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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMU</journal-id>
      <journal-id journal-id-type="nlm-ta">JMIR Mhealth Uhealth</journal-id>
      <journal-title>JMIR mHealth and uHealth</journal-title>
      <issn pub-type="epub">2291-5222</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v8i5e15849</article-id>
      <article-id pub-id-type="pmid">32348264</article-id>
      <article-id pub-id-type="doi">10.2196/15849</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Original Paper</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Original Paper</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Effectiveness of Text Message Interventions for Weight Management in Adolescents: Systematic Review</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Eysenbach</surname>
            <given-names>Gunther</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Lytle</surname>
            <given-names>Leslie</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Job</surname>
            <given-names>Jennifer</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Smith</surname>
            <given-names>Sharlene</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author" corresp="yes">
          <name name-style="western">
            <surname>Partridge</surname>
            <given-names>Stephanie Ruth</given-names>
          </name>
          <degrees>BSc (Hons I), PhD, APD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <address>
            <institution>The University of Sydney</institution>
            <institution>Westmead Applied Research Centre</institution>
            <institution>Faculty of Medicine and Health</institution>
            <addr-line>Department of General Practice</addr-line>
            <addr-line>Acacia House, Westmead Hospital</addr-line>
            <addr-line>Sydney, 2145</addr-line>
            <country>Australia</country>
            <phone>61 288908187</phone>
            <email>stephanie.partridge@sydney.edu.au</email>
          </address>
          <xref rid="aff2" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-5390-3922</ext-link>
        </contrib>
        <contrib id="contrib2" contrib-type="author">
          <name name-style="western">
            <surname>Raeside</surname>
            <given-names>Rebecca</given-names>
          </name>
          <degrees>B Bio Med Sc, MPH</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-2016-6393</ext-link>
        </contrib>
        <contrib id="contrib3" contrib-type="author">
          <name name-style="western">
            <surname>Singleton</surname>
            <given-names>Anna</given-names>
          </name>
          <degrees>BSc (Hons 1), MSc</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-7071-0118</ext-link>
        </contrib>
        <contrib id="contrib4" contrib-type="author">
          <name name-style="western">
            <surname>Hyun</surname>
            <given-names>Karice</given-names>
          </name>
          <degrees>BSc, MAppStat, PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-0164-7725</ext-link>
        </contrib>
        <contrib id="contrib5" contrib-type="author">
          <name name-style="western">
            <surname>Redfern</surname>
            <given-names>Julie</given-names>
          </name>
          <degrees>BSc, BAppSc (Physio Hons 1), PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <xref rid="aff3" ref-type="aff">3</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-8707-5563</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution>The University of Sydney</institution>
        <institution>Westmead Applied Research Centre</institution>
        <institution>Faculty of Medicine and Health</institution>
        <addr-line>Sydney</addr-line>
        <country>Australia</country>
      </aff>
      <aff id="aff2">
        <label>2</label>
        <institution>The University of Sydney</institution>
        <institution>Prevention Research Collaboration, Charles Perkins Centre</institution>
        <institution>Sydney School Public Health</institution>
        <addr-line>Sydney</addr-line>
        <country>Australia</country>
      </aff>
      <aff id="aff3">
        <label>3</label>
        <institution>The George Institute for Global Health</institution>
        <addr-line>Sydney</addr-line>
        <country>Australia</country>
      </aff>
      <author-notes>
        <corresp>Corresponding Author: Stephanie Ruth Partridge <email>stephanie.partridge@sydney.edu.au</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <month>5</month>
        <year>2020</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>26</day>
        <month>5</month>
        <year>2020</year>
      </pub-date>
      <volume>8</volume>
      <issue>5</issue>
      <elocation-id>e15849</elocation-id>
      <history>
        <date date-type="received">
          <day>12</day>
          <month>8</month>
          <year>2019</year>
        </date>
        <date date-type="rev-request">
          <day>8</day>
          <month>12</month>
          <year>2019</year>
        </date>
        <date date-type="rev-recd">
          <day>19</day>
          <month>12</month>
          <year>2019</year>
        </date>
        <date date-type="accepted">
          <day>10</day>
          <month>2</month>
          <year>2020</year>
        </date>
      </history>
      <copyright-statement>©Stephanie Ruth Partridge, Rebecca Raeside, Anna Singleton, Karice Hyun, Julie Redfern. Originally published in JMIR mHealth and uHealth (http://mhealth.jmir.org), 26.05.2020.</copyright-statement>
      <copyright-year>2020</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR mHealth and uHealth, is properly cited. The complete bibliographic information, a link to the original publication on http://mhealth.jmir.org/, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="http://mhealth.jmir.org/2020/5/e15849/" xlink:type="simple"/>
      <abstract>
        <sec sec-type="background">
          <title>Background</title>
          <p>The incidence of obesity among adolescents is increasing. Text messages are a primary communication form for adolescents and potentially a scalable strategy for delivering population health interventions.</p>
        </sec>
        <sec sec-type="objective">
          <title>Objective</title>
          <p>This study aimed to determine the effectiveness of text message interventions in reducing BMI in adolescents and describe characteristics that are common to effective interventions.</p>
        </sec>
        <sec sec-type="methods">
          <title>Methods</title>
          <p>This systematic review included randomized controlled trials of text message lifestyle interventions involving adolescents aged 10 to 19 years with outcomes focused on obesity prevention or management. Primary outcome was objective or self-report change in BMI.</p>
        </sec>
        <sec sec-type="results">
          <title>Results</title>
          <p>In total, 4362 records were identified, and 215 full-text articles were assessed for eligibility. A total of 8 unique studies were identified, including 767 participants, mean age 14.3 (SD 0.9) years, BMI 29.7 (SD 1.6) kg/m2 and 53.1% (407/767) female (31/101, 30.7%-172/172, 100.0%). All interventions were multicomponent. The median active intervention period was 4.5 months. During the active and extended intervention phases, text messages accounted for &#62;50% (8 studies) and &#62;85% (3 studies) of contact points, respectively. Text messages were heterogeneous, with a median of 1.5 text messages sent per week (range: 1-21). A total of 4 studies utilized two-way text message communication with health professionals Of the 8 studies, 7 demonstrated reductions in BMI or BMI z-score in the intervention group compared with the control at the end of the final follow-up. The effect was only statistically significant in 1 study at 6 months. Over 6 months, reductions in BMI (kg/m2) ranged from 1.3% to 4.5% and BMI z-score ranged from 4.2% to 28.1%. Overall quality of the studies was low.</p>
        </sec>
        <sec sec-type="conclusions">
          <title>Conclusions</title>
          <p>Further research is required to elucidate the effectiveness and potential impact of text message interventions on weight and weight-related behaviors in adolescents.</p>
        </sec>
      </abstract>
      <kwd-group>
        <kwd>adolescent</kwd>
        <kwd>text message</kwd>
        <kwd>obesity</kwd>
        <kwd>overweight</kwd>
        <kwd>prevention</kwd>
        <kwd>mHealth</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <sec>
        <title>Background</title>
        <p>The prevalence of overweight and obesity among children and adolescents is now estimated to be 18% globally, with the prevalence of overweight increasing by 47% over the last four decades [<xref ref-type="bibr" rid="ref1">1</xref>]. Lifestyle risk factors, namely, suboptimal diet, physical inactivity, and overweight and obesity are well established during adolescence [<xref ref-type="bibr" rid="ref2">2</xref>-<xref ref-type="bibr" rid="ref4">4</xref>], making this second decade of life (10-19 years) [<xref ref-type="bibr" rid="ref5">5</xref>] a critical period for the development of lifelong health trajectories [<xref ref-type="bibr" rid="ref6">6</xref>]. Weight gain during adolescence is associated with earlier onset type 2 diabetes mellitus and cardiovascular disease (CVD) [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref7">7</xref>]. Compared with adolescents without obesity, adolescents with obesity have increased levels of circulating free fatty acids, which reduce insulin sensitivity, potentially contributing to impaired insulin secretion [<xref ref-type="bibr" rid="ref7">7</xref>]. Moreover, adolescents who gain weight and maintain a high BMI into adulthood have higher odds of developing hypertension, dyslipidemia, and systemic inflammation [<xref ref-type="bibr" rid="ref2">2</xref>]. More short-term adverse health outcomes associated with adolescent overweight and obesity include weight stigma [<xref ref-type="bibr" rid="ref8">8</xref>] and reduced quality of life and self-esteem [<xref ref-type="bibr" rid="ref9">9</xref>]. Interventions to prevent obesity, including combinations of both physical activity and diet interventions have so far remained mainly school based and with limited evidence of effectiveness on BMI [<xref ref-type="bibr" rid="ref10">10</xref>]. Therefore, for health systems to impact population overweight and obesity, interventions need to be personalized, low cost, and scalable with a broad reach to engage all adolescents at risk of obesity.</p>
        <p>The ubiquity of mobile phones has given rise to new ways of delivering health care through mobile health (mHealth) [<xref ref-type="bibr" rid="ref11">11</xref>]. mHealth has the potential to provide personalized, low-cost, and population-wide behavior change programs for obesity prevention and management, particularly for adolescents who are digital frontrunners [<xref ref-type="bibr" rid="ref12">12</xref>]. Adolescent mobile phone ownership is high in both developed and developing countries. For example, over 90% of adolescents in Australia and the United States own a mobile phone [<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref14">14</xref>] and the average age to first own a mobile phone was 10.4 years in Korean children [<xref ref-type="bibr" rid="ref15">15</xref>]. Moreover, adolescents spend on average more than 3 hours per day using a mobile phone, with their device always nearby [<xref ref-type="bibr" rid="ref16">16</xref>], and text messaging remains a primary means of communication [<xref ref-type="bibr" rid="ref13">13</xref>]. As such, text message interventions have the potential to be a wide-reaching and engaging mode of health care delivery for adolescents.</p>
        <p>There is evidence which indicates that text messaging interventions in adults can promote improvements in lifestyle behavior change for weight loss, smoking cessation, physical activity, management of chronic disease and CVD risk, blood pressure lowering, and diabetes care [<xref ref-type="bibr" rid="ref17">17</xref>-<xref ref-type="bibr" rid="ref22">22</xref>]. Text messages are a feasible and acceptable form of communication for adolescents with obesity [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref24">24</xref>]. Features of text messages that are well suited to dietary and physical activity behavior change interventions for adolescent weight management include two-way communication between participant and health professional; direct communication with participants (ie, not required to actively log on to a smartphone app or website for support); and the ability to prompt and reward the repetition of positive behavior change in real time.</p>
        <p>A critical step to translate and disseminate mHealth obesity prevention and management programs for adolescents is to understand the effectiveness and acceptability of the mHealth intervention components, which may help improve the integration of evidence-based practices into health systems. Previous systematic reviews have found limited studies utilizing text messages for improving diet and physical activity behaviors of adolescents [<xref ref-type="bibr" rid="ref25">25</xref>,<xref ref-type="bibr" rid="ref26">26</xref>]. However, Rose et al [<xref ref-type="bibr" rid="ref26">26</xref>] did identify successful behavior change strategies for improved nutrition and physical activity behaviors, namely, education, goal setting, and self-monitoring, which are feasible for delivery via text message. Another review investigating mobile technologies for the prevention and treatment of pediatric obesity found considerable heterogeneity in the three included studies utilizing text messages [<xref ref-type="bibr" rid="ref27">27</xref>].</p>
      </sec>
      <sec>
        <title>Objective</title>
        <p>In recent years, evidence on the effectiveness of interventions delivered via text messages for adolescent weight management have been accumulating but not yet consolidated. Moreover, the collective evidence on text message development and process evaluation data, such as how adolescents engage with and use the text messages, have not been synthesized. Therefore, the aim of this systematic review was (1) to evaluate the effect of interventions delivered via text messages on weight outcomes in an adolescent population and (2) to understand intervention characteristics that are common to effective interventions delivered by text message.</p>
      </sec>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <sec>
        <title>Protocol and Registration</title>
        <p>This systematic review was conducted and reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement guidelines [<xref ref-type="bibr" rid="ref28">28</xref>] (<xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>) and followed the predetermined methods documented in a protocol. The review was registered in the International Prospective Register of Systematic Reviews (PROSPERO; registration number: CRD42018109197).</p>
      </sec>
      <sec>
        <title>Eligibility Criteria</title>
        <p>Studies were included that met the following criteria: (1) randomized controlled trials (RCTs) that included lifestyle interventions of any duration which included mobile phone SMS or text message. Only RCTs were included as they provide the strongest evidence for the benefits of a health care intervention [<xref ref-type="bibr" rid="ref29">29</xref>]; (2) participants were adolescents, defined by the World Health Organization as the second decade of life, 10 to 19 years [<xref ref-type="bibr" rid="ref5">5</xref>], both girls and boys, not pregnant and free of acute illness or chronic disease, as some conditions may influence body weight outcomes or ability to change lifestyle behaviors; (3) only studies focused on obesity prevention or management were included; and (4) studies with interventions of any duration that involved the delivery of text messages via a mobile phone device, including multicomponent interventions that were delivered in part by text message. Studies with interventions that use at least any two of the behavioral techniques (BCTs) to achieve behavior change, for example, goal setting, were included. BCTs are defined as a mechanism of action in an intervention that contributes to positive behavior change [<xref ref-type="bibr" rid="ref30">30</xref>]. The mode of text message delivery included standard SMS or messaging apps like WhatsApp (studies were excluded if they included text messages that are only appointment or other reminders); (5) all study settings were included, that is, health care, community, home, or school based; (6) a comparator group of participants receiving standard care (no messages or some form of control text message); (7) a study outcome of change in body weight measured in BMI or BMI z-score (also called BMI standard deviation scores); (8) studies published in any language were considered; and (9) studies published after 2005 were considered. The cut-off date of 2005 was selected as the current generation of adolescents (<italic>Generation Z</italic>) appeared in the population after 1995, and the oldest of this generation were 10 years old in 1995. The criteria for included studies in this review are summarized in the Population, Intervention, Comparator, Outcomes, and Setting format in <xref ref-type="table" rid="table1">Table 1</xref>.</p>
