                <contrib contrib-type="reviewer">
                    <name>
                        <surname>Wu</surname>
                        <given-names>Jie</given-names>
                    </name>
                </contrib>
                <contrib contrib-type="reviewer">
                    <name>
                        <surname>Cho</surname>
                        <given-names>Jaehee</given-names>
                    </name>
                </contrib>
                <contrib contrib-type="reviewer">
                    <name>
                        <surname>Zhang</surname>
                        <given-names>Tianhua</given-names>
                    </name>
                </contrib>
                <contrib contrib-type="reviewer">
                    <name>
                        <surname>He</surname>
                        <given-names>Ximiao</given-names>
                    </name>
                </contrib>
                <contrib contrib-type="reviewer">
                    <name>
                        <surname>Wu</surname>
                        <given-names>Han</given-names>
                    </name>
                </contrib>
                <contrib contrib-type="reviewer">
                    <name>
                        <surname>Zhang</surname>
                        <given-names>Melvyn</given-names>
                    </name>
                </contrib>
                <contrib contrib-type="reviewer">
                    <name>
                        <surname>Safran Naimark</surname>
                        <given-names>Jenny</given-names>
                    </name>
                </contrib>
            </contrib-group>
            <contrib-group>
                <contrib contrib-type="author" id="contrib1">
                    <name name-style="western">
                        <surname>Xu</surname>
                        <given-names>Wenlong</given-names>
                    </name>
                    <xref rid="aff1" ref-type="aff">1</xref>
                    <ext-link ext-link-type="orcid">http://orcid.org/0000-0001-7632-3269</ext-link>
                </contrib>
                <contrib contrib-type="author" id="contrib2" corresp="yes">
                    <name name-style="western">
                        <surname>Liu</surname>
                        <given-names>Yin</given-names>
                    </name>
                    <xref rid="aff1" ref-type="aff">1</xref>
                    <address>
                        <institution>Department of Neurobiology and Anatomy</institution>
                        <institution>University of Texas Health Science Center at Houston</institution>
                        <addr-line>6431 Fannin Street</addr-line>
                        <addr-line>Houston, TX, </addr-line>
                        <country>United States</country>
                        <phone>1 713 500 5632</phone>
                        <fax>1 713 500 0621</fax>
                        <email>yin.liu@uth.tmc.edu</email>
                    </address>
                    <xref rid="aff2" ref-type="aff">2</xref>
                    <ext-link ext-link-type="orcid">http://orcid.org/0000-0001-7632-3269</ext-link>
                </contrib>
            </contrib-group>
            <aff id="aff1">
                <sup>1</sup>
                <institution>Department of Neurobiology and Anatomy</institution>
                <institution>University of Texas Health Science Center at Houston</institution>
                <addr-line>Houston, TX</addr-line>
                <country>United States</country>
            </aff>
            <aff id="aff2">
                <sup>2</sup>
                <institution>University of Texas Graduate School of Biomedical Science</institution>
                <addr-line>Houston, TX</addr-line>
                <country>United States</country>
            </aff>
            <author-notes>
                <corresp>Corresponding Author: Yin Liu <email>yin.liu@uth.tmc.edu</email>
                </corresp>
            </author-notes>
            <pub-date pub-type="collection">
                <season>Jan-Mar</season>
                <year>2015</year>
            </pub-date>
            <pub-date pub-type="epub">
                <day>18</day>
                <month>03</month>
                <year>2015</year>
            </pub-date>
            <volume>3</volume>
            <issue>1</issue>
            <elocation-id>e28</elocation-id>
            <!--history from ojs - api-xml-->
            <history>
                <date date-type="received">
                    <day>12</day>
                    <month>11</month>
                    <year>2014</year>
                </date>
                <date date-type="rev-request">
                    <day>29</day>
                    <month>11</month>
                    <year>2014</year>
                </date>
                <date date-type="rev-recd">
                    <day>29</day>
                    <month>12</month>
                    <year>2014</year>
                </date>
                <date date-type="accepted">
                    <day>16</day>
                    <month>01</month>
                    <year>2015</year>
                </date>
            </history>
            <!--(c) the authors - correct author names and publication date here if necessary. Date in form ', dd.mm.yyyy' after jmir.org-->
            <copyright-statement>&#169;Wenlong Xu, Yin Liu. Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org), 18.03.2015. </copyright-statement>
            <copyright-year>2015</copyright-year>
            <license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0/">
                <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR mhealth and uhealth, is properly cited. The complete bibliographic information, a link to the original publication on http://mhealth.jmir.org/, as well as this copyright and license information must be included.</p>
            </license>
            <self-uri xlink:href="http://mhealth.jmir.org/2015/1/e28/" xlink:type="simple" />
            <abstract>
                <sec sec-type="background">
                    <title>Background</title>
                    <p>The market of mobile health (mHealth) apps has rapidly evolved in the past decade. With more than 100,000 mHealth apps currently available, there is no centralized resource that collects information on these health-related apps for researchers in this field to effectively evaluate the strength and weakness of these apps.</p>
                </sec>
                <sec sec-type="objective">
                    <title>Objective</title>
