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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMU</journal-id>
      <journal-id journal-id-type="nlm-ta">JMIR Mhealth Uhealth</journal-id>
      <journal-title>JMIR mHealth and uHealth</journal-title>
      <issn pub-type="epub">2291-5222</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
    <article-id pub-id-type="publisher-id">v5i7e93</article-id>
    <article-id pub-id-type="pmid">28698170</article-id>
    <article-id pub-id-type="doi">10.2196/mhealth.7462</article-id>
    <article-categories>
      <subj-group subj-group-type="heading">
        <subject>Original Paper</subject>
      </subj-group>
      <subj-group subj-group-type="article-type">
        <subject>Original Paper</subject>
      </subj-group>
    </article-categories>
    <title-group>
      <article-title>Content Analysis of Smartphone Apps for Smoking Cessation in China: Empirical Study</article-title>
    </title-group>
    <contrib-group>
      <contrib contrib-type="editor">
        <name>
          <surname>Eysenbach</surname>
          <given-names>Gunther</given-names>
        </name>
      </contrib>
    </contrib-group>
    <contrib-group>
      <contrib contrib-type="reviewer">
        <name>
          <surname>Wang</surname>
          <given-names>Jian</given-names>
        </name>
      </contrib>
      <contrib contrib-type="reviewer">
        <name>
          <surname>Tang</surname>
          <given-names>Ying</given-names>
        </name>
      </contrib>
    </contrib-group>
    <contrib-group>
      <contrib contrib-type="author" id="contrib1">
        <name name-style="western">
          <surname>Cheng</surname>
          <given-names>Feng</given-names>
        </name>
        <degrees>MPH, MD</degrees>
        <xref rid="aff1" ref-type="aff">1</xref>
        <ext-link ext-link-type="orcid">http://orcid.org/0000-0002-5599-460X</ext-link>
      </contrib>
      <contrib contrib-type="author" id="contrib2">
        <name name-style="western">
          <surname>Xu</surname>
          <given-names>Junfang</given-names>
        </name>
        <degrees>PhD</degrees>
        <xref rid="aff1" ref-type="aff">1</xref>
        <ext-link ext-link-type="orcid">http://orcid.org/0000-0001-9133-8960</ext-link>
      </contrib>
      <contrib contrib-type="author" id="contrib3">
        <name name-style="western">
          <surname>Su</surname>
          <given-names>Chunyan</given-names>
        </name>
        <degrees>PhD</degrees>
        <xref rid="aff2" ref-type="aff">2</xref>
        <ext-link ext-link-type="orcid">http://orcid.org/0000-0002-7226-4860</ext-link>
      </contrib>
      <contrib contrib-type="author" id="contrib4">
        <name name-style="western">
          <surname>Fu</surname>
          <given-names>Xiaoxing</given-names>
        </name>
        <degrees>PhD</degrees>
        <xref rid="aff3" ref-type="aff">3</xref>
        <ext-link ext-link-type="orcid">http://orcid.org/0000-0002-7370-4127</ext-link>
      </contrib>
      <contrib contrib-type="author" id="contrib5" corresp="yes" equal-contrib="yes">
      <name name-style="western">
        <surname>Bricker</surname>
        <given-names>Jonathan</given-names>
      </name>
      <degrees>PhD</degrees>
      <xref rid="aff4" ref-type="aff">4</xref>
      <address>
        <institution>Division of Public Health Sciences</institution>
        <institution>Fred Hutchinson Cancer Research Center</institution>
        <addr-line>1100 Fairview Avenue North</addr-line>
        <addr-line>Seattle, WA,</addr-line>
        <country>United States</country>
        <phone>1 206 667 5074</phone>
        <email>jbricker@fredhutch.org</email>
      </address>  
      <ext-link ext-link-type="orcid">http://orcid.org/0000-0002-5694-8795</ext-link></contrib>
    </contrib-group>
    <aff id="aff1">
    <sup>1</sup>
    <institution>Research Center for Public Health</institution>
    <institution>School of Medicine</institution>  
    <institution>Tsinghua University</institution>  
    <addr-line>Beijing</addr-line>
    <country>China</country></aff>
    <aff id="aff2">
    <sup>2</sup>
    <institution>School of Journalism and Communication</institution>
    <institution>China Youth University of Political Sciences</institution>  
    <addr-line>Beijing</addr-line>
    <country>China</country></aff>
    <aff id="aff3">
    <sup>3</sup>
    <institution>Institute of Anthropology</institution>
    <institution>Renmin University of China</institution>  
    <addr-line>Beijing</addr-line>
    <country>China</country></aff>