        <table-wrap position="float" id="table1">
          <label>Table 1</label>
          <caption>
            <p>Summary description of Population, Intervention, Comparator, Outcomes, and Setting (PICOS) components.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="200"/>
            <col width="800"/>
            <thead>
              <tr valign="top">
                <td>PICOS components</td>
                <td>Description</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Population</td>
                <td>Individuals (adolescents, 10-19 years) of any demographic background</td>
              </tr>
              <tr valign="top">
                <td>Intervention</td>
                <td>Interventions that include mobile phone SMS or texting intervention</td>
              </tr>
              <tr valign="top">
                <td>Comparator</td>
                <td>Intervention vs usual care</td>
              </tr>
              <tr valign="bottom">
                <td>Outcomes</td>
                <td>Changes in body weight measured in terms of BMI and/or BMI z-score<sup>a</sup></td>
              </tr>
              <tr valign="top">
                <td>Setting</td>
                <td>Randomized controlled trials conducted in any setting</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table1fn1">
              <p><sup>a</sup>Units BMI is above or below average BMI for age- and sex-specific reference values.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
      </sec>
      <sec>
        <title>Information Sources and Searches</title>
        <p>A total of 10 major electronic databases (Pre-Medline, MEDLINE, Cochrane, Cochrane Central Register of Controlled Trials, Excerpta Medica Database, Cumulative Index of Nursing and Allied Health Literature, Allied and Complementary Medicine Database, Informit, Scopus, and Web of Science) were systematically searched until January 21, 2019, and hand searching was conducted until July 12, 2019. The database searches were developed in collaboration with a librarian. Search terms included combinations, truncations, and synonym of the following: (1) adolescent; (2) phone text messaging (mHealth or <italic>telemedicine</italic> or <italic>tele-medicine</italic> or <italic>mobile phone</italic> or <italic>mobile phones</italic> or <italic>cell phones</italic> or <italic>cell phone</italic> or <italic>cell phones</italic> or SMS or <italic>short message service</italic> or <italic>short message</italic> or texting or <italic>text message</italic> or <italic>text messages</italic> or <italic>text messaging</italic> or <italic>text messaged</italic> or <italic>text messaging</italic> or txt or text); and (3) weight loss or weight maintenance (<italic>diet, reducing</italic> or <italic>weight reduction programs</italic> or <italic>weight loss</italic> or <italic>weight maintenance</italic> or <italic>weight loss</italic> or <italic>weight management</italic> or weight and loss or manage* or maintenance or maintain or maintain*). Appropriate RCT filters were used to maximize the identification of RCTs. Additional articles were obtained through a hand search of reference lists, conference proceedings, key journals in the field, abstracts, clinical trial databases, and by contacting experts in the field. Full electronic search strategies for each database and screenshots of all search results are available in <xref ref-type="supplementary-material" rid="app2">Multimedia Appendices 2</xref> and <xref ref-type="supplementary-material" rid="app3">3</xref>.</p>
      </sec>
      <sec>
        <title>Study Selection</title>
        <p>One author (SP) carried out all electronic database searches. Search results across databases were merged using reference management software, Endnote X8 (Camelot UK Bidco Limited, Clarivate Analytics, United Kingdom), and duplicate records of the same study were removed. Study selection followed the process described in the Cochrane Handbook of Systematic Reviews and PRISMA statements. Two researchers (SP and RR) independently screened titles and abstracts to remove irrelevant studies to identify studies that met the inclusion criteria described above using a predetermined eligibility assessment form. Any disagreements were discussed and resolved by consensus between two authors (SP and RR), and a third author was consulted (AS) in the case of unresolved disagreement.</p>
      </sec>
      <sec>
        <title>Data Collection Process</title>
        <p>For studies meeting the inclusion criteria, information was extracted using a predesigned electronic data extraction table based on PRISMA statement [<xref ref-type="bibr" rid="ref28">28</xref>] and data items required for the Cochrane Collaboration’s risk of bias tool [<xref ref-type="bibr" rid="ref29">29</xref>] that was developed and test-piloted for this review. One author extracted (SP) the data, and a second author (RR) independently cross-checked a random 20% of the data for accuracy. Extracted data included data items on study characteristics (design, aim, sample size, active intervention duration, extended intervention duration, follow-up time points, attrition, comparison of dropouts, and recruitment methods), participant characteristics (age, weight, BMI (kg/m<sup>2</sup>) and/or BMI z-score at baseline, gender, and ethnicity), intervention characteristics (components, theoretical underpinning, BCTs using the behavior-specific taxonomy of 40 BCTs for physical activity and healthy eating behaviors [CALO-RE taxonomy] [<xref ref-type="bibr" rid="ref30">30</xref>], setting, peer support, personnel interaction, text message details, and comparators), study outcome measures (method of assessment, changes in body weight measured in BMI change in kg/m<sup>2</sup>, and/or BMI z-score change in units during the intervention and all follow-up period[s], changes in diet, physical activity and/or psychosocial well-being if reported or collected, measures of error, and statistical significance), and adherence measures (number, type, and definition of adherence measures). When two or more articles reported results from the same study, all articles were considered together for complete data extraction. Authors were contacted for missing, incomplete, or unclear data.</p>
      </sec>
      <sec>
        <title>Data Synthesis and Analysis</title>
        <p>The key characteristics of the included studies were summarized in text form and tabulated using the information collected from the data extraction form. The primary outcome of interest was the change in body weight measured in BMI change in kg/m<sup>2</sup> or BMI z-score change in units. Where possible, for all study arms, the mean or median change was recorded at baseline, postintervention, and any additional follow-up(s). Measures of error were standard error or standard deviation and associated <italic>P</italic> values for change between groups at follow-up(s), and overtime were recorded if available. The clinical significance of outcomes was also considered. Modest reductions in BMI z-score (0.01-0.15) in adolescents with overweight or obesity have been associated with improvements in several cardiovascular risk factors and considered to be clinically meaningful [<xref ref-type="bibr" rid="ref31">31</xref>]. More significant improvements in cardiovascular risk can be seen with BMI z-score reductions of &#62;0.25 in adolescents with obesity [<xref ref-type="bibr" rid="ref32">32</xref>]. Interventions were heterogeneous; only 5 studies reported the mean change in BMI, only 4 studies reported the mean change in BMI z-score, and all were at varying follow-up time points. This heterogeneity rendered the sample size too small for a meta-analysis of these outcomes to be conducted at each follow-up time point [<xref ref-type="bibr" rid="ref33">33</xref>].</p>
      </sec>
      <sec>
        <title>Risk of Bias Assessment</title>
        <sec>
          <title>Cochrane Risk of Bias Assessment</title>
          <p>The Cochrane Collaboration’s tool was used to assess the risk of bias at the individual study level [<xref ref-type="bibr" rid="ref29">29</xref>]. The primary sources of systematic bias in trials were assessed including the selection of participants (random sequence generation and allocation concealment methods); performance (blinding of participants and personnel); detection (blinding of outcome assessment); attrition (incomplete outcome data); and reporting (selective reporting of study outcomes). Two authors (SP and RR) independently evaluated each study for risk of bias and permitted a judgment of low risk, high risk, or unclear risk. A third author (AS) was consulted in the case of unresolved disagreement.</p>
        </sec>
      </sec>
      <sec>
        <title>Quality of Evidence Assessment</title>
        <sec>
          <title>Grading of Recommendations Assessment, Development, and Evaluation Assessment</title>
          <p>The quality of the body of evidence was determined using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system [<xref ref-type="bibr" rid="ref34">34</xref>]. In total, 5 categories were considered to ascribe a quality rating: limitations in study designs; consistency of results; the directness of the evidence concerning study populations, intervention design, and outcomes measured; the precision of outcomes; and the presence of publication biases. Two authors (SP and RR) independently evaluated the quality of the body of evidence. A third author (AS) was consulted in the case of unresolved disagreement.</p>
        </sec>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <sec>
        <title>Study Selection</title>
        <p>The search found 4362 articles from all electronic database searches and an additional 4 articles through hand searching of reference lists (<xref rid="figure1" ref-type="fig">Figure 1</xref>). After exclusion of duplicates, 3418 articles were screened by title and abstract, and 3203 were excluded. A total of 215 full-text articles were assessed for edibility, and 201 were excluded with reasons outlined in <xref rid="figure1" ref-type="fig">Figure 1</xref> and <xref ref-type="supplementary-material" rid="app4">Multimedia Appendix 4</xref>. Eight unique studies [<xref ref-type="bibr" rid="ref35">35</xref>-<xref ref-type="bibr" rid="ref42">42</xref>] from 13 publications were included in this review [<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref35">35</xref>-<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref43">43</xref>-<xref ref-type="bibr" rid="ref47">47</xref>].</p>
        <fig id="figure1" position="float">
          <label>Figure 1</label>
          <caption>
            <p>Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) flow diagram of included studies. RCT: randomized controlled trial. CINAHL: Cumulative Index of Nursing and Allied Health Literature; AMED: Allied and Complementary Medicine Database.</p>
          </caption>
          <graphic xlink:href="mhealth_v8i5e15849_fig1.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
      <sec>
        <title>Effectiveness of Interventions</title>
        <sec>
          <title>Body Mass Index</title>
          <p>All studies measuring BMI (kg/m<sup>2</sup>) measured height and weight in person by trained personnel using standardized procedures and calibrated equipment (<xref ref-type="table" rid="table2">Table 2</xref>). The 5 studies calculating BMI z-score specified the country of origin for the age- and sex-specific reference values [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref39">39</xref>-<xref ref-type="bibr" rid="ref42">42</xref>]. Of the 8 studies, 7 demonstrated reductions in BMI or BMI z-score in the intervention group compared with the control at the end of the final follow-up (<xref ref-type="table" rid="table3">Table 3</xref>). The effect was only statistically significant in 1 study at 6 months [<xref ref-type="bibr" rid="ref37">37</xref>]. Significant time by group effects were observed in 3 studies [<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref40">40</xref>]; 2 studies reported the effect of the intervention on both BMI and BMI z-score [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref40">40</xref>], 3 studies reported the effect of the intervention on BMI only [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref38">38</xref>], and 3 studies reported the effect of the intervention on BMI z-score only [<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref42">42</xref>]. A decrease in BMI ranged between 1.3% and 4.5% in the intervention group compared with the control at 6 months, with the exception of 1 study, which saw an increase in BMI of 3.8% in the intervention group compared with the control group at 6 months [<xref ref-type="bibr" rid="ref38">38</xref>]. The 3 studies which reported BMI z-score change at 6 months varied with a decrease of 28.1%, 4.2%, and 4.5% in the intervention group compared with the control [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref42">42</xref>].</p>
          <table-wrap position="float" id="table2">
            <label>Table 2</label>
            <caption>
              <p>Method of BMI and BMI z-score assessment (n=8).</p>
            </caption>
            <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
              <col width="30"/>
              <col width="300"/>
              <col width="670"/>
              <thead>
                <tr valign="top">
                  <td colspan="2">Parameter, author, year, country</td>
                  <td>Method of assessment</td>
                </tr>
              </thead>
              <tbody>
                <tr valign="top">
                  <td colspan="3">
                    <bold>BMI</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Abraham et al, 2015, China [<xref ref-type="bibr" rid="ref35">35</xref>]</td>
                  <td>Height and weight measured in person, by a trained researcher using standard procedures and calibrated equipment</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Bagherniya et al, 2018, Iran [<xref ref-type="bibr" rid="ref36">36</xref>]</td>
                  <td>Height and weight measured in person by a trained researcher in duplicate using standard procedures and calibrated equipment</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Chen et al, 2017, the United States [<xref ref-type="bibr" rid="ref37">37</xref>]</td>
                  <td>Height and weight measured in person, by trained research assistant who was blinded to group assignment</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Love-Osborne et al, 2016, the United States [<xref ref-type="bibr" rid="ref38">38</xref>]</td>
                  <td>Height and weight measured in person with shoes off, repeated twice by study staff</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Nguyen et al, 2012, Australia [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref46">46</xref>]</td>
                  <td>Height and weight measured in person by a trained researcher using standard procedures and calibrated equipment</td>
                </tr>
                <tr valign="top">
                  <td colspan="3">
                    <bold>BMI z-score</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Chen et al, 2017, the United States [<xref ref-type="bibr" rid="ref37">37</xref>]</td>
                  <td>BMI z-scores based on age- and sex-specific reference values (US reference data)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Jensen et al, 2019, the United States [<xref ref-type="bibr" rid="ref42">42</xref>]</td>
                  <td>BMI z-scores based on age- and sex-specific reference values (US reference data)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Mameli et al, 2018, Italy [<xref ref-type="bibr" rid="ref39">39</xref>]</td>
                  <td>BMI z-scores based on age- and sex-specific reference values (Italian reference data)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Nguyen et al, 2012, Australia [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref46">46</xref>]</td>
                  <td>BMI z-scores based on age- and sex-specific reference values (US reference data)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Patrick et al, 2013, the United States [<xref ref-type="bibr" rid="ref41">41</xref>]</td>
                  <td>BMI z-scores based on age- and sex-specific reference values (US reference data)</td>
                </tr>
              </tbody>
            </table>
          </table-wrap>
          <table-wrap position="float" id="table3">
            <label>Table 3</label>
            <caption>
              <p>Mean change in BMI or BMI-z score at follow up(s) (n=8).</p>
            </caption>
            <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
              <col width="20"/>
              <col width="20"/>
              <col width="20"/>
