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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMU</journal-id>
      <journal-id journal-id-type="nlm-ta">JMIR Mhealth Uhealth</journal-id>
      <journal-title>JMIR mHealth and uHealth</journal-title>
      <issn pub-type="epub">2291-5222</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v9i8e30480</article-id>
      <article-id pub-id-type="pmid">34463623</article-id>
      <article-id pub-id-type="doi">10.2196/30480</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Original Paper</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Original Paper</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Promoting Health via mHealth Applications Using a French Version of the Mobile App Rating Scale: Adaptation and Validation Study</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Buis</surname>
            <given-names>Lorraine</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Phantumvanit</surname>
            <given-names>Prathip</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Kanoute</surname>
            <given-names>Aida</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author" corresp="yes" equal-contrib="yes">
          <name name-style="western">
            <surname>Saliasi</surname>
            <given-names>Ina</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <address>
            <institution>Health, Systemic, Process, Research Unit 4129</institution>
            <institution>University Claude Bernard Lyon 1</institution>
            <institution>University of Lyon</institution>
            <addr-line>11 rue Guillaume Paradin</addr-line>
            <addr-line>Lyon, Cedex 08</addr-line>
            <country>France</country>
            <phone>33 0478785745</phone>
            <email>ina.saliasi@univ-lyon.fr</email>
          </address>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-1151-2653</ext-link>
        </contrib>
        <contrib id="contrib2" contrib-type="author" equal-contrib="yes">
          <name name-style="western">
            <surname>Martinon</surname>
            <given-names>Prescilla</given-names>
          </name>
          <degrees>MSc</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-2958-9256</ext-link>
        </contrib>
        <contrib id="contrib3" contrib-type="author">
          <name name-style="western">
            <surname>Darlington</surname>
            <given-names>Emily</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-8671-2022</ext-link>
        </contrib>
        <contrib id="contrib4" contrib-type="author">
          <name name-style="western">
            <surname>Smentek</surname>
            <given-names>Colette</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-7266-3351</ext-link>
        </contrib>
        <contrib id="contrib5" contrib-type="author">
          <name name-style="western">
            <surname>Tardivo</surname>
            <given-names>Delphine</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff2" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-2952-4425</ext-link>
        </contrib>
        <contrib id="contrib6" contrib-type="author">
          <name name-style="western">
            <surname>Bourgeois</surname>
            <given-names>Denis</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-4754-2512</ext-link>
        </contrib>
        <contrib id="contrib7" contrib-type="author">
          <name name-style="western">
            <surname>Dussart</surname>
            <given-names>Claude</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-1091-9139</ext-link>
        </contrib>
        <contrib id="contrib8" contrib-type="author" equal-contrib="yes">
          <name name-style="western">
            <surname>Carrouel</surname>
            <given-names>Florence</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-6823-1636</ext-link>
        </contrib>
        <contrib id="contrib9" contrib-type="author" equal-contrib="yes">
          <name name-style="western">
            <surname>Fraticelli</surname>
            <given-names>Laurie</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-2647-658X</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution>Health, Systemic, Process, Research Unit 4129</institution>
        <institution>University Claude Bernard Lyon 1</institution>
        <institution>University of Lyon</institution>
        <addr-line>Lyon</addr-line>
        <country>France</country>
      </aff>
      <aff id="aff2">
        <label>2</label>
        <institution>Laboratory Anthropology, Health Law, and Medical Ethics, UMR 7268</institution>
        <institution>Aix-Marseille University 2</institution>
        <addr-line>Marseille</addr-line>
        <country>France</country>
      </aff>
      <author-notes>
        <corresp>Corresponding Author: Ina Saliasi <email>ina.saliasi@univ-lyon.fr</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <month>8</month>
        <year>2021</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>31</day>
        <month>8</month>
        <year>2021</year>
      </pub-date>
      <volume>9</volume>
      <issue>8</issue>
      <elocation-id>e30480</elocation-id>
      <history>
        <date date-type="received">
          <day>17</day>
          <month>5</month>
          <year>2021</year>
        </date>
        <date date-type="rev-request">
          <day>22</day>
          <month>6</month>
          <year>2021</year>
        </date>
        <date date-type="rev-recd">
          <day>25</day>
          <month>6</month>
          <year>2021</year>
        </date>
        <date date-type="accepted">
          <day>6</day>
          <month>7</month>
          <year>2021</year>
        </date>
      </history>
      <copyright-statement>©Ina Saliasi, Prescilla Martinon, Emily Darlington, Colette Smentek, Delphine Tardivo, Denis Bourgeois, Claude Dussart, Florence Carrouel, Laurie Fraticelli. Originally published in JMIR mHealth and uHealth (https://mhealth.jmir.org), 31.08.2021.</copyright-statement>