    <aff id="aff4">
    <sup>4</sup>
    <institution>Division of Public Health Sciences</institution>
    <institution>Fred Hutchinson Cancer Research Center</institution>  
    <addr-line>Seattle, WA</addr-line>
    <country>United States</country></aff>
    <author-notes>
      <corresp>Corresponding Author: Jonathan Bricker 
      <email>jbricker@fredhutch.org</email></corresp>
    </author-notes>
    <pub-date pub-type="collection"><month>07</month><year>2017</year></pub-date>
    <pub-date pub-type="epub">
      <day>11</day>
      <month>07</month>
      <year>2017</year>
    </pub-date>
    <volume>5</volume>
    <issue>7</issue>
    <elocation-id>e93</elocation-id>
    <!--history from ojs - api-xml-->
    <history>
      <date date-type="received">
        <day>16</day>
        <month>2</month>
        <year>2017</year>
      </date>
      <date date-type="rev-request">
        <day>30</day>
        <month>3</month>
        <year>2017</year>
      </date>
      <date date-type="rev-recd">
        <day>19</day>
        <month>5</month>
        <year>2017</year>
      </date>
      <date date-type="accepted">
        <day>31</day>
        <month>5</month>
        <year>2017</year>
      </date>
    </history>
    <!--(c) the authors - correct author names and publication date here if necessary. Date in form ', dd.mm.yyyy' after jmir.org-->
    <copyright-statement>©Feng Cheng, Junfang Xu, Chunyan Su, Xiaoxing Fu, Jonathan Bricker. Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org), 11.07.2017.</copyright-statement>
    <copyright-year>2017</copyright-year>
    <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
      <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR mhealth and uhealth, is properly cited. The complete bibliographic information, a link to the original publication on http://mhealth.jmir.org/, as well as this copyright and license information must be included.</p>
    </license>  
    <self-uri xlink:href="http://mhealth.jmir.org/2017/7/e93/" xlink:type="simple"/>
    <abstract>
      <sec sec-type="background">
        <title>Background</title>
        <p>With 360 million smokers, China consumes more cigarettes than any other country in the world. Given that 620 million Chinese own smartphones, smartphone apps for smoking cessation are increasingly used in China to help smokers quit.</p>
      </sec>
      <sec sec-type="objective">
        <title>Objective</title>
        <p>This study analyzed and evaluated the contents of all smoking cessation apps (iOS and Android) available in China, applying the China Clinical Smoking Cessation Guideline (CCSCG; identical to the US Clinical Practice Guideline for Treating Tobacco Use and Dependence) as a framework for analysis.</p>
      </sec>
      <sec sec-type="methods">
        <title>Methods</title>
        <p>We conducted a content analysis of Chinese Android and iOS smoking cessation apps (N=64) designed to assist users in quitting smoking. Each app was independently coded by two raters for its approach to smoking cessation and adherence to the CCSCG. We also recorded the features of smoking cessation apps (eg, release date, size, frequency of downloads, user ratings, type, quality scores by raters, and designers). Linear regression was used to test predictors of popularity and user-rated quality.</p>
      </sec>
      <sec sec-type="results">
        <title>Results</title>
        <p>Chinese smoking cessation apps have low levels of adherence to guidelines, with an average score of 11.1 for Android and 14.6 for iOS apps on a scale of 0 to 46. There was no significant association between popularity, user rating, and the characteristics of apps. However, there was a positive relationship between popularity, user rating, and adherence score.</p>
      </sec>
      <sec sec-type="conclusions">
        <title>Conclusions</title>
        <p>Chinese apps for smoking cessation have low levels of adherence to standard clinical practice guidelines. New apps need be developed and existing apps be revised following evidence-based principles in China.</p>
      </sec>
    </abstract>
    <kwd-group>
      <kwd>smoking cessation</kwd>
      <kwd>smartphone apps</kwd>
      <kwd>China</kwd>