                    <p>The objective of this study was to create a centralized mHealth app repository.  We expect the analysis of information in this repository to provide insights for future mHealth research developments.</p>
                </sec>
                <sec sec-type="methods">
                    <title>Methods</title>
                    <p>We focused on apps from the two most established app stores, the Apple App Store and the Google Play Store. We extracted detailed information of each health-related app from these two app stores via our python crawling program, and then stored the information in both a user-friendly array format and a standard JavaScript Object Notation (JSON) format.</p>
                </sec>
                <sec sec-type="results">
                    <title>Results</title>
                    <p>We have developed a centralized resource that provides detailed information of more than 60,000 health-related apps from the Apple App Store and the Google Play Store. Using this information resource, we analyzed thousands of apps systematically and provide an overview of the trends for mHealth apps.</p>
                </sec>
                <sec sec-type="conclusions">
                    <title>Conclusions</title>
                    <p>This unique database allows the meta-analysis of health-related apps and provides guidance for research designs of future apps in the mHealth field.</p>
                </sec>
            </abstract>
            <kwd-group>
                <kwd>mobile healtlh</kwd>
                <kwd>app repository</kwd>
                <kwd>app database</kwd>
            </kwd-group>
        </article-meta>
    </front>
    <body>
        <sec sec-type="introduction">
            <title> Introduction</title>
            <p>With the constant expansion of mobile health (mHealth) in the past few years, the market of mobile apps related to health is rapidly evolving, making countless new mobile technologies potentially available to the health care system. According to a new report (May 2014) generated by the Research2Guidance firm [<xref ref-type="bibr" rid="ref1">1</xref>], there are more than 100,000 apps falling into the health, fitness, or medical categories, which doubles the market size of that in two and a half years ago. Recently, there have been a number of studies in the field, including the development of a mHealth behavior change system [<xref ref-type="bibr" rid="ref2">2</xref>], the creation of a food database [<xref ref-type="bibr" rid="ref3">3</xref>], and a collaborative effort aiming to integrate apps platform, research data repository, and patient summarization [<xref ref-type="bibr" rid="ref4">4</xref>]. However, there is still a lack of systematic research on the impact of the mHealth apps on health outcomes.</p>
            <p>Currently, most research in this field often investigates the apps individually, either by searching the apps from app stores, or by manually installing each individual app on smartphones or tablets one by one [<xref ref-type="bibr" rid="ref5">5</xref>-<xref ref-type="bibr" rid="ref8">8</xref>] to get the detailed information of each app. For example, Chomutare et al manually installed 488 diabetes related apps to review their features [<xref ref-type="bibr" rid="ref5">5</xref>]. Sama et al manually installed around 400 apps to evaluate existing mHealth app tools [<xref ref-type="bibr" rid="ref6">6</xref>]. Due to the difference in health conditions and app specialization, Tomlinson et al suggested an open mHealth architecture-based platform to facilitate scalable and sustainable health information systems [<xref ref-type="bibr" rid="ref7">7</xref>]. While the app stores provide a wealth of information including the prices and customer reviews for apps [<xref ref-type="bibr" rid="ref9">9</xref>], there is not a centralized resource that collects information of all health-related apps for researchers to systematically evaluate the apps regarding their effectiveness and health outcome. In this study, we aim to obtain a comprehensive view on the mHealth apps by creating an app repository. We expect the analysis of apps in this repository can provide insights for future mHealth research developments.</p>
        </sec>
        <sec sec-type="methods">
            <title>Methods</title>
            <sec>
                <title>Repository Based on the Apple App Store</title>
                <p>Since the Apple App Store (AppStore) is the major representative in the market, we first created an app repository based on all the health related apps from the AppStore. The list of apps was crawled from the Apple iTunes Web pages [<xref ref-type="bibr" rid="ref10">10</xref>], including the pages for the Health &#38; Fitness [<xref ref-type="bibr" rid="ref11">11</xref>] and the Medical [<xref ref-type="bibr" rid="ref12">12</xref>] subcategories. Then using our own crawling program, we extracted detailed information of each app via the iTunes Search app program interface (API) [<xref ref-type="bibr" rid="ref13">13</xref>]. We noticed the results from our data extraction step are in the JavaScript Object Notation (JSON) [<xref ref-type="bibr" rid="ref14">14</xref>] format. For the convenience of researchers, we transferred the files from JSON format to tab-delimited text files encoded with &#8220;utf8mb4&#8221; (flat files with array format), so that researchers can directly import these files to Excel or another program for ease of analysis. In the text files, each row corresponds to an app with 39 features, including the app unique identity (ID), app name, description, user rating count, average user rating, etc. <xref ref-type="table" rid="table1">Table 1</xref> lists all the 39 features along with their annotations.</p>
            </sec>
            <sec>
                <title>Repository Based on the Google Play Store</title>
                <p>Since the Google Play Store (GooglePlay) is now the biggest app store in the market, we also created an app repository based on the information of all popular health-related apps from the GooglePlay. The list of apps was crawled from the GooglePlay Web pages [<xref ref-type="bibr" rid="ref15">15</xref>], including the pages for the HEALTH_AND_FITNESS [<xref ref-type="bibr" rid="ref16">16</xref>] and MEDCIAL [<xref ref-type="bibr" rid="ref17">17</xref>]. We then extracted the detailed information of each popular app using the python HyperText Markup Language parsing tool via the Google Play Search API. For researchers&#8217; convenience, we provided both the JSON format and tab-delimited text files as well. In the text files, each row corresponds to an app with 27 features (<xref ref-type="table" rid="table2">Table 2</xref>), including the app unique ID, app name, description, user rating count, average user rating, etc. Files in both formats (JSON and tab-delimited) can be obtained from the repository website [<xref ref-type="bibr" rid="ref18">18</xref>].</p>
