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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMU</journal-id>
      <journal-id journal-id-type="nlm-ta">JMIR Mhealth Uhealth</journal-id>
      <journal-title>JMIR mHealth and uHealth</journal-title>
      <issn pub-type="epub">2291-5222</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v11i1e40898</article-id>
      <article-id pub-id-type="pmid">36877551</article-id>
      <article-id pub-id-type="doi">10.2196/40898</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Review</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Review</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Design Features Associated With Engagement in Mobile Health Physical Activity Interventions Among Youth: Systematic Review of Qualitative and Quantitative Studies</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Buis</surname>
            <given-names>Lorraine</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Spook</surname>
            <given-names>Jorinde</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Lyons</surname>
            <given-names>Elizabeth</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author" corresp="yes">
          <name name-style="western">
            <surname>Schwarz</surname>
            <given-names>Ayla</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <address>
            <institution>Department of Social Sciences, Chair Group Consumption &#38; Healthy Lifestyles</institution>
            <institution>Wageningen University &#38; Research</institution>
            <addr-line>Hollandseweg 1</addr-line>
            <addr-line>Wageningen, 6706KN</addr-line>
            <country>Netherlands</country>
            <phone>31 0639187108</phone>
            <email>ayla.schwarz@wur.nl</email>
          </address>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-8851-7316</ext-link>
        </contrib>
        <contrib id="contrib2" contrib-type="author">
          <name name-style="western">
            <surname>Winkens</surname>
            <given-names>Laura H H</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-9856-6509</ext-link>
        </contrib>
        <contrib id="contrib3" contrib-type="author">
          <name name-style="western">
            <surname>de Vet</surname>
            <given-names>Emely</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-4452-2367</ext-link>
        </contrib>
        <contrib id="contrib4" contrib-type="author">
          <name name-style="western">
            <surname>Ossendrijver</surname>
            <given-names>Dian</given-names>
          </name>
          <degrees>MSc</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-2292-2458</ext-link>
        </contrib>
        <contrib id="contrib5" contrib-type="author">
          <name name-style="western">
            <surname>Bouwsema</surname>
            <given-names>Kirsten</given-names>
          </name>
          <degrees>MSc</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-6682-2347</ext-link>
        </contrib>
        <contrib id="contrib6" contrib-type="author">
          <name name-style="western">
            <surname>Simons</surname>
            <given-names>Monique</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-6475-4616</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution>Department of Social Sciences, Chair Group Consumption &#38; Healthy Lifestyles</institution>
        <institution>Wageningen University &#38; Research</institution>
        <addr-line>Wageningen</addr-line>
        <country>Netherlands</country>
      </aff>
      <author-notes>
        <corresp>Corresponding Author: Ayla Schwarz <email>ayla.schwarz@wur.nl</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <year>2023</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>6</day>
        <month>3</month>
        <year>2023</year>
      </pub-date>
      <volume>11</volume>
      <elocation-id>e40898</elocation-id>
      <history>
        <date date-type="received">
          <day>8</day>
          <month>7</month>
          <year>2022</year>
        </date>
        <date date-type="rev-request">
          <day>11</day>
          <month>8</month>
          <year>2022</year>
        </date>
        <date date-type="rev-recd">
          <day>2</day>
          <month>11</month>
          <year>2022</year>
        </date>
        <date date-type="accepted">
          <day>21</day>
          <month>12</month>
          <year>2022</year>
        </date>
      </history>
      <copyright-statement>©Ayla Schwarz, Laura H H Winkens, Emely de Vet, Dian Ossendrijver, Kirsten Bouwsema, Monique Simons. Originally published in JMIR mHealth and uHealth (https://mhealth.jmir.org), 06.03.2023.</copyright-statement>
      <copyright-year>2023</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR mHealth and uHealth, is properly cited. The complete bibliographic information, a link to the original publication on https://mhealth.jmir.org/, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://mhealth.jmir.org/2023/1/e40898" xlink:type="simple"/>
      <abstract>
        <sec sec-type="background">
          <title>Background</title>
          <p>Globally, 81% of youth do not meet the physical activity (PA) guidelines. Youth of families with a low socioeconomic position are less likely to meet the recommended PA guidelines. Mobile health (mHealth) interventions are preferred by youth over traditional in-person approaches and are in line with their media preferences. Despite the promise of mHealth interventions in promoting PA, a common challenge is to engage users in the long term or effectively. Earlier reviews highlighted the association of different design features (eg, notifications and rewards) with engagement among adults. However, little is known about which design features are important for increasing engagement among youth.</p>
        </sec>
        <sec sec-type="objective">
          <title>Objective</title>
          <p>To inform the design process of future mHealth tools, it is important to investigate the design features that can yield effective user engagement. This systematic review aimed to identify which design features are associated with engagement in mHealth PA interventions among youth who were aged between 4 and 18 years.</p>
        </sec>
        <sec sec-type="methods">
          <title>Methods</title>
          <p>A systematic search was conducted in EBSCOhost (MEDLINE, APA PsycINFO, and Psychology &#38; Behavioral Sciences Collection) and Scopus. Qualitative and quantitative studies were included if they documented design features associated with engagement. Design features and related behavior change techniques and engagement measures were extracted. Study quality was assessed according to the Mixed Method Assessment Tool, and one-third of all screening and data extraction were double coded by a second reviewer.</p>
        </sec>
        <sec sec-type="results">
          <title>Results</title>
          <p>Studies (n=21) showed that various features were associated with engagement, such as a clear interface, rewards, multiplayer game mode, social interaction, variety of challenges with personalized difficulty level, self-monitoring, and variety of customization options among others, including self-set goals, personalized feedback, progress, and a narrative. In contrast, various features need to be carefully considered while designing mHealth PA interventions, such as sounds, competition, instructions, notifications, virtual maps, or self-monitoring, facilitated by manual input. In addition, technical functionality can be considered as a prerequisite for engagement. Research addressing youth from low socioeconomic position families is very limited with regard to engagement in mHealth apps.</p>
        </sec>
        <sec sec-type="conclusions">
          <title>Conclusions</title>
          <p>Mismatches between different design features in terms of target group, study design, and content translation from behavior change techniques to design features are highlighted and set up in a design guideline and future research agenda.</p>
        </sec>
        <sec sec-type="Trial Registration">
          <title>Trial Registration</title>
          <p>PROSPERO CRD42021254989; https://tinyurl.com/5n6ppz24</p>
        </sec>
      </abstract>
      <kwd-group>
        <kwd>systematic review</kwd>
        <kwd>youth</kwd>
        <kwd>physical activity</kwd>
        <kwd>design features</kwd>
        <kwd>engagement</kwd>
        <kwd>mHealth</kwd>
        <kwd>mobile health</kwd>
        <kwd>mobile phone</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <sec>
        <title>Background</title>
        <p>Physical activity (PA) in youth is associated with a variety of health benefits [<xref ref-type="bibr" rid="ref1">1</xref>], including physical [<xref ref-type="bibr" rid="ref2">2</xref>] and mental health benefits [<xref ref-type="bibr" rid="ref3">3</xref>]. Despite the health benefits, 81% of youth (ie, those in childhood and adolescence) globally do not meet the PA guidelines [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref5">5</xref>] of daily 60 minutes of moderate- to vigorous-intensity physical activity (MVPA) and vigorous activities 3 days per week [<xref ref-type="bibr" rid="ref1">1</xref>]. In Europe, only 19% of adolescents comply with the MVPA guidelines, and higher family affluence is associated with higher levels of MVPA [<xref ref-type="bibr" rid="ref6">6</xref>]. Moreover, PA in youth is reported to track into adulthood, underlying the importance of promoting PA in the youth [<xref ref-type="bibr" rid="ref7">7</xref>,<xref ref-type="bibr" rid="ref8">8</xref>]. Also, the youth of families with a low socioeconomic position (SEP) are less likely to meet the recommended PA guidelines [<xref ref-type="bibr" rid="ref9">9</xref>,<xref ref-type="bibr" rid="ref10">10</xref>]. Therefore, effective and socially acceptable PA interventions are needed [<xref ref-type="bibr" rid="ref11">11</xref>], especially among youth of families with a low SEP. SEP is often measured in terms of education (attainment), income, and occupation status, which are often interrelated and related to the social and economic resources available [<xref ref-type="bibr" rid="ref12">12</xref>].</p>
        <p>Mobile health (mHealth) tools such as smartphone apps can be cost-effective [<xref ref-type="bibr" rid="ref13">13</xref>] in changing total PA [<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref15">15</xref>] and daily steps [<xref ref-type="bibr" rid="ref14">14</xref>]. mHealth interventions are preferred by youth over traditional in-person approaches [<xref ref-type="bibr" rid="ref16">16</xref>-<xref ref-type="bibr" rid="ref18">18</xref>] and are in line with preferences of youth, with regard to multimedia formats (ie, text, sound, and video) [<xref ref-type="bibr" rid="ref19">19</xref>]. Mobile devices and apps have gained popularity in the daily life of increasingly younger age groups of youth, starting at the age of 3 or 4 years already [<xref ref-type="bibr" rid="ref20">20</xref>-<xref ref-type="bibr" rid="ref24">24</xref>]. Families of young children, especially those with a low-SEP background, indicate concern about inappropriate content [<xref ref-type="bibr" rid="ref20">20</xref>], which might suggest that appropriate content might rather be supported by guardians. Appropriate content may refer to different forms of app use that might not necessarily increase current screen time use, as the design of the mHealth intervention may have considered a limited use time frame, only stimulating sporadic screen time (eg, integration to the direct physical environment to stimulate children to go outside and be physically active instead of the requirement of using the digital tool when being physically active) or stimulating the co-use of young children and guardians [<xref ref-type="bibr" rid="ref25">25</xref>]. Earlier systematic reviews indicated that currently, foremost, adults are included in mHealth effectiveness studies, and limited research has been conducted among youth [<xref ref-type="bibr" rid="ref26">26</xref>]. People with high SEP compared with people with low SEP report foremost positive health effects of the same digital intervention [<xref ref-type="bibr" rid="ref27">27</xref>]. Apps are primarily designed for people with high SEP, and people with low SEP are often reported as being difficult to reach [<xref ref-type="bibr" rid="ref28">28</xref>]. In contrast to mHealth apps, youth from low-SEP families engage in more screen time [<xref ref-type="bibr" rid="ref29">29</xref>] and are more involved on the web [<xref ref-type="bibr" rid="ref30">30</xref>] and active [<xref ref-type="bibr" rid="ref31">31</xref>] gaming. This suggests that approaching youth with low SEP via apps (eg, screen and games) can be useful and beneficial, yet other ingredients (eg, tailoring) are needed to reach them effectively in mHealth apps [<xref ref-type="bibr" rid="ref32">32</xref>].</p>
        <p>Despite the promise of digital or mHealth interventions in promoting PA [<xref ref-type="bibr" rid="ref26">26</xref>], a common challenge is to engage users in the long term [<xref ref-type="bibr" rid="ref14">14</xref>] or effectively [<xref ref-type="bibr" rid="ref26">26</xref>]. With regard to including people with a low-SEP background in research, studies identified challenges in reaching the target group [<xref ref-type="bibr" rid="ref33">33</xref>] and engaging them in research [<xref ref-type="bibr" rid="ref28">28</xref>] and in the digital health intervention [<xref ref-type="bibr" rid="ref34">34</xref>]. In addition, eHealth and mHealth studies focus on a general target group and often do not research subgroups (ie, low-SEP groups) [<xref ref-type="bibr" rid="ref35">35</xref>].</p>
        <p>Engagement refers to the involvement and motivation of the user in the intervention [<xref ref-type="bibr" rid="ref36">36</xref>]. It refers to “(1) the extent (e.g., amount, frequency, duration, depth) of usage and (2) the subjective experience characterized by attention, interest and affect” (ie, enjoyment) [<xref ref-type="bibr" rid="ref37">37</xref>]. Attention refers to the degree of focus or absorption versus distraction in the intervention. Interest refers to feelings of interest or fascination versus boredom with the intervention. Enjoyment reflects the enjoyable experience of fun or pleasure versus frustration and annoyance while using the intervention [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref38">38</xref>]. Engagement can contribute to the overall effectiveness of digital interventions [<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref39">39</xref>], meaning that to be effective, it is important that the user experiences a sufficient degree of engagement. The extent of use or dose is less predictive of engagement than the subjective experience to achieve the intended outcomes of the intervention (ie, effective engagement) [<xref ref-type="bibr" rid="ref40">40</xref>]. This means that frequently engaging with the intervention is not always required to be effectively engaged with the intervention or the behavior eventually.</p>
