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<?covid-19-tdm?>
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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMU</journal-id>
      <journal-id journal-id-type="nlm-ta">JMIR Mhealth Uhealth</journal-id>
      <journal-title>JMIR mHealth and uHealth</journal-title>
      <issn pub-type="epub">2291-5222</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v10i6e38614</article-id>
      <article-id pub-id-type="pmid">35679029</article-id>
      <article-id pub-id-type="doi">10.2196/38614</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Viewpoint</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Viewpoint</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Beyond Pathogen Filtration: Possibility of Smart Masks as Wearable Devices for Personal and Group Health and Safety Management</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Buis</surname>
            <given-names>Lorraine</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Hester</surname>
            <given-names>Josiah</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Kim</surname>
            <given-names>Ko Woon</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author" equal-contrib="yes">
          <name name-style="western">
            <surname>Lee</surname>
            <given-names>Peter</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-5433-1882</ext-link>
        </contrib>
        <contrib id="contrib2" contrib-type="author" equal-contrib="yes">
          <name name-style="western">
            <surname>Kim</surname>
            <given-names>Heepyung</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-5950-5060</ext-link>
        </contrib>
        <contrib id="contrib3" contrib-type="author">
          <name name-style="western">
            <surname>Kim</surname>
            <given-names>Yongshin</given-names>
          </name>
          <degrees>BA</degrees>
          <xref rid="aff2" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-4892-8866</ext-link>
        </contrib>
        <contrib id="contrib4" contrib-type="author">
          <name name-style="western">
            <surname>Choi</surname>
            <given-names>Woohyeok</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff3" ref-type="aff">3</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-7336-8653</ext-link>
        </contrib>
        <contrib id="contrib5" contrib-type="author">
          <name name-style="western">
            <surname>Zitouni</surname>
            <given-names>M Sami</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff4" ref-type="aff">4</xref>
          <xref rid="aff5" ref-type="aff">5</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-7629-8702</ext-link>
        </contrib>
        <contrib id="contrib6" contrib-type="author">
          <name name-style="western">
            <surname>Khandoker</surname>
            <given-names>Ahsan</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff4" ref-type="aff">4</xref>
          <xref rid="aff5" ref-type="aff">5</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-0636-1646</ext-link>
        </contrib>
        <contrib id="contrib7" contrib-type="author">
          <name name-style="western">
            <surname>Jelinek</surname>
            <given-names>Herbert F</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff4" ref-type="aff">4</xref>
          <xref rid="aff5" ref-type="aff">5</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-5457-6193</ext-link>
        </contrib>
        <contrib id="contrib8" contrib-type="author">
          <name name-style="western">
            <surname>Hadjileontiadis</surname>
            <given-names>Leontios</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff4" ref-type="aff">4</xref>
          <xref rid="aff5" ref-type="aff">5</xref>
          <xref rid="aff6" ref-type="aff">6</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-9932-9302</ext-link>
        </contrib>
        <contrib id="contrib9" contrib-type="author">
          <name name-style="western">
            <surname>Lee</surname>
            <given-names>Uichin</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <xref rid="aff7" ref-type="aff">7</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-1888-1569</ext-link>
        </contrib>
        <contrib id="contrib10" contrib-type="author" corresp="yes">
          <name name-style="western">
            <surname>Jeong</surname>
            <given-names>Yong</given-names>
          </name>
          <degrees>MD, PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <xref rid="aff8" ref-type="aff">8</xref>
          <address>
            <institution>Department of Bio and Brain Engineering</institution>
            <institution>Korea Advanced Institute of Science and Technology</institution>
            <addr-line>291 Daehak-ro Yuseong gu</addr-line>
            <addr-line>Daejeon, 34141</addr-line>
            <country>Republic of Korea</country>
            <phone>82 423507165</phone>
            <email>yong@kaist.ac.kr</email>
          </address>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-5907-3787</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution>KAIST Institute for Health Science and Technology</institution>
        <institution>Korea Advanced Institute of Science and Technology</institution>
        <addr-line>Daejeon</addr-line>
        <country>Republic of Korea</country>
      </aff>
      <aff id="aff2">
        <label>2</label>
        <institution>Graduate School of Data Science</institution>
        <institution>Korea Advanced Institute of Science and Technology</institution>
        <addr-line>Daejeon</addr-line>
        <country>Republic of Korea</country>
      </aff>
      <aff id="aff3">
        <label>3</label>
        <institution>Information &#38; Electronics Research Institute</institution>
        <institution>Korea Advanced Institute of Science and Technology</institution>
        <addr-line>Daejeon</addr-line>
        <country>Republic of Korea</country>
      </aff>
      <aff id="aff4">
        <label>4</label>
        <institution>Department of Biomedical Engineering</institution>
        <institution>Khalifa University of Science and Technology</institution>
        <addr-line>Abu Dhabi</addr-line>
        <country>United Arab Emirates</country>
      </aff>
      <aff id="aff5">
        <label>5</label>
        <institution>Healthcare Engineering Innovation Center</institution>
        <institution>Khalifa University of Science and Technology</institution>
        <addr-line>Abu Dhabi</addr-line>
        <country>United Arab Emirates</country>
      </aff>
      <aff id="aff6">
        <label>6</label>
        <institution>Department of Electrical and Computer Engineering</institution>
        <institution>Aristotle University of Thessaloniki</institution>
        <addr-line>Thessaloniki</addr-line>
        <country>Greece</country>
      </aff>
      <aff id="aff7">
        <label>7</label>
        <institution>School of Computing</institution>
        <institution>Korea Advanced Institute of Science and Technology</institution>
        <addr-line>Daejeon</addr-line>
        <country>Republic of Korea</country>
      </aff>
      <aff id="aff8">
        <label>8</label>
        <institution>Department of Bio and Brain Engineering</institution>
        <institution>Korea Advanced Institute of Science and Technology</institution>
        <addr-line>Daejeon</addr-line>
        <country>Republic of Korea</country>
      </aff>
      <author-notes>
        <corresp>Corresponding Author: Yong Jeong <email>yong@kaist.ac.kr</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <month>6</month>
        <year>2022</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>21</day>
        <month>6</month>
        <year>2022</year>
      </pub-date>
      <volume>10</volume>
      <issue>6</issue>
      <elocation-id>e38614</elocation-id>
      <history>
        <date date-type="received">
          <day>9</day>
          <month>4</month>
          <year>2022</year>
        </date>
        <date date-type="rev-request">
          <day>29</day>
          <month>4</month>
          <year>2022</year>
        </date>
        <date date-type="rev-recd">
          <day>20</day>
          <month>5</month>
          <year>2022</year>
        </date>
        <date date-type="accepted">
          <day>8</day>
          <month>6</month>
          <year>2022</year>
        </date>
      </history>
      <copyright-statement>©Peter Lee, Heepyung Kim, Yongshin Kim, Woohyeok Choi, M Sami Zitouni, Ahsan Khandoker, Herbert F Jelinek, Leontios Hadjileontiadis, Uichin Lee, Yong Jeong. Originally published in JMIR mHealth and uHealth (https://mhealth.jmir.org), 21.06.2022.</copyright-statement>