                <table-wrap position="float" id="table1">
                    <label>Table 1</label>
                    <caption>
                        <p>The list of 39 features for each app in the AppStore.</p>
                    </caption>
                    <table width="552" border="1" cellpadding="7" cellspacing="0" frame="hsides" rules="groups">
                        <col width="239" />
                        <col width="285" />
                        <thead>
                            <tr valign="top">
                                <td>Feature</td>
                                <td>Annotation</td>
                            </tr>
                        </thead>
                        <tbody>
                            <tr valign="top">
                                <td>trackId</td>
                                <td>Unique app ID</td>
                            </tr>
                            <tr valign="top">
                                <td>artistId</td>
                                <td>Developer ID</td>
                            </tr>
                            <tr valign="top">
                                <td>artistName</td>
                                <td>Name of the developer</td>
                            </tr>
                            <tr valign="top">
                                <td>artistViewUrl</td>
                                <td>The URL for the developer</td>
                            </tr>
                            <tr valign="top">
                                <td>artworkUrl100</td>
                                <td>The URL for the artwork in 100*100 pixels</td>
                            </tr>
                            <tr valign="top">
                                <td>artworkUrl512</td>
                                <td>The URL for the artwork in 512*512 pixels</td>
                            </tr>
                            <tr valign="top">
                                <td>artworkUrl60</td>
                                <td>The URL for the artwork in 60*60 pixels</td>
                            </tr>
                            <tr valign="top">
                                <td>averageUserRating</td>
                                <td>Average of user ratings</td>
                            </tr>
                            <tr valign="top">
                                <td>averageUserRatingForCurrentVersion</td>
                                <td>Average of user ratings for current version</td>
                            </tr>
                            <tr valign="top">
                                <td>bundleId</td>
                                <td>Bundle ID</td>
                            </tr>
                            <tr valign="top">
                                <td>contentAdvisoryRating</td>
                                <td>Content ratings by content advisor</td>
                            </tr>
                            <tr valign="top">
                                <td>currency</td>
                                <td>Currency</td>
                            </tr>
                            <tr valign="top">
                                <td>description</td>
                                <td>Description of the app</td>
                            </tr>
                            <tr valign="top">
                                <td>features</td>
                                <td>Features</td>
                            </tr>
                            <tr valign="top">
                                <td>fileSizeBytes</td>
                                <td>File size in bytes</td>
                            </tr>
                            <tr valign="top">
                                <td>formattedPrice</td>
                                <td>Price in currency format</td>
                            </tr>
                            <tr valign="top">
                                <td>genreIds</td>
                                <td>Categories IDs</td>
                            </tr>
                            <tr valign="top">
                                <td>genres</td>
                                <td>Categories</td>
                            </tr>
                            <tr valign="top">
                                <td>ipadScreenshotUrls</td>
                                <td>The URLs for the iPad screenshot</td>
                            </tr>
                            <tr valign="top">
                                <td>isGameCenterEnabled</td>
                                <td>Whether it is game center enabled</td>
                            </tr>
                            <tr valign="top">
                                <td>kind</td>
                                <td>The kind of content</td>
                            </tr>
                            <tr valign="top">
                                <td>languageCodesISO2A</td>
                                <td>Language codes ISO2A</td>
                            </tr>
                            <tr valign="top">
                                <td>price</td>
                                <td>Price</td>
                            </tr>
                            <tr valign="top">
                                <td>primaryGenreId</td>
                                <td>Primary category ID</td>
                            </tr>
                            <tr valign="top">
                                <td>primaryGenreName</td>
                                <td>Primary category name</td>
                            </tr>
                            <tr valign="top">
                                <td>releaseDate</td>
                                <td>Release date</td>
                            </tr>
                            <tr valign="top">
                                <td>releaseNotes</td>
                                <td>Release notes</td>
                            </tr>
                            <tr valign="top">
                                <td>screenshotUrls</td>
                                <td>The URLs for screenshot</td>
                            </tr>
                            <tr valign="top">
                                <td>sellerName</td>
                                <td>Seller name</td>
                            </tr>