        <p>Currently, engagement is still not commonly reported in terms of use data (ie, extent) [<xref ref-type="bibr" rid="ref26">26</xref>] and experience data (ie, subjective engagement) [<xref ref-type="bibr" rid="ref41">41</xref>]. To improve intervention exposure and related intervention efficacy, it is important to better understand the design features (ie, active ingredients of an app that are in best cases informed by theory and translated into design, often referred to as “persuasive features,” features, and elements) contributing to engagement [<xref ref-type="bibr" rid="ref26">26</xref>]. A review of commercial apps indicated low engagement scores and suggested investigating features that improve engagement with an app among youth [<xref ref-type="bibr" rid="ref42">42</xref>], as the features may differ with those studied in adults [<xref ref-type="bibr" rid="ref37">37</xref>]. Earlier studies reported a common decline in app use over time and called for investigating features that contribute to intervention uptake and engagement [<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref26">26</xref>] also among particular subgroups, such as people with a low-SEP background [<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref32">32</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref44">44</xref>]. For example, research among low-SEP groups indicated that frustration with particular design features and navigations (eg, data log) hampered app use [<xref ref-type="bibr" rid="ref45">45</xref>].</p>
        <p>When designing mHealth interventions, several active ingredients, otherwise indicated as behavior change techniques (BCTs), are applied and translated to app features to foster behavior change. In addition to low engagement scores, existing reviews reveal that a limited number of BCTs, such as instructions, encouragement, rewards, and feedback on performance, which are essential components of interventions to promote behavior change [<xref ref-type="bibr" rid="ref46">46</xref>], are currently applied in mHealth apps [<xref ref-type="bibr" rid="ref42">42</xref>]. BCTs can be directly translated into gamification or app features (eg, goal-setting translated into challenges), here referred to as design features [<xref ref-type="bibr" rid="ref47">47</xref>]. Studies suggest that applying either a larger number of BCTs [<xref ref-type="bibr" rid="ref42">42</xref>]—particular BCTs (eg, self-monitoring, feedback, goal-setting, rewards, reminders, and social support under certain circumstances) or a particular combination of BCTs (eg, problem-solving and rewards) [<xref ref-type="bibr" rid="ref48">48</xref>]—may contribute to engagement in digital interventions [<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref48">48</xref>].</p>
      </sec>
      <sec>
        <title>Objective</title>
        <p>To inform the design process of future mHealth tools, it is important to investigate the design features that can yield effective user engagement. Research has demonstrated that for adults, user guidance, well-designed reminders, self-monitoring, positive feedback, rewards (eg, lottery), goal-setting, personalization, social networking, and health message framing [<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref49">49</xref>] were associated with higher user engagement. However, most studies included adult samples, targeted mental health instead of PA among adolescents, or did not focus on low-SEP groups [<xref ref-type="bibr" rid="ref50">50</xref>-<xref ref-type="bibr" rid="ref52">52</xref>]. To our knowledge, no systematic review that primarily seeks to identify design features in mHealth PA intervention among youth, especially youth from low-SEP families that have been associated with engagement, has yet been conducted. Therefore, this systematic review aimed to identify which features are associated with engagement in mHealth PA interventions among youth who were aged between 4 and 18 years. This could help inform app developers and (digital) behavior change intervention researchers to better integrate engagement during the design process of mobile behavioral change interventions.</p>
      </sec>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <sec>
        <title>Systematic Review</title>
        <p>The research protocol of the review was registered with the International Prospective Register of Systematic Reviews (PROSPERO; #CRD42021254989). Reporting complied with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses; <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref> [<xref ref-type="bibr" rid="ref53">53</xref>]) statement [<xref ref-type="bibr" rid="ref54">54</xref>].</p>
      </sec>
      <sec>
        <title>Search Strategy</title>
        <p>A systematic search was conducted on June 2, 2021, updated on June 24, 2022, and included the following databases: EBSCOhost (MEDLINE, APA PsycINFO, and Psychology &#38; Behavioral Sciences Collection) and Scopus. The search terms that included synonyms relating to engagement and the population (youth), the intervention (mHealth), and outcome (PA) were informed by earlier reviews [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref56">56</xref>] and were eventually reviewed by an academic librarian. <xref ref-type="supplementary-material" rid="app2">Multimedia Appendix 2</xref> provides the complete search terms and synonyms used.</p>
      </sec>
      <sec>
        <title>Eligibility Criteria</title>
        <p>Quantitative, qualitative, and mixed methods studies were included in the review, as engagement is an emerging field of research, and the aim of this review was to gain a broad overview of features that are considered engaging. Available full-text research articles or conference papers were eligible in case they (1) described the development (ie, user-testing) or evaluation of an mHealth intervention (or more broadly the use of healthy lifestyles as long as specific information about PA could be retrieved), designed for PA promotion; (2) reported on the extent of use or subjective experience; (3) reported an association (ie, relation of design features with engagement, either assessed qualitatively and referred to “self-perceived association” or quantitatively referred to “association”); (4) included an intervention that was designed for healthy youth who were aged between 4 and 18 years (in line with Dutch PA guidelines [<xref ref-type="bibr" rid="ref57">57</xref>] and in line with the increasing popularity of mobile devices in the daily life of [increasingly younger] youth) [<xref ref-type="bibr" rid="ref20">20</xref>-<xref ref-type="bibr" rid="ref24">24</xref>] or if the mean sample age was within this range; (5) were written in English; and (6) were published between 2010 and 2021 (owing to the smartphone use increase among youth, the use of mHealth interventions has been increasing since 2010).</p>
        <p>Papers were excluded in case they (1) included a PA intervention that was not mobile based; (2) did not report on the extent of use or subjective experience; (3) did not report an association between a particular intervention feature and engagement; and (4) included either a study population of children who were aged &#60;4 years, adults, or older adults or a population whose mean sample age was not within the range of 4 to 18 years (in line with Dutch national PA recommendation age range). Moreover, editorials, opinion papers, case studies, research protocols, design papers not including any user-testing, book chapters, systematic reviews, or meta-analyses were excluded (<xref ref-type="boxed-text" rid="box1">Textbox 1</xref>).</p>
        <boxed-text id="box1" position="float">
          <title>Inclusion and exclusion criteria.</title>
          <p>
            <bold>Inclusion criteria</bold>
          </p>
          <list list-type="bullet">
            <list-item>
              <p>Population</p>
              <list>
                <list-item>
                  <p>Youth was defined as individuals who were:</p>
                  <list>
                    <list-item>
                      <p>healthy</p>
                    </list-item>
                    <list-item>
                      <p>aged between 4 and 18 years or the mean age of sample in the same age range</p>
                    </list-item>
                  </list>
                </list-item>
              </list>
            </list-item>
            <list-item>
              <p>Intervention</p>
              <list>
                <list-item>
                  <p>Physical activity mobile health interventions that are:</p>
                  <list>
                    <list-item>
                      <p>developed (ie, offered for user-testing) or evaluated</p>
                    </list-item>
                    <list-item>
                      <p>mobile</p>
                    </list-item>
                    <list-item>
                      <p>designed for physical activity promotion (or healthy lifestyle, including physical activity)</p>
                    </list-item>
                    <list-item>
                      <p>designed for the target group of youth (4-18 years old)</p>
                    </list-item>
                  </list>
                </list-item>
              </list>
            </list-item>
            <list-item>
              <p>Comparison</p>
              <list>
                <list-item>
                  <p>Not applicable</p>
                </list-item>
              </list>
            </list-item>
            <list-item>
              <p>Outcome</p>
              <list>
                <list-item>
                  <p>Drivers of the extent of use or subjective experience with regard to physical activity</p>
                </list-item>
              </list>
            </list-item>
            <list-item>
              <p>Study type</p>
              <list>
                <list-item>
                  <p>Quantitative, qualitative, and mixed methods studies that:</p>
                  <list>
                    <list-item>
                      <p>report on behavioral or subjective engagement</p>
                    </list-item>
                    <list-item>
                      <p>report a relation or association between the particular feature and engagement</p>
                    </list-item>
                    <list-item>
                      <p>are original and available full-text research articles or conference paper</p>
                    </list-item>
                  </list>
                </list-item>
              </list>
            </list-item>
          </list>
          <p>
            <bold>Exclusion criteria</bold>
          </p>
          <list list-type="bullet">
            <list-item>
              <p>Population</p>
              <list>
                <list-item>
                  <p>Youth in disease recovery and rehabilitation, experiencing a chronic disease (ie, overweight, obesity, and diabetes)</p>
                </list-item>
                <list-item>
                  <p>Children aged &#60;4 years or mean age not within the age range of 4 to 18 years and adults or older adults</p>
                </list-item>
              </list>
            </list-item>
            <list-item>
              <p>Intervention</p>
              <list>
                <list-item>
                  <p>Physical activity interventions that:</p>
                  <list>
                    <list-item>
                      <p>were still in the early development phase (ie, not offering an app but, for example, only a general discussion about apps, paper mock-ups)</p>
                    </list-item>
                    <list-item>
                      <p>used different formats than mobile</p>
                    </list-item>
                    <list-item>
                      <p>only included wearables (eg, smartwatches) without a mobile health app</p>
                    </list-item>
                  </list>
                </list-item>
              </list>
            </list-item>
            <list-item>
              <p>Comparison</p>
              <list>
                <list-item>
                  <p>Not applicable</p>
                </list-item>
              </list>
            </list-item>
            <list-item>
              <p>Outcome</p>
              <list>
                <list-item>
                  <p>No drivers of the extent of use or subjective experience with regard to physical activity</p>
                </list-item>
              </list>
            </list-item>
            <list-item>
              <p>Study type</p>
              <list>
                <list-item>
                  <p>Quantitative, qualitative, and mixed methods studies that:</p>
                  <list>
                    <list-item>
                      <p>do not report on behavioral or subjective engagement</p>
                    </list-item>
                    <list-item>
                      <p>do not report a relation or association between the particular feature and engagement, for example, engagement is only described in general without any relation to the particular feature</p>
                    </list-item>
                    <list-item>
                      <p>are editorials, opinion papers, case studies, research protocols, or design papers not including any user-testing, book chapters, systematic review, or meta-analysis</p>
                    </list-item>
                  </list>
                </list-item>
              </list>
            </list-item>
          </list>
        </boxed-text>
      </sec>
      <sec>
        <title>Screening and Data Extraction</title>
        <p>All the papers identified through the searches were downloaded into Rayyan software (Rayyan Systems Inc), a systematic review software, and duplicates were removed. A multistep strategy was applied. First, titles and abstracts were screened, followed by full-text reading to determine eligibility (DO). One-third of the titles and abstracts and full texts were reviewed by a second reviewer (KB). Interrater reliability for the titles and abstracts and full texts was substantial and moderate (Cohen κ=0.73 and Cohen κ=0.54), respectively. Disagreements regarding the title and abstract and full texts were resolved through discussion between the reviewers (DO and KB). Any disagreement between the 2 reviewers was discussed, and a third reviewer (AS) was consulted if necessary.</p>