    </kwd-group></article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <p>Tobacco use is one of the most serious public health problems in the world. About 6 million people die every year from tobacco use, and this number is projected to reach about 1 billion by 2030 [<xref ref-type="bibr" rid="ref1">1</xref>,<xref ref-type="bibr" rid="ref2">2</xref>]. China has the largest population of smokers in the world, with an estimate 360 million smokers in 2015 [<xref ref-type="bibr" rid="ref3">3</xref>]. Moreover, the per capita number of cigarettes smoked in China has reached 15.2 per day [<xref ref-type="bibr" rid="ref3">3</xref>]. In China, an astounding 68% of men smoke, as compared to 3.2% of women [<xref ref-type="bibr" rid="ref4">4</xref>]. Cigarette smoking leads 1 million Chinese people to die each year. While China is starting to adopt smoke-free policies and open cessation clinics, if no further tobacco control measures were adopt by the Chinese government, 2 million people in China will die from smoking per year in 2030 and this figure will increase to 3 million by the year 2050, contributing greatly to the Chinese burden of disease [<xref ref-type="bibr" rid="ref4">4</xref>].</p>
      <p>The Chinese government and the community have carried out extensive publicity and education in tobacco control [<xref ref-type="bibr" rid="ref5">5</xref>-<xref ref-type="bibr" rid="ref8">8</xref>]. Many evidence-based smoking cessation methods (eg, psychological and behavioral intervention, telephone intervention therapy, and acupuncture therapy) have been implemented to assist in smoking cessation [<xref ref-type="bibr" rid="ref9">9</xref>-<xref ref-type="bibr" rid="ref12">12</xref>]. To promote smoking cessation for smokers, the first version of the China Clinical Smoking Cessation Guideline (CCSCG), modeled directly from the US Clinical Practice Guideline for Treating Tobacco Use and Dependence [<xref ref-type="bibr" rid="ref13">13</xref>], was issued in 2007 and updated in 2015 and contains empirically supported strategies and recommendations designed to assist health care providers in the delivery of effective treatments for tobacco cessation. These include pharmacological interventions (eg, nicotine replacement therapy) and behavioral interventions (eg, motivational messaging, making a quit plan) [<xref ref-type="bibr" rid="ref14">14</xref>]. While these approaches are valuable, new approaches with high reach and low cost are needed to control tobacco use on a broad scale. Smartphones may offer one such new approach. About 50% of the Chinese population, which is roughly 620 million people, own smartphones [<xref ref-type="bibr" rid="ref15">15</xref>]. Because of the portability of smartphones, which enable access 24 hours a day, long-term management and reinforcement of health behaviors via smartphone apps has promise [<xref ref-type="bibr" rid="ref16">16</xref>-<xref ref-type="bibr" rid="ref20">20</xref>].</p>
      <p>In recent years, smartphone app interventions have been increasingly used as platforms for health promotion including facilitating smoking cessation [<xref ref-type="bibr" rid="ref21">21</xref>,<xref ref-type="bibr" rid="ref22">22</xref>], providing diabetes education [<xref ref-type="bibr" rid="ref23">23</xref>], encouraging attendance of primary care appointments [<xref ref-type="bibr" rid="ref24">24</xref>], and even encouraging sunscreen application [<xref ref-type="bibr" rid="ref25">25</xref>]. For smokers, smoking cessation is the single most important change they can make to their behavior to improve their life expectancy and quality of life [<xref ref-type="bibr" rid="ref26">26</xref>-<xref ref-type="bibr" rid="ref27">27</xref>]. Currently, several studies have evaluated the content of smoking cessation apps in high-income countries especially in America. A recent study found that smoking cessation apps were downloaded more than 700,000 times every month [<xref ref-type="bibr" rid="ref28">28</xref>]. In another study, almost half of smokers had used an app to support their quit attempt [<xref ref-type="bibr" rid="ref29">29</xref>]. If such apps support behavior change, they could confer a considerable benefit to public health considering the significant risks of smoking [<xref ref-type="bibr" rid="ref30">30</xref>]. Indeed, current evidence has demonstrated the usefulness of mobile technology in supporting smoking cessation [<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref25">25</xref>,<xref ref-type="bibr" rid="ref31">31</xref>].</p>
      <p>In China, there were approximately 137 million health and fitness app users in 2015 [<xref ref-type="bibr" rid="ref15">15</xref>]. A variety of smartphone apps for smoking cessation were released between 2009 and 2016 in China. About 70 apps are aimed at helping smokers quit in China, but very little is known about their content, which is important for determining their potential value for smoking cessation. To address this issue, this study analyzed and evaluated the contents of all smoking cessation apps (iOS &#38; Android) available in China, applying the CCSCG as a framework for analysis [<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref32">32</xref>].</p>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <sec>