                            <tr valign="top">
                                <td>sellerUrl</td>
                                <td>The URL for the seller</td>
                            </tr>
                            <tr valign="top">
                                <td>supportedDevices</td>
                                <td>Supported devices</td>
                            </tr>
                            <tr valign="top">
                                <td>trackCensoredName</td>
                                <td>Name (censored)</td>
                            </tr>
                            <tr valign="top">
                                <td>trackContentRating</td>
                                <td>Content rating</td>
                            </tr>
                            <tr valign="top">
                                <td>trackName</td>
                                <td>App name</td>
                            </tr>
                            <tr valign="top">
                                <td>trackViewUrl</td>
                                <td>The URL for the app</td>
                            </tr>
                            <tr valign="top">
                                <td>userRatingCount</td>
                                <td>The number of user ratings</td>
                            </tr>
                            <tr valign="top">
                                <td>userRatingCountForCurrentVersion</td>
                                <td>The number of user ratings for current version</td>
                            </tr>
                            <tr valign="top">
                                <td>version</td>
                                <td>Version number</td>
                            </tr>
                            <tr valign="top">
                                <td>wrapperType</td>
                                <td>The name of object</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
                <table-wrap position="float" id="table2">
                    <label>Table 2</label>
                    <caption>
                        <p>The list of 27 features for each app in the GooglePlay.</p>
                    </caption>
                    <table width="550" border="1" cellpadding="7" cellspacing="0" frame="hsides" rules="groups">
                        <col width="239" />
                        <col width="283" />
                        <thead>
                            <tr valign="top">
                                <td>Features</td>
                                <td>Annotation</td>
                            </tr>
                        </thead>
                        <tbody>
                            <tr valign="top">
                                <td>trackId</td>
                                <td>Unique app ID</td>
                            </tr>
                            <tr valign="top">
                                <td>artworkUrl</td>
                                <td>The URL for the artwork</td>
                            </tr>
                            <tr valign="top">
                                <td>averageUserRating</td>
                                <td>Average of user ratings</td>
                            </tr>
                            <tr valign="top">
                                <td>badge</td>
                                <td>Developer badge</td>
                            </tr>
                            <tr valign="top">
                                <td>category</td>
                                <td>Category</td>
                            </tr>
                            <tr valign="top">
                                <td>contentRating</td>
                                <td>Content rating</td>
                            </tr>
                            <tr valign="top">
                                <td>description</td>
                                <td>Description of the app</td>
                            </tr>
                            <tr valign="top">
                                <td>developerEmail</td>
                                <td>Developer email address</td>
                            </tr>
                            <tr valign="top">
                                <td>developerId</td>
                                <td>Developer ID</td>
                            </tr>
                            <tr valign="top">
                                <td>developerName</td>
                                <td>Name of the developer</td>
                            </tr>
                            <tr valign="top">
                                <td>developerPrivacy</td>
                                <td>The link to the developer privacy notation</td>
                            </tr>
                            <tr valign="top">
                                <td>developerWebsite</td>
                                <td>Developer website</td>
                            </tr>
                            <tr valign="top">
                                <td>fileSize</td>
                                <td>File size</td>
                            </tr>
                            <tr valign="top">
                                <td>formattedPrice</td>
                                <td>Price in currency format</td>
                            </tr>
                            <tr valign="top">
                                <td>inAppPurchase</td>
                                <td>Whether it is in app purchase or not</td>
                            </tr>
                            <tr valign="top">
                                <td>installs</td>
                                <td>Number of installations</td>
                            </tr>
                            <tr valign="top">
                                <td>price</td>
                                <td>Price</td>
                            </tr>
                            <tr valign="top">
                                <td>releaseNotes</td>
                                <td>Release notes</td>
                            </tr>
                            <tr valign="top">
                                <td>requiresAndroid</td>
                                <td>Android OS requirement</td>
                            </tr>
                            <tr valign="top">
                                <td>screenshotUrls</td>
                                <td>The URLs for screenshot</td>
                            </tr>
                            <tr valign="top">
                                <td>screenshotVideoUrls</td>