        <p>Data extraction was completed by both reviewers (DO and KB). Disagreement regarding data extraction was resolved through discussion between the reviewers (DO and KB). Background information (1-3) was extracted by one reviewer (DO), and the rest of the data (4-7) were extracted by two reviewers (DO and KB): (1) publication information (author and year); (2) study information (country and target group [number, percentage of female, percentage of people of low SEP, mean age, and age range]), and 3) app description (name, device, operating system, aim, and theory used; based on the mHealth taxonomy) [<xref ref-type="bibr" rid="ref58">58</xref>]; (4) engagement measures (engagement measure or definition); (5) presence of BCT and, if present, behavioral change measures (based on the ABACUS scale) [<xref ref-type="bibr" rid="ref59">59</xref>]; (6) design features (type of feature and 1 feature vs multiple features); and (7) association with engagement (short summary of association of particular features and engagement). The engagement measure of the original individual study was extracted (ie, usability, motivation, enjoyment, and liking) and then coded according to attention (ie, paying attention to mHealth app), interest (ie, feeling interested in mHealth app), and enjoyment (ie, experiencing enjoyment while using it; <xref ref-type="boxed-text" rid="box2">Textbox 2</xref>) [<xref ref-type="bibr" rid="ref37">37</xref>].</p>
        <p>As the researchers of this study were not aware of one framework of design features, 3 (digital) behavior scientist researchers (AS, LW, and MS) developed a coding frame to code all design features based on earlier studies on PA apps; gamification (ie, application of any features [eg, badges, points, avatars etc] in a nongame setting); and game research (ie, full-fledged and rule-based games) [<xref ref-type="bibr" rid="ref61">61</xref>]. Free codes were created if they did not suit 1 category. Owing to the design process of translating BCTs into design features, obviously, overlap between the features and BCTs occurs (ie, goals vs goal-setting). Design features were coded as interface esthetics, challenges, narrative, levels, feedback, monitoring, customization or personalization, reinforcement, navigation, goals, social, progress, and credibility (<xref ref-type="boxed-text" rid="box3">Textbox 3</xref>).</p>
        <boxed-text id="box2" position="float">
          <title>Coding scheme of engagement and definitions.</title>
          <p>
            <bold>Interest</bold>
          </p>
          <list list-type="bullet">
            <list-item>
              <p>Experiencing interest, boredom, fascination, intrigue, or indifference [<xref ref-type="bibr" rid="ref37">37</xref>]</p>
            </list-item>
            <list-item>
              <p>Cognitive state that is occurring spontaneously and relates to liking and willful engagement [<xref ref-type="bibr" rid="ref60">60</xref>]</p>
            </list-item>
          </list>
          <p>
            <bold>Attention</bold>
          </p>
          <list list-type="bullet">
            <list-item>
              <p>Experiencing focus, inattention, absorption, distraction, or mindfulness [<xref ref-type="bibr" rid="ref37">37</xref>]</p>
            </list-item>
            <list-item>
              <p>Cognitive state of focused awareness and relates to focalization and concentration [<xref ref-type="bibr" rid="ref60">60</xref>]</p>
            </list-item>
          </list>
          <p>
            <bold>Enjoyment</bold>
          </p>
          <list list-type="bullet">
            <list-item>
              <p>Experiencing frustration, annoyance, enjoyment, fun, or pleasure [<xref ref-type="bibr" rid="ref37">37</xref>]</p>
            </list-item>
            <list-item>
              <p>Relates to the sensory experience and relates to pleasure and activation [<xref ref-type="bibr" rid="ref60">60</xref>]</p>
            </list-item>
          </list>
        </boxed-text>
        <boxed-text id="box3" position="float">
          <title>Coding framework for design features and definitions.</title>
          <p>
            <bold>Interface esthetics</bold>
          </p>
          <list list-type="bullet">
            <list-item>
              <p>Graphics, color, sound, music, and language [<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref56">56</xref>]</p>
            </list-item>
          </list>
          <p>
            <bold>Challenges</bold>
          </p>
          <list list-type="bullet">
            <list-item>
              <p>“Time-limited goals or competitions” [<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref62">62</xref>-<xref ref-type="bibr" rid="ref64">64</xref>]</p>
            </list-item>
          </list>
          <p>
            <bold>Narrative</bold>
          </p>
          <list list-type="bullet">
            <list-item>
              <p>Story [<xref ref-type="bibr" rid="ref54">54</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref63">63</xref>]</p>
            </list-item>
            <list-item>
              <p>Levels [<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref64">64</xref>]</p>
            </list-item>
            <list-item>
              <p>Feedback [<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref63">63</xref>]</p>
            </list-item>
          </list>
          <p>
            <bold>Monitoring</bold>
          </p>
          <list list-type="bullet">
            <list-item>
              <p>Self-monitoring, monitoring, and tracking of user’s behavior (eg, smartphone sensor and wearable) [<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref65">65</xref>]</p>
            </list-item>
          </list>
          <p>
            <bold>Customization or personalization</bold>
          </p>
          <list list-type="bullet">
            <list-item>
              <p>Assessment of user’s characteristics and provision of personal information and avatars [<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref63">63</xref>]</p>
            </list-item>
          </list>
          <p>
            <bold>Reinforcement</bold>
          </p>
          <list list-type="bullet">
            <list-item>
              <p>Reminders and rewards (badges, points, unlockable content [“access to enhanced functionality or content for accumulating experience or achieving a specific goal”], leaderboard, certificates, medals, cash or gifts, congratulation messages, and updates) [<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref62">62</xref>-<xref ref-type="bibr" rid="ref65">65</xref>]</p>
            </list-item>
          </list>
          <p>
            <bold>Navigation</bold>
          </p>
          <list list-type="bullet">
            <list-item>
              <p>Navigation support (menu bar, search bar, etc), instructions, and guidance [<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref56">56</xref>]</p>
            </list-item>
          </list>
          <p>
            <bold>Goals</bold>
          </p>
          <list list-type="bullet">
            <list-item>
              <p>“Performance-based measures and targets,” either set by the app or by the user itself [<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref63">63</xref>-<xref ref-type="bibr" rid="ref65">65</xref>]</p>
            </list-item>
          </list>
          <p>
            <bold>Social</bold>
          </p>
          <list list-type="bullet">
            <list-item>
              <p>Social messages (communicating with others), “performance is publicly displayed,” community, competition (compete with each other), and collaboration (work together) [<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref62">62</xref>-<xref ref-type="bibr" rid="ref65">65</xref>]</p>
            </list-item>
          </list>
          <p>
            <bold>Progress</bold>
          </p>
          <list list-type="bullet">
            <list-item>
              <p>Progress, achievement, and levels [<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref62">62</xref>-<xref ref-type="bibr" rid="ref64">64</xref>]</p>
            </list-item>
          </list>
          <p>
            <bold>Credibility</bold>
          </p>
          <list list-type="bullet">
            <list-item>
              <p>Absence of advertisement, credible sources or information, privacy policy, and password protection [<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref63">63</xref>]</p>
            </list-item>
          </list>
        </boxed-text>
      </sec>
      <sec>
        <title>Quality Assessment</title>
        <p>Quality was assessed according to the Mixed Method Assessment Tool [<xref ref-type="bibr" rid="ref66">66</xref>], and it was not used as a basis for study exclusion but to support the interpretation of results (<xref ref-type="supplementary-material" rid="app3">Multimedia Appendix 3</xref> [<xref ref-type="bibr" rid="ref67">67</xref>-<xref ref-type="bibr" rid="ref87">87</xref>]). All the studies were coded by 1 reviewer (DO), and one-third of the studies were double coded (KB). Interrater reliability was substantial (κ=0.63). Any disagreement between the 2 reviewers was discussed, and a third reviewer (AS) was consulted if necessary.</p>
      </sec>
      <sec>
        <title>Synthesis of Results</title>
        <p>A systematic narrative format [<xref ref-type="bibr" rid="ref88">88</xref>] structured around the design features that were associated with engagement was applied. All the features that have been actually tested (ie, user-testing) were reported. In case the same study also provided suggestions by participants to further develop the app (ie, hypothetical design features not tested but suggested), this was marked explicitly as a suggestion. In addition, the presence or absence of BCTs was outlined, indicating whether theories had been applied in the design phase of design features or not. A subgroup analysis was conducted for youth from low-SEP families. The categorization of SEP was derived from the classification of the original studies. Research results were not grouped by the origin of the data (ie, qualitative, quantitative, or mixed methods), but it was indicated explicitly for each research outcome.</p>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <sec>
        <title>Description of Included Studies</title>
        <p>In total, 21 studies were included in this review (<xref rid="figure1" ref-type="fig">Figure 1</xref>). The studies originated from different countries (15) and were conducted in Europe (n=10), North America (n=4), Australia (n=3), Asia (n=3), and South America (n=1). These studies were published between 2012 and 2021. Mobile interventions were used and evaluated by youth who were aged between 3 and 18 years. Sample sizes ranged from 5 to 354 youths, with a total sample size of 1443 youths. All the studies retrieved informed consents from parents and youth participants, except for 5 studies that only collected consent from the youth participants alone [<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref68">68</xref>] or from the school principal [<xref ref-type="bibr" rid="ref70">70</xref>], were conducted in parent-child dyads [<xref ref-type="bibr" rid="ref69">69</xref>], or did not clearly state this [<xref ref-type="bibr" rid="ref71">71</xref>]. Studies included different engagement measures varying from acceptability, experience, usability, motivation, feasibility, enjoyment, engagement, satisfaction, or interest. When categorizing the measures in terms of interest, attention, or enjoyment, most studies (15/21, 71%) measured solely interest, especially in terms of features that were in general liked by the users. A combination of interest and attention (2/21, 10%), solely attention (1/21, 5%), solely enjoyment (1/21, 5%), or solely engagement (2/21, 10%) was rarely studied. Engagement was mainly measured as the primary outcome in some studies (14/21, 67%). Most studies (12/21, 57%) used a mixed methods design, ranging from posttest prototype studies to quasi-experimental studies to randomized controlled trials, mixed with designs such as qualitative exit interviews, focus groups, or think-aloud studies. In total, 24% (5/21) of studies included a qualitative study design (interview and focus group study), and 19% (4/21) of studies included a quantitative study design (experimental design with quantitative survey). Studies relevant to this review included qualitative data (10/21, 48%), quantitative data (4/21, 19%), or mixed methods data (7/21, 33%) to determine the association between design features and engagement.</p>
        <fig id="figure1" position="float">
          <label>Figure 1</label>
          <caption>
            <p>PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flowchart illustrating the inclusion and exclusion of studies. PA: physical activity.</p>
          </caption>
          <graphic xlink:href="mhealth_v11i1e40898_fig1.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
        <p>On the basis of Mixed Method Assessment Tool [<xref ref-type="bibr" rid="ref66">66</xref>], the quality of the included studies was mixed. In general, the studies that measured engagement as the primary study outcome had a moderate to high quality, especially scoring high on transparency regarding the data collection methods and analysis. Studies that focused on engagement as a secondary outcome scored rather low on the quality of the study design applicable to measure engagement (eg, including nonvalidated methods such as a number of open exit questions in a larger randomized controlled trial), although the studies scored high on the design (eg, randomized controlled trial) to measure the primary outcome (eg, PA).</p>
      </sec>
      <sec>
        <title>mHealth Interventions</title>