        <title>Data Sources</title>
        <p>A total of 101 relevant iPhone apps were identified by searching for keywords “quit smoking,” “stop smoking,” and “smoking cessation” in Mandarin Chinese in the iPhone app store in February 2016. A total of 74 apps—53 irrelevant apps (eg, tobacco knowledge apps, male health apps and medical health apps), 5 duplicate apps, 2 apps which could not be opened, and 14 English language apps—were excluded by checking the content after download. The remaining 27 iPhone smoking cessation apps, including 26 free and 1 paid app, were evaluated for the study.</p>
        <p>A total of 145 Android apps were identified from the 360 Assistant app store (86 apps) and Baidu Assistant app store (59 apps), which account for 87.4% of all Android app downloads in China, by searching for the keywords “quit smoking,” “stop smoking,” and “smoking cessation” in Mandarin Chinese in February 2016. A total of 108 apps—21 irrelevant apps (eg, tobacco advertisement apps, expertise in the tobacco industry apps), 15 duplicate apps, 7 prior version apps, and 65 English language apps—were excluded by checking the content after download. The remaining 37 free Android smoking cessation apps were evaluated for this study. In total, the analytical sample included 64 apps (<xref ref-type="fig" rid="figure1">Figure 1</xref>).</p>
      </sec>
      <sec>
        <title>Coding of Smoking Cessation Apps</title>
        <p>For each app, descriptive information was retrieved regarding its characteristics (ie, release date, size, type), popularity (frequency of downloads), and user rating (ie, app was rated ranging from 1 to 5 stars) (<xref ref-type="table" rid="table1">Table 1</xref>). Apps were categorized into different types: (1) calculators, that calculate number of days, amount of money saved, health improvements since quitting; (2) calendars, that track number of cigarettes per day, smoking pattern, and mood; (3) hypnosis, that use hypnosis techniques for smoking cessation; (4) rationing, that ration the number of cigarettes for a specific time period; and (5) other, for apps that did not fall into the previous categories or fell into multiple categories.</p>
        <fig id="figure1" position="float">
          <label>Figure 1</label>
          <caption>
            <p>Procedure for selecting Chinese smoking cessation apps.</p>
          </caption>
          <graphic xlink:href="mhealth_v5i7e93_fig1.jpg" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
        <p>Apps were also coded for their level of adherence to the CCSCG [<xref ref-type="bibr" rid="ref14">14</xref>]. To measure adherence to the CCSCG, an index of 23 items was developed that closely followed the guidelines. Each app was independently coded by two reviewers on each of the 23 items in the adherence index using a score ranging from 0 to 2. A score of 2 indicated that the feature was fully present, a score of 1 indicated that the feature was partially present, and a score of 0 indicated that it was not present at all. For example, for the guideline to recommend the use of medicine, apps that did not mention medicine received a score of 0, apps that partially mentioned medicine received a score of 1, and a clear and strong mention (fully presented the specific drug, proper use, dosing, and common side effects) for medicine received a score of 2.</p>
        <p>A total of 87% (20/23) of items were ratings of concrete features, which by their very nature did not lend themselves to rater judgment and interpretation. For example, the Ask criterion measures whether or not the app asks the user if he or she smokes, and if so, how many cigarettes per day. The concrete quality of these ratings was reflected in the fact that there was 100% interrater agreement for these 20 items.</p>
        <p>In 13% (3/23) of items, the guidelines were subjective (eg, presence of practical advice for quitting smoking). For these 3 items, there was a small fraction of interrater disagreement: 23% of the time for the iPhone apps and 15% for the Android apps. In these cases, we minimized subjectivity of rating with two coders discussing and resolved disagreement when the score differed by 1 (19% for iPhone and 8% for Android) and averaged the scores. When the score differed by 2 (5% for iPhone and 1% for Android), a gold standard outside coder resolved score discrepancies 100% of the time. The maximum possible score on the index was 46 for each app.</p>