      <copyright-year>2021</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR mHealth and uHealth, is properly cited. The complete bibliographic information, a link to the original publication on https://mhealth.jmir.org/, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://mhealth.jmir.org/2021/8/e30480" xlink:type="simple"/>
      <abstract>
        <sec sec-type="background">
          <title>Background</title>
          <p>In the recent decades, the number of apps promoting health behaviors and health-related strategies and interventions has increased alongside the number of smartphone users. Nevertheless, the validity process for measuring and reporting app quality remains unsatisfactory for health professionals and end users and represents a public health concern. The Mobile Application Rating Scale (MARS) is a tool validated and widely used in the scientific literature to evaluate and compare mHealth app functionalities. However, MARS is not adapted to the French culture nor to the language.</p>
        </sec>
        <sec sec-type="objective">
          <title>Objective</title>
          <p>This study aims to translate, adapt, and validate the equivalent French version of MARS (ie, MARS-F).</p>
        </sec>
        <sec sec-type="methods">
          <title>Methods</title>
          <p>The original MARS was first translated to French by two independent bilingual scientists, and their common version was blind back-translated twice by two native English speakers, culminating in a final well-established MARS-F. Its comprehensibility was then evaluated by 6 individuals (3 researchers and 3 nonacademics), and the final MARS-F version was created. Two bilingual raters independently completed the evaluation of 63 apps using MARS and MARS-F. Interrater reliability was assessed using intraclass correlation coefficients. In addition, internal consistency and validity of both scales were assessed. Mokken scale analysis was used to investigate the scalability of both MARS and MARS-F.</p>
        </sec>
        <sec sec-type="results">
          <title>Results</title>
          <p>MARS-F had a good alignment with the original MARS, with properties comparable between the two scales. The correlation coefficients (<italic>r</italic>) between the corresponding dimensions of MARS and MARS-F ranged from 0.97 to 0.99. The internal consistencies of the MARS-F dimensions <italic>engagement</italic> (<italic>ω</italic>=0.79), <italic>functionality</italic> (<italic>ω</italic>=0.79), <italic>esthetics</italic> (<italic>ω</italic>=0.78), and <italic>information quality</italic> (<italic>ω</italic>=0.61) were acceptable and that for the overall MARS score (<italic>ω</italic>=0.86) was good. Mokken scale analysis revealed a strong scalability for MARS (Loevinger H=0.37) and a good scalability for MARS-F (H=0.35).</p>
        </sec>
        <sec sec-type="conclusions">
          <title>Conclusions</title>
          <p>MARS-F is a valid tool, and it would serve as a crucial aid for researchers, health care professionals, public health authorities, and interested third parties, to assess the quality of mHealth apps in French-speaking countries.</p>
        </sec>
      </abstract>
      <kwd-group>
        <kwd>mobile health apps</kwd>
        <kwd>eHealth</kwd>
        <kwd>Mobile App Rating Scale</kwd>
        <kwd>MARS</kwd>
        <kwd>quality assessment tool</kwd>
        <kwd>rating scale evolution</kwd>
        <kwd>validation</kwd>
        <kwd>mHealth</kwd>
        <kwd>mHealth applications</kwd>
        <kwd>health applications</kwd>
        <kwd>mobile health</kwd>
        <kwd>digital health</kwd>
        <kwd>digital health tools</kwd>
        <kwd>application validation</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <p>In the last few decades, smartphones have radically modified our daily life, as seen by the increasing number of smartphone users worldwide. In parallel to this, an exponential growth of mobile health (mHealth) apps has been observed [<xref ref-type="bibr" rid="ref1">1</xref>]. Such apps offer an attractive and promising interface for health education and community health promotion [<xref ref-type="bibr" rid="ref2">2</xref>]. mHealth apps are currently becoming handheld devices that can disseminate a variety of health-promoting knowledge and promote healthy behaviors relating, for example, to dietary habits [<xref ref-type="bibr" rid="ref3">3</xref>], weight control [<xref ref-type="bibr" rid="ref4">4</xref>], physical activity [<xref ref-type="bibr" rid="ref5">5</xref>], addictive behaviors (ie, smoking), and mental health (ie, managing stress and depression) [<xref ref-type="bibr" rid="ref1">1</xref>]. mHealth apps represent an alternative to or complement face-to-face communication between health care professionals and users of the health care system for primary prevention [<xref ref-type="bibr" rid="ref6">6</xref>], as well as patients for secondary prevention [<xref ref-type="bibr" rid="ref7">7</xref>]. They offer an affordable platform that reaches a large audience with possible positive implications for public health, especially health promotion and prevention strategies [<xref ref-type="bibr" rid="ref1">1</xref>].</p>
      <p>Before the deployment of an app on the web, the app store reviews it as well as its updates, in order to determine whether it is reliable, performs as expected, respects user privacy, and is free of objectionable content such as offensive language or nudity. However, the review by the developer is not comprehensive enough to enable end users, health professionals, and researchers to identify and evaluate the quality of mHealth apps [<xref ref-type="bibr" rid="ref8">8</xref>,<xref ref-type="bibr" rid="ref9">9</xref>]. The most common way to select an mHealth app that is currently available on the app market is by using publicly available information, and by considering easily available attributes such as title, price, star ratings, reviews, or downloads, instead of validated scientific content [<xref ref-type="bibr" rid="ref10">10</xref>]. To date, certification and trust labels for mobile apps are not widely endorsed [<xref ref-type="bibr" rid="ref11">11</xref>].</p>