                                <td>The URLs for video screenshot</td>
                            </tr>
                            <tr valign="top">
                                <td>trackName</td>
                                <td>App name</td>
                            </tr>
                            <tr valign="top">
                                <td>trackViewUrl</td>
                                <td>The URL for the app</td>
                            </tr>
                            <tr valign="top">
                                <td>updated</td>
                                <td>Update date</td>
                            </tr>
                            <tr valign="top">
                                <td>userRatingCount</td>
                                <td>The number of user ratings</td>
                            </tr>
                            <tr valign="top">
                                <td>userRatingCountDistribution</td>
                                <td>The numbers of ratings with 5, 4, 3, 2, or 1 stars</td>
                            </tr>
                            <tr valign="top">
                                <td>version</td>
                                <td>Version number</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
            </sec>
        </sec>
        <sec sec-type="results">
            <title>Results</title>
            <sec>
                <title>Apps From Apple App Store</title>
                <p>In the US market, there are 74,211 apps listed in the Apple iTunes Health &#38; Fitness and Medical subcategories as of December 4, 2014. By removing duplicated entries, we obtained 62,621 totally unique apps in these two subcategories. We note the category of each app is defined by the app&#8217;s owner (developer or seller) and approved by Apple&#8217;s customer service, so the app categorization was done in the server side (API) and was used directly as our app selection criteria. The primary categories of some apps are neither Health &#38; Fitness nor Medical, but others, such as Lifestyle, Education, Sports, Food &#38; Drink, or Games. To reduce the ambiguity, we only included the 47,883 apps with either Health &#38; Fitness or Medical as their primary category in our app repository. In addition to the US market, this repository contains the information of mHealth apps from the AppStore distributed in four other countries with the most established Internet markets [<xref ref-type="bibr" rid="ref19">19</xref>]: (1) China (CN), (2) Japan (JP), (3) Brazil (BR), and (4) Russia (RU). There are 27,157 and 21,607 unique apps in the categories of Health &#38; Fitness and Medical from the top five countries of the AppStore, respectively, leading to 48,764 totally unique health-related apps from the top five countries. In both categories, there are slightly more apps available in the United States than in any of the other four countries (<xref ref-type="table" rid="table3">Table 3</xref>). Overall, more than 98.19% (47,883/48,764) of these unique apps are available in the United States.</p>
                <table-wrap position="float" id="table3">
                    <label>Table 3</label>
                    <caption>
                        <p>The number of apps in different stores and regions.</p>
                    </caption>
                    <table width="711" border="1" cellpadding="7" cellspacing="0" frame="hsides" rules="groups">
                        <col width="238" />
                        <col width="47" />
                        <col width="41" />
                        <col width="42" />
                        <col width="69" />
                        <col width="82" />
                        <col width="94" />
                        <thead>
                            <tr valign="bottom">
                                <td>Store_region_category</td>
                                <td>Apps<sup>a</sup>
                                </td>
                                <td>Free apps</td>
                                <td>% of free apps</td>
                                <td>Sum of user ratings<sup>b</sup>
                                </td>
                                <td>Sum of user ratings (free)<sup>c</sup>
                                </td>
                                <td>% of user ratings (free apps)</td>
                            </tr>
                        </thead>
                        <tbody>
                            <tr valign="top">
                                <td>AppStore_BR_Health&#38;Fitness</td>
                                <td>25,931</td>
                                <td>16,761</td>
                                <td>65</td>
                                <td>79,738</td>
                                <td>60,924</td>
                                <td>76</td>
                            </tr>
                            <tr valign="top">
                                <td>AppStore_BR_Medical</td>
                                <td>20,047</td>
                                <td>13,313</td>
                                <td>66</td>
                                <td>24,169</td>
                                <td>18,074</td>
                                <td>75</td>
                            </tr>
                            <tr valign="top">
                                <td>AppStore_CN_Health&#38;Fitness</td>
                                <td>25,845</td>
                                <td>16,732</td>
                                <td>65</td>
                                <td>164,314</td>
                                <td>137,011</td>
                                <td>83</td>
                            </tr>
                            <tr valign="top">
                                <td>AppStore_CN_Medical</td>
                                <td>19,857</td>
                                <td>13,173</td>
                                <td>66</td>
                                <td>14,765</td>
                                <td>12,128</td>
                                <td>82</td>
                            </tr>
                            <tr valign="top">
                                <td>AppStore_JP_Health&#38;Fitness</td>
                                <td>25,962</td>
                                <td>16,809</td>
                                <td>65</td>
                                <td>204,012</td>
                                <td>141,292</td>
                                <td>69</td>
                            </tr>
                            <tr valign="top">
                                <td>AppStore_JP_Medical</td>