      </sec>
      <sec>
        <title>Statistical Analysis</title>
        <p>The statistical analysis was performed using SPSS version 20.0 software (IBM Corp). Total <italic>n</italic>, percentages, mean, and standard deviation were calculated to describe the features of apps. Weighted Cohen’s kappa and intraclass correlation coefficient were used to evaluate interrater agreement. In addition, to identify features of the apps which were associated with the popularity and user-rated quality, linear regression was used to test predictors of popularity (frequency of download) and user-rated quality (user rating with number of stars). Analyses regarding the user-rated quality of the apps were restricted to the apps that had star ratings (73% of the apps), and analyses regarding the popularity of apps were limited to the Android apps because iOS does not release data on the frequency of downloads for iPhone apps. The sample of 64 had 99% power to observe an effect size of 36.8% for the analysis of predictors of quality and downloads.</p>
        <table-wrap position="float" id="table1">
          <label>Table 1</label>
          <caption>
            <p>Characteristics of Chinese smoking cessation apps.</p>
          </caption>
          <table width="75%" cellpadding="8" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="101*"/>
            <col width="93*"/>
            <col width="62*"/>
            <thead>
              <tr valign="top">
                <td>Characteristic</td>
                <td><break/></td>
                <td>Amount</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td><bold>Release d</bold><bold>ate, n (%)</bold></td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>2009</td>
                <td>2 (3)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>2010</td>
                <td>1 (2)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>2011</td>
                <td>6 (9)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>2012</td>
                <td>8 (13)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>2013</td>
                <td>8 (13)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>2014</td>
                <td>12 (19)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>2015</td>
                <td>6 (9)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>2016</td>
                <td>1 (2)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Unknown</td>
                <td>20 (31)</td>
              </tr>
              <tr valign="top">
                <td>Average file size (in megabytes), mean (SD)</td>
                <td><break/></td>
                <td>11.05 (14.28)</td>
              </tr>
              <tr valign="top">
                <td><bold>Frequency of downloads<sup>a</sup></bold><bold>, n (%)</bold></td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>10-100</td>
                <td>4 (11)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>100-1000</td>
                <td>12 (33)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>1000-10,000</td>
                <td>14 (39)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>&#62;10,000</td>
                <td>6 (17)</td>
              </tr>
              <tr valign="top">
                <td><bold>User ratings, n (%)</bold></td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>1 star</td>
                <td>2 (3)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>2 stars</td>
                <td>6 (9)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>3 stars</td>
                <td>28 (44)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>4 stars</td>
                <td>8 (13)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>5 stars</td>
                <td>3 (5)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Missing</td>
                <td>17 (27)</td>
              </tr>
              <tr valign="top">
                <td><bold>Function<sup>b</sup></bold><bold>, n (%)</bold></td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Calculator</td>
                <td>34 (53)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Calendar</td>
                <td>27 (42)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Hypnosis</td>
                <td>1 (2)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Rationing</td>