      <p>Few mHealth apps available on the market have undergone a thorough validation process based on high-level evidence that can be a potential problem for the safety of end users [<xref ref-type="bibr" rid="ref9">9</xref>]. In order to evaluate the validity and functionality of mHealth apps objectively, several standardized scales have been developed for health care professionals [<xref ref-type="bibr" rid="ref12">12</xref>]. The Mobile Application Rating Scale (MARS) was developed by Stoyanov et al [<xref ref-type="bibr" rid="ref8">8</xref>] in the English language, and, to date, it is considered the reference scale for health care professionals in the scientific literature. The Italian, Spanish, German, and Arabic versions of MARS have already been produced and validated [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref13">13</xref>-<xref ref-type="bibr" rid="ref15">15</xref>]. The 23-item scale assesses the quality of health-related apps through four objective dimensions relating to the quality of the mHealth app (engagement, functionality, esthetics, and information) and one subjective dimension (subjective app quality and perceived impact).</p>
      <p>The aim of this study is to develop and validate a French version of the Mobile App Rating Scale (MARS-F) as a multidimensional measure for trialing, classifying, and rating the quality of mHealth apps.</p>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <sec>
        <title>Study Design</title>
        <p>The validation of this study followed and applied a well-established process of cross-cultural adaptation [<xref ref-type="bibr" rid="ref16">16</xref>], translation and back-translation, review, piloting, and psychometric evaluation.</p>
      </sec>
      <sec>
        <title>Cultural Adaptation and Translation</title>
        <p>First, the translation of MARS from English to French was conducted by two independent bilingual scientists (IS and LF). Following the review, discussion, and comparison of their two forward translations, they agreed upon a common pilot version of MARS-F. Second, this common pilot version was blind back-translated by two bilingual native English speakers with different educational backgrounds—a researcher in public health and educational sciences (ED) and a nonacademic professional (ADB). Third, the two bilingual scientists (IS and LF) compared the back-translated version with the original English version. After mutual discussion, they agreed upon the final French version of the scale (MARS-F). Finally, 6 other people (3 researchers and 3 nonacademic professionals) evaluated the comprehensibility of this finalized French version. Their comments were considered, and the final MARS-F version was thus created (<xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>).</p>
      </sec>
      <sec>
        <title>Selection of Apps</title>
        <p>The inclusion process consisted of three different phases: searching, screening, and determining the eligibility criteria of nutrition health-related apps. The search for apps was conducted from March 10, 2021, to March 17, 2021, on the French Apple Store (iOS) and Google Play Store (Android). No truncation or use of logic operators (AND, OR, and NOT) was possible while searching in the Google Play Store and iOS Store. Hence, in order to select the nutrition health-related apps, the following search terms were used separately: “nutrition” (nutrition), “diététique” (dietetics), “alimentation” (food intake), “régime alimentaire” (diet), and “manger sain” (healthy eating). Apps were included if they were available free of charge or at least free of charge during 7 days from both the iOS Store and Google Play Store. Duplicate copies of apps between the two stores were excluded, resulting in a total of 63 apps (<xref rid="figure1" ref-type="fig">Figure 1</xref>).</p>
        <fig id="figure1" position="float">
          <label>Figure 1</label>
          <caption>
            <p>Flowchart of the app selection process.</p>
          </caption>
          <graphic xlink:href="mhealth_v9i8e30480_fig1.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
      <sec>
        <title>Raters’ Training</title>
        <p>To complete the evaluation process of apps, we used the rating methodology previously described by Stoyanov et al [<xref ref-type="bibr" rid="ref8">8</xref>]. We made a video with an introduction of the French MARS scale, and an exercise on how to rate a nutrition mobile app (available on request to the corresponding author). Two individuals with a master’s degree in medical sciences (FC and PM), and who were fluent in both French and English, were instructed on how to serve as raters by watching the video. With a view to ensure that the raters were sufficiently trained, they were asked to download and evaluate 10 apps that were randomly selected from those meeting our inclusion criteria using MARS and MARS-F. Each app rater tested each app for at least 15 minutes before they carried out their evaluation. Raters then compared their individual rating scores for each app. When their individual rating scores varied by at least 2 points, they discussed their findings until they aligned their rating approaches and agreed on the score.</p>
      </sec>
      <sec>
        <title>Data Analysis</title>
        <sec>
          <title>Intraclass Correlation</title>
          <p>The two raters completed the evaluation of the remaining 53 apps independently. The intraclass correlation coefficients (ICCs) were calculated to measure the interrater reliability of the items, the subscales, and total MARS scores with absolute agreement between the raters. An ICC of &#60;0.50 was interpreted as poor; 0.51-0.75, as moderate; 0.76-0.89, as good; and &#62;0.90, as excellent correlation [<xref ref-type="bibr" rid="ref17">17</xref>]. We excluded item 19 due to missing values.</p>
        </sec>
        <sec>
          <title>Internal Consistency</title>