              <col width="210"/>
              <col width="0"/>
              <col width="140"/>
              <col width="0"/>
              <col width="120"/>
              <col width="0"/>
              <col width="110"/>
              <col width="0"/>
              <col width="180"/>
              <col width="0"/>
              <col width="180"/>
              <thead>
                <tr valign="top">
                  <td colspan="5">Author, year, citation, outcome, follow-up timepoint (months), and study arms</td>
                  <td colspan="2">Mean difference within groups (SD)</td>
                  <td colspan="2">Effect size (%)</td>
                  <td colspan="2">Level of effect size<sup>a</sup></td>
                  <td colspan="2">Mean difference <break/>between groups</td>
                  <td>Mean difference between groups over time</td>
                </tr>
              </thead>
              <tbody>
                <tr valign="top">
                  <td colspan="14">
                    <bold>Abraham et al, 2015, China [<xref ref-type="bibr" rid="ref35">35</xref>]</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td colspan="13">
                    <bold>BMI</bold>
                  </td>
                </tr>
                <tr valign="bottom">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td colspan="4">
                    <bold>3</bold>
                  </td>
                  <td colspan="2">
                    <bold>0.6 decrease</bold>
                  </td>
                  <td colspan="2">
                    <bold>+</bold>
                  </td>
                  <td colspan="2">
                    <bold><italic>P</italic>=.14</bold>
                  </td>
                  <td colspan="2">
                    <bold>NR<sup>b</sup></bold>
                  </td>
                </tr>
                <tr valign="bottom">
                  <td rowspan="7">
                    <break/>
                  </td>
                  <td rowspan="7">
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>IT<sup>c</sup></td>
                  <td colspan="2">0 (NR)</td>
                  <td colspan="2">
                    <break/>
                  </td>
                  <td colspan="2">
                    <break/>
                  </td>
                  <td colspan="2">
                    <break/>
                  </td>
                  <td colspan="2">
                    <break/>
                  </td>
                </tr>
                <tr valign="bottom">
                  <td>
                    <break/>
                  </td>
                  <td>sLMP<sup>d</sup></td>
                  <td colspan="2">0.4 (NR)</td>
                  <td colspan="2">
                    <break/>
                  </td>
                  <td colspan="2">
                    <break/>
                  </td>
                  <td colspan="2">
                    <break/>
                  </td>
                  <td colspan="2">
                    <break/>
                  </td>
                </tr>
                <tr valign="bottom">
                  <td>
                    <break/>
                  </td>
                  <td>C<sup>e</sup></td>
                  <td colspan="2">0.2 (NR)</td>
                  <td colspan="2">
                    <break/>
                  </td>
                  <td colspan="2">
                    <break/>
                  </td>
                  <td colspan="2">
                    <break/>
                  </td>
                  <td colspan="2">
                    <break/>
                  </td>
                </tr>
                <tr valign="top">
                  <td colspan="4">
                    <bold>6</bold>
                  </td>
                  <td colspan="2">
                    <bold>1.3 decrease</bold>
                  </td>
                  <td colspan="2">
                    <bold>+</bold>
                  </td>
                  <td colspan="2">
                    <bold><italic>P</italic>=.07</bold>
                  </td>
                  <td colspan="2">
                    <bold>NR</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td rowspan="3">
                    <break/>
                  </td>
                  <td>IT</td>
                  <td colspan="2">−0.1 (NR)</td>
                  <td colspan="2">
                    <break/>
                  </td>
                  <td colspan="2">
                    <break/>
                  </td>
                  <td colspan="2">
                    <break/>
                  </td>
                  <td colspan="2">
                    <break/>
                  </td>
                </tr>
                <tr valign="top">
                  <td>sLMP</td>
                  <td colspan="2">−0.5 (NR)</td>
                  <td colspan="2">
                    <break/>
                  </td>
                  <td colspan="2">
                    <break/>
                  </td>
                  <td colspan="2">
                    <break/>
                  </td>
                  <td colspan="2">
                    <break/>
                  </td>
                </tr>
                <tr valign="top">
                  <td>C</td>
                  <td colspan="2">0.3 (NR)</td>
                  <td colspan="2">
                    <break/>
                  </td>
                  <td colspan="2">
                    <break/>
                  </td>
                  <td colspan="2">
                    <break/>
                  </td>
                  <td colspan="2">
                    <break/>
                  </td>
                </tr>
                <tr valign="top">
                  <td colspan="14">
                    <bold>Bagherniya et al, 2018, Iran [<xref ref-type="bibr" rid="ref36">36</xref>]</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td colspan="13">
                    <bold>BMI</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td colspan="12">
                    <bold>3.5</bold>
                  </td>
                </tr>
                <tr valign="bottom">
                  <td rowspan="5">
                    <break/>
                  </td>
                  <td rowspan="5">
                    <break/>
                  </td>
                  <td rowspan="2">
                    <break/>
                  </td>
                  <td>I<sup>f</sup></td>
                  <td colspan="2">NR</td>
                  <td colspan="2">NR</td>
                  <td colspan="2">NR</td>
                  <td colspan="2">NR</td>
                  <td colspan="2">NR</td>
                </tr>
                <tr valign="bottom">
                  <td>C</td>
                  <td colspan="2">NR</td>
                  <td colspan="2">—<sup>g</sup></td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                </tr>
                <tr valign="top">
                  <td colspan="12">
                    <bold>7</bold>
                  </td>
                </tr>
                <tr valign="bottom">
                  <td rowspan="2">
                    <break/>
                  </td>
                  <td>I</td>
                  <td colspan="2">−0.7 (NR)</td>
                  <td colspan="2">3.9 decrease</td>
                  <td colspan="2">
                    <bold>+</bold>
                  </td>
                  <td colspan="2"><italic>P</italic>=.13</td>
                  <td colspan="2"><italic>P</italic>&#60;.001</td>
                </tr>
                <tr valign="bottom">
                  <td>C</td>
                  <td colspan="2">0.4 (NR)</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                </tr>
                <tr valign="top">
                  <td colspan="14">
                    <bold>Chen et al, 2017, the United States [<xref ref-type="bibr" rid="ref37">37</xref>]</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td colspan="13">
                    <bold>BMI</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td colspan="12">
                    <bold>3</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td rowspan="9">
                    <break/>
                  </td>
                  <td rowspan="5">
                    <break/>
                  </td>
                  <td rowspan="2">
                    <break/>
                  </td>
                  <td>I</td>
                  <td colspan="2">−0.4 (NR)</td>
                  <td colspan="2">3.3 decrease</td>
                  <td colspan="2">
                    <bold>+</bold>
                  </td>
                  <td colspan="2">NR</td>
                  <td colspan="2">NR</td>
                </tr>
                <tr valign="top">
                  <td>C</td>
                  <td colspan="2">0.46 (NR)</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                </tr>
                <tr valign="top">
                  <td colspan="12">
                    <bold>6</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td rowspan="2">
                    <break/>
                  </td>
                  <td>I</td>
                  <td colspan="2">−0.44 (NR)</td>
                  <td colspan="2">4.5 decrease</td>
                  <td colspan="2">
                    <bold>+ +</bold>
                  </td>
                  <td colspan="2">−1.05 (SE 1.22, 90% CI −3.09 to 0.95); <italic>P</italic>=.39</td>
                  <td colspan="2">−0.58 (SE 0.13, 90% CI −0.84 to −0.40); <italic>P</italic>=.001</td>
                </tr>
                <tr valign="top">
                  <td>C</td>
                  <td colspan="2">0.83 (NR)</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                </tr>
                <tr valign="top">
                  <td colspan="13">
                    <bold>BMI z-score</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td colspan="12">
                    <bold>6</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td rowspan="2">
                    <break/>
                  </td>
                  <td rowspan="2">
                    <break/>
                  </td>
                  <td>I</td>
                  <td colspan="2">−0.18 (NR)</td>
                  <td colspan="2">28.1 decrease</td>
                  <td colspan="2">
                    <bold>+ + +</bold>
                  </td>
                  <td colspan="2">−0.15 (SE 0.15, 90% CI −0.40 to 0.09); <italic>P</italic>=.001</td>
                  <td colspan="2">−0.12 (SE 0.03, 90% CI −0.16 to −0.07); <italic>P</italic>=.001</td>
                </tr>
                <tr valign="top">
                  <td>C</td>
                  <td colspan="2">0.26 (NR)</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                </tr>
                <tr valign="top">
                  <td colspan="14">
                    <bold>Jensen et al, 2019, the United States [<xref ref-type="bibr" rid="ref42">42</xref>]</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td colspan="13">
                    <bold>BMI z-score</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td colspan="12">
                    <bold>6</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td rowspan="2">
                    <break/>
                  </td>
                  <td rowspan="2">
                    <break/>
                  </td>
                  <td rowspan="2">
                    <break/>
                  </td>
                  <td>I</td>
                  <td colspan="2">−0.09 (NR)</td>
                  <td colspan="2">4.2 decrease</td>
                  <td colspan="2">
                    <bold>+</bold>
                  </td>
                  <td colspan="2">Not statistically significant, <italic>P</italic> value, NR</td>
                  <td colspan="2">NR</td>
                </tr>
                <tr valign="top">
                  <td>C</td>
                  <td colspan="2">−0.03 (NR)</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                </tr>
                <tr valign="top">
                  <td colspan="14">
                    <bold>Love-Osborne et al, 2016, the United States [<xref ref-type="bibr" rid="ref38">38</xref>]</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td colspan="13">
                    <bold>BMI z-score</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td colspan="12">
                    <bold>6-8</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td rowspan="2">
                    <break/>
                  </td>
                  <td rowspan="2">
                    <break/>
                  </td>
                  <td rowspan="2">
                    <break/>
                  </td>
                  <td>I</td>
                  <td colspan="2">1.2 (NR)</td>
                  <td colspan="2">3.8 increase</td>
                  <td colspan="2">
                    <bold>+</bold>
                  </td>
                  <td colspan="2">NR</td>
                  <td colspan="2">NR</td>
                </tr>
                <tr valign="top">
                  <td>C</td>
                  <td colspan="2">0.0 (NR)</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                </tr>
                <tr valign="top">
                  <td colspan="14">
                    <bold>Mameli et al, 2018, Italy [<xref ref-type="bibr" rid="ref39">39</xref>]</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td colspan="13">
                    <bold>BMI z-score</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td colspan="12">
                    <bold>3</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td rowspan="2">
                    <break/>
                  </td>
                  <td rowspan="2">
                    <break/>
                  </td>
                  <td rowspan="2">
                    <break/>
                  </td>
                  <td>I</td>
                  <td colspan="2">NR</td>
                  <td colspan="2">NR</td>
                  <td colspan="2">NR</td>
                  <td colspan="2">0.00 (95% CI −0.11 to 0.12); <italic>P</italic>&#62;.05</td>
                  <td colspan="2">0.01 (95% CI −0.15 to 0.18); <italic>P</italic>=.87</td>
                </tr>
                <tr valign="top">
                  <td>C</td>
                  <td colspan="2">NR</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                </tr>
                <tr valign="top">
                  <td colspan="14">
                    <bold>Nguyen et al, 2012, Australia [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref46">46</xref>]</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td colspan="13">
                    <bold>BMI</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td colspan="12">
                    <bold>2</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td rowspan="18">
                    <break/>
                  </td>
                  <td rowspan="8">
                    <break/>
                  </td>
                  <td rowspan="2">
                    <break/>
                  </td>
                  <td>I</td>
                  <td colspan="2">NR</td>
                  <td colspan="2">NR</td>
                  <td colspan="2">NR</td>
                  <td colspan="2">NR</td>
                  <td colspan="2">NR</td>
                </tr>
                <tr valign="top">
                  <td>C</td>
                  <td colspan="2">NR</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                </tr>
                <tr valign="top">
                  <td colspan="12">
                    <bold>12</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td rowspan="2">
                    <break/>
                  </td>
                  <td>I</td>
                  <td colspan="2">0.6 (NR)</td>
                  <td colspan="2">1.9 increase</td>
                  <td colspan="2">
                    <bold>+</bold>
                  </td>
                  <td colspan="2">0.1 (95% CI −1.2 to 1.3); <italic>P</italic>&#62;.05</td>
                  <td colspan="2">0.1 (95% CI −0.3 to 0.4); <italic>P</italic>&#62;.05</td>
                </tr>
                <tr valign="top">
                  <td>C</td>
                  <td colspan="2">0.0 (NR)</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                </tr>
                <tr valign="top">
                  <td colspan="12">
                    <bold>24</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td rowspan="2">
                    <break/>
                  </td>
                  <td>I</td>
                  <td colspan="2">0.0 (NR)</td>
                  <td colspan="2">3.2 decrease</td>
                  <td colspan="2">
                    <bold>+</bold>
                  </td>
                  <td colspan="2">0.1 (95% CI −1.2 to 1.3); <italic>P</italic>&#62;.05</td>
                  <td colspan="2">0.8 (95% CI 0.2 to 1.4); <italic>P</italic>&#60;.05</td>
                </tr>
                <tr valign="top">
                  <td>C</td>
                  <td colspan="2">1.0 (NR)</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                </tr>