        <p>In general, the mobile interventions tested in the included studies (N=21) were either developed for commercial purposes (n=4, 19%) or for study purposes (n=17, 81%). Most of the interventions (14/21, 67%) were designed to improve PA behavior. In addition, 33% (7/21) of studies focused also on additional health behaviors associated with a healthy lifestyle (eg, nutrition or sleep) in addition to PA behavior. The studies included different types of mHealth interventions, ranging from mobile games (10/21, 48%) to mobile apps (8/21, 38%) to mobile text messaging systems (3/21, 14%). Mobile games mainly focused on PA (9/10, 90% studies); included different PA activities (ie, ranging from simple arm movements such as swinging arm to complex full-body movement such as running); and applied different inputs (ie, ranging from manual input to camera data to Bluetooth, GPS, or PA sensor data). Games ranged from short-term activities (eg, push-ups) to long-term gameplay (eg, location-based treasure hunt games). Mobile apps ranged from narrative-driven PA guidance to GPS-tracking information. Mobile text messaging systems especially focused on generating and adapting goal-setting, facilitating self-monitoring, and providing feedback [<xref ref-type="bibr" rid="ref72">72</xref>,<xref ref-type="bibr" rid="ref73">73</xref>] and informative content (ie, quizzes and factoids) [<xref ref-type="bibr" rid="ref74">74</xref>]. Furthermore, 67% (2/3) of the studies focused also on health behaviors other than PA (<xref ref-type="supplementary-material" rid="app4">Multimedia Appendix 4</xref> [<xref ref-type="bibr" rid="ref67">67</xref>-<xref ref-type="bibr" rid="ref87">87</xref>]). The interventions tested in the included studies were perceived as engaging by the youth. Youth liked to play games that aimed to increase their PA level and evaluated apps or text messaging systems as easy to use and supportive in improving PA or lifestyle behaviors. Multiple studies (6/21, 29%) found that poor functionality and technical issues are considered a barrier for engagement with mobile interventions [<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref75">75</xref>-<xref ref-type="bibr" rid="ref77">77</xref>] and suggested to include technical improvements [<xref ref-type="bibr" rid="ref76">76</xref>].</p>
        <p>In the following section, all the design features are summarized, starting with the design feature researched most often. A detailed overview of the results is presented in <xref ref-type="table" rid="table1">Table 1</xref>. All tested design features (ie, features offered to participants via an app and actually tested) are outlined as an association between the particular design feature and engagement (either as self-perceived association in qualitative studies or as tested association in quantitative studies). In case the participants provided further suggestions on design features that might be included in a future version (ie, feature not tested or only hypothetical), it was explicitly referred to as a suggestion. The results section concludes with a subanalysis on BCTs and low-SEP subgroups.</p>
        <table-wrap position="float" id="table1">
          <label>Table 1</label>
          <caption>
            <p>Design features and association with user engagement.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="30"/>
            <col width="30"/>
            <col width="550"/>
            <col width="170"/>
            <col width="220"/>
            <thead>
              <tr valign="top">
                <td colspan="3">Details</td>
                <td>Association (ie, tested)</td>
                <td>Suggestion (ie, hypothetical)</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td colspan="5">
                  <bold>Interface aesthetics</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">
                  <bold>Language</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>PA<sup>a</sup> and nutrition messages (ranging from information to quizzes)</td>
                <td>[<xref ref-type="bibr" rid="ref74">74</xref>]<sup>b,c</sup> [<xref ref-type="bibr" rid="ref67">67</xref>]<sup>b,d</sup> [<xref ref-type="bibr" rid="ref74">74</xref>]<sup>b,c</sup></td>
                <td>[<xref ref-type="bibr" rid="ref67">67</xref>]<sup>d</sup></td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Familiar content</td>
                <td>[<xref ref-type="bibr" rid="ref74">74</xref>]<sup>c,e</sup></td>
                <td>N/A<sup>f</sup></td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Short messages</td>
                <td>[<xref ref-type="bibr" rid="ref78">78</xref>]<sup>b,g</sup> [<xref ref-type="bibr" rid="ref74">74</xref>]<sup>b,c</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Cheerful and personal tone</td>
                <td>[<xref ref-type="bibr" rid="ref78">78</xref>]<sup>b,g</sup> [<xref ref-type="bibr" rid="ref74">74</xref>]<sup>b,c</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">
                  <bold>Visual</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Clearly presented text</td>
                <td>[<xref ref-type="bibr" rid="ref68">68</xref>]<sup>b</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Large text blocks and complicated language</td>
                <td>[<xref ref-type="bibr" rid="ref68">68</xref>]<sup>e,g</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Clear and realistic visualization (eg, infographics, figures, tables, pictures, symbols, and videos)</td>
                <td>[<xref ref-type="bibr" rid="ref79">79</xref>]<sup>b,g</sup> [<xref ref-type="bibr" rid="ref68">68</xref>]<sup>b,g</sup></td>
                <td>[<xref ref-type="bibr" rid="ref68">68</xref>]<sup>g</sup> [<xref ref-type="bibr" rid="ref67">67</xref>]<sup>d</sup> [<xref ref-type="bibr" rid="ref76">76</xref>]<sup>c</sup> [<xref ref-type="bibr" rid="ref77">77</xref>]<sup>d</sup></td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Quality not reflecting reality</td>
                <td>[<xref ref-type="bibr" rid="ref70">70</xref>]<sup>e,g</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">
                  <bold>Sound</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Sounds associated with arm movements or game activities</td>
                <td>[<xref ref-type="bibr" rid="ref75">75</xref>,<xref ref-type="bibr" rid="ref80">80</xref>]<sup>b,c</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Sounds associated with every click</td>
                <td>[<xref ref-type="bibr" rid="ref81">81</xref>]<sup>e,g</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Monotone and robotic voice</td>
                <td>[<xref ref-type="bibr" rid="ref75">75</xref>]<sup>c,e</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">
                  <bold>General interface</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Lack of sophistication</td>
                <td>[<xref ref-type="bibr" rid="ref75">75</xref>]<sup>c,e</sup> [<xref ref-type="bibr" rid="ref79">79</xref>]<sup>e,g</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td colspan="5">
                  <bold>Reinforcement</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">
                  <bold>Rewards</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Tangible rewards (prize, medal, new Pokémon, and healthy real-world actions)</td>
                <td>[<xref ref-type="bibr" rid="ref75">75</xref>,<xref ref-type="bibr" rid="ref82">82</xref>]<sup>b,c</sup> [<xref ref-type="bibr" rid="ref78">78</xref>]<sup>b,g</sup></td>
                <td>[<xref ref-type="bibr" rid="ref83">83</xref>]<sup>c</sup> [<xref ref-type="bibr" rid="ref78">78</xref>]<sup>g</sup></td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Intangible rewards (achievement, encouragement, evolving Pokémon, and comparisons)</td>
                <td>[<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref81">81</xref>]<sup>b,g</sup> [<xref ref-type="bibr" rid="ref82">82</xref>,<xref ref-type="bibr" rid="ref84">84</xref>]<sup>b,c</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">
                  <bold>Messages</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Messages sent at random times, maximum frequency &#60;2 times per day</td>
                <td>[<xref ref-type="bibr" rid="ref74">74</xref>]<sup>b,c</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Frequency and timing of messages</td>
                <td>[<xref ref-type="bibr" rid="ref78">78</xref>]<sup>e,g</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Receiving reminders</td>
                <td>[<xref ref-type="bibr" rid="ref79">79</xref>]<sup>g,h</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">
                  <bold>Reinforcement</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Leaderboard</td>
                <td>[<xref ref-type="bibr" rid="ref76">76</xref>]<sup>h,c</sup> [<xref ref-type="bibr" rid="ref87">87</xref>]<sup>h,d</sup> [<xref ref-type="bibr" rid="ref85">85</xref>]<sup>e,c</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td colspan="5">
                  <bold>Navigation</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">
                  <bold>PA instructions</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Instructions on PA (eg, video)</td>
                <td>[<xref ref-type="bibr" rid="ref67">67</xref>]<sup>b,d</sup></td>
                <td>[<xref ref-type="bibr" rid="ref71">71</xref>]<sup>g</sup> [<xref ref-type="bibr" rid="ref86">86</xref>]<sup>c</sup></td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Textual and unclear instructions on physical missions</td>
                <td>[<xref ref-type="bibr" rid="ref71">71</xref>]<sup>e,g</sup> [<xref ref-type="bibr" rid="ref83">83</xref>,<xref ref-type="bibr" rid="ref85">85</xref>,<xref ref-type="bibr" rid="ref86">86</xref>]<sup>c,e</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">
                  <bold>In-app instructions</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Clear and intuitive in-app instructions</td>
                <td>[<xref ref-type="bibr" rid="ref84">84</xref>]<sup>b,c</sup></td>
                <td>[<xref ref-type="bibr" rid="ref80">80</xref>]<sup>c</sup></td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Written manual and unclear instructions</td>
                <td>[<xref ref-type="bibr" rid="ref78">78</xref>]<sup>e,g</sup> [<xref ref-type="bibr" rid="ref76">76</xref>]<sup>c,e</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">
                  <bold>Layout</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Straightforward and simple layout</td>
                <td>[<xref ref-type="bibr" rid="ref84">84</xref>]<sup>b,c</sup></td>
                <td>[<xref ref-type="bibr" rid="ref67">67</xref>]<sup>d</sup> [<xref ref-type="bibr" rid="ref83">83</xref>]<sup>c</sup></td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Scrolling to find information</td>
                <td>[<xref ref-type="bibr" rid="ref68">68</xref>]<sup>e,g</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Lack of logical flow between different modules</td>
                <td>[<xref ref-type="bibr" rid="ref68">68</xref>]<sup>e,g</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">
                  <bold>Navigation</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Finding and recognizing items on a map</td>
                <td>[<xref ref-type="bibr" rid="ref70">70</xref>]<sup>e,g</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Difficulty reading the map</td>
                <td>[<xref ref-type="bibr" rid="ref76">76</xref>]<sup>c,e</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Controls reacting slowly</td>
                <td>[<xref ref-type="bibr" rid="ref78">78</xref>]<sup>e,g</sup> [<xref ref-type="bibr" rid="ref85">85</xref>]<sup>c,e</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td colspan="5">
                  <bold>Social</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">
                  <bold>Multiplayer</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Socializing and multiplayer capabilities (eg, friends)</td>
                <td>[<xref ref-type="bibr" rid="ref80">80</xref>]<sup>b,c</sup> [<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref78">78</xref>,<xref ref-type="bibr" rid="ref81">81</xref>]<sup>b,g</sup></td>
                <td>[<xref ref-type="bibr" rid="ref76">76</xref>,<xref ref-type="bibr" rid="ref80">80</xref>,<xref ref-type="bibr" rid="ref82">82</xref>]<sup>c</sup> [<xref ref-type="bibr" rid="ref71">71</xref>]<sup>d</sup></td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">
                  <bold>Social messages</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Sharing results and postings</td>
                <td>[<xref ref-type="bibr" rid="ref78">78</xref>]<sup>b,g</sup> [<xref ref-type="bibr" rid="ref83">83</xref>]<sup>b,c</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Social networking</td>
                <td>[<xref ref-type="bibr" rid="ref84">84</xref>]<sup>c,e</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Replying messages or chat</td>
                <td>[<xref ref-type="bibr" rid="ref74">74</xref>]<sup>b,c</sup></td>
                <td>[<xref ref-type="bibr" rid="ref82">82</xref>]<sup>c</sup></td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">
                  <bold>Competition</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Competing against classmates</td>
                <td>[<xref ref-type="bibr" rid="ref71">71</xref>]<sup>g,h</sup> [<xref ref-type="bibr" rid="ref82">82</xref>]<sup>c,h</sup> [<xref ref-type="bibr" rid="ref87">87</xref>]<sup>d,h</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Competing with friends</td>
                <td>[<xref ref-type="bibr" rid="ref87">87</xref>]<sup>d,h</sup> [<xref ref-type="bibr" rid="ref78">78</xref>]<sup>b,g</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">
                  <bold>Cooperation</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Cooperation and togetherness</td>
                <td>[<xref ref-type="bibr" rid="ref82">82</xref>]<sup>b,c</sup></td>
                <td>[<xref ref-type="bibr" rid="ref82">82</xref>]<sup>c</sup></td>
              </tr>
              <tr valign="top">
                <td colspan="5">
                  <bold>Challenges</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">
                  <bold>Types of challenges</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Searching for items (eg, QR codes, bombs, Pokémon, and tags)</td>
                <td>[<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref71">71</xref>,<xref ref-type="bibr" rid="ref81">81</xref>]<sup>b,g</sup> [<xref ref-type="bibr" rid="ref82">82</xref>]<sup>b,c</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>PA missions</td>
                <td>[<xref ref-type="bibr" rid="ref84">84</xref>]<sup>b,c</sup> [<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref71">71</xref>,<xref ref-type="bibr" rid="ref78">78</xref>]<sup>b,g</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">
                  <bold>Variety</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Repetitive game with lack of progression or clear end goal</td>
                <td>[<xref ref-type="bibr" rid="ref78">78</xref>]<sup>e,g</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Larger variety of actions (eg, special events, season-themed challenges, and new missions or minigames)</td>
                <td>N/A</td>
                <td>[<xref ref-type="bibr" rid="ref78">78</xref>]<sup>g</sup> [<xref ref-type="bibr" rid="ref76">76</xref>,<xref ref-type="bibr" rid="ref82">82</xref>]<sup>c</sup> [<xref ref-type="bibr" rid="ref77">77</xref>]<sup>d</sup></td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">