          <p>The internal consistency of MARS-F and its subscales were also assessed as a measure of scale reliability, as reported in the original MARS study. We used the omega coefficient instead of the Cronbach alpha coefficient, as it is commonly used to assess reliability as described in the literature. The omega coefficient provides justifiably higher estimates of reliability than the Cronbach alpha coefficient [<xref ref-type="bibr" rid="ref18">18</xref>]. The robust procedure introduced by Zhang and Yuan was used to estimate omega values, with the objective to obtain a closer estimate to the population value without being overwhelmingly affected by a few overbearing observations [<xref ref-type="bibr" rid="ref19">19</xref>]. Reliability was assessed as follows: <italic>ω</italic>&#60;0.50 was interpreted as unacceptable internal consistency; <italic>ω</italic>=0.51-0.59, as poor consistency; <italic>ω</italic>=0.60-0.69, as questionable consistency; <italic>ω</italic>=0.70-0.79, as acceptable consistency; <italic>ω</italic>=0.80-0.89, as good consistency; and <italic>ω</italic>&#62;0.90, as excellent consistency.</p>
        </sec>
        <sec>
          <title>Validity</title>
          <p>To establish an indicator of validity, we investigated the subscale correlations between MARS-F and its original English version. In addition, we calculated the overall correlation between the total MARS score and total MARS-F score. The correlation coefficient ranges between –1 and 1. The closer the coefficient is to 1, the stronger the positive linear relationship between the variables. The closer the coefficient is to –1, the stronger the negative linear relationship between the variables. Mean comparisons were also performed between the corresponding dimensions of MARS and MARS-F, and <italic>P</italic> values were adjusted for multiple testing according to Holmes’ method [<xref ref-type="bibr" rid="ref20">20</xref>]. For all dimensions compared, we considered a <italic>P</italic> value &#60;.05 as statistically significant.</p>
        </sec>
        <sec>
          <title>Mokken Scale Analysis</title>
          <p>Mokken scale analysis (MSA) is a technique used for scaling test and questionnaire data closely. This technique is related to the nonparametric item response theory [<xref ref-type="bibr" rid="ref21">21</xref>,<xref ref-type="bibr" rid="ref22">22</xref>]. The latent monotonicity and nonintersection are two necessary preconditions to use the MSA. Loevinger H is the key parameter of this scale. For item <italic>i</italic>, the scaling parameter is H<sub>i</sub>, and H<sub>k</sub> is the scaling parameter for the overall scalability of all items in the scale k. H<sub>i</sub> indicates the strength of the relationship between a latent variable (eg, app quality) and item <italic>i</italic>. The SE values of the scalability coefficients of the item pairs were also calculated. A scale is considered weak if H is &#60;0.4, moderate if H is ≥0.4 but &#60;0.49, and strong if H is &#62;0.5 [<xref ref-type="bibr" rid="ref21">21</xref>,<xref ref-type="bibr" rid="ref23">23</xref>]. MSA was conducted for both MARS and MARS-F to assess the scalability of the mean scores. As recommended by van der Ark, the reliability of the scales was additionally assessed using the Molenaar-Sijtsma (MS) method [<xref ref-type="bibr" rid="ref24">24</xref>], λ-2, and latent class reliability coefficient (LCRC) [<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref25">25</xref>].</p>
        </sec>
        <sec>
          <title>Statistical Analysis</title>
          <p>R software (version 4.0.5; R Foundation for Statistical Computing) was used for all analyses. The correlations, ICC, and MSA were conducted using the R packages psych (function corr.test) (version 1.8.12), coefficient alpha (function omega) (version 0.5) and mokken (function coefH) (version 1.8.12). The two preconditions of latent monotonicity and nonintersection were tested using the functions check.monotonicity and check.restscore from the package mokken. The statistics related to the reliability of the scales were provided using the function check.reliability.</p>
        </sec>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <sec>
        <title>Calibration During Raters’ Training</title>
        <p>Among the 10 common apps, the mean scores of the dimensions <italic>engagement</italic> (<italic>t<sub>10</sub></italic>=–0.76, <italic>P</italic>=.44), <italic>functionality</italic> (<italic>t<sub>53</sub></italic>=–0.11, <italic>P</italic>=.90), <italic>esthetics</italic> (<italic>t<sub>53</sub></italic>=0.22, <italic>P</italic>=.82), and <italic>information quality</italic> (<italic>t<sub>33</sub></italic>=–0.35, <italic>P</italic>=.72) were equivalent in both versions. The internal consistencies of MARS (<italic>ω</italic>=0.86, 95% CI 0.56-0.96) and MARS-F (<italic>ω</italic>=0.78, 95% CI 0.32-0.94) were good and acceptable, respectively, and the MSA revealed strong scalability (H=0.47; SE=0.07).</p>
      </sec>
      <sec>
        <title>Descriptive Data and Mean Comparisons</title>
        <p>The ICCs for MARS (0.88, 95% CI 0.79-0.93) and MARS-F (0.89, 95% CI 0.8-0.93) were high. The mean and SD scores of the items in MARS and MARS-F are presented in <xref ref-type="table" rid="table1">Table 1</xref>. The mean scores of the dimensions <italic>engagement</italic> (<italic>t<sub>53</sub></italic>=–0.34, <italic>P</italic>=.72), <italic>functionality</italic> (<italic>t<sub>53</sub></italic>=–0.47, <italic>P</italic>=.63), <italic>esthetics</italic> (<italic>t<sub>53</sub></italic>=.09, <italic>P</italic>=.92), and <italic>information quality</italic> (<italic>t<sub>33</sub></italic>=0, <italic>P</italic>&#62;.99) were equivalent between MARS and MARS-F.</p>
        <table-wrap position="float" id="table1">
          <label>Table 1</label>
          <caption>
            <p>Summary of item and scale scores for the original version of the Mobile App Rating Scale (MARS) and the French version of MARS (MARS-F) (n=53 apps).</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="30"/>
            <col width="470"/>
            <col width="250"/>
            <col width="250"/>
            <thead>
              <tr valign="top">
                <td colspan="2">Dimension</td>