      <copyright-year>2022</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR mHealth and uHealth, is properly cited. The complete bibliographic information, a link to the original publication on https://mhealth.jmir.org/, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://mhealth.jmir.org/2022/6/e38614" xlink:type="simple"/>
      <abstract>
        <p>Face masks are an important way to combat the COVID-19 pandemic. However, the prolonged pandemic has revealed confounding problems with the current face masks, including not only the spread of the disease but also concurrent psychological, social, and economic complications. As face masks have been worn for a long time, people have been interested in expanding the purpose of masks from protection to comfort and health, leading to the release of various “smart” mask products around the world. To envision how the smart masks will be extended, this paper reviewed 25 smart masks (12 from commercial products and 13 from academic prototypes) that emerged after the pandemic. While most smart masks presented in the market focus on resolving problems with user breathing discomfort, which arise from prolonged use, academic prototypes were designed for not only sensing COVID-19 but also general health monitoring aspects. Further, we investigated several specific sensors that can be incorporated into the mask for expanding biophysical features. On a larger scale, we discussed the architecture and possible applications with the help of connected smart masks. Namely, beyond a personal sensing application, a group or community sensing application may share an aggregate version of information with the broader population. In addition, this kind of collaborative sensing will also address the challenges of individual sensing, such as reliability and coverage. Lastly, we identified possible service application fields and further considerations for actual use. Along with daily-life health monitoring, smart masks may function as a general respiratory health tool for sports training, in an emergency room or ambulatory setting, as protection for industry workers and firefighters, and for soldier safety and survivability. For further considerations, we investigated design aspects in terms of sensor reliability and reproducibility, ergonomic design for user acceptance, and privacy-aware data-handling. Overall, we aim to explore new possibilities by examining the latest research, sensor technologies, and application platform perspectives for smart masks as one of the promising wearable devices. By integrating biomarkers of respiration symptoms, a smart mask can be a truly cutting-edge device that expands further knowledge on health monitoring to reach the next level of wearables.</p>
      </abstract>
      <kwd-group>
        <kwd>smart mask</kwd>
        <kwd>pathogen filtration</kwd>
        <kwd>COVID-19</kwd>
        <kwd>protective equipment</kwd>
        <kwd>digital health</kwd>
        <kwd>wearable</kwd>
        <kwd>smart device</kwd>
        <kwd>wearable device</kwd>
        <kwd>sensor</kwd>
        <kwd>health monitoring</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <p>After the World Health Organization declared COVID-19 a “pandemic” (a global epidemic) attributed to SARS-CoV-2 infection [<xref ref-type="bibr" rid="ref1">1</xref>], masks have been used by the general population all over the world for precautionary health reasons [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref3">3</xref>]. As a result, people wear masks at all times and in all places; however, the pandemic has revealed the limitations of current mask deployments regarding not only the spread of the disease but also concurrent psychological, social, and economic complications.</p>
      <p>To improve these limitations, smart face masks designed with electronic sensors have been recently proposed. The continuous use of masks has led to the designs of various face mask products, which have become available on the market. The term “smart” has been used to signify possible additional functionalities of the “smart (face) masks” around the world, leading to an expansion of the mask’s usage, including masks for protection, health, and environmental sensing [<xref ref-type="bibr" rid="ref4">4</xref>-<xref ref-type="bibr" rid="ref6">6</xref>]. </p>
      <p>While the COVID-19 pandemic is seemingly under control owing to vaccination, there is a need for innovative, Internet of Things (IoT)–based smart-mask solutions to help people transition to a postpandemic world, where the emergence of infectious SARS-CoV-2 variants is prevalent along with the heightened possibility of further, yet unknown, virus pandemics, and to combat airborne diseases [<xref ref-type="bibr" rid="ref7">7</xref>,<xref ref-type="bibr" rid="ref8">8</xref>]. In combination with data-driven applications, IoT and smart connected technologies can play a critical role in individual protection and extend to group sensing for the prevention, mitigation, and continuous remote monitoring of patients. Such a benefit of group sensing is shown with a contact-tracing app, where it could instruct a person in close contact with patients with COVID-19 to quickly self-isolate to reduce disease transmission [<xref ref-type="bibr" rid="ref9">9</xref>].</p>
      <p>Here we present a viewpoint for smart masks in the form of emerging IoT-based solutions by examining the current status of smart masks, potential sensors for their functional expansion, connected architecture of smart masks for individual and group health care, and further considerations for actual deployment of such technology in the field. The details are as follows:</p>
      <list list-type="bullet">
        <list-item>
          <p>Current status of existing commercial and academic smart masks</p>
        </list-item>
        <list-item>
          <p>Smart mask expansion in terms of personal health care and disease diagnosis</p>
        </list-item>
        <list-item>
          <p>Connected architecture and applications of smart masks</p>
        </list-item>
        <list-item>
          <p>Further real-world considerations</p>
        </list-item>
      </list>
    </sec>
    <sec>
      <title>Features and Applications of Current Smart Masks in the Field</title>
      <p>Relevant smart masks available in the market were found through web searches, including Amazon, using the following search terms: “Smart Mask,” “Facial,” and “Electronics.” The search for publications was performed using 5 databases (Google Scholar, Web of Science, ScienceDirect, PubMed, and EBSCO) on the basis of the following combinations of search terms: “Smart mask” OR “Smart face mask,” “sensor,” “IoT,” AND “Healthcare.”</p>
      <p>We defined 3 major inclusion criteria of reports on smart masks in this review.. Specifically, these criteria involve the following: (1) sensing: sensors attached to the mask; (2) actuation: functional manipulation of the mask; and (3) connectivity: communicating sensor data using mobile, cloud storage, or IoT-based networks. Only articles published between January 2020 and May 2022 were included to examine smart masks developed after the COVID-19 outbreak. Finally, the study selection procedure resulted in 12 smart mask products and 13 smart mask research prototypes reported in this study. <xref ref-type="table" rid="table1">Tables 1</xref> and <xref ref-type="table" rid="table2">2</xref> list their functions and features, respectively. Detailed selection criteria are provided in <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>.</p>
      <table-wrap position="float" id="table1">
        <label>Table 1</label>
        <caption>
          <p>Commercially available smart masks with their key features.</p>
        </caption>
        <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
          <col width="30"/>
          <col width="300"/>
          <col width="0"/>
          <col width="320"/>
          <col width="0"/>
          <col width="350"/>
          <thead>
            <tr valign="top">
              <td colspan="3">Name and purpose</td>
              <td colspan="2">Function</td>
              <td>Feature</td>
            </tr>
          </thead>
          <tbody>
            <tr valign="top">
              <td colspan="6">
                <bold>Air control with respiration rate–sensing</bold>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>AO AIR Atmos mask [<xref ref-type="bibr" rid="ref10">10</xref>]</td>
              <td colspan="2">Automatic fan control with respiration rate–sensing and filter status check</td>
              <td colspan="2">
                <list list-type="bullet">
                  <list-item>
                    <p>S<sup>a</sup>: Filter status and respiration</p>