                                <td>19,961</td>
                                <td>13,250</td>
                                <td>66</td>
                                <td>21,008</td>
                                <td>16,426</td>
                                <td>78</td>
                            </tr>
                            <tr valign="top">
                                <td>AppStore_RU_Health&#38;Fitness</td>
                                <td>25,926</td>
                                <td>16,774</td>
                                <td>65</td>
                                <td>139,488</td>
                                <td>96,348</td>
                                <td>69</td>
                            </tr>
                            <tr valign="top">
                                <td>AppStore_RU_Medical</td>
                                <td>19,912</td>
                                <td>13,198</td>
                                <td>66</td>
                                <td>19,736</td>
                                <td>15,679</td>
                                <td>79</td>
                            </tr>
                            <tr valign="top">
                                <td>AppStore_US_Health&#38;Fitness</td>
                                <td>26,762</td>
                                <td>17,521</td>
                                <td>65</td>
                                <td>3,596,338</td>
                                <td>2,877,808</td>
                                <td>80</td>
                            </tr>
                            <tr valign="top">
                                <td>AppStore_US_Medical</td>
                                <td>21,121</td>
                                <td>14,357</td>
                                <td>68</td>
                                <td>866,582</td>
                                <td>671,408</td>
                                <td>77</td>
                            </tr>
                            <tr valign="top">
                                <td>AppStore_Top5Regions_Health&#38;Fitness</td>
                                <td>27,157</td>
                                <td>17,813</td>
                                <td>66</td>
                                <td>4,183,890</td>
                                <td>3,313,383</td>
                                <td>79</td>
                            </tr>
                            <tr valign="top">
                                <td>AppStore_Top5Regions_Medical</td>
                                <td>21,607</td>
                                <td>14,729</td>
                                <td>68</td>
                                <td>946,260</td>
                                <td>733,715</td>
                                <td>78</td>
                            </tr>
                            <tr valign="top">
                                <td>GooglePlay_US_Health&#38;Fitness</td>
                                <td>6894</td>
                                <td>5155</td>
                                <td>75</td>
                                <td>10,921,244</td>
                                <td>10,446,157</td>
                                <td>96</td>
                            </tr>
                            <tr valign="top">
                                <td>GooglePlay_US_Medical</td>
                                <td>5378</td>
                                <td>3180</td>
                                <td>59</td>
                                <td>900,476</td>
                                <td>852,068</td>
                                <td>95</td>
                            </tr>
                        </tbody>
                    </table>
                    <table-wrap-foot>
                        <fn id="table3fn1">
                            <p>
                                <sup>a</sup> Apps, the total number of apps in each specified combination of store, region, and category.</p>
                        </fn>
                        <fn id="table3fn2">
                            <p>
                                <sup>b</sup> Sum of user ratings, the total number of ratings received from app users.</p>
                        </fn>
                        <fn id="table3fn3">
                            <p>
                                <sup>c</sup> Sum of user ratings, free, the total number of ratings received for free apps.</p>
                        </fn>
                    </table-wrap-foot>
                </table-wrap>
            </sec>
            <sec>
                <title>Apps From Google Play Store</title>
                <p>The repository also contains information of the most popular apps from the GooglePlay in the United States. For the GooglePlay, the Web pages only list the most popular or the newest released apps in each category based on their release dates and daily user usage. Since the GooglePlay Web pages are updated daily, to get a comprehensive list of all the apps, we collected the app IDs available on the GooglePlay with our crawling program every day from July 24 to December 6, 2014, and combined the results to get a list of 14,817 unique app IDs. We then excluded the inactive apps that are no longer available on the GooglePlay. In addition, as we did for the AppStore, we also excluded the apps with their primary category other than HEALTH_AND_FITNESS or MEDICAL. Finally, we obtained a list of 12,272 totally unique apps, including 6894 and 5378 apps in the subcategories of HEALTH_AND_FITNESS and MEDICAL, respectively. <xref ref-type="table" rid="table3">Table 3</xref> gives the total number of apps and the total number of user ratings received in each category. Considering the fact that the GooglePlay apps in our repository are among the most popular ones, and GooglePlay represents the biggest app store now, it is not surprising to see that the number of user ratings received for the Health &#38; Fitness apps in GooglePlay is more than two times higher than the sum of user ratings collected from the top five countries for the AppStore apps in the same category.</p>
            </sec>
            <sec>
                <title>Price Factors and App Release Trend</title>