                <td colspan="2">Score, mean (SD)</td>
              </tr>
              <tr valign="top">
                <td colspan="2">
                  <break/>
                </td>
                <td>MARS</td>
                <td>MARS-F</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td colspan="2">
                  <bold>Engagement</bold>
                </td>
                <td>2.83 (0.89)</td>
                <td>2.85 (0.88)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Item 1</td>
                <td>2.67 (0.81)</td>
                <td>2.63 (0.82)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Item 2</td>
                <td>2.97 (0.74)</td>
                <td>2.90 (0.78)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Item 3</td>
                <td>2.65 (0.94)</td>
                <td>2.66 (0.92)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Item 4</td>
                <td>2.60 (0.99)</td>
                <td>2.84 (0.95)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Item 5</td>
                <td>3.24 (0.80)</td>
                <td>3.20 (0.79)</td>
              </tr>
              <tr valign="top">
                <td colspan="2">
                  <bold>Functionality</bold>
                </td>
                <td>4.32 (0.72)</td>
                <td>4.35 (0.72)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Item 6</td>
                <td>4.09 (0.87)</td>
                <td>4.11 (0.85)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Item 7</td>
                <td>4.25 (0.63)</td>
                <td>4.29 (0.62)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Item 8</td>
                <td>4.30 (0.59)</td>
                <td>4.31 (0.64)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Item 9</td>
                <td>4.64 (0.64)</td>
                <td>4.67 (0.63)</td>
              </tr>
              <tr valign="top">
                <td colspan="2">
                  <bold>Esthetics</bold>
                </td>
                <td>3.33 (0.79)</td>
                <td>3.32 (0.82)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Item 10</td>
                <td>3.73 (0.64)</td>
                <td>3.75 (0.62)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Item 11</td>
                <td>3.26 (0.77)</td>
                <td>3.23 (0.83)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Item 12</td>
                <td>3.00 (0.79)</td>
                <td>3.00 (0.80)</td>
              </tr>
              <tr valign="top">
                <td colspan="2">
                  <bold>Information quality</bold>
                </td>
                <td>3.25 (1.08)</td>
                <td>3.25 (1.08)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Item 13</td>
                <td>3.96 (0.39)</td>
                <td>3.96 (0.39)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Item 14</td>
                <td>3.78 (0.70)</td>
                <td>3.75 (0.71)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Item 15</td>
                <td>3.50 (0.75)</td>
                <td>3.49 (0.75)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Item 16</td>
                <td>3.21 (0.80)</td>
                <td>3.22 (0.76)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Item 17</td>
                <td>3.42 (0.98)</td>
                <td>3.43 (0.99)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Item 18</td>
                <td>1.64 (0.90)</td>
                <td>1.66 (0.90)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Item 19</td>
                <td>N/A<sup>a</sup></td>
                <td>N/A<sup>a</sup></td>
              </tr>
              <tr valign="top">
                <td colspan="2">Overall mean</td>
                <td>3.43 (0.43)</td>
                <td>3.44 (0.43)</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table1fn1">
              <p><sup>a</sup>N/A: this item on information quality could not be rated because it was nonapplicable.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
      </sec>
      <sec>
        <title>Internal Consistency</title>
        <p>The internal consistency of MARS and MARS-F and their subscales is presented in <xref ref-type="table" rid="table2">Table 2</xref>. The internal consistency of the MARS dimension <italic>engagement</italic> (<italic>ω</italic>=0.82, 95% CI 0.79-0.87) was good. The internal consistencies of the dimensions <italic>functionality</italic> (<italic>ω</italic>=0.80, 95% CI 0.74-0.85) and <italic>esthetics</italic> (<italic>ω</italic>=0.79, 95% CI 0.73-0.88) were acceptable and that for <italic>information quality</italic> (<italic>ω</italic>=0.64, 95% CI 0.49-0.70) indicated questionable consistency. The internal consistency of the overall MARS score was good (<italic>ω</italic>=0.87, 95% CI 0.83-0.91).</p>
        <p>For MARS-F, the internal consistencies were acceptable for the dimensions <italic>engagement</italic> (<italic>ω</italic>=0.79, 95% CI 0.72-0.83), <italic>functionality</italic> (<italic>ω</italic>=0.79, 95% CI 0.73-0.85), <italic>esthetics</italic> (<italic>ω</italic>=0.78, 95% CI 0.71-0.82), and <italic>information quality</italic> (<italic>ω</italic>=0.61, 95% CI 0.53-0.65). The internal consistency of the overall MARS score was good (<italic>ω</italic>=0.86, 95% CI 0.85-0.90).</p>
        <table-wrap position="float" id="table2">
          <label>Table 2</label>
          <caption>
            <p>Internal consistency per dimension for the original version of the Mobile App Rating Scale (MARS) and the French version of MARS (MARS-F).</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="300"/>
            <col width="350"/>
            <col width="350"/>
            <thead>
              <tr valign="top">
                <td>Dimension</td>
                <td colspan="2">Internal consistency, <italic>ω</italic> (95% CI)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>MARS</td>
                <td>MARS-F</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Engagement</td>
                <td>0.82 (0.79-0.87)</td>