                  <bold>Difficulty level</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Difficulty level of the challenges that suit a player’s skill level</td>
                <td>[<xref ref-type="bibr" rid="ref81">81</xref>]<sup>b,g</sup></td>
                <td>[<xref ref-type="bibr" rid="ref80">80</xref>]<sup>c</sup></td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">
                  <bold>Time limit</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Time given (to diffuse bombs)</td>
                <td>[<xref ref-type="bibr" rid="ref70">70</xref>]<sup>g,h</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td colspan="5">
                  <bold>Monitoring</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">
                  <bold>Manual input</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Manual input of multiple activities or behaviors</td>
                <td>[<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref69">69</xref>]<sup>e,g</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Remembering multiple behaviors</td>
                <td>[<xref ref-type="bibr" rid="ref79">79</xref>]<sup>e,g</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Run logs and PA diary</td>
                <td>[<xref ref-type="bibr" rid="ref84">84</xref>]<sup>b,c</sup> [<xref ref-type="bibr" rid="ref67">67</xref>]<sup>b,d</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">
                  <bold>Device</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Monitoring via phone (eg, SMS text messaging and smartphone)</td>
                <td>[<xref ref-type="bibr" rid="ref73">73</xref>]<sup>b,d</sup> [<xref ref-type="bibr" rid="ref71">71</xref>]<sup>b,g</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Monitoring via external sensor (eg, pedometer, wearables, and heart rate monitor)</td>
                <td>[<xref ref-type="bibr" rid="ref73">73</xref>]<sup>b,d</sup> [<xref ref-type="bibr" rid="ref71">71</xref>]<sup>b,g</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Monitoring with real-time information</td>
                <td>[<xref ref-type="bibr" rid="ref83">83</xref>]<sup>b,c</sup> [<xref ref-type="bibr" rid="ref77">77</xref>]<sup>d,h</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">
                  <bold>Self-monitoring</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Self-reflection</td>
                <td>[<xref ref-type="bibr" rid="ref72">72</xref>]<sup>c,h</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Ability to track multiple behaviors</td>
                <td>[<xref ref-type="bibr" rid="ref79">79</xref>]<sup>g,h</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td colspan="5">
                  <bold>Goals</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">
                  <bold>Self-set goals</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Personal, self-selected goals</td>
                <td>[<xref ref-type="bibr" rid="ref67">67</xref>]<sup>b,d</sup> [<xref ref-type="bibr" rid="ref78">78</xref>,<xref ref-type="bibr" rid="ref79">79</xref>]<sup>b,g</sup> [<xref ref-type="bibr" rid="ref76">76</xref>]<sup>c,h</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">
                  <bold>Type of goals</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Choosing between different types of goals</td>
                <td>[<xref ref-type="bibr" rid="ref84">84</xref>]<sup>b,c</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Goals helped to perform PA</td>
                <td>[<xref ref-type="bibr" rid="ref83">83</xref>]<sup>b,c</sup> [<xref ref-type="bibr" rid="ref67">67</xref>]<sup>b,d</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">
                  <bold>Goals</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Goal reminders</td>
                <td>[<xref ref-type="bibr" rid="ref72">72</xref>,<xref ref-type="bibr" rid="ref76">76</xref>]<sup>b,c</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td colspan="5">
                  <bold>Customization</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">
                  <bold>Types of customization</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Ability to customize user account, own music, choosing the type of PA, and personal goals</td>
                <td>[<xref ref-type="bibr" rid="ref78">78</xref>,<xref ref-type="bibr" rid="ref79">79</xref>]<sup>b,g</sup> [<xref ref-type="bibr" rid="ref83">83</xref>,<xref ref-type="bibr" rid="ref84">84</xref>]<sup>b,c</sup></td>
                <td>[<xref ref-type="bibr" rid="ref83">83</xref>]<sup>c</sup></td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">
                  <bold>Avatars</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Avatars (and additional sports equipment)</td>
                <td>[<xref ref-type="bibr" rid="ref69">69</xref>]<sup>b,g</sup></td>
                <td>[<xref ref-type="bibr" rid="ref69">69</xref>]<sup>g</sup></td>
              </tr>
              <tr valign="top">
                <td colspan="5">
                  <bold>Feedback</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">
                  <bold>Types of feedback</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Feedback message on goals, weekly PA, real-time information, and individualized feedback</td>
                <td>[<xref ref-type="bibr" rid="ref67">67</xref>]<sup>b,d</sup> [<xref ref-type="bibr" rid="ref83">83</xref>]<sup>b,c</sup> [<xref ref-type="bibr" rid="ref79">79</xref>]<sup>b,g</sup> [<xref ref-type="bibr" rid="ref77">77</xref>]<sup>d,h</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">
                  <bold>Representation</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Feedback presented in graphs or via SMS text messages</td>
                <td>[<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref73">73</xref>]<sup>b,d</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td colspan="5">
                  <bold>PA input</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">
                  <bold>PA input</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Variety of arm movements and physical exercise</td>
                <td>[<xref ref-type="bibr" rid="ref80">80</xref>]<sup>b,c</sup> [<xref ref-type="bibr" rid="ref71">71</xref>]<sup>b,g</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Running, PA, and FMS<sup>i</sup> components</td>
                <td>[<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref81">81</xref>]<sup>g,h</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td colspan="5">
                  <bold>Narrative</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">
                  <bold>Characters</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Variety of virtual components (eg, zombies), weapons, and ways to increase character abilities</td>
                <td>[<xref ref-type="bibr" rid="ref80">80</xref>,<xref ref-type="bibr" rid="ref84">84</xref>]<sup>b,c</sup></td>
                <td>[<xref ref-type="bibr" rid="ref78">78</xref>]<sup>g</sup></td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">
                  <bold>Setting</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Realistic</td>
                <td>[<xref ref-type="bibr" rid="ref80">80</xref>]<sup>b,c</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>More world to explore</td>
                <td>N/A</td>
                <td>[<xref ref-type="bibr" rid="ref78">78</xref>]<sup>g</sup></td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">
                  <bold>Story</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Complex story line</td>
                <td>N/A</td>
                <td>[<xref ref-type="bibr" rid="ref70">70</xref>]<sup>g</sup> [<xref ref-type="bibr" rid="ref80">80</xref>,<xref ref-type="bibr" rid="ref86">86</xref>]<sup>c</sup></td>
              </tr>
              <tr valign="top">
                <td colspan="5">
                  <bold>Levels</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">
                  <bold>Increasing levels</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Gradually increasing levels</td>
                <td>[<xref ref-type="bibr" rid="ref84">84</xref>]<sup>b,c</sup></td>
                <td>[<xref ref-type="bibr" rid="ref69">69</xref>]<sup>g</sup></td>
              </tr>
              <tr valign="top">
                <td colspan="5">
                  <bold>Credibility</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="2">Messages originating from nutrition professionals</td>
                <td>[<xref ref-type="bibr" rid="ref74">74</xref>]<sup>b,c</sup></td>
                <td>N/A</td>
              </tr>
              <tr valign="top">
                <td colspan="5">
                  <bold>Other features</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">
                  <bold>Push notifications</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Additional push notifications</td>
                <td>N/A</td>
                <td>[<xref ref-type="bibr" rid="ref80">80</xref>]<sup>c</sup></td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">
                  <bold>GPS</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Reduce GPS latency</td>
                <td>N/A</td>
                <td>[<xref ref-type="bibr" rid="ref76">76</xref>]<sup>c</sup></td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table1fn1">
              <p><sup>a</sup>PA: physical activity.</p>
            </fn>
            <fn id="table1fn2">
              <p><sup>b</sup>Positive association between features and engagement.</p>
            </fn>
            <fn id="table1fn3">
              <p><sup>c</sup>Qualitative studies, assessing self-perceived association.</p>
            </fn>
            <fn id="table1fn4">
              <p><sup>d</sup>Quantitative studies, assessing association.</p>
            </fn>
            <fn id="table1fn5">
              <p><sup>e</sup>Negative association between features and engagement.</p>
            </fn>
            <fn id="table1fn6">
              <p><sup>f</sup>N/A: not applicable.</p>
            </fn>
            <fn id="table1fn7">
              <p><sup>g</sup>Mixed methods studies.</p>
            </fn>
            <fn id="table1fn8">
              <p><sup>h</sup>Positive and negative associations between features and engagement.</p>
            </fn>
            <fn id="table1fn9">
              <p><sup>i</sup>FMS: fundamental movement skills.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
      </sec>
      <sec>
        <title>Interface Esthetics</title>
        <p>Clear and short messages with positive and personal tone and relevant content were associated with engagement in youth [<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref74">74</xref>,<xref ref-type="bibr" rid="ref78">78</xref>]. Engagement was hampered by lack of sophistication in the interface (eg, game graphics, sound effects, and camera use) [<xref ref-type="bibr" rid="ref75">75</xref>,<xref ref-type="bibr" rid="ref79">79</xref>]. Youth preferred a clear and understandable layout [<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref76">76</xref>] and text with clear headlines and a large font size supported with infographics, figures, and tables [<xref ref-type="bibr" rid="ref68">68</xref>]. The design of progress graphs was identified as an important contributor to engagement in terms of readability [<xref ref-type="bibr" rid="ref79">79</xref>]. Too much text or large text blocks, as well as heavy and complicated language, were considered to hamper usability [<xref ref-type="bibr" rid="ref68">68</xref>]. Participants suggested to include more pictures, symbols, and videos to make the app more attractive [<xref ref-type="bibr" rid="ref68">68</xref>]; improved or realistic visuals [<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref76">76</xref>,<xref ref-type="bibr" rid="ref77">77</xref>]; or general interfaces [<xref ref-type="bibr" rid="ref76">76</xref>]. Youth liked sounds that were associated with their movements or game activities [<xref ref-type="bibr" rid="ref75">75</xref>,<xref ref-type="bibr" rid="ref80">80</xref>]. However, robotic and monotonic voices [<xref ref-type="bibr" rid="ref75">75</xref>] or sound associated with clicks could negatively impact engagement [<xref ref-type="bibr" rid="ref81">81</xref>].</p>
      </sec>
      <sec>
        <title>Reinforcement</title>
        <p>Youth enjoyed winning tangible rewards [<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref75">75</xref>,<xref ref-type="bibr" rid="ref78">78</xref>,<xref ref-type="bibr" rid="ref82">82</xref>] and suggested offering rewards (ie, in apps that have not introduced rewards earlier) [<xref ref-type="bibr" rid="ref78">78</xref>,<xref ref-type="bibr" rid="ref83">83</xref>]. Intangible rewards (eg, feeling of achievement [<xref ref-type="bibr" rid="ref81">81</xref>] and encouragement [<xref ref-type="bibr" rid="ref84">84</xref>]) were especially interesting for the youth. Messages that were sent at random times were preferred over messages sent at preset times. The preferred frequency of the messages was less than twice per day [<xref ref-type="bibr" rid="ref74">74</xref>]. In the study by Martin et al [<xref ref-type="bibr" rid="ref78">78</xref>], participants expressed concerns about the frequency and timing of messages. The timing should be appropriate, for example, not receiving messages at a moment when one is not able to act on the messages [<xref ref-type="bibr" rid="ref74">74</xref>,<xref ref-type="bibr" rid="ref78">78</xref>]. Mixed results with regard to leaderboards were noted. Youth enjoyed leaderboards when beating persons placed above them but they did not enjoy being at the top of the leaderboard. In addition, leaderboards could lead to too much competition that could result in teasing [<xref ref-type="bibr" rid="ref76">76</xref>]. In another study, adolescents particularly indicated that they missed seeing the other player’s scores [<xref ref-type="bibr" rid="ref85">85</xref>].</p>
      </sec>
      <sec>
        <title>Navigation</title>