                <td>8 (13)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Other</td>
                <td>21 (33)</td>
              </tr>
              <tr valign="top">
                <td><bold>Designers, n (%)</bold></td>
                <td><break/></td>
                <td><break/></td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Individuals or technology companies</td>
                <td>58 (91)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Government agencies</td>
                <td>3 (0)</td>
              </tr>
              <tr valign="top">
                <td><break/></td>
                <td>Unidentified sources</td>
                <td>3 (0)</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table1fn1">
              <p><sup>a</sup>Android apps only.</p>
            </fn>
            <fn id="table1fn2">
              <p><sup>b</sup>A total of 42% of apps had multiple functions.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <sec>
        <title>Basic Features</title>
        <p>The characteristics of the 64 smoking cessation apps included in the analysis are presented in <xref ref-type="table" rid="table1">Table 1</xref>. Smartphone apps for smoking cessation started to appear in China in 2009. The largest number of app releases (12, 19%) was in the year 2010. The average size for all apps in the sample was 11.05 MB, and the frequency of download for 83% of apps was less than 10,000 times. The modal user rating for most apps (44%) was 3 or 4 stars (out of 5). Most apps used a calculator approach (53%), followed by calendar (42%), other (33%), rationing (13%), and hypnosis (2%). Most apps (91%) were designed and developed by individuals or technology companies rather than government agencies.</p>
      </sec>
      <sec>
        <title>Adherence Scores</title>
        <p>With a maximum score on the index of 46, the average score was 14.6 for iPhone apps and 11.1 for Android apps (<xref ref-type="app" rid="app1">Multimedia Appendix 1</xref>). For iPhone, the Quit Smoking at Once app had the highest score of 38, while apps 30 Day Messages for Quitting and Common Medical Knowledge received the lowest score of 2.5. For Android, the Quit Smoking App had the highest score of 25, while the apps 30 Day Quit Message, Quitting App, and Self-Awareness of Smoking Habits had the lowest score of 3.</p>
      </sec>
      <sec>
        <title>Influencing Factors</title>
        <p>There was no significant association between popularity, user rating, and the characteristics of apps (<italic>P</italic>&#62;.05). However, there was a positive relationship between popularity, user rating, and adherence score as seen in <xref ref-type="table" rid="table2">Table 2</xref>.</p>
        <table-wrap position="float" id="table2">
          <label>Table 2</label>
          <caption>
            <p>Regression analysis of app characteristics on app popularity and user-rated quality .</p>
          </caption>
          <table width="100%" cellpadding="8" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="94*"/>
            <col width="38*"/>
            <col width="45*"/>
            <col width="40*"/>
            <col width="39*"/>
            <thead>
              <tr valign="top">
                <td rowspan="2">App characteristics</td>
                <td colspan="2">Popularity</td>
                <td colspan="2">User-rated quality</td>
              </tr>
              <tr valign="top">
                <td>Beta</td>
                <td><italic>P</italic> value</td>
                <td>Beta</td>
                <td><italic>P</italic> value</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Release date</td>
                <td>0.180</td>
                <td>.639</td>
                <td>–0.033</td>
                <td>.934</td>
              </tr>
              <tr valign="top">
                <td>Average file size</td>
                <td>0.024</td>
                <td>.953</td>
                <td>–0.255</td>
                <td>.537</td>
              </tr>
              <tr valign="top">
                <td>Type</td>
                <td>0.375</td>
                <td>.354</td>
                <td>0.116</td>
                <td>.786</td>
              </tr>
              <tr valign="top">
                <td>Frequency of <break/>downloads</td>
                <td>—</td>
                <td>—</td>
                <td>0.123</td>
                <td>.712</td>
              </tr>
              <tr valign="top">
                <td>User rating</td>
                <td>0.116</td>