                <td>0.79 (0.72-0.83)</td>
              </tr>
              <tr valign="top">
                <td>Functionality</td>
                <td>0.80 (0.74-0.85)</td>
                <td>0.79 (0.73-0.85)</td>
              </tr>
              <tr valign="top">
                <td>Esthetics</td>
                <td>0.79 (0.73-0.88)</td>
                <td>0.78 (0.71-0.82)</td>
              </tr>
              <tr valign="top">
                <td>Information quality</td>
                <td>0.64 (0.49-0.70)</td>
                <td>0.61 (0.53-0.65)</td>
              </tr>
              <tr valign="top">
                <td>Overall mean</td>
                <td>0.87 (0.83-0.91)</td>
                <td>0.86 (0.85-0.90)</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
      </sec>
      <sec>
        <title>Validity</title>
        <p>The correlation coefficients between the corresponding dimensions of MARS and MARS-F ranged from 0.97 to 0.99. <italic>P</italic> values were adjusted for multiple testing according to Holmes’ method (<xref ref-type="table" rid="table3">Table 3</xref>). Correlations between the respective items are presented in <xref ref-type="supplementary-material" rid="app2">Multimedia Appendix 2</xref>.</p>
        <table-wrap position="float" id="table3">
          <label>Table 3</label>
          <caption>
            <p>Correlation between the English and French versions of the Mobile App Rating Scale.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="30"/>
            <col width="350"/>
            <col width="150"/>
            <col width="0"/>
            <col width="150"/>
            <col width="0"/>
            <col width="150"/>
            <col width="0"/>
            <col width="170"/>
            <thead>
              <tr valign="top">
                <td colspan="2">Dimension</td>
                <td colspan="2">Engagement FR</td>
                <td colspan="2">Functionality FR</td>
                <td colspan="2">Esthetics FR</td>
                <td>Information quality FR</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td colspan="9">
                  <bold>Engagement ENG</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <italic>r</italic>
                </td>
                <td>0.98</td>
                <td colspan="2">0.30</td>
                <td colspan="2">0.57</td>
                <td colspan="2">0.63</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td><italic>P</italic> value</td>
                <td>&#60;.001</td>
                <td colspan="2">.02</td>
                <td colspan="2">&#60;.001</td>
                <td colspan="2">&#60;.001</td>
              </tr>
              <tr valign="top">
                <td colspan="9">
                  <bold>Functionality ENG</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <italic>r</italic>
                </td>
                <td>0.24</td>
                <td colspan="2">0.98</td>
                <td colspan="2">0.49</td>
                <td colspan="2">0.28</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td><italic>P</italic> value</td>
                <td>.03</td>
                <td colspan="2">&#60;.001</td>
                <td colspan="2">&#60;.001</td>
                <td colspan="2">.02</td>
              </tr>
              <tr valign="top">
                <td colspan="9">
                  <bold>Esthetics ENG</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <italic>r</italic>
                </td>
                <td>0.52</td>
                <td colspan="2">0.50</td>
                <td colspan="2">0.99</td>
                <td colspan="2">0.52</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td><italic>P</italic> value</td>
                <td>&#60;.001</td>
                <td colspan="2">&#60;.001</td>
                <td colspan="2">&#60;.001</td>
                <td colspan="2">&#60;.001</td>
              </tr>
              <tr valign="top">
                <td colspan="9">
                  <bold>Information quality ENG</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <italic>r</italic>
                </td>
                <td>0.66</td>
                <td colspan="2">0.34</td>
                <td colspan="2">0.56</td>
                <td colspan="2">0.97</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td><italic>P</italic> value</td>
                <td>&#60;.001</td>
                <td colspan="2">.01</td>
                <td colspan="2">&#60;.001</td>
                <td colspan="2">&#60;.001</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
      </sec>
      <sec>
        <title>MSA Results</title>
        <p>MSA results for both versions of the scale (ie, MARS and MARS-F) are summarized in the <xref ref-type="table" rid="table4">Table 4</xref>. MSA for MARS revealed strong scalability (H=0.37; SE=0.03). There was no violation of monotonicity because the item step response functions were nondecreasing functions; likewise, there was no violation of nonintersection because the item step response functions do not intersect. The internal consistency of this scale was acceptable (MS=0.88; λ-2=0.88; LCRC=0.89). MSA for MARS-F revealed good scalability (H=0.35; SE=0.03). The internal consistency of this scale was acceptable (MS=0.88; λ-2=0.89; LCRC=0.90). The scalability results of MARS and MARS-F are presented in <xref rid="figure2" ref-type="fig">Figure 2</xref>.</p>
        <table-wrap position="float" id="table4">
          <label>Table 4</label>
          <caption>
            <p>Mokken scale analysis for the original version of the Mobile App Rating Scale (MARS) and the French version of MARS (MARS-F).</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="700"/>
            <col width="150"/>
            <col width="150"/>
            <thead>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>MARS</td>
                <td>MARS-F</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Loevinger H coefficient</td>
                <td>0.37</td>
                <td>0.35</td>
              </tr>
              <tr valign="top">
                <td>Standard errors of the scalability coefficients of the item pairs</td>