                  </list-item>
                  <list-item>
                    <p>A<sup>b</sup>: Fan on/off control</p>
                  </list-item>
                  <list-item>
                    <p>C<sup>c</sup>: Bluetooth</p>
                  </list-item>
                </list>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>LG PuriCare (2nd Gen) [<xref ref-type="bibr" rid="ref11">11</xref>]</td>
              <td colspan="2">Automatic fan control with respiration rate–sensing</td>
              <td colspan="2">
                <list list-type="bullet">
                  <list-item>
                    <p>S: Respiration rate</p>
                  </list-item>
                  <list-item>
                    <p>A: Fan on/off control</p>
                  </list-item>
                  <list-item>
                    <p>C: Bluetooth</p>
                  </list-item>
                </list>
              </td>
            </tr>
            <tr valign="top">
              <td colspan="6">
                <bold>Ventilation</bold>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>ATMOBLUE Face Mask [<xref ref-type="bibr" rid="ref12">12</xref>]</td>
              <td colspan="2">Three fan speed modes and air quality check</td>
              <td colspan="2">
                <list list-type="bullet">
                  <list-item>
                    <p>S: Air quality</p>
                  </list-item>
                  <list-item>
                    <p>A: Fan speed control</p>
                  </list-item>
                  <list-item>
                    <p>C: Bluetooth</p>
                  </list-item>
                </list>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>Belovedone Air Purifier [<xref ref-type="bibr" rid="ref13">13</xref>]</td>
              <td colspan="2">Two fan speed modes</td>
              <td colspan="2">
                <list list-type="bullet">
                  <list-item>
                    <p>A: Control fan speed</p>
                  </list-item>
                </list>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>Philips Fresh Air Mask [<xref ref-type="bibr" rid="ref14">14</xref>]</td>
              <td colspan="2">Three fan speed modes</td>
              <td colspan="2">
                <list list-type="bullet">
                  <list-item>
                    <p>A: Control fan speed</p>
                  </list-item>
                </list>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>Xiaomi Purely [<xref ref-type="bibr" rid="ref15">15</xref>]</td>
              <td colspan="2">Three fan speed modes</td>
              <td colspan="2">
                <list list-type="bullet">
                  <list-item>
                    <p>A: Control fan speed</p>
                  </list-item>
                </list>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>CSE&#38;L AIRVISOR [<xref ref-type="bibr" rid="ref16">16</xref>]</td>
              <td colspan="2">Three fan speed modes</td>
              <td colspan="2">
                <list list-type="bullet">
                  <list-item>
                    <p>A: Control fan speed</p>
                  </list-item>
                </list>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>CELLRETURN CX9 [<xref ref-type="bibr" rid="ref17">17</xref>]</td>
              <td colspan="2">Sterilization and LED skin care</td>
              <td colspan="2">
                <list list-type="bullet">
                  <list-item>
                    <p>A: LED<sup>d</sup> sterilization and skin care</p>
                  </list-item>
                </list>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>Razer Zephyr [<xref ref-type="bibr" rid="ref18">18</xref>]</td>
              <td colspan="2">Two fan speed modes and lighting</td>
              <td colspan="2">
                <list list-type="bullet">
                  <list-item>
                    <p>A: Control fan speed and customizable lighting zones</p>
                  </list-item>
                  <list-item>
                    <p>C: Bluetooth</p>
                  </list-item>
                </list>
              </td>
            </tr>
            <tr valign="top">
              <td colspan="6">
                <bold>Communication aid</bold>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>CLIU Pro [<xref ref-type="bibr" rid="ref19">19</xref>]</td>
              <td colspan="2">Air quality check and built-in microphone</td>
              <td colspan="2">
                <list list-type="bullet">
                  <list-item>
                    <p>S: Air quality, mask wear time, and head motion</p>
                  </list-item>
                  <list-item>
                    <p>C: Bluetooth</p>
                  </list-item>
                </list>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>Donut Robotics C-FACE [<xref ref-type="bibr" rid="ref20">20</xref>]</td>
              <td colspan="2">Speech to text and voice translation</td>
              <td colspan="2">
                <list list-type="bullet">
                  <list-item>
                    <p>A: speech-to-text message, voice call, and translation</p>
                  </list-item>
                  <list-item>
                    <p>C: Bluetooth</p>
                  </list-item>
                </list>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>TrendyNow365 LED Mask [<xref ref-type="bibr" rid="ref21">21</xref>]</td>
              <td colspan="2">Text display on mask surface</td>
              <td colspan="2">
                <list list-type="bullet">
                  <list-item>
                    <p>A: Display custom LED letters</p>
                  </list-item>
                  <list-item>
                    <p>C: Bluetooth</p>
                  </list-item>
                </list>
              </td>
            </tr>
          </tbody>
        </table>
        <table-wrap-foot>
          <fn id="table1fn1">
            <p><sup>a</sup>S: sensing.</p>
          </fn>
          <fn id="table1fn2">
            <p><sup>b</sup>A: actuation.</p>
          </fn>
          <fn id="table1fn3">
            <p><sup>c</sup>C: connectivity.</p>
          </fn>
          <fn id="table1fn4">
            <p><sup>d</sup>LED: light-emitting diode.</p>
          </fn>
        </table-wrap-foot>
      </table-wrap>
      <table-wrap position="float" id="table2">
        <label>Table 2</label>
        <caption>
          <p>Smart mask research prototypes from academic journals.</p>
        </caption>
        <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
          <col width="30"/>
          <col width="270"/>
          <col width="350"/>
          <col width="350"/>
          <thead>
            <tr valign="top">
              <td colspan="2">Name and purpose</td>
              <td>Function</td>
              <td>Feature</td>
            </tr>
          </thead>
          <tbody>
            <tr valign="top">
              <td colspan="4">
                <bold>External pathogen detection and elimination</bold>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>ADAPT [<xref ref-type="bibr" rid="ref22">22</xref>]</td>
              <td>Pathogen sensing and mist spray activation</td>
              <td>
                <list list-type="bullet">
                  <list-item>
                    <p>S<sup>a</sup>: Airborne particle sensing</p>
                  </list-item>
                  <list-item>
                    <p>A<sup>b</sup>: Mitigation module on/off</p>
                  </list-item>
                  <list-item>
                    <p>C<sup>c</sup>: Bluetooth</p>
                  </list-item>
                </list>
              </td>
            </tr>
            <tr valign="top">
              <td colspan="4">
                <bold>COVID-19 detection</bold>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>SARS-CoV-2-sensing face mask [<xref ref-type="bibr" rid="ref23">23</xref>]</td>
              <td>Detects COVID-19 infection</td>
              <td>
                <list list-type="bullet">
                  <list-item>
                    <p>S: Paper-based nucleic acid diagnostics</p>
                  </list-item>
                </list>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>Lightweight and zero-power smart face mask [<xref ref-type="bibr" rid="ref24">24</xref>]</td>
              <td>Monitor cough and check mask-wearing</td>
              <td>
                <list list-type="bullet">
                  <list-item>
                    <p>S: Mask deformation</p>
                  </list-item>
                  <list-item>
                    <p>C: RF<sup>d</sup> transponder</p>
                  </list-item>
                </list>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>AG47-SmartMask [<xref ref-type="bibr" rid="ref25">25</xref>]</td>