                <tr valign="top">
                  <td colspan="13">
                    <bold>BMI z score</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td colspan="12">
                    <bold>2</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td rowspan="8">
                    <break/>
                  </td>
                  <td rowspan="2">
                    <break/>
                  </td>
                  <td>I</td>
                  <td colspan="2">NR</td>
                  <td colspan="2">NR</td>
                  <td colspan="2">NR</td>
                  <td colspan="2">NR</td>
                  <td colspan="2">NR</td>
                </tr>
                <tr valign="top">
                  <td>C</td>
                  <td colspan="2">NR</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                </tr>
                <tr valign="top">
                  <td colspan="12">
                    <bold>12</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td rowspan="2">
                    <break/>
                  </td>
                  <td>I</td>
                  <td colspan="2">−0.06 (NR)</td>
                  <td colspan="2">1.0 increase</td>
                  <td colspan="2">
                    <bold>+</bold>
                  </td>
                  <td colspan="2">−0.00 (95% CI −0.11 to 0.10); <italic>P</italic>&#62;.05</td>
                  <td colspan="2">−0.09 (95% CI −0.12 to −0.06); <italic>P</italic>&#60;.001</td>
                </tr>
                <tr valign="top">
                  <td>C</td>
                  <td colspan="2">−0.08 (NR)</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                </tr>
                <tr valign="top">
                  <td colspan="12">
                    <bold>24</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td rowspan="2">
                    <break/>
                  </td>
                  <td>I</td>
                  <td colspan="2">−0.2 (NR)</td>
                  <td colspan="2">5.4 decrease</td>
                  <td colspan="2">
                    <bold>+ +</bold>
                  </td>
                  <td colspan="2">−0.01 (95% CI −0.11 to 0.10); <italic>P</italic>&#62;.05</td>
                  <td colspan="2">−0.13 (95% CI −0.20 to −0.06); <italic>P</italic>&#60;.05</td>
                </tr>
                <tr valign="top">
                  <td>C</td>
                  <td colspan="2">−0.09 (NR)</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                </tr>
                <tr valign="top">
                  <td colspan="14">
                    <bold>Patrick et al, 2013, the United States [<xref ref-type="bibr" rid="ref41">41</xref>]</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td colspan="13">
                    <bold>BMI z score</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td colspan="12">
                    <bold>6</bold>
                  </td>
                </tr>
                <tr valign="bottom">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>W<sup>h</sup></td>
                  <td colspan="2">−0.1 (NR)</td>
                  <td colspan="2">4.5 decrease</td>
                  <td colspan="2">
                    <bold>+ +</bold>
                  </td>
                  <td colspan="2">NR</td>
                  <td colspan="2"><italic>P</italic>=.93</td>
                </tr>
                <tr valign="bottom">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>WG<sup>i</sup></td>
                  <td colspan="2">0.0 (NR)</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                </tr>
                <tr valign="bottom">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>WSMS<sup>j</sup></td>
                  <td colspan="2">−0.1 (NR)</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>C</td>
                  <td colspan="2">0.0 (NR)</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                  <td colspan="2">—</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td colspan="4">
                    <bold>12</bold>
                  </td>
                  <td colspan="2">
                    <bold>4.5 decrease</bold>
                  </td>
                  <td colspan="2">
                    <bold>+ +</bold>
                  </td>
                  <td colspan="2">
                    <bold>NR</bold>
                  </td>
                  <td colspan="2">
                    <bold>—</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>W</td>
                  <td colspan="2">−0.1 (NR)</td>
                  <td colspan="2">
                    <break/>
                  </td>
                  <td colspan="2">
                    <break/>
                  </td>
                  <td colspan="2">
                    <break/>
                  </td>
                  <td colspan="2">
                    <break/>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>WG</td>
                  <td colspan="2">−0.2 (NR)</td>
                  <td colspan="2">
                    <break/>
                  </td>
                  <td colspan="2">
                    <break/>
                  </td>
                  <td colspan="2">
                    <break/>
                  </td>
                  <td colspan="2">
                    <break/>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>WSMS</td>
                  <td colspan="2">−0.1 (NR)</td>
                  <td colspan="2">
                    <break/>
                  </td>
                  <td colspan="2">
                    <break/>
                  </td>
                  <td colspan="2">
                    <break/>
                  </td>
                  <td colspan="2">
                    <break/>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>
                    <break/>
                  </td>
                  <td>C</td>
                  <td colspan="2">0.0 (NR)</td>
                  <td colspan="2">
                    <break/>
                  </td>
                  <td colspan="2">
                    <break/>
                  </td>
                  <td colspan="2">
                    <break/>
                  </td>
                  <td colspan="2">
                    <break/>
                  </td>
                </tr>
              </tbody>
            </table>
            <table-wrap-foot>
              <fn id="table3fn1">
                <p><sup>a</sup>+ denotes effect size 0%–4%; + + denotes effect size 5%–9%; + + + denotes effect size ≥10%.</p>
              </fn>
              <fn id="table3fn2">
                <p><sup>b</sup>NR: not reported.</p>
              </fn>
              <fn id="table3fn3">
                <p><sup>c</sup>IT: Internet intervention group.</p>
              </fn>
              <fn id="table3fn4">
                <p><sup>b</sup>NR: not reported.</p>
              </fn>
              <fn id="table3fn5">
                <p><sup>d</sup>sLMP: Simplified Lifestyle Modification Program intervention group.</p>
              </fn>
              <fn id="table3fn6">
                <p><sup>e</sup>C: Control.</p>
              </fn>
              <fn id="table3fn7">
                <p><sup>f</sup>I: Intervention.</p>
              </fn>
              <fn id="table3fn8">
                <p><sup>g</sup>Not applicable.</p>
              </fn>
              <fn id="table3fn9">
                <p><sup>h</sup>W: website only.</p>
              </fn>
              <fn id="table3fn10">
                <p><sup>i</sup>WG: website + group.</p>
              </fn>
              <fn id="table3fn11">
                <p><sup>j</sup>WSMS: website + text messages.</p>
              </fn>
            </table-wrap-foot>
          </table-wrap>
          <p>At 3 months, Abraham et al [<xref ref-type="bibr" rid="ref35">35</xref>] investigated the mean difference in BMI (kg/m<sup>2</sup>) between the intervention and control groups and found no effect (<italic>P</italic>=.04) on BMI (kg/m<sup>2</sup>). At 6 months, 3 studies investigated the mean difference in BMI between the intervention and control groups and found no effect [<xref ref-type="bibr" rid="ref36">36</xref>-<xref ref-type="bibr" rid="ref38">38</xref>]. Two studies found significant group by time effects for mean decreases in BMI (kg/m<sup>2</sup>) from baseline to 6 months [<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref37">37</xref>]. Chen et al [<xref ref-type="bibr" rid="ref36">36</xref>] reported a decrease in BMI of 0.58 kg/m<sup>2</sup> (SE 0.13; 90% CI −0.84 to −0.40; <italic>P</italic>=.001) [<xref ref-type="bibr" rid="ref37">37</xref>] and the other study reported only a value of <italic>P</italic>&#60;.001 [<xref ref-type="bibr" rid="ref36">36</xref>]. Nguyen et al found that the intervention with adjunctive electronic contact including text messages (once per month from 2 months) compared with group-based behavioral lifestyle intervention only had no effect at 12 (BMI 0.01 kg/m<sup>2</sup>; 95% CI −1.2 to 1.3; <italic>P</italic>&#62;.05) [<xref ref-type="bibr" rid="ref40">40</xref>] or 24 months (BMI 0.01 kg/m<sup>2</sup>; 95% CI −1.2 to 1.3; <italic>P</italic>&#62;.05) [<xref ref-type="bibr" rid="ref46">46</xref>]. From baseline to 24 months, there was a significant group by time effect for BMI, with a mean decrease between the intervention and control groups of 0.8 kg/m<sup>2</sup> (95% CI 0.2 to 1.4; <italic>P</italic>&#60;.05) [<xref ref-type="bibr" rid="ref46">46</xref>].</p>
          <p>At 3 months, Mameli et al [<xref ref-type="bibr" rid="ref39">39</xref>] found comparable mean decreases in BMI z-score between the intervention and control groups (−0.03 units, 95% CI 0.14 to 0.09 vs −0.04 units, 95% CI 0.16 to 0.08, respectively), which were not significantly different (<italic>P</italic>&#62;.05) and no time effect from baseline to 3 months was observed (<italic>P</italic>=.87). At 6 months, Chen et al [<xref ref-type="bibr" rid="ref37">37</xref>] found a significant mean difference in BMI z-scores between groups of −0.15 units (SE 0.15; 90% CI −0.40 to 0.09; <italic>P</italic>=.001) and a significant decrease in BMI z-score over time between groups (−0.12 units; SE 0.03; 90% CI −0.16 to −0.07; <italic>P</italic>=.001). Jensen et al [<xref ref-type="bibr" rid="ref42">42</xref>] found that BMI z-score did not differ across the intervention and control groups at 6 months (<italic>P</italic> value not reported). However, participants in the intervention group significantly decreased BMI z-score by 0.32 units compared with baseline values (<italic>P</italic>&#60;.01), whereas the control group participants did not decrease BMI z-score over the 6 months (<italic>P</italic>=.63). Similar to the results for BMI, Nguyen et al [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref46">46</xref>] found no significant difference in BMI z-score between groups at 12 and 24 months (<italic>P</italic>&#62;.05). However, from baseline to 12 and 24 months, there was a significant group by time effect for BMI z-score, with a mean decrease between the intervention and control groups of 0.09 units (95% CI −0.12 to −0.06; <italic>P</italic>&#60;.001) and 0.13 units (95% CI −0.20 to −0.06; <italic>P</italic>&#60;.05), respectively. Patrick et al [<xref ref-type="bibr" rid="ref41">41</xref>] found no difference in BMI z-score from baseline, 6, and 12 months between groups (<italic>P</italic>=.93).</p>
        </sec>
        <sec>
          <title>Lifestyle Outcomes</title>
          <p>There was limited overlap in secondary outcomes between studies, which limited comparisons. In total, 3 studies measured blood pressure, and no consistent significant differences were shown between the intervention and control groups. Abraham et al [<xref ref-type="bibr" rid="ref35">35</xref>] found no decrease in systolic or diastolic blood pressure between the intervention and control groups. Chen et al [<xref ref-type="bibr" rid="ref37">37</xref>] found a significant reduction in diastolic blood pressure of 2.66 mmHg over 6 months between the intervention and control groups (90% CI −4.02 to −1.31; <italic>P</italic>=.001). Whereas Nguyen et al [<xref ref-type="bibr" rid="ref40">40</xref>] found the intervention group had a mean higher systolic blood pressure difference of 3 mmHg at 12 and 24 months only after adjusting for sex, age, and perceived athletic ability. Bagherniya et al [<xref ref-type="bibr" rid="ref36">36</xref>] and Nguyen et al [<xref ref-type="bibr" rid="ref40">40</xref>] found no effect of the intervention on waist circumference at 6 months or 12 and 24 months, respectively. A total of 4 studies measured physical activity using different instruments, including a 0 to 10 scale of physical activity validated in Chinese youth [<xref ref-type="bibr" rid="ref35">35</xref>], a short question adapted from the California Health Interview Survey [<xref ref-type="bibr" rid="ref37">37</xref>], and a 7-day physical activity recall interview [<xref ref-type="bibr" rid="ref41">41</xref>] or physical activity questionnaire [<xref ref-type="bibr" rid="ref36">36</xref>]. Chen et al [<xref ref-type="bibr" rid="ref37">37</xref>] observed a significant increase of 0.40 physical activity days per week in the intervention group compared with the control group over the 6 months (90% CI 0.15 to 0.66; <italic>P</italic>=.01) [<xref ref-type="bibr" rid="ref37">37</xref>] and Bagherniya et al [<xref ref-type="bibr" rid="ref36">36</xref>] found the intervention group significantly increased daily minutes of physical activity compared with controls at 6 months (<italic>P</italic>&#60;.001). Two studies assessed the quality of life using the Impact on Weight Quality of Life–Kids [<xref ref-type="bibr" rid="ref42">42</xref>] and the pediatric quality of life inventory [<xref ref-type="bibr" rid="ref41">41</xref>]. Jensen et al [<xref ref-type="bibr" rid="ref42">42</xref>] found no between-group difference in the weight-related quality of life. However, both groups demonstrated significant improvements in parent-report scores (<italic>P</italic>s&#60;.05) [<xref ref-type="bibr" rid="ref42">42</xref>], and Patrick et al [<xref ref-type="bibr" rid="ref41">41</xref>] found positive correlations between physical functioning quality of life and behavior change strategies in girls. Body fat percentage was measured in 2 studies at 6 months, and no differences were observed [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref41">41</xref>]. Dietary intakes were measured in 2 studies via short self-report questions on fruit, vegetable, and sugar-sweetened beverage intake [<xref ref-type="bibr" rid="ref37">37</xref>] or by a food frequency questionnaire [<xref ref-type="bibr" rid="ref41">41</xref>] at 6 months, and no differences were observed. Other outcomes included waist-to-height ratio, stress, depression self-efficacy, and social support for behavior change, of which none were consistent between studies.</p>
        </sec>
      </sec>
      <sec>
        <title>Study Characteristics</title>
        <p>All RCTs included in the review were published in English [<xref ref-type="bibr" rid="ref35">35</xref>-<xref ref-type="bibr" rid="ref41">41</xref>]. The median sample size was 75 participants (range 40-172 participants), with a total of 767 participants (<xref ref-type="table" rid="table4">Table 4</xref>). In all, 2 studies recruited participants from obesity clinics [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref39">39</xref>], 3 studies recruited from primary care [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref42">42</xref>], 2 studies recruited from schools [<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref38">38</xref>], and the remaining study utilized several recruitment strategies [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref45">45</xref>] (<xref ref-type="table" rid="table5">Table 5</xref>). Participants ranged in age from 12 to 18 years, with a mean age of 14.3 years (SD 0.9). All participants had overweight (BMI on 85th-95th percentile) or obesity (BMI&#62;95th percentile) with a mean BMI of 29.7 kg/m<sup>2</sup> (SD 1.6). One study reported the mean participant BMI percentile for age and sex at baseline, which was 91.5 (SD 4.2) [<xref ref-type="bibr" rid="ref42">42</xref>]. On average, 53% of participants were female (range 27%-100%). Overall, 6 studies reported participant ethnicity [<xref ref-type="bibr" rid="ref35">35</xref>-<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref42">42</xref>], with 2 studies recruiting 100% of participants who were Chinese [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref37">37</xref>]; in 1 study, 100% of the participants were Persian [<xref ref-type="bibr" rid="ref36">36</xref>]; in 1 study, 64% of the participants were white [<xref ref-type="bibr" rid="ref42">42</xref>], and the samples in the remaining 2 studies were predominately Hispanic [<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref41">41</xref>]. In all, 5 studies with a follow-up at 2 to 3 months had a median attrition rate of 6.8% (range 0%-30.4%) [<xref ref-type="bibr" rid="ref35">35</xref>-<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref40">40</xref>]. The median attrition rate increased for each subsequent follow-up: 15% at 6 to 8 months (range 0%-38.5%, n=6 studies) [<xref ref-type="bibr" rid="ref35">35</xref>-<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref42">42</xref>]; 26.9% at 12 months (range 12.3%-46.2%, n=2 studies) [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref41">41</xref>]; and 38.5% at 24 months (range 25.9%-41.1%, n=1 study) [<xref ref-type="bibr" rid="ref40">40</xref>].</p>