                <td>.712</td>
                <td>—</td>
                <td>—</td>
              </tr>
              <tr valign="top">
                <td>Adherence score</td>
                <td>0.323</td>
                <td>.398</td>
                <td>0.090</td>
                <td>.823</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
      </sec>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Principal Findings</title>
        <p>This was the first study to analyze the content of all publicly available smoking cessation apps in China. The results showed that Chinese apps generally lack the content that is consistent with the CCSCG [<xref ref-type="bibr" rid="ref14">14</xref>]. The number of existing smoking cessation apps in China is smaller than that of America because of the poorer development of eHealth interventions in China [<xref ref-type="bibr" rid="ref33">33</xref>]. However, the adherence score of Chinese apps to the CCSCG is consistent with analyses of English apps (average adherence scores for iPhone and Android are 14.2 and 11.7, respectively, on 0 to 42 score) [<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref34">34</xref>]. One reason may be that the developers of Chinese and English apps are not aware of or do not understand the importance of clinical practice guidelines, as most designers of smoking cessation apps are individuals or companies without any background in clinical practice for tobacco cessation. Indeed, the adherence of smoking cessation apps designed by government agencies was higher than that of other designers in the study.</p>
        <p>The results showed that the content of Chinese apps is primarily limited to calculators (eg, money saved by not smoking) and calendars (eg, showing smoking patterns over time). While such tracking-derived information is potentially useful, it vastly underutilizes the potential of smartphone apps to provide evidence-based advice, motivation, and training in skills to cope with cravings and recover from relapses. In addition, the sensors (eg, Global Positioning System) already built into most smartphones make it possible for smartphone apps to provide sophisticated just-in-time and in-the-moment intervention for smoking cessation. In sum, the content of current Chinese apps was generally simplistic, and the potential for improvement is enormous.</p>
        <p>Compared to the large population of smokers and smartphone owners, Chinese language smoking cessation apps had relatively few downloads. Indeed, only 6 Android apps in Chinese had more than 10,000 total downloads. However, 35.2% of US smoking cessation apps had more than 10,000 downloads with 7.8% having more than 100,000 downloads [<xref ref-type="bibr" rid="ref33">33</xref>]. This disparity may be due to Chinese smokers’ lack of awareness of smoking cessation apps and smoking cessation advice in general. In traditional Chinese culture, smoking functions as a way to make social connections, smooth social interactions, and express one’s social and economic position. Furthermore, in the comments on smoking cessation apps, many users said that stopping smoking was very easy and they will be lucky to avoid the health consequences of smoking, which implies they do not want or understand the value of smoking cessation assistance [<xref ref-type="bibr" rid="ref35">35</xref>]. Once they download an app, users appear to respond positively to it if it follows the CCSCG, as the adherence score was positively related to app popularity and user-used quality. However, more research is needed to understand what Chinese smokers know about smoking cessation advice, their interest in receiving it, and methods to overcome barriers they may have to using it. When smoking cessation apps that follow the CCSCG are developed that are appropriate and motivating to Chinese smokers, it would be highly valuable to test their efficacy. Indeed, the need for efficacy data is underscored by the fact that to date only randomized trials of smoking cessation apps developed in English have been published [<xref ref-type="bibr" rid="ref36">36</xref>]. When Chinese apps show promise in randomized trials, public health media campaigns to widely publicize their existence and potential value for smokers would serve the role of promoting the adoption of proven interventions on a broad scale.</p>