              <td>Monitor cardio-respiratory variables and to detect cough</td>
              <td>
                <list list-type="bullet">
                  <list-item>
                    <p>S: Breathe pattern, skin/DSV<sup>e</sup> temperature, humidity, air pressure, HR<sup>f</sup>, and SpO2<sup>g</sup></p>
                  </list-item>
                  <list-item>
                    <p>C: Bluetooth</p>
                  </list-item>
                </list>
              </td>
            </tr>
            <tr valign="top">
              <td colspan="4">
                <bold>Respiratory disease–monitoring</bold>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>Smart face mask with Heat flux sensor [<xref ref-type="bibr" rid="ref26">26</xref>]</td>
              <td>Noninvasive body temperature and breathing rate–monitoring</td>
              <td>
                <list list-type="bullet">
                  <list-item>
                    <p>S: Facial skin temperature and breathing rate</p>
                  </list-item>
                  <list-item>
                    <p>C: LoRa<sup>h</sup> and Wi-Fi</p>
                  </list-item>
                </list>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>Smart facemask for wireless CO<sub>2</sub> monitoring [<xref ref-type="bibr" rid="ref27">27</xref>]</td>
              <td>Monitor CO<sub>2</sub> in DSV</td>
              <td>
                <list list-type="bullet">
                  <list-item>
                    <p>S: CO2 concentration</p>
                  </list-item>
                  <list-item>
                    <p>C: NFC<sup>i</sup></p>
                  </list-item>
                </list>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>Smart face mask with ultrathin pressure sensor [<xref ref-type="bibr" rid="ref28">28</xref>]</td>
              <td>Breath monitoring</td>
              <td>
                <list list-type="bullet">
                  <list-item>
                    <p>S: DSV pressure change</p>
                  </list-item>
                  <list-item>
                    <p>C: Wi-Fi connection</p>
                  </list-item>
                </list>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>Smart face mask with wearable pressure sensor [<xref ref-type="bibr" rid="ref29">29</xref>]</td>
              <td>Breath monitoring</td>
              <td>
                <list list-type="bullet">
                  <list-item>
                    <p>S: DSV pressure change</p>
                  </list-item>
                  <list-item>
                    <p>C: Bluetooth connection</p>
                  </list-item>
                </list>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>Smart medical mask for health care personnel [<xref ref-type="bibr" rid="ref30">30</xref>]</td>
              <td>Detect respiratory breathing, fever, and alert possible face irritation</td>
              <td>
                <list list-type="bullet">
                  <list-item>
                    <p>S: DSV temperature,    
                        mask strain</p>
                  </list-item>
                  <list-item>
                    <p>C: Wi-Fi</p>
                  </list-item>
                </list>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>Lab-on-Mask [<xref ref-type="bibr" rid="ref31">31</xref>]</td>
              <td>Monitor cardio-respiratory variables</td>
              <td>
                <list list-type="bullet">
                  <list-item>
                    <p>S: HR, BP<sup>j</sup>, SpO2, and skin temperature</p>
                  </list-item>
                  <list-item>
                    <p>C: Bluetooth connection</p>
                  </list-item>
                </list>
              </td>
            </tr>
            <tr valign="top">
              <td colspan="4">
                <bold>General health monitoring</bold>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>FaceMask [<xref ref-type="bibr" rid="ref32">32</xref>]</td>
              <td>Monitor cardio-respiratory variables and mask-wearing</td>
              <td>
                <list list-type="bullet">
                  <list-item>
                    <p>S: Humidity, DSV or external temperature, volatile organic compounds. And head motion</p>
                  </list-item>
                  <list-item>
                    <p>C: Bluetooth connection</p>
                  </list-item>
                </list>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>Facebit [<xref ref-type="bibr" rid="ref33">33</xref>]</td>
              <td>Monitor HR, respiration rate, mask fit, and wear time</td>
              <td>
                <list list-type="bullet">
                  <list-item>
                    <p>S: HR, respiration rate, mask fit, and wear time</p>
                  </list-item>
                  <list-item>
                    <p>C: Bluetooth</p>
                  </list-item>
                </list>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>Masquare [<xref ref-type="bibr" rid="ref34">34</xref>]</td>
              <td>Monitor cardio-respiratory variables</td>
              <td>
                <list list-type="bullet">
                  <list-item>
                    <p>S: Respiratory pressure,    
                        HR, SpO2, and head motion</p>
                  </list-item>
                  <list-item>
                    <p>C: Bluetooth</p>
                  </list-item>
                </list>
              </td>
            </tr>
          </tbody>
        </table>
        <table-wrap-foot>
          <fn id="table2fn1">
            <p><sup>a</sup>S: sensing.</p>
          </fn>
          <fn id="table2fn2">
            <p><sup>b</sup>A: actuation.</p>
          </fn>
          <fn id="table2fn3">
            <p><sup>c</sup>C: connectivity.</p>
          </fn>
          <fn id="table2fn4">
            <p><sup>d</sup>RF: radiofrequency.</p>
          </fn>
          <fn id="table2fn5">
            <p><sup>e</sup>DSV: dead space volume.</p>
          </fn>
          <fn id="table2fn6">
            <p><sup>f</sup>HR: heart rate.</p>
          </fn>
          <fn id="table2fn7">
            <p><sup>g</sup>SpO<sub>2</sub>: blood oxygen saturation.</p>
          </fn>
          <fn id="table2fn8">
            <p><sup>h</sup>LoRa: long range.</p>
          </fn>
          <fn id="table2fn9">
            <p><sup>i</sup>NFC: near-field connection.</p>
          </fn>
          <fn id="table2fn10">
            <p><sup>j</sup>BP: blood pressure.</p>
          </fn>
        </table-wrap-foot>
      </table-wrap>
      <p>Most commercial masks used in daily life provide actuations based on use, such as exchangeable filters, self-sterilizers, embodied microphones, and integrated fans. In total, 4 smart masks had sensing capabilities such as air pathogen check, filter status, and breath monitoring. In total, 11 smart masks included actuation with mostly inner fan speed control and LED lighting control. A total of 7 smart masks supported a connectivity feature through a Bluetooth connection with the smartphone. The masks that supported all 3 features (ie, sensing, actuation, and connectivity) were those of Atmos AO AIR [<xref ref-type="bibr" rid="ref10">10</xref>], LG PuriCare (2nd Gen) [<xref ref-type="bibr" rid="ref11">11</xref>], and ATMOBLUE [<xref ref-type="bibr" rid="ref12">12</xref>]. These smart masks offer inner fan control actuation and Bluetooth connectivity while using different sensing (filter, respiration rate, and air-quality checks). Commercial masks have focused on mitigating discomfort such as breathing difficulty, excessive moisture inside the mask, fogging of glasses, and hygiene problems caused by long-term use [<xref ref-type="bibr" rid="ref35">35</xref>-<xref ref-type="bibr" rid="ref37">37</xref>]. Besides protection, the masks of CLIU [<xref ref-type="bibr" rid="ref19">19</xref>], Donut Robotics [<xref ref-type="bibr" rid="ref20">20</xref>], and TrendyNow365 [<xref ref-type="bibr" rid="ref21">21</xref>] aimed to overcome speech problems with mask-wearing. Additional investigations, such as mask material, weight, and battery usage time, are presented in <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>.</p>