        <table-wrap position="float" id="table4">
          <label>Table 4</label>
          <caption>
            <p>Characteristics of included studies (n=8).</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="130"/>
            <col width="60"/>
            <col width="70"/>
            <col width="110"/>
            <col width="60"/>
            <col width="100"/>
            <col width="100"/>
            <col width="100"/>
            <col width="150"/>
            <col width="120"/>
            <thead>
              <tr valign="top">
                <td>Author, year, country</td>
                <td>Study design</td>
                <td>Total (n)</td>
                <td>I<sup>a</sup> (n)</td>
                <td>C (n)</td>
                <td>Active (months)<sup>b</sup></td>
                <td>Extended (months)<sup>b</sup></td>
                <td>Follow-up(s) (months)</td>
                <td>Attrition at follow-up(s) (%)</td>
                <td>Dropouts compared</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Abraham et al, 2015, China [<xref ref-type="bibr" rid="ref35">35</xref>]</td>
                <td>RCT<sup>c</sup></td>
                <td>48</td>
                <td>IT<sup>d</sup>: 16; sLMP<sup>e</sup>: 16</td>
                <td>16</td>
                <td>3</td>
                <td>3</td>
                <td>3, 6</td>
                <td>3 months: 0; 6 months: 0</td>
                <td>Not applicable</td>
              </tr>
              <tr valign="top">
                <td>Bagherniya et al, 2018, Iran [<xref ref-type="bibr" rid="ref36">36</xref>]</td>
                <td>RCT</td>
                <td>172</td>
                <td>87</td>
                <td>85</td>
                <td>7</td>
                <td>0</td>
                <td>3.5, 7</td>
                <td>3.5 months: I: 10.3; C<sup>f</sup>: 2.4; 7 months: I: 16.1; C: 4.7</td>
                <td>Not reported</td>
              </tr>
              <tr valign="top">
                <td>Chen et al, 2017, the United States [<xref ref-type="bibr" rid="ref37">37</xref>]</td>
                <td>RCT</td>
                <td>40</td>
                <td>23</td>
                <td>17</td>
                <td>3</td>
                <td>3</td>
                <td>3, 6</td>
                <td>3 months: I: 0; C: 0; 6 months: I: 8.7; C: 11.8</td>
                <td>Not reported</td>
              </tr>
              <tr valign="top">
                <td>Jensen et al, 2019, the United States [<xref ref-type="bibr" rid="ref42">42</xref>]</td>
                <td>RCT</td>
                <td>47</td>
                <td>29</td>
                <td>18</td>
                <td>6</td>
                <td>0</td>
                <td>6</td>
                <td>6 months: I: 34; C: 33</td>
                <td>No difference</td>
              </tr>
              <tr valign="top">
                <td>Love-Osborne et al, 2016, the United States [<xref ref-type="bibr" rid="ref38">38</xref>]</td>
                <td>RCT</td>
                <td>165</td>
                <td>TM<sup>g</sup>: 38; NTM<sup>h</sup>: 44</td>
                <td>83</td>
                <td>6-8</td>
                <td>0</td>
                <td>6-8</td>
                <td>I: 5; C: 11</td>
                <td>No difference</td>
              </tr>
              <tr valign="top">
                <td>Mameli et al, 2018, Italy [<xref ref-type="bibr" rid="ref39">39</xref>]</td>
                <td>RCT</td>
                <td>43</td>
                <td>23</td>
                <td>20</td>
                <td>3</td>
                <td>0</td>
                <td>3</td>
                <td>I: 30.4; C: 25</td>
                <td>No difference</td>
              </tr>
              <tr valign="top">
                <td>Nguyen et al, 2012, Australia [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref46">46</xref>]</td>
                <td>RCT</td>
                <td>151</td>
                <td>73</td>
                <td>78</td>
                <td>2</td>
                <td>22</td>
                <td>2, 12, 24</td>
                <td>2 months: I: 6.8; C: 11.5; 12 months: I: 12.3; C: 15.4; 24 months: I: 41.1; C: 35.9</td>
                <td>No difference</td>
              </tr>
              <tr valign="top">
                <td>Patrick et al, 2013, the United States [<xref ref-type="bibr" rid="ref41">41</xref>]</td>
                <td>RCT</td>
                <td>101</td>
                <td>W<sup>i</sup>: 26; WG<sup>j</sup>: 26; WSMS<sup>k</sup>: 24</td>
                <td>25</td>
                <td>12</td>
                <td>0</td>
                <td>6, 12</td>
                <td>6 months: W: 31.0; WG: 38.5; WSMS: 22.7; C: 37.5; 12 months: W: 31.0; WG: 46.2; WSMS: 22.7; C: 33.3</td>
                <td>No difference</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table4fn1">
              <p><sup>a</sup>I: intervention.</p>
            </fn>
            <fn id="table4fn2">
              <p><sup>b</sup>Intervention duration.</p>
            </fn>
            <fn id="table4fn3">
              <p><sup>c</sup>RCT: randomized controlled trial.</p>
            </fn>
            <fn id="table4fn4">
              <p><sup>d</sup>IT: Internet intervention group.</p>
            </fn>
            <fn id="table4fn5">
              <p><sup>e</sup>sLMP: Simplified Lifestyle Modification Program intervention group.</p>
            </fn>
            <fn id="table4fn6">
              <p><sup>f</sup>C: control.</p>
            </fn>
            <fn id="table4fn7">
              <p><sup>g</sup>TM: text message.</p>
            </fn>
            <fn id="table4fn8">
              <p><sup>h</sup>NTM: no text message.</p>
            </fn>
            <fn id="table4fn9">
              <p><sup>i</sup>W: website only.</p>
            </fn>
            <fn id="table4fn10">
              <p><sup>j</sup>WG: website + group.</p>
            </fn>
            <fn id="table4fn11">
              <p><sup>k</sup>WSMS: website + text messages.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
        <table-wrap position="float" id="table5">
          <label>Table 5</label>
          <caption>
            <p>Characteristics of participants from included studies (n=8).</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="160"/>
            <col width="180"/>
            <col width="100"/>
            <col width="110"/>
            <col width="90"/>
            <col width="110"/>
            <col width="100"/>
            <col width="150"/>
            <thead>
              <tr valign="top">
                <td>Author, year, country</td>
                <td>Recruitment of population</td>
                <td>Age range, years</td>
                <td>Age (years), mean (IQR or SD)</td>
                <td>BMI range</td>
                <td>BMI (kg/m<sup>2</sup>), mean (IQR or SD)</td>
                <td>Female (%)</td>
                <td>Ethnicity, other SES<sup>a</sup> factors (%)</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Abraham et al, 2015, China [<xref ref-type="bibr" rid="ref35">35</xref>]</td>
                <td>Obesity clinic</td>
                <td>12-18</td>
                <td>IT<sup>b</sup>: 14.9<sup>c</sup> (13.7-16.2); sLMP<sup>d</sup>: 14.1<sup>c</sup> (13.5-15.3); C<sup>e</sup>: 14.3<sup>c</sup> (13.5-15.8)</td>
                <td>&#62;95th</td>
                <td>IT: 29.3<sup>c</sup> (26.7-30.9); sLMP: 31.5<sup>c</sup> (29.8-33.7); C: 30.1<sup>c</sup> (28.4-32.3)</td>
                <td>39.6</td>
                <td>Chinese: 100; Parent tertiary education: 27</td>
              </tr>
              <tr valign="top">
                <td>Bagherniya et al, 2018, Iran [<xref ref-type="bibr" rid="ref36">36</xref>]</td>
                <td>Government and private schools</td>
                <td>12-16</td>
                <td>I<sup>f</sup>: 13.5 (0.7); C: 13.4 (0.6)</td>
                <td>≥85th</td>
                <td>I: 29.2 (3.9); C: 27.2 (2.9)</td>
                <td>100</td>
                <td>Persian: 100; Parent tertiary education: 100</td>
              </tr>
              <tr valign="top">
                <td>Chen et al, 2017, the United States [<xref ref-type="bibr" rid="ref37">37</xref>]</td>
                <td>Primary care providers</td>
                <td>13-18</td>
                <td>I: 15.0 (1.7); C: 14.8 (1.6)</td>
                <td>≥85th</td>
                <td>I: 27.4 (3.3); C: 28.4 (4.4)</td>
                <td>42</td>
                <td>Chinese American: 100; Parent mean years of education: 10</td>
              </tr>
              <tr valign="top">
                <td>Jensen et al, 2019, the United States [<xref ref-type="bibr" rid="ref42">42</xref>]</td>
                <td>Primary care pediatric practices</td>
                <td>12-18</td>
                <td>15.0 (1.5)</td>
                <td>≥85th; &#60;95</td>
                <td>91.5 (4.2) (BMI %)</td>
                <td>79</td>
                <td>Hispanic: 23; African American: 2</td>
              </tr>
              <tr valign="top">
                <td>Love-Osborne et al, 2016, the United States [<xref ref-type="bibr" rid="ref38">38</xref>]</td>
                <td>Public schools</td>
                <td>12-18</td>
                <td>I: 15.7 (1.5); C: 16.0 (1.5)</td>
                <td>≥85th</td>
                <td>I: 31.9 (6.2); C: 31.6 (6.5)</td>
                <td>I: 58; C: 46</td>
                <td>Hispanic: I: 88 and C: 89</td>
              </tr>
              <tr valign="top">
                <td>Mameli et al, 2018, Italy [<xref ref-type="bibr" rid="ref39">39</xref>]</td>
                <td>Obesity clinic</td>
                <td>10-17</td>
                <td>I: 12.6 (1.7<sup>g</sup>); C: 12.4 (2.2<sup>g</sup>)</td>
                <td>≥95th</td>
                <td>I: 29.6 (3.3<sup>g</sup>); C: 28.6 (2.6<sup>g</sup>)</td>
                <td>I: 31<sup>g</sup>; C:43<sup>g</sup></td>
                <td>Parent tertiary education: 17<sup>g</sup></td>
              </tr>
              <tr valign="top">
                <td>Nguyen et al, 2012, Australia [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref46">46</xref>]</td>
                <td>Media, schools, health professionals and community organizations</td>
                <td>13-16</td>
                <td>I: 14.0 (0.9); C: 14.2 (1.0)</td>
                <td>1.0-2.5<sup>h</sup></td>
                <td>I: 30.8 (4.2); C: 30.8 (3.5)</td>
                <td>27</td>
                <td>Not reported</td>
              </tr>
              <tr valign="top">
                <td>Patrick et al, 2013, the United States [<xref ref-type="bibr" rid="ref41">41</xref>]</td>
                <td>Pediatric primary care</td>
                <td>12-16</td>
                <td>W<sup>i</sup>: 14.1 (1.4); WG<sup>j</sup>: 14.3 (1.5); WSMS<sup>k</sup>: 14.3 (1.8); C: 14.5 (1.5)</td>
                <td>&#62;85th</td>
                <td>W: 2.2 (0.07)<sup>l</sup>; WG: 2.2 (0.07)<sup>l</sup>; WSMS: 2.2 (0.07)<sup>l</sup>; C: 2.2 (0.07)<sup>l</sup></td>
                <td>63</td>
                <td>Hispanic: 74</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table5fn1">
              <p><sup>a</sup>SES: socioeconomic status.</p>
            </fn>
            <fn id="table5fn2">
              <p><sup>b</sup>IT: Internet intervention group.</p>
            </fn>
            <fn id="table5fn3">
              <p><sup>c</sup>Median age and BMI (IQR).</p>
            </fn>
            <fn id="table5fn4">
              <p><sup>d</sup>sLMP: Simplified Lifestyle Modification Program intervention group.</p>
            </fn>
            <fn id="table5fn5">
              <p><sup>e</sup>C: control.</p>
            </fn>
            <fn id="table5fn6">
              <p><sup>f</sup>I: intervention.</p>
            </fn>
            <fn id="table5fn7">
              <p><sup>g</sup>Completers-only data</p>
            </fn>
            <fn id="table5fn8">
              <p><sup>h</sup>95% confidence intervals</p>
            </fn>
            <fn id="table5fn9">
              <p><sup>i</sup>W: website only.</p>
            </fn>
            <fn id="table5fn10">
              <p><sup>j</sup>WG: website + group.</p>
            </fn>
            <fn id="table5fn11">
              <p><sup>k</sup>WSMS: website + text messages.</p>
            </fn>
            <fn id="table5fn12">
              <p><sup>l</sup>BMI z-score (standard error).</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
      </sec>
      <sec>
        <title>Intervention Characteristics</title>
        <p>A total of 5 studies were two-arm RCTs [<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref42">42</xref>], 2 were three-arm RCTs [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref38">38</xref>], and 1 a four-arm RCT (<xref ref-type="table" rid="table5">Table 5</xref>) [<xref ref-type="bibr" rid="ref41">41</xref>]. The median active intervention period was 4.5 months (range 2-12 months) and 2 studies had an extended intervention period of 3 months [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref37">37</xref>], and 1 had 22 months [<xref ref-type="bibr" rid="ref40">40</xref>]. In all, 5 studies followed up participants at 2 to 3 months [<xref ref-type="bibr" rid="ref35">35</xref>-<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref40">40</xref>], 6 studies at 6 to 7 months [<xref ref-type="bibr" rid="ref35">35</xref>-<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref42">42</xref>], 2 studies at 12 months [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref41">41</xref>] and 1 study at 24 months [<xref ref-type="bibr" rid="ref40">40</xref>]. All interventions were multicomponent, and no interventions were delivered solely via text messages (<xref ref-type="table" rid="table6">Table 6</xref>). Two studies had intervention groups consisting of Web-based educational modules delivered via a website and text messages [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref41">41</xref>]; 2 studies had intervention groups which provided participants wearable devices and access to smartphone apps and text messages [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref39">39</xref>], and the remaining 4 studies had intervention groups which involved in-person individual or group sessions with health professionals and text messages [<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref42">42</xref>]. In all, 4 studies were grounded in the social cognitive theory [<xref ref-type="bibr" rid="ref35">35</xref>-<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref40">40</xref>]. Overall, 2 studies were primarily set in an obesity clinic [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref39">39</xref>], 2 in high schools [<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref38">38</xref>], 3 in primary care [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref42">42</xref>], and 1 was mostly online [<xref ref-type="bibr" rid="ref41">41</xref>]. The majority of studies encouraged peer support from parents, and all studies included interactions with research and health professionals. Control conditions consisted of usual care, with 6 of the 8 studies including control conditions with in-person educational or information sessions [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref39">39</xref>-<xref ref-type="bibr" rid="ref42">42</xref>].</p>