        <p>Instructions related on the one hand to instructions of the in-app functions and on the other hand to instructions related to PA activities. In both cases, well-outlined instructions could support engagement [<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref84">84</xref>], and suggestions were made to design clear, simple, and intuitive instructions [<xref ref-type="bibr" rid="ref80">80</xref>] with the addition of visual components [<xref ref-type="bibr" rid="ref71">71</xref>,<xref ref-type="bibr" rid="ref86">86</xref>]. Unclear instructions on requested movements [<xref ref-type="bibr" rid="ref83">83</xref>,<xref ref-type="bibr" rid="ref85">85</xref>,<xref ref-type="bibr" rid="ref86">86</xref>] or unclear [<xref ref-type="bibr" rid="ref76">76</xref>] textual [<xref ref-type="bibr" rid="ref71">71</xref>,<xref ref-type="bibr" rid="ref78">78</xref>] instructions could hamper engagement. The wish for clear instructions had been underlined by a straightforward and simple layout [<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref83">83</xref>,<xref ref-type="bibr" rid="ref84">84</xref>]. Working with a map was considered difficult [<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref76">76</xref>]. Laine and Suk [<xref ref-type="bibr" rid="ref70">70</xref>] reported that the quality of the map tile was perceived as poor, which made it difficult to identify one’s current location. In addition, Robertson et al [<xref ref-type="bibr" rid="ref76">76</xref>] reported that children experienced difficulties in understanding the map representation in the game interface. Interestingly, both studies integrated the Google Maps (Google Inc) services, which hampered PA and interrupted engagement. To find and recognize targets, the map resolution and targets should be clear. Furthermore, controls facilitating navigation through the app were negatively associated with engagement in case they were reacting slowly [<xref ref-type="bibr" rid="ref78">78</xref>,<xref ref-type="bibr" rid="ref85">85</xref>].</p>
      </sec>
      <sec>
        <title>Social</title>
        <p>Multiplayer gameplay was considered important for engaging, socializing [<xref ref-type="bibr" rid="ref80">80</xref>,<xref ref-type="bibr" rid="ref81">81</xref>], and playing with friends [<xref ref-type="bibr" rid="ref70">70</xref>] and setting challenges for friends [<xref ref-type="bibr" rid="ref78">78</xref>]. In different studies, multiplayer gameplay was suggested to include in future versions of the app [<xref ref-type="bibr" rid="ref76">76</xref>,<xref ref-type="bibr" rid="ref77">77</xref>,<xref ref-type="bibr" rid="ref80">80</xref>,<xref ref-type="bibr" rid="ref82">82</xref>]. However, competing with friends revealed mixed results. Martin et al [<xref ref-type="bibr" rid="ref78">78</xref>] found a positive association with engagement [<xref ref-type="bibr" rid="ref78">78</xref>], and as outlined previously, leaderboards could affect high competition (see <italic>Reinforcement</italic> section); however, when competition was compared with cooperation, the latter was preferred [<xref ref-type="bibr" rid="ref71">71</xref>,<xref ref-type="bibr" rid="ref82">82</xref>,<xref ref-type="bibr" rid="ref87">87</xref>]. This was also quantitatively assessed by Nuijten et al [<xref ref-type="bibr" rid="ref87">87</xref>], who found that intergroup competition (ie, collaboration within class and competing against other classes) increased engagement in comparison with intragroup competition (ie, individual competition). Competing with others was suggested by youth for future app versions [<xref ref-type="bibr" rid="ref80">80</xref>]. Cooperation and togetherness were considered important during gameplay [<xref ref-type="bibr" rid="ref82">82</xref>,<xref ref-type="bibr" rid="ref87">87</xref>], and an extension to collaborate with others was suggested for future app versions [<xref ref-type="bibr" rid="ref82">82</xref>]. Social interaction in terms of messages to the research team [<xref ref-type="bibr" rid="ref74">74</xref>], postings [<xref ref-type="bibr" rid="ref83">83</xref>], and sharing results [<xref ref-type="bibr" rid="ref78">78</xref>] was considered to contribute to engagement. A chat function [<xref ref-type="bibr" rid="ref82">82</xref>] or a social platform [<xref ref-type="bibr" rid="ref80">80</xref>] was suggested for a future app version. Direito et al [<xref ref-type="bibr" rid="ref84">84</xref>] described that children seldom or never used the social networking features and disliked sharing their runs or status updates.</p>
      </sec>
      <sec>
        <title>Challenges</title>
        <p>Youth suggested increasing the variety of actions or (mini) games available, indicating that they liked a wide variety of challenges to choose from when playing a game [<xref ref-type="bibr" rid="ref77">77</xref>,<xref ref-type="bibr" rid="ref78">78</xref>]. In addition, the new content was considered important, for example, season-themed challenges or special events [<xref ref-type="bibr" rid="ref76">76</xref>,<xref ref-type="bibr" rid="ref78">78</xref>,<xref ref-type="bibr" rid="ref82">82</xref>]. Youth liked activities organized around a hunt, including activities of finding and scanning objects [<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref71">71</xref>,<xref ref-type="bibr" rid="ref81">81</xref>,<xref ref-type="bibr" rid="ref82">82</xref>] or missions, for example, PA-related workout missions [<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref71">71</xref>,<xref ref-type="bibr" rid="ref78">78</xref>,<xref ref-type="bibr" rid="ref84">84</xref>]. Youth liked games that made a connection between energy expenditure in real life and the energy level in a game [<xref ref-type="bibr" rid="ref78">78</xref>]. Repetitive challenges with a lack of progression or clear end goals negatively impacted engagement [<xref ref-type="bibr" rid="ref78">78</xref>]. The difficulty level of the challenges needed to fit the users’ level [<xref ref-type="bibr" rid="ref80">80</xref>,<xref ref-type="bibr" rid="ref81">81</xref>], as challenges that were not adjusted to a younger age appeared to negatively impact young kids’ enjoyment [<xref ref-type="bibr" rid="ref81">81</xref>]. This finding was supported by the study done by Arteaga et al [<xref ref-type="bibr" rid="ref80">80</xref>], in which children suggested including multiple challenges that fit the different levels of individual players. The study by Laine and Suk [<xref ref-type="bibr" rid="ref70">70</xref>] reported mixed results regarding a time limit paired with challenges.</p>
      </sec>
      <sec>
        <title>Monitoring</title>
        <p>Manual input hampered engagement [<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref79">79</xref>], although youth liked to make use of logbooks [<xref ref-type="bibr" rid="ref84">84</xref>] and diaries [<xref ref-type="bibr" rid="ref67">67</xref>]. Using devices [<xref ref-type="bibr" rid="ref71">71</xref>,<xref ref-type="bibr" rid="ref73">73</xref>] to track real-time information was appreciated and perceived as useful [<xref ref-type="bibr" rid="ref77">77</xref>,<xref ref-type="bibr" rid="ref83">83</xref>]. Youth endorsed the self-monitoring function but had complaints relating to discomfort while wearing the monitoring device [<xref ref-type="bibr" rid="ref72">72</xref>]. The accelerometer that was used in this study was not part of the intervention but was used to measure the PA outcome. The perceived discomfort might have influenced the use of the intervention. Including the function to track multiple health behaviors, on the one hand, engaged youth but, on the other hand, challenged them by the need to remember multiple behaviors [<xref ref-type="bibr" rid="ref79">79</xref>].</p>
      </sec>
      <sec>
        <title>Goals</title>
        <p>Self-set goals were considered important [<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref76">76</xref>,<xref ref-type="bibr" rid="ref78">78</xref>,<xref ref-type="bibr" rid="ref79">79</xref>]. However, choosing a goal was considered cognitively challenging [<xref ref-type="bibr" rid="ref76">76</xref>]. Specific goals on PA or different types of goals were considered to contribute to engagement [<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref83">83</xref>,<xref ref-type="bibr" rid="ref84">84</xref>]. The feeling of achieving a goal contributed to enjoyment [<xref ref-type="bibr" rid="ref76">76</xref>]. Reminders to set goals were considered useful [<xref ref-type="bibr" rid="ref72">72</xref>].</p>
      </sec>
      <sec>
        <title>Customization</title>
        <p>Youth liked to customize their accounts (eg, removing features such as friends, goal-setting, and training plans) [<xref ref-type="bibr" rid="ref79">79</xref>,<xref ref-type="bibr" rid="ref83">83</xref>]; choose the type of PA they wanted to perform [<xref ref-type="bibr" rid="ref83">83</xref>]; sort their personal goals [<xref ref-type="bibr" rid="ref78">78</xref>]; and listen to their own music [<xref ref-type="bibr" rid="ref84">84</xref>]. Youth in general suggested including the possibility of customizing one’s account [<xref ref-type="bibr" rid="ref83">83</xref>].</p>
        <p>Youth liked to engage with avatars [<xref ref-type="bibr" rid="ref69">69</xref>], and children (10-12 years old) suggested including dragons (35%), followed by a dinosaur (25%), and suggested to upgrade their avatar with personal equipment [<xref ref-type="bibr" rid="ref69">69</xref>].</p>
      </sec>
      <sec>
        <title>Feedback</title>
        <p>Participants considered regular feedback on achievements and goals [<xref ref-type="bibr" rid="ref67">67</xref>], which is individualized and in real time to contribute to engagement [<xref ref-type="bibr" rid="ref79">79</xref>,<xref ref-type="bibr" rid="ref83">83</xref>]. However, feedback based on dynamic tailoring did not reveal to contribute to overall engagement but contributed to narrative sensation (ie, feeling of presence) [<xref ref-type="bibr" rid="ref77">77</xref>]. Feedback that was shared via SMS text messaging and presented in graphs was highly valued [<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref73">73</xref>].</p>
      </sec>
      <sec>
        <title>PA Input</title>
        <p>Youth enjoyed upper-body movements [<xref ref-type="bibr" rid="ref80">80</xref>] compared with full-body movement such as running. However, requiring running to proceed in the game achieved mixed results (ie, facilitating and hampering) on engagement [<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref71">71</xref>,<xref ref-type="bibr" rid="ref81">81</xref>].</p>
      </sec>
      <sec>
        <title>Narrative</title>
        <p>Youth liked the addition of a narrative, including a variety of characters [<xref ref-type="bibr" rid="ref78">78</xref>,<xref ref-type="bibr" rid="ref80">80</xref>,<xref ref-type="bibr" rid="ref84">84</xref>] and settings [<xref ref-type="bibr" rid="ref78">78</xref>] that are realistic [<xref ref-type="bibr" rid="ref80">80</xref>], and the addition of a (complex) story, which was suggested by various studies [<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref80">80</xref>,<xref ref-type="bibr" rid="ref86">86</xref>].</p>
      </sec>
      <sec>
        <title>Levels</title>
        <p>Gradually increasing levels [<xref ref-type="bibr" rid="ref84">84</xref>] were considered important, and higher upgrade levels, referring to unlocking new levels as the player proceeds, were suggested to be added [<xref ref-type="bibr" rid="ref69">69</xref>].</p>
      </sec>
      <sec>
        <title>Credibility</title>
        <p>Youth found it important to receive information from a credible source as nutrition professionals [<xref ref-type="bibr" rid="ref74">74</xref>].</p>
      </sec>
      <sec>
        <title>Other Features</title>
        <p>Youth suggested including additional push notifications [<xref ref-type="bibr" rid="ref80">80</xref>] and reducing the GPS latency [<xref ref-type="bibr" rid="ref76">76</xref>].</p>
      </sec>
      <sec>
        <title>Included BCTs</title>
        <p>In total, 19% (4/21) of the studies did not include any reference to BCTs [<xref ref-type="bibr" rid="ref68">68</xref>,<xref ref-type="bibr" rid="ref71">71</xref>,<xref ref-type="bibr" rid="ref82">82</xref>,<xref ref-type="bibr" rid="ref86">86</xref>]; 19% (4/21) of studies did only include a reference to BCTs in the results [<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref73">73</xref>,<xref ref-type="bibr" rid="ref74">74</xref>,<xref ref-type="bibr" rid="ref80">80</xref>]; and 33% (7/21) of studies did include a reference to BCTs in the methods and results; however, they did not particularly refer to it as BCT [<xref ref-type="bibr" rid="ref67">67</xref>,<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref75">75</xref>,<xref ref-type="bibr" rid="ref77">77</xref>,<xref ref-type="bibr" rid="ref78">78</xref>,<xref ref-type="bibr" rid="ref84">84</xref>,<xref ref-type="bibr" rid="ref87">87</xref>]. Furthermore, 29% (6/21) of studies included a particular reference to BCTs and included the outline of the BCT in the methods and results [<xref ref-type="bibr" rid="ref72">72</xref>,<xref ref-type="bibr" rid="ref76">76</xref>,<xref ref-type="bibr" rid="ref79">79</xref>,<xref ref-type="bibr" rid="ref81">81</xref>,<xref ref-type="bibr" rid="ref83">83</xref>,<xref ref-type="bibr" rid="ref85">85</xref>]. In general, 57% (12/21) of studies included theory in the development of the app (4/21, 19% excluded as apps developed for commercial purposes). In addition, 81% (17/21) of studies included several BCTs (ranging from 2-10), which were partly related to the design features outlined in <xref ref-type="table" rid="table1">Table 1</xref>. The particular BCTs were not adopted in <xref ref-type="table" rid="table1">Table 1</xref>, as they have been translated into design features. The BCTs that were most often mentioned were feedback (11/21, 52%), social comparison (11/21, 52%), goal-setting (10/21, 48%), rewards (10/21, 48%), monitoring (9/21, 43%), and encouragement (6/21, 29%).</p>
      </sec>
      <sec>
        <title>Subanalysis SEP</title>
        <p>In total, 29% (6/21) of the studies (all from countries that form the Global North) included a substantial target population of low SEP [<xref ref-type="bibr" rid="ref72">72</xref>,<xref ref-type="bibr" rid="ref75">75</xref>-<xref ref-type="bibr" rid="ref77">77</xref>,<xref ref-type="bibr" rid="ref86">86</xref>,<xref ref-type="bibr" rid="ref87">87</xref>]; however, 33% (2/6) of studies eventually included a large percentage of high-SEP children (34% to 75%) [<xref ref-type="bibr" rid="ref72">72</xref>,<xref ref-type="bibr" rid="ref76">76</xref>]. In only 33% (2/6) of studies [<xref ref-type="bibr" rid="ref75">75</xref>,<xref ref-type="bibr" rid="ref76">76</xref>], the SEP was indicated as a direct study aim, and in 33% (2/6) of studies [<xref ref-type="bibr" rid="ref77">77</xref>,<xref ref-type="bibr" rid="ref86">86</xref>], a mix in SEP was desired. Low SEP was defined differently (ie, neighborhood site, family income, family affluence, parents’ education level, and youth education level), which made it difficult to compare studies, and engaging design features were not presented for different SEP categories. Therefore, subanalysis of the different design features could not be conducted.</p>
      </sec>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Principal Findings</title>