      <p>While commercial smart masks were focused on user comfort, academic prototypes were designed for sensing capabilities such as health monitoring and disease detection. For example, in terms of COVID-19 detection, Nguyen et al [<xref ref-type="bibr" rid="ref23">23</xref>] integrated a cell-free sensor to detect SARS-CoV-2, and Ye et al [<xref ref-type="bibr" rid="ref24">24</xref>] and Fois et al [<xref ref-type="bibr" rid="ref25">25</xref>] focused on detecting abnormalities such as coughing behavior. Not specific to COVID-19 but to cope with general respiratory disease, Lazaro et al [<xref ref-type="bibr" rid="ref26">26</xref>], Escobedo et al [<xref ref-type="bibr" rid="ref27">27</xref>], Zhong et al [<xref ref-type="bibr" rid="ref28">28</xref>], Yang et al [<xref ref-type="bibr" rid="ref29">29</xref>], Kim et al [<xref ref-type="bibr" rid="ref30">30</xref>], and Pan et al [<xref ref-type="bibr" rid="ref31">31</xref>] monitored breathing patterns. From a general health monitoring perspective, Gravina et al [<xref ref-type="bibr" rid="ref32">32</xref>], Curtiss et al [<xref ref-type="bibr" rid="ref33">33</xref>], and Fischer et al [<xref ref-type="bibr" rid="ref34">34</xref>] monitored biosignals such as heart rate, respiration rate, and body temperature. Acquired sensor readings were then analyzed through smartphone apps for display.</p>
      <p>All prototype masks were considered with regard to their physiological sensing capabilities. A total of 12 smart masks were considered with connectivity features using Bluetooth connectivity, near-field communication (NFC), a long range, and Wi-Fi connectivity with the smartphone. Ye et al [<xref ref-type="bibr" rid="ref24">24</xref>] further demonstrated a radiofrequency (RF) feature using silver nanowires attached to the inner layer for monitoring cough and mask usage. Overall, the current features of smart masks available in the market offer environmental (air quality) monitoring, mask quality–monitoring, and functions for user comfort. On the other hand, research prototypes can be summarized as health monitoring and respiratory disease detection.</p>
    </sec>
    <sec>
      <title>Possible Directions for Feature Extension</title>
      <p>Our investigation of research prototypes showed that existing masks support health monitoring and disease diagnosis on the basis of vital signs such as respiration, blood oxygen saturation, and body temperature. In this section, we further explore what other biosignals can be measured and what applications can be used through a smart mask as a wearable device for health care and safety. In addition, we argue that it is critical to reduce the posterior auricular (back of the ear) discomfort and pain caused by long-term wearing of the mask, as witnessed by a mask frame extension that supports an ear strap introduced recently [<xref ref-type="bibr" rid="ref38">38</xref>]. In consideration of the ear strap frame, we would like to present a viewpoint on the extension of the application of the smart mask and its potential as a biosignal measuring device. To systematically search for feasible sensors, the expressions “smart” and “intelligent” textiles or “wearable electronic” are keywords used for selection. Sensors that sense and react to biosignals, environmental conditions, or stimuli, such as those from breath, skin, head motion, air, or other sources, were investigated. Multiple biosignal sources can be recorded around the face with sensors incorporated into the smart masks to measure biosignals and interior or exterior environmental factors [<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref39">39</xref>].</p>
      <p>For the facial part of the mask, pressure sensors can be used to obtain the respiration rate and inhalation volume to monitor breathing patterns [<xref ref-type="bibr" rid="ref28">28</xref>,<xref ref-type="bibr" rid="ref29">29</xref>]. These are piezoelectric-like sensors that are sensitive enough to respond to exhale volume pressure and flexible, lightweight, and energy-efficient circuits that can fit into the mask. With continuous monitoring of breathing patterns, we expect to observe users’ lung health or screen patients with chronic lung disease [<xref ref-type="bibr" rid="ref40">40</xref>]. In addition to analyzing breath, chemical sensors can be used as markers for personal health problems and respiratory diseases by targeting specific molecules [<xref ref-type="bibr" rid="ref41">41</xref>-<xref ref-type="bibr" rid="ref48">48</xref>]. These sensors are based on metal oxides whose target compounds can be easily switched with specific reagents. Several applications include acetone for diabetes [<xref ref-type="bibr" rid="ref41">41</xref>-<xref ref-type="bibr" rid="ref43">43</xref>], hydrogen sulfide for small intestinal bacterial overgrowth [<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref45">45</xref>], and toluene for lung cancer diagnosis [<xref ref-type="bibr" rid="ref46">46</xref>-<xref ref-type="bibr" rid="ref48">48</xref>].</p>
      <p>As the mask directly contacts the facial skin, a photoplethysmographic (PPG) sensor can be adopted to conduct pulse oximetry and measure heart rate variability, oxygen saturation, and blood pressure. These metrics are widely researched for indirect measures of physical and mental health [<xref ref-type="bibr" rid="ref49">49</xref>-<xref ref-type="bibr" rid="ref51">51</xref>], physical stress [<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref49">49</xref>], and hypertension or hypotension [<xref ref-type="bibr" rid="ref51">51</xref>-<xref ref-type="bibr" rid="ref53">53</xref>], respectively. Electrooculography (EOG) [<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref55">55</xref>], electrodermal activity (EDA) [<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref57">57</xref>], and electromyography (EMG) [<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref53">53</xref>] can also be adopted to measure various biophysical signals that arise from facial skin. For example, eye-blinking EOG measures have been linked to attention [<xref ref-type="bibr" rid="ref58">58</xref>] and may infer the user’s mental state. The electrodermal response from EDA and facial muscle activation from EMG can be used as a measure of emotion such as anxiety or depression [<xref ref-type="bibr" rid="ref55">55</xref>-<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref59">59</xref>]. In addition, facial surface EMG was adopted for monitoring pain through facial expressions [<xref ref-type="bibr" rid="ref60">60</xref>] (<xref ref-type="table" rid="table3">Table 3</xref>).</p>
      <table-wrap position="float" id="table3">
        <label>Table 3</label>
        <caption>
          <p>Possible sensor integration on the masks.</p>
        </caption>
        <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
          <col width="30"/>
          <col width="30"/>
          <col width="30"/>
          <col width="30"/>
          <col width="410"/>
          <col width="0"/>
          <col width="470"/>
          <thead>
            <tr valign="top">
              <td colspan="6">Sensors and features</td>
              <td>Applications</td>
            </tr>
          </thead>
          <tbody>
            <tr valign="top">
              <td colspan="7">
                <bold>Location: mask main body</bold>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td colspan="6">
                <bold>Type: biosignal information</bold>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td colspan="5">
                <bold>Source: breath (respiration)</bold>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td colspan="4">
                <bold>Pressure sensor</bold>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>Respiration rate or volume</td>
              <td colspan="2">Personal health or sport [<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref28">28</xref>]</td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td colspan="4">
                <bold>Chemical sensor</bold>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>Ketone: acetone</td>
              <td colspan="2">Personal health or disease (diabetes) [<xref ref-type="bibr" rid="ref41">41</xref>-<xref ref-type="bibr" rid="ref43">43</xref>]</td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>Hydrogen sulfide</td>
              <td colspan="2">Personal health [<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref45">45</xref>]</td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>Toluene</td>
              <td colspan="2">Personal health or disease (lung cancer) [<xref ref-type="bibr" rid="ref46">46</xref>-<xref ref-type="bibr" rid="ref48">48</xref>]</td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td colspan="5">
                <bold>Source: facial blood vessels</bold>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td colspan="4">
                <bold>Photoplethysmography sensor</bold>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>Heart rate variability</td>
              <td colspan="2">Physical health or mental health [<xref ref-type="bibr" rid="ref49">49</xref>-<xref ref-type="bibr" rid="ref51">51</xref>]</td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>Oxygen saturation</td>