                <p>According to <xref ref-type="table" rid="table3">Table 3</xref>, we can deduce that the average number of user ratings received per app in the Health &#38; Fitness category is significantly higher than that in the Medical category, regardless of app stores. Because the number of user ratings reflects the popularity of the app, this comparison result indicates apps in the Health &#38; Fitness category are more popular than those in the Medical category. We further investigated the effect of app prices on their popularity among users. Overall, a majority of mHealth apps are free, especially in the GooglePlay, as high as 74.78% (5155/6894) of apps in the category of Health&#38; Fitness are free apps. Based on <xref ref-type="table" rid="table3">Table 3</xref>, we can see that the average number of user ratings per free app is always higher than that for a nonfree app. In addition, if we use the average number of user ratings per app as a measure for app popularity, the significantly high percentage of user ratings provided by GooglePlay free app users (95.57%, 11,298,225/11,821,720) suggests the GooglePlay users prefer free apps, compared to the AppStore users.</p>
                <p>Based on the release date information of each app included in our repository, we can analyze the trend of mHealth apps available in the AppStore. We plotted the number of apps released in each quarter since the third quarter of 2008 (<xref ref-type="fig" rid="figure1">Figure 1</xref> shows this). From this figure, we can see that the apps in the Health &#38; Fitness category show a quadratic growth (R<sup>2</sup> = 0.9867), while the apps in the Medical category demonstrate a linear growth (R<sup>2</sup> = 0.9823). The patterns in the top five countries are similar for both the Health &#38; Fitness and Medical subcategories. The GooglePlay doesn&#8217;t contain the released date information of apps; instead, only the updated date information is available. More than 76.57% (9397/12,272) of the apps were updated in the last two quarters. Therefore, the trend for apps in GooglePlay was not analyzed in this study.</p>
                <fig id="figure1" position="float">
                    <label>Figure 1</label>
                    <caption>
                        <p>The trend of the number of released mHealth apps in the Apple App Store (AppStore). 2008Q3: third quarter of year 2008. BR: Brazil; CN: China; JP: Japan; RU: Russia; US: United States.</p>
                    </caption>
                    <graphic xlink:href="mhealth_v3i1e28_fig1.jpg" alt-version="no" mimetype="image" position="float" xlink:type="simple" />
                </fig>
            </sec>
        </sec>
        <sec sec-type="discussion">
            <title>Discussion</title>
            <sec>
                <title>The mHealth App Repository</title>
                <p>The mHealthApps repository allows us to analyze thousands of apps in the market systematically and efficiently, and can be utilized to provide an overview of the trends for mHealth apps. The repository is scheduled to be updated quarterly. Detailed information of all these apps can be freely requested from the repository website [<xref ref-type="bibr" rid="ref18">18</xref>], but will be restricted for personal and noncommercial use only. A unique feature of our repository is that it provides a new dimension of information of apps, such as the user behavior, which is neglected by many other studies in the field. The user behavior data, including the average user rating, the number of user ratings received per app, and the distribution of user ratings in the five-star rating system are based on millions of mHealth apps users worldwide, and have been tested on the real market. The repository also contains other information, such as the price, the released/updated date, and the app descriptions, which can be used for further business marketing, activity analysis, detail subcategories decomposition, and so on.</p>
            </sec>
            <sec>
                <title>Limitations</title>
                <p>It is noted that our study has some limitations. First, the category of each app is submitted by the app&#8217;s owner and approved by the app store. Therefore, the accuracy of app categorization is beyond our control. Additional strategy based on nature language processing would be necessary to ensure all the apps included in our repository are health-related. Second, we only retrieved mHealth apps from the two most established system platforms, the iOS (AppStore) and the Android (GooglePlay), there are also apps from other platforms, such as the Windows Phone Store [<xref ref-type="bibr" rid="ref20">20</xref>] and the BlackBerry World [<xref ref-type="bibr" rid="ref21">21</xref>]. Third, our repository is limited in the regions the information was extracted from. For the AppStore, we only extracted apps information from the top 5 regions according to the market size, which neglects information from other well developed countries such as Australia and European countries (different stores are separated by different languages), as well as from fast developing regions such as Africa and India. For the Android platform, we only extracted apps information from the GooglePlay US store, due to the complex Android markets in other countries. For example, in China, the major Android stores include Baidu Shouji Zhushou [<xref ref-type="bibr" rid="ref22">22</xref>], Tencent Yingyongbao [<xref ref-type="bibr" rid="ref23">23</xref>], and 360 Shouji Zhushou [<xref ref-type="bibr" rid="ref24">24</xref>], while the GooglePlay is not among the major Android stores. Fourth, the number of apps from the GooglePlay is limited due to the availability of apps on the GooglePlay website, which only lists up to 600 of the most popular apps every day. Our repository is based on the lists of apps accumulated between July 24 and December 6, 2014. In spite of these limitations, we expect this mHealth app repository will not only serve as a centralized information resource for researchers to perform meta-analysis on current apps, but also provide guidance for future research designs in the mHealth field.</p>
            </sec>
        </sec>
    </body>
    <back>
        <app-group>
            <app id="app1">
                <title>Multimedia Appendix 1</title>
                <p>Zip flat file with array format for AppStore Health &#38; Fitness apps in United States.</p>
                <media xlink:href="mhealth_v3i1e28_app1.gz" xlink:title="GZ File, 25MB" />
            </app>
            <app id="app2">
                <title>Multimedia Appendix 2</title>
                <p>Zip flat file with array format for AppStore Health &#38; Fitness apps in China.</p>
                <media xlink:href="mhealth_v3i1e28_app2.gz" xlink:title="GZ File, 24MB" />
            </app>
            <app id="app3">
                <title>Multimedia Appendix 3</title>
                <p>Zip flat file with array format for AppStore Health &#38; Fitness apps in Japan.</p>