        <p>This systematic review presents the results of 21 studies that assessed the associations between features and engagement with mHealth PA interventions. According to our knowledge, this is the first mHealth intervention review that focused on PA and youth, with an additional focus on low-SEP background.</p>
        <p>The results showed that various design features, such as a clear interface; rewards; multiplayer game mode; facilitation of social interaction; variety of challenges with personalized difficulty level; self-monitoring options; and a variety of customization options among others, including self-set goals, personalized feedback, progress, and a narrative, were positively associated with engagement. In contrast, various features, such as sounds, leaderboards, competition, instructions, timing of messages or notifications, maps, or self-monitoring facilitated by manual input, that have been negatively associated with engagement need to be carefully considered while designing mHealth PA interventions. In addition, technical functionality can be considered as a prerequisite for engagement.</p>
        <p>When comparing the results with those of research in adults, several features are shared, such as a simple and structured interface, tailored and positive feedback on PA levels [<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref89">89</xref>,<xref ref-type="bibr" rid="ref90">90</xref>], progress [<xref ref-type="bibr" rid="ref90">90</xref>], well-designed reminders (eg, timing and frequency of notifications) [<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref89">89</xref>], rewards [<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref91">91</xref>-<xref ref-type="bibr" rid="ref93">93</xref>], self-monitoring [<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref44">44</xref>], goal-setting, [<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref44">44</xref>], clear navigation [<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref44">44</xref>], accurate tracking function [<xref ref-type="bibr" rid="ref43">43</xref>], personalization (eg, goals) [<xref ref-type="bibr" rid="ref94">94</xref>], and the offer of a variety of features [<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref95">95</xref>]. Technical difficulties were also negatively influencing engagement in adults [<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref89">89</xref>].</p>
        <p>Several features that have been in particular noted for adults, yet not in this review on youth, are credential sources, adequate privacy settings [<xref ref-type="bibr" rid="ref43">43</xref>], and content preventing the occurrence of surprises [<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref43">43</xref>]. Sharing accomplishments via social media was considered less engaging in adults [<xref ref-type="bibr" rid="ref90">90</xref>] than in youth. Although the studies among youth provided mixed results on competition, literature on adults suggests including competition [<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref90">90</xref>], leaderboards [<xref ref-type="bibr" rid="ref91">91</xref>], and hierarchical status (eg, progressive status report) [<xref ref-type="bibr" rid="ref91">91</xref>]. In gamification research, leaderboards are considered the most common feature implemented (alongside points, goals, and progress) [<xref ref-type="bibr" rid="ref96">96</xref>,<xref ref-type="bibr" rid="ref97">97</xref>], and this seems to be considered with care when addressing youth for PA promotion. In studies including adults, no direct links with narratives, avatars, a hunt, difficulties with manual input, sounds, or virtual location maps were found. Research on using these design features for interventions in youth is limited, according to the results of this review.</p>
        <p>This review focused on design features that have been tested by youth and included hypothetical or suggested features of the same studies but did not extend the search to studies that only provided ideas or suggestions that have not been tested (ie, cocreation study on app development without user-testing). Earlier studies have indicated that what users may request and what they actually engage with in practice do not have to match [<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref98">98</xref>]. In the studies in this review, several features were tested and included as further suggestions, which may underline the importance of the match between what youth would like to have included and what they actually engage with. The following results are in line with existing research on app development (ie, no user-testing) among youth: (1) clear user interface esthetics (ie, youthful visuals) [<xref ref-type="bibr" rid="ref99">99</xref>,<xref ref-type="bibr" rid="ref100">100</xref>]; (2) rewards, referring to a fair reward system [<xref ref-type="bibr" rid="ref100">100</xref>,<xref ref-type="bibr" rid="ref101">101</xref>], rewards that progressively increase [<xref ref-type="bibr" rid="ref102">102</xref>], and social rewards (ie, storybooks with interactive questions) [<xref ref-type="bibr" rid="ref103">103</xref>]; and (3) multiplayer mode, facilitating competition [<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref100">100</xref>] and comparison (eg, leaderboards) [<xref ref-type="bibr" rid="ref55">55</xref>], as well as cooperation [<xref ref-type="bibr" rid="ref103">103</xref>,<xref ref-type="bibr" rid="ref104">104</xref>]. Several features that have been suggested and tested in the studies included in this review were not found in existing research, and these include (1) chat functions (although with mixed results), (2) increasing difficulty level, (3) customizing user content, and (4) adding a variety of avatars and characters. In addition, several features have been suggested but have not been tested, and these include (1) meaningful information [<xref ref-type="bibr" rid="ref99">99</xref>,<xref ref-type="bibr" rid="ref100">100</xref>], including PA-related tips and plans [<xref ref-type="bibr" rid="ref101">101</xref>], and (2) variety and content updates [<xref ref-type="bibr" rid="ref102">102</xref>].</p>
        <p>Features that have been solely suggested in this review (ie, not tested) relate to (1) adding video and moving figures that navigate the PA and app instructions, (2) adding a storyline, and (3) including additional push notifications. Other research suggests that a clear navigation that is self-explanatory is important [<xref ref-type="bibr" rid="ref99">99</xref>], yet that notifications evoke mixed results on engagement [<xref ref-type="bibr" rid="ref101">101</xref>]. Features that have been suggested in other research, but not in this review, include (1) in-app events [<xref ref-type="bibr" rid="ref104">104</xref>] and (2) GPS and map editors [<xref ref-type="bibr" rid="ref105">105</xref>,<xref ref-type="bibr" rid="ref106">106</xref>]. This review contributes to the body of research and highlights that although maps can be suggested by youth, they can be very challenging when applied in practice, risking hampering engagement. Additional features that especially could hamper engagement include a small number of available minigames [<xref ref-type="bibr" rid="ref106">106</xref>], no instant feedback [<xref ref-type="bibr" rid="ref102">102</xref>] or personalized feedback by email [<xref ref-type="bibr" rid="ref101">101</xref>], lengthy texts, and difficult navigation [<xref ref-type="bibr" rid="ref99">99</xref>]. Future studies are needed to conduct experimental testing on features that yield inconclusive evidence so far among others competition, leaderboards, and notifications, as it may be possible that the results may differ for different subgroups of youth. We recommend that designers and health researchers consider designing a clear interface and an appropriate and fair reward system, enabling social interaction, and providing a variety of content, which is preferably customizable.</p>
        <p>Earlier research indicates how a variety of design features are designed and implemented in mobile apps [<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref107">107</xref>]. This is also indicated in other research outlining the challenges of how BCTs are operationalized [<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref108">108</xref>-<xref ref-type="bibr" rid="ref110">110</xref>]. In other words, the content or the active ingredient of the intervention may still differ by how it is delivered, in which context, or in which combinations (ie, design features, including gamification elements and BCTs) it is applied [<xref ref-type="bibr" rid="ref111">111</xref>]. An ontology, as proposed by West and Michie [<xref ref-type="bibr" rid="ref112">112</xref>], and tools such as SciModeller that integrate multiple pieces of empirical data [<xref ref-type="bibr" rid="ref113">113</xref>] can eventually contribute to this knowledge and help researchers and mHealth developers apply and build on this knowledge. This review focused on whether the app design has been informed by or has been based on relating BCTs or behavioral theories and concluded that BCTs are often not outlined in detail, and there is no particular translation of BCTs to app content. This review only included 33% (7/21) of studies that made a clear translation from a particular BCT to a design feature. A scoping review not only summarized the challenges in mHealth design in translating BCTs to an mHealth feature but also raised challenges with regard to integrating ideas from different perspectives (ie, BCTs, user needs, and stakeholder views), which can result in conflicting ideas [<xref ref-type="bibr" rid="ref110">110</xref>]. Existing research on mHealth, focusing on app features, BCTs, or both, points to the challenge of mapping which features or BCTs work in isolation or in combination with others [<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref114">114</xref>]. Furthermore, a wide applicability exists with regard to creating design features that are often designed from scratch. In light of the Open Digital Health initiative [<xref ref-type="bibr" rid="ref115">115</xref>], we recommend making mHealth apps and data accessible to be able to reuse or continue working on existing design features that have been proven to be effective for engagement. By this, we can start mapping working design features for different user groups in different contexts [<xref ref-type="bibr" rid="ref115">115</xref>,<xref ref-type="bibr" rid="ref116">116</xref>].</p>
        <p>Different systematic reviews focusing on the effectiveness of mHealth interventions have also focused on BCTs. However, a large number of the reviews map the number of BCTs that have been included in an intervention [<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref117">117</xref>] or the BCTs that have been included [<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref117">117</xref>]. However, there is dearth of research that identifies the individual or interaction effects of design features or BCTs in mHealth interventions among youth. Several studies have identified that modeling is an effective BCT for children. With regard to adolescents, providing consequences for behavior, providing information on others’ approval, facilitating intention formation, self-monitoring, using behavioral contract [<xref ref-type="bibr" rid="ref118">118</xref>], and providing individualization support [<xref ref-type="bibr" rid="ref25">25</xref>] were positive predictors of PA effect size. Providing instructions was negatively predictive of study effect size [<xref ref-type="bibr" rid="ref118">118</xref>]. In future reviews, it would be interesting to map the similarities and differences between design features that contribute to engagement in the mHealth intervention (ie, microengagement) and BCTs that contribute to the behavioral change effectiveness (ie, macroengagement) to identify effective design features [<xref ref-type="bibr" rid="ref40">40</xref>]. However, limited BCTs are researched in effectiveness studies, especially among youth [<xref ref-type="bibr" rid="ref119">119</xref>]. Therefore, more individual studies are needed before this comparison can be made. Future studies may, therefore, test the effectiveness of individual BCTs and combinations of BCTs on behavioral changes in factorial designs [<xref ref-type="bibr" rid="ref120">120</xref>] in youth. Future studies should also consider testing both microengagement and macroengagement in the same mHealth intervention [<xref ref-type="bibr" rid="ref40">40</xref>] to better inform how to increase engagement in the mHealth intervention (ie, microengagement) and translate this to behavioral change, which can be engaged in the long term in the absence of any intervention (ie, macroengagement).</p>
        <p>This review underlines that research addressing youth from low-SEP families is very limited with regard to engagement in mHealth apps. Although it is often argued that apps can be a suitable platform to reach diverse groups of youth, it is striking that only 7 studies have been identified that aim to involve youth from different SEP backgrounds. Unfortunately, it was not possible to conduct a subanalysis because the features were not directly linked to the SEP position. Studies that succeeded in addressing a large percentage of children with low SEP recruited participants via schools [<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref77">77</xref>,<xref ref-type="bibr" rid="ref86">86</xref>]. From this review, it cannot be directly derived which recruitment strategy leads to lower percentages of children with low SEP, as especially, the measures of low SEP differ greatly. We advocate for more research that includes youth from low-SEP families early in the development phase and user-testing and suggest recruiting youth from low-SEP background via schools. Further research in adults suggested that personal contact between study staff and participants is essential and that community sites (comparable with school settings) created a sense of community and support [<xref ref-type="bibr" rid="ref121">121</xref>]. Thereby, youth who have the potential to book the greatest health gains (ie, often youth with low-SEP or low-PA levels) are addressed appropriately, which may contribute to reducing health inequalities and the digital divide [<xref ref-type="bibr" rid="ref44">44</xref>]. A scoping review highlighted the need to further investigate user engagement studies in low-SEP groups and called for future in-depth formative studies [<xref ref-type="bibr" rid="ref95">95</xref>]. Existing research indicates that multimedia, personalization, variation, and gamification [<xref ref-type="bibr" rid="ref95">95</xref>], such as competition [<xref ref-type="bibr" rid="ref116">116</xref>], can contribute to engagement in mHealth apps among young adults with low-SEP backgrounds. We advocate to start testing these features in youth with low SEP.</p>