              <td colspan="2">Physical stress [<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref49">49</xref>]</td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>Blood pressure</td>
              <td colspan="2">Hypertension or hypotension [<xref ref-type="bibr" rid="ref51">51</xref>-<xref ref-type="bibr" rid="ref53">53</xref>]</td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td colspan="5">
                <bold>Source: skin</bold>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td colspan="4">
                <bold>Electrooculography sensor</bold>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>Eye blink</td>
              <td colspan="2">Concentration [<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref55">55</xref>]</td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td colspan="4">
                <bold>Electrodermal activity sensor</bold>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>Electrodermal response</td>
              <td colspan="2">Emotion [<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref57">57</xref>]</td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td colspan="4">
                <bold>Temperature sensor</bold>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>Temperature change</td>
              <td colspan="2">Communicable diseases [<xref ref-type="bibr" rid="ref25">25</xref>,<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref32">32</xref>]</td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td colspan="4">
                <bold>Electromyography sensor</bold>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>Facial muscle</td>
              <td colspan="2">Emotion [<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref59">59</xref>]</td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>Facial muscle</td>
              <td colspan="2">Pain [<xref ref-type="bibr" rid="ref60">60</xref>]</td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td colspan="5">
                <bold>Source: head</bold>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td colspan="4">
                <bold>Inertial measurement unit</bold>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>Motion</td>
              <td colspan="2">Posture [<xref ref-type="bibr" rid="ref61">61</xref>]</td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td colspan="6">
                <bold>Type: environmental information</bold>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td colspan="5">
                <bold>Source: air</bold>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td colspan="4">
                <bold>Chemical sensor</bold>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>Environment air quality</td>
              <td colspan="2">Local air quality [<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref39">39</xref>]</td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td colspan="5">
                <bold>Source: external temperature</bold>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td colspan="4">
                <bold>Thermometer</bold>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>Temperature</td>
              <td colspan="2">Local temperature [<xref ref-type="bibr" rid="ref62">62</xref>]</td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td colspan="5">
                <bold>Source: external humidity</bold>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td colspan="4">
                <bold>Humidity sensor</bold>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>Humidity</td>
              <td colspan="2">Local humidity [<xref ref-type="bibr" rid="ref63">63</xref>-<xref ref-type="bibr" rid="ref65">65</xref>]</td>
            </tr>
            <tr valign="top">
              <td colspan="7">
                <bold>Location: mask support frame</bold>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td colspan="6">
                <bold>Type: biosignal information</bold>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td colspan="5">
                <bold>Source: ear</bold>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td colspan="4">
                <bold>Electroencephalography sensor</bold>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>Brain activity</td>
              <td colspan="2">Drowsiness or fatigue [<xref ref-type="bibr" rid="ref66">66</xref>]</td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td colspan="5">
                <bold>Source: neck</bold>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td colspan="4">
                <bold>Inertial measurement unit sensor</bold>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>Motion</td>
              <td colspan="2">Posture [<xref ref-type="bibr" rid="ref61">61</xref>]</td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td colspan="4">
                <bold>Electrocardiographic sensor</bold>
              </td>
            </tr>
            <tr valign="top">
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>
                <break/>
              </td>
              <td>Heart</td>
              <td colspan="2">Heart disease [<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref68">68</xref>]</td>
            </tr>
          </tbody>
        </table>
      </table-wrap>
      <p>A smart mask can also measure air pollution and several other environmental variables such as air quality [<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref39">39</xref>], temperature [<xref ref-type="bibr" rid="ref62">62</xref>], and humidity [<xref ref-type="bibr" rid="ref63">63</xref>-<xref ref-type="bibr" rid="ref65">65</xref>]. The inclusion of sensing air-tightness and the quality of filters can help ensure the additional benefits of smart masks by improving safety by providing an air-tight fit around the face. If the mask uses a support frame, such as a head or neck strap, electroencephalography (EEG) and electrocardiography (ECG) sensors can be applied to measure the electrical activity of the brain and heart. EEG signals have been used to detect a user's fatigue or drowsiness like fatigue in driving [<xref ref-type="bibr" rid="ref66">66</xref>]. Integrating ECG can be an advantage over PPG readings as it records the heart’s electrical activity at its source [<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref68">68</xref>]. Lastly, inertial measurement unit sensors can be attached to the ear strap for activity sensing that can discern fall or head collision [<xref ref-type="bibr" rid="ref61">61</xref>]. The possible sensor attachments on a facial mask and ear strap are depicted in <xref rid="figure1" ref-type="fig">Figure 1</xref>.</p>
      <fig id="figure1" position="float">
        <label>Figure 1</label>
        <caption>
          <p>The possible sensor attachments on (A) a facial mask and (B) the ear strap. ECG: electrocardiography; EEG: electroencephalography; EMG: electromyography; EOG: electrooculography; GSR: Galvanic skin response; PPG: photoplethysmography.</p>
        </caption>
        <graphic xlink:href="mhealth_v10i6e38614_fig1.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
      </fig>
    </sec>
    <sec>
      <title>Toward Connected Smart Masks</title>
      <p>In this section, we attempt to seek opportunities beyond personal protective equipment to group management, so-called group-sensing, through connected smart masks as wearable devices for health care and safety. The advantages of group-sensing include continuously measuring and managing a population's physical and mental health through the sensors inside the smart mask or via connected smart mask platforms. Such advantages are particularly useful in dealing with infectious diseases that spread through contact and saliva, such as COVID-19 [<xref ref-type="bibr" rid="ref69">69</xref>]. The smart masks of those at risk can be managed, and remote caregiving can be supported via connected devices. As in a prior study on smartwatches [<xref ref-type="bibr" rid="ref70">70</xref>], their everyday health conditions (eg, breathing and heart rates) can be tracked and analyzed to detect early signs of respiratory behavior changes, which could be related to COVID-19 infection. Namely, beyond a personal sensing application, a group or community sensing application may share an aggregate version of information with the broader population. The architecture of connected masks is shown in <xref rid="figure2" ref-type="fig">Figure 2</xref> by extending prior mobile sensing architecture [<xref ref-type="bibr" rid="ref71">71</xref>,<xref ref-type="bibr" rid="ref72">72</xref>].</p>