        <p>The median number of text messages sent each week was 1.5 (range 1-21 text messages; <xref ref-type="table" rid="table7">Table 7</xref>). One study specified that 3 text messages were sent each day; however, it was not specified if this was every day [<xref ref-type="bibr" rid="ref42">42</xref>]. In this study, control participants also received a form of control text messages, and both groups demonstrated reductions in BMI z-score [<xref ref-type="bibr" rid="ref42">42</xref>]. In all, 4 studies used one-way text messages (participants unable to reply) [<xref ref-type="bibr" rid="ref36">36</xref>-<xref ref-type="bibr" rid="ref39">39</xref>] and 4 studies used two-way text messages (participants able to respond) [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref40">40</xref>-<xref ref-type="bibr" rid="ref42">42</xref>]. A total of 4 studies had personalized text messages [<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref42">42</xref>], 2 studies had semipersonalized text messages [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref40">40</xref>], and 2 studies did not have personalized text messages [<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref37">37</xref>]. Overall, 6 studies utilized text messages in the active intervention phase, ranging from 17% to 100% of the intervention contact points [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref42">42</xref>]. In all, 2 studies utilized text messages only in the extended intervention phase accounting for 100% [<xref ref-type="bibr" rid="ref37">37</xref>] and 60% [<xref ref-type="bibr" rid="ref40">40</xref>] of the intervention contact points. Both studies with text messages only in the extended phase had significant between-group differences in BMI or BMI z-score at the end of follow-up [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref40">40</xref>]. The 4 studies, which personalized the text messages, had text message content–related individual behavioral goals [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref38">38</xref>] or utilized data from wearables [<xref ref-type="bibr" rid="ref39">39</xref>] or self-reported text messages [<xref ref-type="bibr" rid="ref42">42</xref>] to provide personalized feedback on lifestyle behaviors. All 4 studies did not significantly affect BMI outcomes. The BCTs used in the text messages are presented in <xref ref-type="supplementary-material" rid="app5">Multimedia Appendix 5</xref>. The number of domains ranged from 3 to 5, with all text messages in each study utilizing goals and planning and credible source. The number of BCTs ranged from 4 to 8, with all text messages in each study using goal setting for behaviors and credible source.</p>
        <p>A total of 3 studies provided details about the development of the intervention content broadly [<xref ref-type="bibr" rid="ref37">37</xref>] or text messages [<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref42">42</xref>]. Abraham et al [<xref ref-type="bibr" rid="ref35">35</xref>] conducted focus groups with 11 Chinese American adolescents asking open-ended questions about the use of text messages in the program, and adolescents agreed that individualized weekly text message reminders could be a good way to enhance motivation to adopt healthy behaviors. No further details about the text message development were provided. Chen et al [<xref ref-type="bibr" rid="ref37">37</xref>] formed an advisory group consisting of two primary care physicians and four adolescents and consulted other adolescents (n=10) via a focus group. The advisory group identified the purpose and goals of the intervention and focus groups and piloted the procedures and appropriateness of the intervention content. Adolescents <italic>liked the program</italic> and minor changes were made. No specific details relating to text message development were provided. In a separate publication, Jensen et al [<xref ref-type="bibr" rid="ref24">24</xref>] detailed the process of text message development. The iterative process involved the development of an evidence-based text message bank by the research team, which was then tested in a pilot study with 20 adolescents (mean age 14 years, 85% female, 77% white) who received 1 text message per day for 3 months [<xref ref-type="bibr" rid="ref24">24</xref>]. Feedback was provided at monthly intervals and at the end of the study. Overall, participants liked the text messages, liked receiving them after school, and they could recall topics the text messages addressed. The most popular text messages were recipe ideas, followed by testimonials and messages with pictures. Most found the messages personally relevant, and messages helped them to make healthy choices and kept them focused on weight management. A greater variety of messages were suggested. The findings informed the RCT.</p>
        <p>In total, 6 studies provided results related to the rates of replies of text messages during the intervention. Abraham et al [<xref ref-type="bibr" rid="ref35">35</xref>] found 78.3% of participants responded to text messages about diet goals and 77.5% of participants responded to text messages about exercise goals. In a study by Nguyen et al [<xref ref-type="bibr" rid="ref40">40</xref>], response rates were lower, with messages about healthy eating and booster session reinforcement having the highest reply rates (42% and 34%, respectively), whereas text messages about self-esteem or stress management had the lowest response rates (4%). Jensen et al [<xref ref-type="bibr" rid="ref42">42</xref>] found over 6 months that intervention participants sent self-monitoring text messages on 47% of intervention days compared with only 22% control participants [<xref ref-type="bibr" rid="ref42">42</xref>]. Intervention participants demonstrated significantly higher self-monitoring adherence (<italic>P</italic>&#60;.01) than control participants. The 3 text messages per day were helpful for 85% of intervention participants. However, 69% of intervention participants found the text message content annoying and repetitive. Over half (54%) would prefer fewer and more personalized text messages.</p>
        <p>Love-Osborne et al [<xref ref-type="bibr" rid="ref38">38</xref>] sent an average of 12 personal goal-related text messages and 12 text messages to remind participants to return log sheets about their weekly weight and lifestyle behaviors. However, it was reported that only few adolescents turned in log sheets in either group. Only 1 study asked participants to rate the helpfulness of text messages, with 27 of 39 adolescents rating the messages <italic>somewhat helpful</italic> or <italic>very helpful</italic> [<xref ref-type="bibr" rid="ref40">40</xref>]. One study, which included Fitbit and website education resource in addition to text messages, found that the 100% of participants would recommend the program to others and 91% shared the Fitbit data with their primary care provider [<xref ref-type="bibr" rid="ref37">37</xref>]. Only 1 study detailed that text messages were sent from an automated computer system capable of tailoring the text messages using an algorithm based on participant feedback via text message [<xref ref-type="bibr" rid="ref42">42</xref>]. No other studies provided details about the system or infrastructure used to deliver the text messages. One study reported a research assistant spent 2 hours per week sending personalized text messages [<xref ref-type="bibr" rid="ref35">35</xref>].</p>
        <table-wrap position="float" id="table6">
          <label>Table 6</label>
          <caption>
            <p>Characteristics of interventions (n=8).</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="30"/>
            <col width="180"/>
            <col width="80"/>
            <col width="110"/>
            <col width="100"/>
            <col width="170"/>
            <col width="160"/>
            <col width="170"/>
            <thead>
              <tr valign="top">
                <td colspan="2">Author, year, country, and intervention description</td>
                <td>Theory</td>
                <td>Setting</td>
                <td>Peer support</td>
                <td>Intervention personnel interaction</td>
                <td>Comparator description</td>
                <td>Comparator personnel interaction</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td colspan="8">
                  <bold>Abraham et al, 2015, China [<xref ref-type="bibr" rid="ref35">35</xref>]</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>IT<sup>a</sup>: usual care + 12 website lessons + text messages</td>
                <td>TTM<sup>b</sup>; SCT<sup>c</sup></td>
                <td>Obesity clinic; website; mobile phone</td>
                <td>Parents</td>
                <td>IT: usual care</td>
                <td>Usual care: physician check-ups with obesity counselling</td>
                <td>3 in-person sessions for adolescents with their parent(s)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>sLMP<sup>d</sup>: usual care+ 4 counselling sessions</td>
                <td>SCT</td>
                <td>Obesity clinic</td>
                <td>Parents</td>
                <td>sLMP: usual care + 4 in-person counselling sessions with nutritionist</td>
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
              </tr>
              <tr valign="top">
                <td colspan="8">
                  <bold>Bagherniya et al, 2018, Iran [<xref ref-type="bibr" rid="ref36">36</xref>]</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>I<sup>e</sup>: 14 sports workshops + 7 counselling sessions + up to 60 fun exercise sessions + up to 60 competitive sports sessions + up to 3 family activity sessions + text messages<sup>f</sup></td>
                <td>SCT</td>
                <td>School; local gyms; mobile phone</td>
                <td>Parents; teachers</td>
                <td>I: 14 in-person sport group workshops (personnel not specified) + 7 in-person sports counselling sessions (personnel not specified) + up to 56 fun group exercise sessions with specialist in physical education</td>
                <td>Control group: education classes, lectures, printed handbook</td>
                <td>3 in-person educational classes for adolescents; 2 in-person lectures for parents/teachers</td>
              </tr>
              <tr valign="top">
                <td colspan="8">
                  <bold>Chen et al, 2017, the United States [<xref ref-type="bibr" rid="ref37">37</xref>]</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>I: Fitbit Flex monitoring device + APP<sup>g</sup> for self-monitoring diet, physical activity + iStart Smart 8-module online education program with in-app messages + text messages (extended intervention only)</td>
                <td>SCT</td>
                <td>Primary care; mobile phone</td>
                <td>Nil</td>
                <td>I: In-person demonstrations on how to access Fitbit data and iSmart 8-module online education program</td>
                <td>Control group: pedometer, paper food and activity diary, 8 module online program</td>
                <td>Nil</td>
              </tr>
              <tr valign="top">
                <td colspan="8">
                  <bold>Jensen et al, 2019, the United States [<xref ref-type="bibr" rid="ref42">42</xref>]</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>I: Single in-person 50 min MI<sup>h</sup> session + self-monitoring and adaptive text messages</td>
                <td>MI</td>
                <td>Primary care</td>
                <td>Nil</td>
                <td>I: Single in-person MI session with a clinical physiologist doctoral student designed to elicit motivation for change, assess potential barriers to change, and reinforce weight-related behavior change talk and education on Stoplight Eating Plan</td>
                <td>Control group: In-person MI session + self-monitoring text messages</td>
                <td>1 in-person MI session</td>
              </tr>
              <tr valign="top">
                <td colspan="8">
                  <bold>Love-Osborne et al, 2016, the United States [<xref ref-type="bibr" rid="ref38">38</xref>]</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>I: Health Educator visits + paper-based self-monitoring log sheet + text messages (TMs<sup>i</sup> subgroup of intervention group)<sup>j</sup></td>
                <td>MI</td>
                <td>School; mobile phone</td>
                <td>Nil</td>
                <td>I: Up to 8 in-person visits with health educator</td>
                <td>Not reported</td>
                <td>Not reported</td>
              </tr>
              <tr valign="top">
                <td colspan="8">
                  <bold>Mameli et al, 2018, Italy [<xref ref-type="bibr" rid="ref39">39</xref>]</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>I: Participants provided a WB<sup>k</sup> + APP and asked to record the real-time food intake</td>
                <td>Not reported</td>
                <td>Obesity clinic; mobile phone</td>
                <td>Parents</td>
                <td>I: In-person training session on how to use WB and APP</td>
                <td>Control group: Mediterranean diet advice + instruction to increase physical activity and decrease sedentary time</td>
                <td>1 in-person baseline information session</td>
              </tr>
              <tr valign="top">
                <td colspan="8">
                  <bold>Nguyen et al, 2012, Australia [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref46">46</xref>]</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>I: Loozit group program of seven 75-min group sessions during active phase + seven 60-min group sessions during extended phase + ATC<sup>l</sup> including 32 emails or text messages+ 14 TC<sup>m</sup> sessions</td>
                <td>SCT</td>
                <td>Primary care; hospital; mobile phone</td>
                <td>Parents</td>
                <td>I: Active phase, 7 in-person group sessions with trained dietitians + Extended phase, 7 in-person group sessions + 32 emails or text messages + 14 TC sessions all with trained dietitians</td>
                <td>Control group: Loozit Program only</td>
                <td>Active phase, 7 in-person group sessions with trained dietitians + Extended phase, 7 in-person group sessions with trained dietitians</td>
              </tr>
              <tr valign="top">
                <td colspan="8">
                  <bold>Patrick et al, 2013, the United States [<xref ref-type="bibr" rid="ref41">41</xref>]</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>WSMS<sup>n</sup>: W<sup>o</sup> + text messages</td>
                <td>BDM<sup>p</sup>; TTM</td>
                <td>Website; mobile phone</td>
                <td>Nil</td>
                <td>WSMS: communication with health counsellor via text message</td>
                <td>Control group: printed educational material + encouraged to attend three 60-min group nutrition sessions at local hospital + monthly mailed tip sheets</td>
                <td>Up to 3 in-person group nutrition sessions</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>WG<sup>q</sup>: W + 12 90-min group sessions + 24 health coaching calls</td>
                <td>BDM; TTM</td>
                <td>Website</td>
                <td>Parents</td>
                <td>WG: In-person group sessions with health counsellor</td>
                <td>Not reported</td>
                <td>Not reported</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>W: wkly check-in emails + monthly mailed tip sheets + access to program website + website tutorials</td>
                <td>BDM; TTM</td>
                <td>Website</td>
                <td>Nil</td>
                <td>W: communication with health counsellor via email</td>
                <td>Not reported</td>
                <td>Not reported</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table6fn1">
              <p><sup>a</sup>IT: Internet intervention group.</p>
            </fn>
            <fn id="table6fn2">
              <p><sup>b</sup>TTM: transtheoretical model.</p>
            </fn>
            <fn id="table6fn3">
              <p><sup>c</sup>SCT: social cognitive theory.</p>
            </fn>
            <fn id="table6fn4">
              <p><sup>d</sup>sLMP: Simplified Lifestyle Modification Program intervention group.</p>
            </fn>
            <fn id="table6fn5">
              <p><sup>e</sup>I: intervention.</p>
            </fn>
            <fn id="table6fn6">
              <p><sup>f</sup>In addition, parent text messages and newsletters and increased sports equipment in schools.</p>
            </fn>
            <fn id="table6fn7">
              <p><sup>g</sup>APP: smartphone app.</p>
            </fn>
            <fn id="table6fn8">
              <p><sup>h</sup>MI: motivational interviewing.</p>
            </fn>
            <fn id="table6fn9">
              <p><sup>i</sup>TMs: text messages group.</p>
            </fn>
            <fn id="table6fn10">
              <p><sup>j</sup>All participants in the intervention group (TMs and NTMs) were offered text messages during the second school semester.</p>
            </fn>
            <fn id="table6fn11">
              <p><sup>k</sup>WB: wristband.</p>
            </fn>
            <fn id="table6fn12">
              <p><sup>l</sup>ATC: additional therapeutic contact.</p>
            </fn>
            <fn id="table6fn13">
              <p><sup>m</sup>TC: telephone coaching.</p>
            </fn>
            <fn id="table6fn14">
              <p><sup>n</sup>WSMS: website + text messages.</p>
            </fn>
            <fn id="table6fn15">
              <p><sup>o</sup>W: website only.</p>
            </fn>
            <fn id="table6fn16">
              <p><sup>p</sup>BDM: behavioral determinants model.</p>
            </fn>
            <fn id="table6fn17">
              <p><sup>q</sup>WG: website + group.</p>
            </fn>
            <fn id="table6fn18">
              <p><sup>r</sup>Separate sessions for adolescents and parents or caregivers.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
        <table-wrap position="float" id="table7">
          <label>Table 7</label>
          <caption>
            <p>Text message details of included studies (n=8).</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="160"/>
            <col width="110"/>
            <col width="100"/>
            <col width="120"/>
            <col width="350"/>
            <col width="160"/>
            <thead>