                <media xlink:href="mhealth_v3i1e28_app3.gz" xlink:title="GZ File, 25MB" />
            </app>
            <app id="app4">
                <title>Multimedia Appendix 4</title>
                <p>Zip flat file with array format for AppStore Health &#38; Fitness apps in Brazil.</p>
                <media xlink:href="mhealth_v3i1e28_app4.gz" xlink:title="GZ File, 24MB" />
            </app>
            <app id="app5">
                <title>Multimedia Appendix 5</title>
                <p>Zip flat file with array format for AppStore Health &#38; Fitness apps in Russia.</p>
                <media xlink:href="mhealth_v3i1e28_app5.gz" xlink:title="GZ File, 25MB" />
            </app>
            <app id="app6">
                <title>Multimedia Appendix 6</title>
                <p>Zip flat file with array format for AppStore Medical apps in United States.</p>
                <media xlink:href="mhealth_v3i1e28_app6.gz" xlink:title="GZ File, 19MB" />
            </app>
            <app id="app7">
                <title>Multimedia Appendix 7</title>
                <p>Zip flat file with array format for AppStore Medical apps in China.</p>
                <media xlink:href="mhealth_v3i1e28_app7.gz" xlink:title="GZ File, 18MB" />
            </app>
            <app id="app8">
                <title>Multimedia Appendix 8</title>
                <p>Zip flat file with array format for AppStore Medical apps in Japan.</p>
                <media xlink:href="mhealth_v3i1e28_app8.gz" xlink:title="GZ File, 19MB" />
            </app>
            <app id="app9">
                <title>Multimedia Appendix 9</title>
                <p>Zip flat file with array format for AppStore Medical apps in Brazil.</p>
                <media xlink:href="mhealth_v3i1e28_app9.gz" xlink:title="GZ File, 19MB" />
            </app>
            <app id="app10">
                <title>Multimedia Appendix 10</title>
                <p>Zip flat file with array format for AppStore Medical apps in Russia.</p>
                <media xlink:href="mhealth_v3i1e28_app10.gz" xlink:title="GZ File, 19MB" />
            </app>
            <app id="app11">
                <title>Multimedia Appendix 11</title>
                <p>Zip flat file with array format for GooglePlay Health &#38; Fitness apps in United States.</p>
                <media xlink:href="mhealth_v3i1e28_app11.gz" xlink:title="GZ File, 6MB" />
            </app>
            <app id="app12">
                <title>Multimedia Appendix 12</title>
                <p>Zip flat file with array format for GooglePlay Medical apps in United States.</p>
                <media xlink:href="mhealth_v3i1e28_app12.gz" xlink:title="GZ File, 4MB" />
            </app>
            <app id="app13">
                <title>Multimedia Appendix 13</title>
                <p>Disclaimer.</p>
                <media xlink:href="mhealth_v3i1e28_app13.txt" xlink:title="TXT File, 802B" />
            </app>
        </app-group>
        <glossary>
            <title>Abbreviations</title>
            <def-list>
                <def-item>
                    <term id="abb1">API</term>
                    <def>
                        <p>app program interface</p>
                    </def>
                </def-item>
                <def-item>
                    <term id="abb2">apps</term>
                    <def>
                        <p>apps</p>
                    </def>
                </def-item>
                <def-item>
                    <term id="abb3">AppStore</term>
                    <def>
                        <p>Apple App Store</p>
                    </def>
                </def-item>
                <def-item>
                    <term id="abb4">BR</term>
                    <def>
                        <p>Brazil</p>
                    </def>
                </def-item>
                <def-item>
                    <term id="abb5">CN</term>
                    <def>
                        <p>China</p>
                    </def>
                </def-item>
                <def-item>
                    <term id="abb6">GooglePlay</term>
                    <def>
                        <p>Google Play Store</p>
                    </def>
                </def-item>
                <def-item>
                    <term id="abb7">ID</term>
                    <def>
                        <p>identity</p>
                    </def>
                </def-item>
                <def-item>
                    <term id="abb8">JP</term>
                    <def>
                        <p>Japan</p>
                    </def>
                </def-item>
                <def-item>
                    <term id="abb9">JSON</term>
                    <def>
                        <p>JavaScript Object Notation</p>
                    </def>
                </def-item>
                <def-item>
                    <term id="abb10">mHealth</term>
                    <def>
                        <p>mobile health</p>
                    </def>
                </def-item>
                <def-item>
                    <term id="abb11">RU</term>
                    <def>
                        <p>Russia</p>
                    </def>
                </def-item>
            </def-list>
        </glossary>
        <ack>
            <p>This work is supported in part by National Institutes of Health grant R01 LM010022 and the seed grant from the University of Texas Health Science Center at Houston.</p>
            <p>Disclaimer: According to the Terms of Use by Apple (https://www.apple.com/legal/internet-services/terms/site.html) and the GooglePlay (https://play.google.com/intl/en_us/about/play-terms.html), we claim our work is exclusively for research and non-commercial informational purpose.
To comply with the websites Terms of Use by Apple and GooglePlay, we now restrict the public anonymous access to the complete data repository. Instead, the URL link for downloading the most updated dataset will only be sent to the users upon request, and is limited for personal and non-commercial use only. When sending your request, please indicate your school or institute, the version you need, and use the subject such as &#8220;Request mHealthApps 2014 Q4 version&#8221; with an email to:
komunling@gmail.com, or Yin.liu@uth.tmc.edu. </p>
        </ack>
        <fn-group>
            <fn fn-type="con">
                <p>WX and YL conceived of the idea and wrote the paper. WX performed the derivations, implemented the algorithm, and prepared the data.</p>
            </fn>
            <fn fn-type="conflict">
                <p>None declared.</p>
            </fn>
        </fn-group>
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