      <p>For group sensing, the smart mask should be able to transmit the collected data to the server by using wireless communication protocols such as Wi-Fi, long-term evolution, 4G and 5G networks, Zigbee, and narrowband IoT without manual operation [<xref ref-type="bibr" rid="ref73">73</xref>]. Besides, the analysis results should allow the user to take action or receive an alarm related to a particular hazard. Most smart masks integrate communication modules to use smartphones for displaying sensing results and as a gateway terminal to interact on the web [<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref33">33</xref>,<xref ref-type="bibr" rid="ref74">74</xref>,<xref ref-type="bibr" rid="ref75">75</xref>]. In addition, smartphones allow short-distance connections such as Bluetooth, NFC, and radiofrequency identification, where acquired data can be transferred to local IoT gateways [<xref ref-type="bibr" rid="ref73">73</xref>]. Furthermore, server clouds and relevant analytics technology are required to store smart mask data and process large sets of data to develop applications such as health care, safety monitoring, and intervention for the users. This kind of collaborative sensing will also address the challenges of individual sensing, such as reliability and coverage [<xref ref-type="bibr" rid="ref76">76</xref>].</p>
      <p>The information gathered in cloud servers can be used with machine learning (ML) and data mining applications [<xref ref-type="bibr" rid="ref75">75</xref>,<xref ref-type="bibr" rid="ref77">77</xref>]. The advantages of utilizing ML for group sensing results are system optimization and acquired data processing [<xref ref-type="bibr" rid="ref77">77</xref>]. For instance, collecting data on device failures, usage time, filter, and battery can be analyzed for design considerations and maintaining the optimal operation of a smart mask. Furthermore, Gravina et al [<xref ref-type="bibr" rid="ref32">32</xref>] reported the application of ML in smart masks, where they tested mask wear classification from sensor signals. In terms of data mining, a more detailed air quality map can be created as the user wears a smart mask with environmental sensors and moves around places collecting data. Moreover, GPS for community sensing can facilitate real-time sensing and location-based monitoring of masks and actions of multiple users in some local environments, such as COVID-19 contact-tracing, local airborne pathogen detection, or emergency services.</p>
      <fig id="figure2" position="float">
        <label>Figure 2</label>
        <caption>
          <p>Connected smart mask architecture.</p>
        </caption>
        <graphic xlink:href="mhealth_v10i6e38614_fig2.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
      </fig>
      <p>With modern technological advances, it has become possible to collect big data and create new knowledge that we have not been able to analyze before. Unlike conventional wearable devices, smart masks can collect biomarkers of respiration or the respiratory system and expand further knowledge on wearables. Previous work by Curtiss et al [<xref ref-type="bibr" rid="ref33">33</xref>] and Hyysalo et al [<xref ref-type="bibr" rid="ref75">75</xref>] shows detailed aspects of the connected smart mask platform and deployment considerations. Curtiss et al’s [<xref ref-type="bibr" rid="ref33">33</xref>] Facebit smart mask accompanies a mobile app that displays sensing results such as heart rate, respiration rate, mask fit, and wear time. This app communicates with Facebit through Bluetooth and stores data in a local database. For now, stored data are used to track a user’s mask-wearing time and send a notification to replace the mask. As an open-source smart mask research platform, this work demonstrates proof-of-concept connected smart masks and presents further research on personalizing algorithms and applications for respiratory health tools. Hyysalo [<xref ref-type="bibr" rid="ref75">75</xref>] illustrated the software architecture of the smart mask platform, including the mask, mobile app, and backend health artificial intelligence. In addition, this study envisioned a smart mask ecosystem [<xref ref-type="bibr" rid="ref78">78</xref>,<xref ref-type="bibr" rid="ref79">79</xref>]—a collection of infrastructure, analytics, and applications, to draw personal health trajectories.</p>
    </sec>
    <sec>
      <title>Further Considerations for Real-World Use</title>
      <p>Lastly, we present and discuss viewpoints on the application fields of the connected mask and further considerations for practical use. As the smart face mask is a promising respiratory monitoring tool, we explored relevant fields where it can benefit direct needs. Aside from the primary field of daily-life health-monitoring, we envision several real-world uses such as sports training, ambulatory setting, industry and firefighter safety masks, and military applications. In the following sections, several directions for real-world deployment scenarios of smart masks are first discussed. Thereafter, we discuss sensor accuracy and reproducibility issues, most critical ones in measuring biosignals through all wearable devices. Ergonomic design for the general population needs to be considered for public acceptance of smart masks. Finally, privacy-aware data-handling is necessary for security to collect and manage personal biosignals.</p>
    </sec>
    <sec>
      <title>Service Application for Real-World Use</title>
      <sec>
        <title>Daily Life Health Monitoring</title>
        <p>The smart mask presents an opportunity to apply advanced analytics to health care. The analysis of physiological changes, such as breathing pattern, pulse rate, and tidal volume, enables us to monitor respiratory health, diagnose relevant diseases, and point of care through continuous monitoring. In addition, other various features can be obtained, as we discussed in the possible sensor extension scenarios, for instance, stress and fatigue [<xref ref-type="bibr" rid="ref80">80</xref>].</p>
      </sec>
      <sec>
        <title>Sports Training</title>
        <p>In particular, smart masks can be adopted for measuring the cardiopulmonary exercise load, which is an important index in evaluating exercise capacity. Previously, this was done by wearing additional equipment in wired or wireless form with controlled settings [<xref ref-type="bibr" rid="ref81">81</xref>]. This test can be easily accessible to the general population; for example, in a gymnasium or through home-based training through smart mask application. Furthermore, owing to the recent COVID-19 pandemic, there is increasing demand for indoor exercise platforms such as Zwift [<xref ref-type="bibr" rid="ref82">82</xref>], where individuals can virtually compete with users on the internet and measure exercise ability and improvements. The smart mask can contribute as a wearable device for additional exercise measures in such settings.</p>
      </sec>
      <sec>
        <title>Emergency Room or Ambulatory Settings</title>
        <p>In the emergency room or ambulatory settings, masks have been used to deliver air and monitor respiration. We expect smart masks to be adopted to track health status without any additional device. Additionally, nosocomial infections, such as ventilator-associated pneumonia, can be detected with the use of the smart mask [<xref ref-type="bibr" rid="ref83">83</xref>].</p>
      </sec>
      <sec>
        <title>Industry Workers and Firefighters</title>
        <p>Many workers at coal mines, construction sites, and chemical plants and firefighters at fire scenes are prone to hazardous gas; thus, wearing a mask is mandatory for safety issues. Smart masks can be used to track the health status of people who have been poisoned by gas or toxic substances or have been exposed by measuring the surrounding situation. Besides, real-time environmental monitoring can ensure user safety and prompt responses to fast-changing hazardous events through the detection of gas leakage or toxic events [<xref ref-type="bibr" rid="ref84">84</xref>].</p>
      </sec>
      <sec>
        <title>Soldier Safety and Survivability</title>
        <p>Recently, there has been ongoing research on wearable devices such as vests and helmets to collect biosignals for the safety and survival of soldiers [<xref ref-type="bibr" rid="ref85">85</xref>]. The smart mask can also be a promising wearable device in respiratory monitoring. It is expected that safety and survival can be further improved by collecting the soldier’s biosignals, location information, or information about the surrounding environment. These measures help monitor the soldier's physical and mental health status and decision-making. Moreover, breath analysis can predict and monitor the onset of pulmonary injury due to various environmental and infectious exposures [<xref ref-type="bibr" rid="ref86">86</xref>].</p>
      </sec>
    </sec>
    <sec>
      <title>Accurate and Reliable Sensors</title>