              <tr valign="bottom">
                <td>Author, year, country</td>
                <td>Duration, n</td>
                <td>Direction</td>
                <td>Personalized</td>
                <td>Content</td>
                <td>Intervention (%)<sup>a</sup></td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Abraham et al, 2015, China [<xref ref-type="bibr" rid="ref35">35</xref>]</td>
                <td>1/week</td>
                <td>Two-way</td>
                <td>Semi</td>
                <td>Individual diet and exercise goals</td>
                <td>Active: 46; Extended: 100</td>
              </tr>
              <tr valign="top">
                <td>Bagherniya et al, 2018, Iran [<xref ref-type="bibr" rid="ref36">36</xref>]</td>
                <td>1/week</td>
                <td>One-way</td>
                <td>No</td>
                <td>Main goals of program, strategies to overcome barriers</td>
                <td>Active: 17</td>
              </tr>
              <tr valign="top">
                <td>Chen et al, 2017, the United States [<xref ref-type="bibr" rid="ref37">37</xref>]</td>
                <td>2/week</td>
                <td>One-way</td>
                <td>No</td>
                <td>Reinforced adoption and maintenance of healthy lifestyles and weight management practices</td>
                <td>Active: 0; Extended: 100</td>
              </tr>
              <tr valign="top">
                <td>Jensen et al, 2019, the United States [<xref ref-type="bibr" rid="ref42">42</xref>]</td>
                <td>3/day</td>
                <td>Two-way</td>
                <td>Yes</td>
                <td>Self-monitoring text messages: participants sent text messages reporting 4 behaviors; Adaptive text messages: Evidenced-based intervention content delivered in a gain-frame format (indicating what might be gained from adopting healthier behaviors)</td>
                <td>Active: 100</td>
              </tr>
              <tr valign="top">
                <td>Love-Osborne et al, 2016, the United States [<xref ref-type="bibr" rid="ref38">38</xref>]</td>
                <td>2/week</td>
                <td>One-way</td>
                <td>Yes</td>
                <td>One individualized goal-related text message and one reminder to return self-monitoring log sheet</td>
                <td>Active: 93</td>
              </tr>
              <tr valign="top">
                <td>Mameli et al, 2018, Italy [<xref ref-type="bibr" rid="ref39">39</xref>]</td>
                <td>1/week</td>
                <td>One-way</td>
                <td>Yes</td>
                <td>Using previous 7-day WB<sup>b</sup> and app data, feedback about dietary compliance and quality, energy gap, sedentary time, physical activity and suggestions on how to reach each of 5 goals</td>
                <td>Active: 100</td>
              </tr>
              <tr valign="top">
                <td>Nguyen et al, 2012, Australia [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref46">46</xref>]</td>
                <td>1/month</td>
                <td>Two-way</td>
                <td>Semi</td>
                <td>Reinforce key healthy lifestyle principles covered during the active phase and extended phase group sessions</td>
                <td>Active: 0; Extended: 60</td>
              </tr>
              <tr valign="top">
                <td>Patrick et al, 2013, the United States [<xref ref-type="bibr" rid="ref41">41</xref>]</td>
                <td>3/week</td>
                <td>Two-way</td>
                <td>Yes</td>
                <td>Related to weekly challenges and intervention goals</td>
                <td>Active: 75</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table7fn1">
              <p><sup>a</sup>Percentage of intervention delivered by text message was determined by (number of text message contact points ÷ total number of contact points)×100. Each in-person session, website session, or text message is counted as one contact point.</p>
            </fn>
            <fn id="table7fn2">
              <p><sup>b</sup>WB: wristband.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
      </sec>
      <sec>
        <title>Risk of Bias Assessment</title>
        <sec>
          <title>Cochrane Risk of Bias Assessment</title>
          <p>Overall, the majority of studies were classified as having a low or unclear risk of bias across all main sources of bias (<xref rid="figure2" ref-type="fig">Figure 2</xref> and <xref ref-type="supplementary-material" rid="app6">Multimedia Appendix 6</xref>). In all, 5 studies described a random component in the sequence generation process, permitting a judgment of low risk of bias for random sequence generation [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref42">42</xref>]; 5 studies provided insufficient information to determine if the allocation was adequately concealed [<xref ref-type="bibr" rid="ref36">36</xref>-<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref41">41</xref>]; and 7 studies did not provide adequate information to determine if there was blinding of participants and personnel to the intervention [<xref ref-type="bibr" rid="ref35">35</xref>-<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref40">40</xref>-<xref ref-type="bibr" rid="ref42">42</xref>]. One study stated that there was no blinding and was classified as high risk [<xref ref-type="bibr" rid="ref39">39</xref>]. One study has blinded outcome assessment [<xref ref-type="bibr" rid="ref36">36</xref>], 1 study had no blinding of outcome assessment [<xref ref-type="bibr" rid="ref39">39</xref>], and the remaining studies were unclear [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref40">40</xref>-<xref ref-type="bibr" rid="ref42">42</xref>]. A total of 7 studies adequately addressed incomplete data permitting a judgment of low risk of bias [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref37">37</xref>-<xref ref-type="bibr" rid="ref42">42</xref>]. Overall, 4 studies were rated low risk of bias for selected reporting as they provided a study protocol or trial registration which prespecified all outcome [<xref ref-type="bibr" rid="ref35">35</xref>-<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref40">40</xref>].</p>
          <fig id="figure2" position="float">
            <label>Figure 2</label>
            <caption>
              <p>Risk of bias assessment summary.</p>
            </caption>
            <graphic xlink:href="mhealth_v8i5e15849_fig2.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
          </fig>
        </sec>
        <sec>
          <title>Grading of Recommendations Assessment, Development, and Evaluation Overall Assessment</title>
          <p>The search attempted to identify all interventions for weight loss or management in adolescents delivered via text messages to answer the research question. In the body of studies identified (n=8), there were limitations in study design, variant populations, complex interventions, and potential publication bias resulting in an overall low-quality rating (<xref ref-type="table" rid="table8">Table 8</xref>).</p>
          <table-wrap position="float" id="table8">
            <label>Table 8</label>
            <caption>
              <p>Overall assessment of quality in 8 studies (767 participants in total) of weight loss or weight management interventions in adolescents delivered via text message using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system.</p>
            </caption>
            <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
              <col width="270"/>
              <col width="730"/>
              <thead>
                <tr valign="top">
                  <td>Category</td>
                  <td>Rating with reason</td>
                </tr>
              </thead>
              <tbody>
                <tr valign="top">
                  <td>Study limitations</td>
                  <td>−2 quality levels due to very serious limitations</td>
                </tr>
                <tr valign="top">
                  <td>Consistency</td>
                  <td>No subtraction in levels</td>
                </tr>
                <tr valign="top">
                  <td>Directness</td>
                  <td>−1 quality level, as the interventions are indirect</td>
                </tr>
                <tr valign="top">
                  <td>Precision</td>
                  <td>No subtraction of levels due to good precision</td>
                </tr>
                <tr valign="top">
                  <td>Publication bias</td>
                  <td>−1 quality level, as publication bias cannot be ruled out</td>
                </tr>
                <tr valign="top">
                  <td>Overall quality</td>
                  <td>Low: our confidence in the effect estimate is limited</td>
                </tr>
              </tbody>
            </table>
          </table-wrap>
        </sec>
        <sec>
          <title>Study Limitations</title>
          <p>All 8 included studies were RCTs. However, within each of the primary sources of bias, there was insufficient information to permit judgments. In all, 3 studies did not provide sufficient detail on the random sequence generation [<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref41">41</xref>], and 5 studies did not provide adequate detail on the allocation concealment to permit judgment based on selection bias [<xref ref-type="bibr" rid="ref36">36</xref>-<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref41">41</xref>]. A total of 7 studies did not provide sufficient detail of blinding methods for participants and personnel [<xref ref-type="bibr" rid="ref35">35</xref>-<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref40">40</xref>-<xref ref-type="bibr" rid="ref42">42</xref>], and 1 study did not blind participants and personnel [<xref ref-type="bibr" rid="ref39">39</xref>]. The blinding of the outcome assessment was unclearly described in 6 studies [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref40">40</xref>-<xref ref-type="bibr" rid="ref42">42</xref>], and 1 study did not blind participants or personnel to the outcome assessment [<xref ref-type="bibr" rid="ref39">39</xref>]. Attrition bias was rated as low risk in 7 studies, and the median attrition rate was below 20% at 3 and 6 months [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref37">37</xref>-<xref ref-type="bibr" rid="ref41">41</xref>]. However, attrition rates increased above 20% for the 2 studies with 12- and 24-month follow-ups [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref41">41</xref>]. Reporting bias was rated as low risk in 4 studies [<xref ref-type="bibr" rid="ref35">35</xref>-<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref40">40</xref>] and unclear in 4 studies due to insufficient information reported in the publication [<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref42">42</xref>], further limiting the quality of the body of evidence.</p>
        </sec>
        <sec>
          <title>Consistency</title>
          <p>Overall, 4 of the 5 studies found the interventions with text messages did not significantly decrease BMI in intervention participants compared with control participants. Of 5 studies, 3 found the interventions with text messages did not significantly decrease BMI z-score in intervention participants compared with control participants. This result suggests a trend toward no effect. However, no studies reported any subgroup analyses on the effect of text messages only. Therefore, it cannot be determined if text messages were responsible for the intervention effect on BMI or BMI z-score.</p>
        </sec>
        <sec>
          <title>Directness</title>
          <p>Comparisons between the control and intervention arms were direct for the included interventions; variations in the study design, populations, and interventions resulted in the overall body of evidence were indirect. The population of all interventions were adolescents, 10 to 19 years. However, 3 studies recruited all adolescents who were Chinese [<xref ref-type="bibr" rid="ref35">35</xref>], Chinese American [<xref ref-type="bibr" rid="ref37">37</xref>], or Persian [<xref ref-type="bibr" rid="ref36">36</xref>], 2 studies recruited adolescents who were predominately Hispanic [<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref41">41</xref>], 1 study recruited adolescents who were predominately white [<xref ref-type="bibr" rid="ref42">42</xref>], and 2 studies did not report ethnicity of adolescent participants [<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref40">40</xref>]. Only 4 studies reported the parents’ education level (range 17%-100% with tertiary education) [<xref ref-type="bibr" rid="ref35">35</xref>-<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref39">39</xref>]. The population is not representative of the broader adolescent population.</p>
          <p>This review allowed for the inclusion of studies that used text messages as a component of a multicomponent intervention. Consequently, all studies used text messages in combination with other intervention components. In addition, 2 studies only used text messages during the extended intervention phase [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref40">40</xref>], and no studies evaluated the effectiveness of only the text message intervention delivery with respect to BMI. All studies measured BMI according to standardized procedures. However, the overall evidence is an indirect representation of the effect of weight management or weight loss interventions delivered via text messages on BMI.</p>
        </sec>
        <sec>
          <title>Precision</title>
          <p>A total of 6 studies reported power calculations and 3 studies were pilot or feasibility studies. All power calculations were based on the primary outcome of BMI (measured as BMI kg/m<sup>2</sup> or BMI z-score). Sample size varied from 40 to 172 participants, with a total of 767 participants, which is considered a sufficient body of evidence for addressing the research question.</p>
        </sec>
        <sec>
          <title>Publication Bias</title>
          <p>A comprehensive search was conducted to ensure that all the available literature was retrieved. This search included major electronic databases, hand searching of reference lists, clinical trial databases and the gray literature, and contacting authors for additional information. Also, as text messages often formed part of larger multicomponent interventions, a conservative approach for full-text screening was adopted to ensure all possible studies were included. However, we may have missed unpublished interventions with insignificant results or negative findings. Therefore, publication bias cannot be ruled out.</p>
        </sec>
      </sec>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Principal Findings</title>
        <p>In this review, we assessed 8 studies that investigated the effectiveness of interventions delivered by text messages for weight management in adolescent populations with overweight or obesity. Of the 8 studies, 7 demonstrated reductions in BMI or BMI z-score in the intervention group compared with the control group at the end of the final follow-up. The effect was only statistically significant in 1 study at 6 months [<xref ref-type="bibr" rid="ref37">37</xref>]. Significant time by group effects were observed in 3 studies [<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref40">40</xref>]. The intervention characteristics were heterogenous and multicomponent. However, in the 8 studies, text messages accounted for over 50% of intervention contact points during the active phase, and for the 3 studies with an extended intervention phase, text messages accounted for over 85% of the intervention contact points. Despite text messages accounting for large proportions of the intervention, it cannot be determined if the effects are attributable to the text messages, as no studies utilized a factorial study design and limited process evaluation data to elucidate the characteristics and effects of only text message intervention delivery on BMI outcomes. Also, the overall quality of the body of evidence was rated as low, and this restricts the conclusions that can be drawn. Taking these findings together, this review found that there is limited high-quality evidence for the effectiveness of text messages for weight management in adolescents with overweight or obesity; we, therefore, propose suggestions for improved research design.</p>
      </sec>
      <sec>
        <title>Comparison With Prior Work</title>