                <td>0.03</td>
                <td>0.03</td>
              </tr>
              <tr valign="top">
                <td>Molenaar-Sijtsma coefficient</td>
                <td>0.88</td>
                <td>0.88</td>
              </tr>
              <tr valign="top">
                <td>Lambda-2</td>
                <td>0.88</td>
                <td>0.89</td>
              </tr>
              <tr valign="top">
                <td>Latent class reliability coefficient</td>
                <td>0.89</td>
                <td>0.90</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
        <fig id="figure2" position="float">
          <label>Figure 2</label>
          <caption>
            <p>Loevinger (H<sub>k</sub>) coefficients (overall scalability of all items in the scale) for the Mobile App Rating Scale (MARS) and the French version of the Mobile App Rating Scale (MARS-F) depending on various dimensions.</p>
          </caption>
          <graphic xlink:href="mhealth_v9i8e30480_fig2.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Principal Results</title>
        <p>This study aimed to develop and evaluate MARS-F to enable French health care professionals to assess the quality of mHealth apps. To our knowledge, this is the first cultural adaptation, translation, and validity evaluation of the original MARS in French.</p>
        <p>Nutrition-related apps were identified using well-defined and selected search terms in both two app stores (Google Play Store and Apple Store). This was done to avoid methodological challenges such as ranking algorithms or irrelevant results because the indexing of apps is usually determined by a developer who is most interested in promoting the app.</p>
        <p>With a view to provide a comparable interpretation of statistical indicators, the methodology was chosen to be similar to previous adaptations of the scale [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref8">8</xref>,<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref26">26</xref>]. In addition, 63 apps were included, which is higher than the minimum sample size of 41 apps required to confirm that interrater reliability lies within 0.15 of a sample observation of 0.80, with 87% assurance [<xref ref-type="bibr" rid="ref26">26</xref>]. We used the same strategy that led to the Italian version of MARS except that the team included apps by searching and screening across three app stores (Google Play, Apple, and Windows Stores). As per the validation of the German version of MARS, each search term was provided separately, as no truncation or use of logic operators (AND, OR, and NOT) was possible in the Google Play and Apple Store. In our study, two raters downloaded and then evaluated 10 apps that were randomly selected for training and piloting purposes as in the initial English version of MARS against 5 apps in the Italian [<xref ref-type="bibr" rid="ref2">2</xref>], Spanish [<xref ref-type="bibr" rid="ref13">13</xref>], and German development versions [<xref ref-type="bibr" rid="ref14">14</xref>].</p>
        <p>The interrater reliability of MARS and MARS-F were aligned, with overlapping CI values. The ICCs for MARS-F were also comparable to the Arabic (0.84, 95% CI 0.82-0.85) [<xref ref-type="bibr" rid="ref15">15</xref>] and German versions of MARS (0.83, 95% CI 0.82-0.85) [<xref ref-type="bibr" rid="ref14">14</xref>], and they were slightly lower than the Italian version of MARS (0.96, CI 0.90-0.91) [<xref ref-type="bibr" rid="ref2">2</xref>] (<xref ref-type="supplementary-material" rid="app3">Multimedia Appendix 3</xref>).</p>
        <p>The internal consistency of the overall MARS score was good and that of MARS-F was acceptable for the dimensions <italic>engagement</italic>, <italic>functionality</italic>, <italic>esthetics</italic>, and <italic>information quality</italic>. The internal consistency of the German version of MARS was good for <italic>engagement</italic> and excellent for <italic>functionality</italic> and <italic>esthetics</italic>. On the other hand, the internal consistency of <italic>information quality</italic> was acceptable. For the Arabic version of MARS, the internal consistency was good for <italic>engagement</italic> and <italic>esthetics</italic>, good for <italic>information quality</italic>, and acceptable for <italic>functionality</italic> [<xref ref-type="bibr" rid="ref15">15</xref>]. All Cronbach alpha coefficients were judged to be at least acceptable for the Italian version of MARS [<xref ref-type="bibr" rid="ref2">2</xref>], and these values were high for the Spanish [<xref ref-type="bibr" rid="ref13">13</xref>] version of MARS.</p>
        <p>MSA results for MARS-F revealed a good scalability (H=0.35, SE=0.03), and the use of total MARS-F score was found to be appropriate. Additionally, we obtained a high correspondence between MARS-F and the original MARS [<xref ref-type="bibr" rid="ref8">8</xref>], which demonstrates proven validity.</p>
        <p>The same methodology was used for the validation of the German (apps targeting anxiety), Italian (primary prevention), Spanish (health and fitness apps), and Arabic versions (health and fitness apps). Our results were consistent with the findings of the research teams that developed and validated the Italian, Spanish, German, and Arabic versions of the MARS [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref15">15</xref>] (<xref ref-type="supplementary-material" rid="app3">Multimedia Appendix 3</xref>).</p>
      </sec>
      <sec>
        <title>Limitations</title>
        <p>The first possible limitation could be that the validation of MARS-F is based on the evaluation of nutrition-related apps, whereas MARS is applicable to mHealth apps. The second limitation could be attributed to the fact that MARS-F was elaborated by native speakers living in France. French speakers can have diverse cultures according to their country. Therefore, further adaptation could be required. The third limitation concerns item 19 on information quality. This item could not be rated because raters choose the response option “non applicable,” which allows raters to skip an item if the app does not contain any health-related information (eg, nutrition apps in this study). The same item was also excluded from all calculations in the Italian version of MARS because of lack of ratings [<xref ref-type="bibr" rid="ref2">2</xref>]. This item evaluates the evidence-based literature relating to the nutrition app assessed, and it is worth noting that many apps have not yet been scientifically evaluated.</p>