      <p>One major requirement for such predictive diagnostics is that sensor information must be accurate and reliable. The type of sensor and its placement affect the measurements. For instance, potential inaccuracies rise with excessive motion artifacts involving many physical activities, such as sports, firefighting, or military action. Although the reviewed articles described potential applications and demands for health intervention, they provided little evidence related to the usability and practicality of the proposed device. As the temperature and humidity rise owing to mask-wearing, the adhesion between the sensor and the skin may decrease, and sweat generated by humidity may negatively affect accurate sensor signal measurement. Beyond sensing accuracy and reliability, it is important to consider additional metrics, such as smart mask interoperability, versatility, power consumption, and durability, to examine the usefulness of the system as well as comfort and ease of use for different population characteristics [<xref ref-type="bibr" rid="ref87">87</xref>,<xref ref-type="bibr" rid="ref88">88</xref>].</p>
    </sec>
    <sec>
      <title>Ergonomic Design for Usability</title>
      <p>If users wear heavy equipment such as a helmet for a long time, it can strain their head and neck [<xref ref-type="bibr" rid="ref89">89</xref>-<xref ref-type="bibr" rid="ref91">91</xref>]. Masks with smart functions also increase in weight, unlike existing masks, owing to the addition of batteries, sensors, and fans. Therefore, it places a burden on the head and neck and may cause deformation in posture. If the systems within smart masks became more complicated, these could become more uncomfortable and make users reluctant to wear them. Detailed surveys on usability and performance evaluation from daily life trials need to be conducted to ascertain the usability of smart masks [<xref ref-type="bibr" rid="ref92">92</xref>-<xref ref-type="bibr" rid="ref94">94</xref>]. Maximizing and optimizing the battery lifetime of the smart mask ensures user satisfaction and comfort [<xref ref-type="bibr" rid="ref95">95</xref>,<xref ref-type="bibr" rid="ref96">96</xref>]. If the device supports recharging, the rechargeable battery of the mask is a major contributor to the mask’s weight. If the communication between the smart mask and the smartphone requires much energy and acquiring data from sensors may rapidly drain the battery, a larger battery capacity is then required. Thus, the overall weight of the mask increases. Therefore, in developing a smart mask, it is necessary to consider the battery size and material related to weight. In addition, since the material of their mask is in contact with the skin surface, it is necessary to use an approved suitable material [<xref ref-type="bibr" rid="ref97">97</xref>]. Overall, the potential reluctance of users can be reduced by incorporating simple protocols for the number of sensors and user specificity, comfort, including weight, and fashion considerations for the general population [<xref ref-type="bibr" rid="ref98">98</xref>,<xref ref-type="bibr" rid="ref99">99</xref>].</p>
    </sec>
    <sec>
      <title>Privacy-Aware Data-Handling</title>
      <p>One challenge in developing connected smart mask architecture systems is the collection of personal information and privacy infringement. With the advancement of the IoT, real-time monitoring data are shared and analyzed to identify factors related to events. Although this monitoring is intended to assist users, some aspects of personal privacy are violated [<xref ref-type="bibr" rid="ref100">100</xref>-<xref ref-type="bibr" rid="ref104">104</xref>]. Prior studies have shown that privacy concerns related to wearable cameras are often influenced by users’ social, behavioral, and environmental contexts [<xref ref-type="bibr" rid="ref105">105</xref>]. For example, wearable camera users are often conscious of bystander privacy, and likewise, bystanders are concerned about potential privacy violations (eg, subtleness and ease of recording) [<xref ref-type="bibr" rid="ref106">106</xref>]. In addition, advanced data processing methods may have privacy implications. For instance, personal physiological data or location information can be misused because of poor data management policies. In these scenarios, health monitoring results may encourage the tracking of work performance (ie, using the data for secondary purposes without explicit consent). This practice may influence the review of workers’ performances and may cause monitoring to become a surveillance practice beyond health monitoring. Beyond secondary use, the security of the devices themselves can also be problematic, as the low computing power within smart mask systems may make them vulnerable to unauthenticated access [<xref ref-type="bibr" rid="ref107">107</xref>,<xref ref-type="bibr" rid="ref108">108</xref>]. As smart mask technology is still in its infancy, these implications are not yet fully understood and should be considered in future implementation strategies.</p>
    </sec>
    <sec>
      <title>Conclusions</title>
      <p>This study examined recent smart masks in conjunction with accompanying systems that could be used to prevent COVID-19 and other respiratory diseases. We then offered our viewpoints on smart masks in the form of emerging IoT solutions. Reviewing commercially available smart masks revealed the trend that smart masks were mainly designed to address user discomfort. However, recent research prototypes were taking further steps, not only dealing with COVID-19 but toward general health monitoring by supporting breathing and physiological signal sensing. Thus, we sought further functional expansion on smart masks by investigating previous mobile sensing studies. In addition, we extensively discussed novel opportunities for group health management through a connected smart masks platform. We believe that smart masks can serve as a truly cutting-edge device that expands the coverage of health monitoring and helps reach the next level of wearables.</p>
    </sec>
  </body>
  <back>
    <app-group>
      <supplementary-material id="app1">
        <label>Multimedia Appendix 1</label>
        <p>Table showing specifications of 12 commercially available smart masks.</p>
        <media xlink:href="mhealth_v10i6e38614_app1.docx" xlink:title="DOCX File , 19 KB"/>
      </supplementary-material>
    </app-group>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">EDA</term>
          <def>
            <p>electrodermal activity</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb2">EMG</term>
          <def>
            <p>electromyography</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb3">EOG</term>
          <def>
            <p>electrooculography</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb4">IoT</term>
          <def>
            <p>Internet of Things</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb5">KAIST</term>
          <def>
            <p>Korea Advanced Institute of Science &#38; Technology</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb6">ML</term>
          <def>
            <p>machine Learning</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb7">NFC</term>
          <def>
            <p>near-field communication</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb8">PPG</term>
          <def>
            <p>photoplethysmography</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <ack>
      <p>This research was supported by the 2022 Smart project of the Korea Advanced Institute of Science &#38; Technology and Khalifa University (KAIST-KU) Joint Research Center, KAIST, Daejeon, Korea, and the Basic Science Research Program through the National Research Foundation of Korea funded by the Korean government’s Ministry of Science and Information and Communication Technology (2020R1A4A1018774).</p>
    </ack>
    <fn-group>
      <fn fn-type="con">
        <p>PL and HK wrote and equally contributed to drafting of the manuscript. YK performed a database search for study selection and wrote data for <xref ref-type="table" rid="table1">Tables 1</xref> and <xref ref-type="table" rid="table2">2</xref>. HK provided data for <xref ref-type="table" rid="table3">Table 3</xref>. WC, MSZ, AHK, HFJ, LH, UL, and YJ contributed to the critical revision of the paper, and all authors reviewed the final manuscript.</p>
      </fn>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
    <ref-list>
      <ref id="ref1">
        <label>1</label>
        <nlm-citation citation-type="web">
          <article-title>Coronavirus disease 2019 (COVID-19): situation report, 73</article-title>
          <source>World Health Organization</source>
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