        <p>In this review, we identified a heterogeneity of engagement measures, which has also been identified in earlier reviews [<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref114">114</xref>,<xref ref-type="bibr" rid="ref122">122</xref>,<xref ref-type="bibr" rid="ref123">123</xref>]. In addition, several measures only reflect one construct of engagement and do not measure the multidimensional concept of engagement [<xref ref-type="bibr" rid="ref55">55</xref>]. Furthermore, research studies included in this review did not distinguish between different features that can be considered in different stages of engagement. Research suggests that engagement is a dynamic process rather than a state, although it is often measured as a state (ie, 1 postintervention questionnaire on engagement instead of cyclic measurement) [<xref ref-type="bibr" rid="ref124">124</xref>]. On the basis of earlier research, it may however be stated that features such as a clear interface are especially important for the initial stage of engagement (ie, attention grabbing) [<xref ref-type="bibr" rid="ref124">124</xref>]. Features that sustain engagement may relate to social interaction, a variety of challenges with personalized difficulty level, self-monitoring and customization options, and narratives [<xref ref-type="bibr" rid="ref77">77</xref>]. Disengaging may relate to certain types of sounds, leaderboards, instructions, messages or notifications, competition, and self-monitoring facilitated by manual input. Features that reengaged or nonengaged users have not been identified in this review. However, for example, Janko et al [<xref ref-type="bibr" rid="ref69">69</xref>] discussed unlockable avatars and upgrading levels as possible features that may contribute to reengagement. Research on young adults indicated that users did not engage (ie, nonengagement) owing to low uptake of the intervention among peers [<xref ref-type="bibr" rid="ref49">49</xref>]. The reasons for disengagement mentioned in this review relate to factors outside the mHealth intervention (eg, holidays, competing after-school activities, weather, school policies, and unstructured or leisure settings) [<xref ref-type="bibr" rid="ref76">76</xref>,<xref ref-type="bibr" rid="ref77">77</xref>,<xref ref-type="bibr" rid="ref81">81</xref>,<xref ref-type="bibr" rid="ref83">83</xref>,<xref ref-type="bibr" rid="ref87">87</xref>], yet nonadherence has not been linked to design features. Future research is needed to identify particular features in different stages of engagement to grasp engagement as a multidimensional and dynamic process [<xref ref-type="bibr" rid="ref124">124</xref>]. Thereby, designers can improve design features according to the stage of engagement (eg, include particular features to reengage users and prevent them from sustained disengagement). Furthermore, engagement may also be related to the setting in which the mHealth tool is implemented. The activity that competes with the mHealth tool is central. Earlier research indicated that pupils tend to choose to engage with an mHealth tool in order not to participate in class in a school setting [<xref ref-type="bibr" rid="ref125">125</xref>]. In comparison, mHealth tools are often challenged in leisure time, and the competition with other apps or leisure activities is central [<xref ref-type="bibr" rid="ref126">126</xref>,<xref ref-type="bibr" rid="ref127">127</xref>]. Future studies should focus on the implementation of mHealth tool and investigate differences in engagement in either voluntary versus more obligatory settings.</p>
        <p>In terms of comparability, the Persuasive Systems Design (PSD) model could have helped map the different design features. PSD is often used in research to outline persuasive design elements. The model maps different persuasive design elements in primary task support, dialogue support, system credibility support, and social support. When comparing the PSD model with the coding scheme applied in this systematic review, a number of similarities can be identified. In terms of primary task support, navigation (PSD model: tunneling), personalization, and self-monitoring are identified. In terms of dialogue support, rewards, messages (PSD model: reminders), and interface aesthetics (PSD model: liking) can be identified. Liking is very broadly defined as “visually attractive” in the PSD model and has been criticized in earlier research [<xref ref-type="bibr" rid="ref128">128</xref>]. It finds more detail in the coding of our systematic review (ie, interplay of interface elements such as sounds, visuals, and language). In terms of system credibility support, only credibility (PSD model: expertise) can be identified. In terms of social support, reinforcement (PSD model: social comparison), social messages (PSD model: social facilitation), cooperation, and competition can be identified. Design features that are difficult to code in terms of the PSD model are challenges, levels, feedback, avatars, and narratives and are predominately game elements and refer to achievement- and immersion-based features [<xref ref-type="bibr" rid="ref96">96</xref>]. These have also been identified in earlier research, distinguishing their research from the PSD model [<xref ref-type="bibr" rid="ref129">129</xref>,<xref ref-type="bibr" rid="ref130">130</xref>]. On the one hand, this emphasizes the challenge to identify and apply a complete list of design elements. As a proposed solution, Geuens et al [<xref ref-type="bibr" rid="ref128">128</xref>] created a website that derived from the PSD model and mapped a working list of adaptable features. However, it should be noted that this list is currently not complete in terms of gamification elements. On the other hand, the large number of similarities between the PSD model and the coding frame of this systematic review suggest that various research studies may have found (to a certain degree) a consensus on design features. A revision of the PSD model, adapted by, for example, gamification elements, could help create an updated list of design features that are widely applicable to designers and researchers.</p>
      </sec>
      <sec>
        <title>Strengths and Limitations</title>
        <p>As identified in an earlier review [<xref ref-type="bibr" rid="ref55">55</xref>], this review included a larger number of studies reporting the foremost positive associations, which may bias the overview in features that are either unrelated or negatively associated and may not be reported (ie, publication bias). In addition, the strength of associations has not been included in the individual studies, owing to a lack of high-quality experimental studies. In addition, heterogeneity among studies with regard to engagement measures was identified, making direct comparison challenging; this has also been identified in earlier studies [<xref ref-type="bibr" rid="ref114">114</xref>]. This systematic review maps a large number of features that are associated with engagement individually. The interaction of different features and their effect on engagement is still not researched and needs to be considered in future engagement studies, for example, experimental factorial designs [<xref ref-type="bibr" rid="ref41">41</xref>]. Individual studies included small sample sizes, and only a small number of studies focused on low SEP. Using different SEP measures and mixing them with high-SEP measures made it challenging to compare studies and prevented us from conducting a subanalysis based on the SEP background. Therefore, the findings might not be transferable to low-SEP groups and this underlines the need for future research. In addition, the variability in SEP measures made it difficult to standardize SEP thresholds and compare between countries, as youth from a low-SEP background may not be equivalent in terms of studies and countries, and disparity occurs even in different parts of one country. Studies that included SEP measures were exclusively from countries of the Global North, emphasizing that in general, a minority of studies focused on the Global South (4/21, 19%), and none focused on SEP. As the search was limited to English, this review may not have included all available and relevant research on this topic. Earlier research outlines the differences in the effectiveness of mHealth intervention on behavioral outcomes and engagement among very young children and older children. Research further suggests that preferences for design features may differ between different age groups of youth. This systematic review did not cluster for different age groups because of the limited number of studies that, for example, focus on the very young children (aged &#60;4 years) [<xref ref-type="bibr" rid="ref25">25</xref>]. More individual studies are needed among very young children to identify whether age differences exist. Earlier research suggests that gender differences in games may exist [<xref ref-type="bibr" rid="ref131">131</xref>-<xref ref-type="bibr" rid="ref137">137</xref>]. None of the included studies in this systematic review distinguished between gender for design features in mHealth interventions. In future research, it can therefore be considered to investigate possible differences in future user-testing. The quality of the studies was mixed, indicating in general that study designs with regard to measuring engagement need to evolve. Especially, studies that focus on engagement as a secondary outcome need to operationalize engagement clearly and report the methods transparently. In this review, no validated design feature taxonomy has been used for coding, although it was based on existing overviews of design features [<xref ref-type="bibr" rid="ref114">114</xref>]. In this review, all study designs were included, and this provided a comprehensive overview of relating research on engagement and triangulated evidence. This is the first review identifying mHealth design features among youth with the aim of promoting PA. This review was based on the PRISMA guidelines and succeeded in providing a coherent overview of all nuances relating to a good quality assessment and high interrater reliability.</p>
      </sec>
      <sec>
        <title>Conclusions</title>
        <p>The results indicate that a clear interface; an appropriate and fair reward system; social interaction; and a variety of app content (ie, missions, content, and characters) that are preferably customizable can contribute to engagement in mHealth PA interventions for youth. Design features, such as sounds, competition, instructions, notifications, virtual maps, or self-monitoring facilitated by manual input, that were negatively associated with engagement need to be carefully considered when designing mHealth PA interventions. In addition, technical functionality can be considered a prerequisite for engagement. Research addressing youth from low-SEP families is very limited with regard to engagement in mHealth apps, and design features often lack a sufficient degree of operationalization based on behavioral change theories or techniques. Future studies are needed to further test design features in youth, particularly youth from low-SEP families, and to evolve engagement measures.</p>
      </sec>
    </sec>
  </body>
  <back>
    <app-group>
      <supplementary-material id="app1">
        <label>Multimedia Appendix 1</label>
        <p>PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) checklist.</p>
        <media xlink:href="mhealth_v11i1e40898_app1.docx" xlink:title="DOCX File , 40 KB"/>
      </supplementary-material>
      <supplementary-material id="app2">
        <label>Multimedia Appendix 2</label>
        <p>Full search strategy.</p>
        <media xlink:href="mhealth_v11i1e40898_app2.docx" xlink:title="DOCX File , 29 KB"/>
      </supplementary-material>
      <supplementary-material id="app3">
        <label>Multimedia Appendix 3</label>
        <p>Quality check Mixed Method Assessment Tool.</p>
        <media xlink:href="mhealth_v11i1e40898_app3.xlsx" xlink:title="XLSX File  (Microsoft Excel File), 58 KB"/>
      </supplementary-material>
      <supplementary-material id="app4">
        <label>Multimedia Appendix 4</label>
        <p>Data extraction of the studies included in the systematic review.</p>
        <media xlink:href="mhealth_v11i1e40898_app4.xlsx" xlink:title="XLSX File  (Microsoft Excel File), 53 KB"/>
      </supplementary-material>
    </app-group>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">BCT</term>
          <def>
            <p>behavior change technique</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb2">mHealth</term>
          <def>
            <p>mobile health</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb3">MVPA</term>
          <def>
            <p>moderate- to vigorous-intensity physical activity</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb4">PRISMA</term>
          <def>
            <p>Preferred Reporting Items for Systematic Reviews and Meta-Analyses</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb5">PROSPERO</term>
          <def>
            <p>International Prospective Register of Systematic Reviews</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb6">PSD</term>
          <def>
            <p>Persuasive Systems Design</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb7">SEP</term>
          <def>
            <p>socioeconomic position</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <ack>
      <p>This review was supported by the mVital@2040 project, which is a part of the Vitality Academy and connected to the EWUU Alliance (Eindhoven University of Technology, Wageningen University &#38; Research, Utrecht University, and University Medical Centre Utrecht). The project and AS were funded by the Wageningen University &#38; Research. MS initiated and acquired the funding for the mVital@2040 project.</p>
    </ack>
    <fn-group>
      <fn fn-type="con">
        <p>AS was responsible for leading all stages of the review. AS established the research protocol, which was reviewed by MS and LHHW. DO conducted the search and data extraction under the supervision of LHHW and drafted the first version of the methods and results. KB served as the second reviewer for search and data extraction. The search was updated by AS. AS was responsible for drafting the manuscript, which was written together with MS, LHHW, and EdV. The manuscript was eventually reviewed and adapted by MS, LHHW, EdV, DO, and KB.</p>
      </fn>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
    <ref-list>
      <ref id="ref1">
        <label>1</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Chaput</surname>
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