      </sec>
      <sec>
        <title>Future Perspectives</title>
        <p>With 300 billion French-speakers worldwide [<xref ref-type="bibr" rid="ref27">27</xref>], the translation of MARS could be of special interest. Owing to its wide use in the assessment of mHealth apps in the scientific literature, we chose to translate MARS into French to provide a reliable and understandable tool for health professionals to get an evidence-based sense of the quality and reliability of chosen mHealth apps. Other rating scales such as App Quality Evaluation (AQEL) [<xref ref-type="bibr" rid="ref28">28</xref>], ENLIGHT [<xref ref-type="bibr" rid="ref29">29</xref>], and the app evaluation model from the American Psychiatric Association [<xref ref-type="bibr" rid="ref30">30</xref>] could also represent relevant tools to evaluate mHealth apps for further investigations. All these scales were created for the evaluation of mHealth apps, except AQEL that specifically evaluates nutrition-related apps [<xref ref-type="bibr" rid="ref28">28</xref>]. Several studies have demonstrated that nutrition is one of the key factors in oral and general health [<xref ref-type="bibr" rid="ref31">31</xref>]. It would be interesting to translate this scale into French and to evaluate the nutrition-related apps included in our study.</p>
        <p>Alongside the assessment process of mHealth apps, the patient’s involvement in such processes should also be considered. The user version of the MARS (uMARS) [<xref ref-type="bibr" rid="ref32">32</xref>] should be translated and evaluated for reliability and validity. Mobile technology represents an innovative opportunity to assist end users in improving their management of their chronic conditions. Such in-the-pocket devices could be adapted to the specific needs of populations. As an example, mHealth apps could be used for young people’s transition to adult care services [<xref ref-type="bibr" rid="ref33">33</xref>], to support active adults [<xref ref-type="bibr" rid="ref34">34</xref>], or to promote healthy aging [<xref ref-type="bibr" rid="ref35">35</xref>]. mHealth apps are valuable for the primary and secondary prevention of chronic diseases, especially for controlling individual risk factors and preventing the snowball effect of chronic diseases with aging [<xref ref-type="bibr" rid="ref31">31</xref>].</p>
      </sec>
      <sec>
        <title>Conclusions</title>
        <p>To conclude, MARS-F would be a crucial aid for researchers, health care professionals, public health authorities, and interested third parties, to assess the quality of mHealth apps in French-speaking countries. In addition, French app developers could use this French version as a tool to evaluate and improve the quality of their apps prior to market launch. MARS-F is an important cornerstone to app quality assessment with the purpose to identify reliable and valid apps for the benefit of end users.</p>
      </sec>
    </sec>
  </body>
  <back>
    <app-group>
      <supplementary-material id="app1">
        <label>Multimedia Appendix 1</label>
        <p>French version of the Mobile Application Rating Scale (MARS-F).</p>
        <media xlink:href="mhealth_v9i8e30480_app1.pdf" xlink:title="PDF File  (Adobe PDF File), 190 KB"/>
      </supplementary-material>
      <supplementary-material id="app2">
        <label>Multimedia Appendix 2</label>
        <p>Correlation coefficients between the respective items of the Mobile App Rating Scale (MARS) and the French version of the Mobile App Rating Scale (MARS-F).</p>
        <media xlink:href="mhealth_v9i8e30480_app2.xlsx" xlink:title="XLSX File  (Microsoft Excel File), 12 KB"/>
      </supplementary-material>
      <supplementary-material id="app3">
        <label>Multimedia Appendix 3</label>
        <p>Comparison of internal consistencies and the Mokken Scale Analysis between Mobile App Rating Scale in English and other available translations of the scale.</p>
        <media xlink:href="mhealth_v9i8e30480_app3.pdf" xlink:title="PDF File  (Adobe PDF File), 57 KB"/>
      </supplementary-material>
    </app-group>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">AQEL</term>
          <def>
            <p>app quality evaluation</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb2">ICC</term>
          <def>
            <p>intraclass correlation coefficients</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb3">LCRC</term>
          <def>
            <p>latent class reliability coefficient</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb4">MARS</term>
          <def>
            <p>Mobile Application Rating Scale</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb5">MARS-F</term>
          <def>
            <p>Mobile Application Rating Scale–French</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb6">MSA</term>
          <def>
            <p>Mokken Scale Analysis</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb7">MS</term>
          <def>
            <p>Molenaar-Sijtsma</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb8">uMARS</term>
          <def>
            <p>user version of the Mobile Application Rating Scale</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <ack>
      <p>We would like to thank Catherine Billard, Adeline Darlington-Bernard, Géraldine Seveste for their contribution in the translation process.</p>
    </ack>
    <fn-group>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
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          <pub-id pub-id-type="pmcid">PMC4751336</pub-id>
        </nlm-citation>
      </ref>
    </ref-list>
  </back>
</article>