        <p>There were only 8 RCT studies included in this review, which utilized text messages for weight management intervention delivery in adolescent populations. The small evidence base may indicate that digital research strategies in this area is in its infancy. However, it also well-recognized that investments into research for adolescent obesity prevention have not kept pace with population growth [<xref ref-type="bibr" rid="ref48">48</xref>]. Many of the successes in childhood obesity prevention over recent times have been the result of targeted investment in interventions benefiting younger children [<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref50">50</xref>]. Investing in obesity prevention and management interventions into adolescence is critical to consolidating these successes. A 2019 Cochrane review of 153 RCTs testing the effectiveness of a range of interventions that include diet or physical activity components, or both, designed to prevent obesity in children found only 20% (31/153) of studies targeted adolescents aged 13 to 18 years [<xref ref-type="bibr" rid="ref10">10</xref>]. Over 50% (85/153) of interventions were targeted at children aged 6 to 12 years. The review concluded that strategies for changing diet or physical activity levels, or both, of children to help prevent them from becoming overweight or obese are effective in making modest reductions in BMI z-score in children aged 6 to 12 years. Similar to the finding of the current systematic review, the Cochrane review found limited evidence for adolescents aged 13 to 18 years, and the diet and physical activity strategies given to them in the studies did not reduce their BMI z-score [<xref ref-type="bibr" rid="ref10">10</xref>]. Interventions to prevent obesity, including combinations of both physical activity and diet interventions, have so far remained mainly school based and with limited evidence of effective digital intervention strategies. A 2017 systematic review, which focused on digital interventions for improving the diet and physical activity behaviors of adolescents, identified only 4 text message interventions [<xref ref-type="bibr" rid="ref26">26</xref>]. The 4 interventions were heterogenous and were ineffective at improving physical activity and dietary behaviors [<xref ref-type="bibr" rid="ref26">26</xref>].</p>
        <p>The interventions included in this review were also heterogenous, and in the most part, text messages formed a part of larger, complex, and multicomponent interventions. A systematic review by Moores et al [<xref ref-type="bibr" rid="ref51">51</xref>], which included all study types of community-based interventions for the treatment of overweight and obesity in adolescents, found that digital technology was utilized in less than half of the 21 included interventions for adolescents, and text messages were only utilized as a part of larger interventions in 4 studies in total. The authors concluded that the inclusion of digital technology did not improve program effectiveness. Similar to the studies included in this review, the interventions were evaluated in traditional RCTs as an aggregation of components. As the traditional RCT evaluates the intervention only as a whole, this evaluation did not enable the isolation of the individual effects of the text messages. Greater consideration in intervention design is required to understand individual user preferences and their engagement with the different intervention components, particularly newer digital technologies. In future studies, this may be achieved through the creation and evaluation of an adaptive intervention using factorial research designs, such as the sequential multiple assessment randomized trial study designs [<xref ref-type="bibr" rid="ref52">52</xref>]. Post hoc process evaluations were conducted in 5 of the 8 studies included in this review, which allowed some understanding of individual user preferences and how adolescents engaged with and used the text messages. The 3 studies which involved adolescents in the text message development found high adherence rates measured by text message responses and high overall approval ratings [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref42">42</xref>].</p>
        <p>Adolescents are digital frontrunners and their lack of input into digital technologies to manage their health and well-being is likely to result in ineffective levels of engagement and, subsequently, ineffective interventions [<xref ref-type="bibr" rid="ref48">48</xref>]. Only 3 of the 8 studies included in this review engaged adolescents in the text message development [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref42">42</xref>]. The most comprehensive text message development with adolescents was conducted by Jensen et al [<xref ref-type="bibr" rid="ref42">42</xref>], who before the start of the intervention, tested the text messages in a 3-month feasibility study and surveyed adolescents about the text message content, timings, and interactivity at monthly intervals and semistructured interviews at the end of the study [<xref ref-type="bibr" rid="ref24">24</xref>]. This participatory development process allowed the researchers to develop a text message bank that was engaging for participants in the intervention study, with 85% of participants finding the text messages helpful. Similarly, another feasibility study utilized extensive participatory methods with adolescents to develop 300 healthy lifestyle messages and a delivery protocol [<xref ref-type="bibr" rid="ref53">53</xref>]. The participatory partnership with adolescents allowed researchers to understand adolescents’ preferred text message tone and appreciate adolescents’ sensitivity to the language. For example, messages that used an authoritarian tone were strongly disliked by adolescents. This finding was also highlighted in a process evaluation of a 6-month maintenance text message intervention with adolescents with overweight or obesity [<xref ref-type="bibr" rid="ref54">54</xref>]. The text message program, which followed an 8-week in-person intervention, was developed without adolescent consultation, and the adolescents described a sense of shame when receiving the text messages and parents perceived the text messages as impersonal. Thus, co-design may increase the likelihood of acceptable text messages and, subsequently, may result in effective engagement in future interventions for adolescents.</p>
        <p>Other characteristics related to text message intervention engagement include dose and interactivity. Of the 8 interventions in the current review, 4 had a low dose of text messages of once per month [<xref ref-type="bibr" rid="ref40">40</xref>] or once per week [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref39">39</xref>]. Moreover, only 4 of the included studies utilized two-way text message communication, which allowed participants to have varying levels of interaction with research staff or health professionals [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref40">40</xref>-<xref ref-type="bibr" rid="ref42">42</xref>]. Jensen et al [<xref ref-type="bibr" rid="ref42">42</xref>] requested both groups self-report behaviors to the research team via text message [<xref ref-type="bibr" rid="ref42">42</xref>]. Participants in the intervention group, who also received adaptive text messages (evidenced-based intervention content delivered in a gain-frame format indicating what might be gained from adopting healthier behaviors), demonstrated significantly greater self-reporting adherence compared with the control group (<italic>P</italic>&#60;.01). Comparably, a text messaging program on adolescent reproductive health, which compared one-way text messages with reproductive health information vs interactive text messages with reproductive health quizzes, found interactive text messages increased reproductive knowledge by 24% vs 11% in the one-way text message group [<xref ref-type="bibr" rid="ref55">55</xref>]. The interactive text message group was instead sent one multiple-choice quiz question each week. When the participant responded, they immediately received a confirmatory text message informing them whether they answered correctly along with the correct answer and additional information, which corresponded to the information provided in the unidirectional text message. Moreover, a momentary ecological assessment using text messages to assess the adolescent’s health information needs found adolescents are willing to use text messaging to report their health information in real time [<xref ref-type="bibr" rid="ref56">56</xref>]. The research team sent 3 text messages per week asking adolescents if they had any questions about their health and where did they look for the answer. Adolescents responded to 90% of the 3 text messages sent each week by the research team. Adolescents’ most frequently reported questions were about diet and exercise, and adolescents had heightened awareness and health information needs regarding issues related to obesity. Importantly, this sample of adolescents was from a lower socioeconomic status, and text messages showed promise for engaging at-risk and hard-to-reach populations. Future interventions may consider interactive two-way text messages as an intervention delivery strategy for adolescent populations given the demonstration of acceptability in formative research. Unlike other digital technologies, such as online websites and smartphone apps, text messages are inexpensive to develop and to send and receive, and they do not require an internet connection.</p>
        <p>To determine the effectiveness of text message interventions for adolescent weight management, consistent outcome measures of body weight are required. Moreover, consistency in secondary outcome measures is essential for behaviors that underlie weight management, such as diet and physical activity behaviors, which have independent effects of their own on health [<xref ref-type="bibr" rid="ref57">57</xref>]. In the 8 included studies, the primary outcome of interest was weight change measured either using BMI z-score or BMI. BMI z-score is a widely accepted way of assessing a child’s weight status using measures of relative weight adjusted for child age and sex in their country. Of the 5 studies which reported BMI z-score, 2 studies provided insufficient details (groups means at baseline and follow-up time points) to determine an effect size [<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref42">42</xref>] and 3 studies only reported BMI [<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref38">38</xref>]. In growing adolescents, BMI varies with age and sex. As a result, for BMI to be meaningful in adolescents, it must be compared with a reference-standard that accounts for child age and sex [<xref ref-type="bibr" rid="ref58">58</xref>]. Studies which report outcomes in BMI usually have small effect sizes compared with studies reporting BMI z-scores [<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref59">59</xref>]. For example, Chen et al [<xref ref-type="bibr" rid="ref37">37</xref>] had a BMI effect size of 4.5% at 6 months and BMI z-score effect size of 28.1% at 6 months [<xref ref-type="bibr" rid="ref37">37</xref>]. This difference in outcome measures limits a quantitative comparison in effect between studies.</p>
      </sec>
      <sec>
        <title>Strengths and Limitations</title>
        <p>The strengths of this systematic review include the use of a comprehensive search strategy, developed in conjunction with an experienced librarian. A thorough full-text search was undertaken as text messages often form part of larger multicomponent interventions and all publications in any language were considered. Moreover, a comprehensive quality assessment was undertaken using the Cochrane Risk of Bias tool and GRADE tool. Emails were sent to corresponding authors to obtain missing details and for clarification of text message implementation and outcome measures. Hence, more information was obtained than was published. However, several methodological limitations in this review restrict the conclusions that can be drawn. No studies were identified, which were text message–only interventions. This limited the conclusions that were drawn from the review. The risk of bias and methodological quality of the studies in the review was low and reflected the exploratory nature of text message–delivered interventions as research in this area is in its infancy. Only RCTs were included in the current review, and small uncontrolled studies were excluded, which may bias the results. Moreover, due to heterogenous intervention designs and missing outcome data, the sample size was too small for a meta-analysis of these outcomes to be conducted at each follow-up time point.</p>
      </sec>
      <sec>
        <title>Conclusions</title>
        <p>This review demonstrates that there is limited evidence to suggest text messages are an effective tool to deliver interventions for weight management in adolescents with overweight or obesity. Interventions delivered by text message for adolescent weight management were heterogeneous, and the small number of studies indicates research in this area is in its infancy. Although very little high-quality research has been done in the adolescent population, there is high-quality research in adult populations that suggests text messages are an effective tool for the delivery of chronic disease management programs. Further research is required to elucidate the effectiveness and potential impact of only text message interventions on weight and weight-related behaviors in adolescents. Specifically, high-quality studies that evaluate text messages as the only modality of intervention delivery are required.</p>
      </sec>
    </sec>
  </body>
  <back>
    <app-group>
      <supplementary-material id="app1">
        <label>Multimedia Appendix 1</label>
        <p>Preferred Reporting Items for Systematic Reviews and Meta-Analysis checklist.</p>
        <media xlink:href="mhealth_v8i5e15849_app1.doc" xlink:title="DOC File , 64 KB"/>
      </supplementary-material>
      <supplementary-material id="app2">
        <label>Multimedia Appendix 2</label>
        <p>Full electronic search strategies for each database.</p>
        <media xlink:href="mhealth_v8i5e15849_app2.docx" xlink:title="DOCX File , 42 KB"/>
      </supplementary-material>
      <supplementary-material id="app3">
        <label>Multimedia Appendix 3</label>
        <p>Screenshots of full electronic search strategies for each.</p>
        <media xlink:href="mhealth_v8i5e15849_app3.docx" xlink:title="DOCX File , 3875 KB"/>
      </supplementary-material>
      <supplementary-material id="app4">
        <label>Multimedia Appendix 4</label>
        <p>Full text excluded and the reason for exclusion (n=201).</p>
        <media xlink:href="mhealth_v8i5e15849_app4.docx" xlink:title="DOCX File , 57 KB"/>
      </supplementary-material>
      <supplementary-material id="app5">
        <label>Multimedia Appendix 5</label>
        <p>Behaviour change techniques, text message development and process measures in individual included studies (n=8).</p>
        <media xlink:href="mhealth_v8i5e15849_app5.docx" xlink:title="DOCX File , 29 KB"/>
      </supplementary-material>
      <supplementary-material id="app6">
        <label>Multimedia Appendix 6</label>
        <p>The Cochrane Collaboration’s tool for assessing risk of bias in individual included studies (n=8).</p>
        <media xlink:href="mhealth_v8i5e15849_app6.docx" xlink:title="DOCX File , 24 KB"/>
      </supplementary-material>
    </app-group>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">BCTs</term>
          <def>
            <p>behavioral techniques</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb2">CVD</term>
          <def>
            <p>cardiovascular disease</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb3">GRADE</term>
          <def>
            <p>Grading of Recommendations Assessment, Development, and Evaluation</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb4">mHealth</term>
          <def>
            <p>mobile health</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb5">PRISMA</term>
          <def>
            <p>Preferred Reporting Items for Systematic Reviews and Meta-Analysis</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb6">RCTs</term>
          <def>
            <p>randomized controlled trials</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <ack>
      <p>The authors would like to thank the University of Sydney librarian, Edward Luca for his assistance with setting up the database search strategy. The authors disclose receipt of the following financial support for this research: SP is cofunded by a National Health and Medical Research Council/National Heart Foundation Early Career Fellowship (APP1157438); AS is funded by the University of Sydney’s Research Training Program Scholarship and the Westmead Applied Research Centre’s Westmead Applied Research Centre Supplementary Postgraduate Research Scholarship in Breast Cancer; KH is funded by a National Heart Foundation Postdoctoral Fellowship (102138); and JR is funded by a National Health and Medical Research Council Career Development Fellowship (APP1143538).</p>
    </ack>
    <fn-group>
      <fn fn-type="con">
        <p>SP, RR, AS, KH, and JF developed the research question. SP drafted the manuscript, and RR assisted with screening, extraction, data tabulation, quality assessment, and interpretation of findings. KH provided statistical advice regarding quantitative synthesis. All authors have read and contributed to the final manuscript.</p>
      </fn>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
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