        <p>An important future research question is how to effectively reach a general population of smokers. A recent US survey of smokers showed that 91% had experience using smartphone apps [<xref ref-type="bibr" rid="ref37">37</xref>], which suggests that a smoking cessation app in the United States could potentially reach users with demographics that are generally representative of the overall population of US smokers. Research is now needed to determine what fraction of the Chinese smokers have experience using apps and would be interested in using one to quit smoking, with the aim of determining demographic characteristics of the target population for quit smoking apps in China. As the purchase of iPhone and Android smartphones is rising among old and young people with lower socioeconomic status in China [<xref ref-type="bibr" rid="ref38">38</xref>], the potential utility of smoking cessation apps for Chinese smokers will grow.</p>
        <p>The results of the current studies in the United States and China indicate that despite the recent expansion of smartphone platforms and increased availability of apps for cessation, existing apps still lack many elements that are generally recommended for quitting smoking. We recommend that future research integrate the content of the clinical practice guidelines that have been proven effective in randomized clinical trails [<xref ref-type="bibr" rid="ref39">39</xref>-<xref ref-type="bibr" rid="ref41">41</xref>]. Once guidelines are integrated into to the content of Chinese language smartphone apps, these apps can be tested in randomized trials of Chinese smokers.</p>
        <p>The proliferation of smartphones can now make them valuable health promotion tools. This study presents an evidence-based evaluation of a tool (smoking cessation apps) for health promotion in China that could inform health policy makers of an eHealth intervention with promise for widespread public health impact. As these apps proliferate in China, there is a great potential that data scientists can analyze large databases of users to understand patterns of use to inform personal tailoring of app content to specific users.</p>
      </sec>
      <sec>
        <title>Limitations</title>
        <p>This study has limitations. First, like other content analysis, the data were rated by trained raters. Our method for minimizing rater bias was having 87% of all items be of concrete criterion with the remaining 13% having a small fraction of disagreement that was resolved 100% of the time via a rigorous process described in the methods. Second, the coding measured the presence or absence of the clinical guideline, not the degree to which that guideline was followed or presented effectively. Finally, not all app users provided quality ratings. In the study, an app’s number of stars was used as an indicator of its user-perceived quality, so the generalizability of those results is unknown.</p>
      </sec>
      <sec>
        <title>Conclusions</title>
        <p>Chinese apps for smoking cessation lack content that is known to be effective for smoking cessation. Including content based on China’s clinical practice guidelines would be extremely valuable for improving existing apps and informing the development of new apps and thereby increasing the chances they will make a significant impact on the smoking epidemic in China.</p>
      </sec>
    </sec>
  </body>
  <back>
    <app-group>
      <app id="app1">
        <title>Multimedia Appendix 1</title>
        <p>The adherence score of Chinese apps to the China Clinical Smoking Cessation Guideline.</p>
        <media xlink:href="mhealth_v5i7e93_app1.pdf" xlink:title="PDF File (Adobe PDF File), 23KB"/>
      </app>
    </app-group>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">CCSCG</term>
          <def>
            <p>China Clinical Smoking Cessation Guideline</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <ack>
      <p>We are grateful to Yingqian Xiang, Renye Zhang, Qing Wang, and Xinli Li for their assistance in collecting data on available smoking cessation apps. This work was supported by grant from Tsinghua University Education Foundation (project number 202400025). Dr Bricker’s work on this paper was partly supported by a US National Cancer Institute Grant (project number R01CA200165).</p>
    </ack>
    <fn-group>
      <fn fn-type="conflict">
        <p>FC, JX, CS, and XF declare no competing interests. In July 2016, JB was a consultant to GlaxoSmithKline, the manufacturer of nicotine replacement therapies. He currently serves on the scientific advisory board of Chrono Therapeutics, the manufacturer of a nicotine replacement therapy delivery device.</p>
      </fn>
    </fn-group>
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