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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMU</journal-id>
      <journal-id journal-id-type="nlm-ta">JMIR Mhealth Uhealth</journal-id>
      <journal-title>JMIR mHealth and uHealth</journal-title>
      <issn pub-type="epub">2291-5222</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v11i1e46558</article-id>
      <article-id pub-id-type="pmid">38055318</article-id>
      <article-id pub-id-type="doi">10.2196/46558</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Review</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Review</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Mobile Technology–Based Interventions for Stroke Self-Management Support: Scoping Review</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Buis</surname>
            <given-names>Lorraine</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Peeples</surname>
            <given-names>Malinda</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Nabovati</surname>
            <given-names>Ehsan</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author">
          <name name-style="western">
            <surname>Thompson</surname>
            <given-names>Alexandra N</given-names>
          </name>
          <degrees>MScOT</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <xref rid="aff2" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-9539-6620</ext-link>
        </contrib>
        <contrib id="contrib2" contrib-type="author">
          <name name-style="western">
            <surname>Dawson</surname>
            <given-names>Deirdre R</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <xref rid="aff2" ref-type="aff">2</xref>
          <xref rid="aff3" ref-type="aff">3</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-7517-6121</ext-link>
        </contrib>
        <contrib id="contrib3" contrib-type="author">
          <name name-style="western">
            <surname>Legasto-Mulvale</surname>
            <given-names>Jean Michelle</given-names>
          </name>
          <degrees>MScPT</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <xref rid="aff4" ref-type="aff">4</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-0311-0227</ext-link>
        </contrib>
        <contrib id="contrib4" contrib-type="author">
          <name name-style="western">
            <surname>Chandran</surname>
            <given-names>Nivetha</given-names>
          </name>
          <degrees>HBSc</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0009-0000-6151-7087</ext-link>
        </contrib>
        <contrib id="contrib5" contrib-type="author">
          <name name-style="western">
            <surname>Tanchip</surname>
            <given-names>Chelsea</given-names>
          </name>
          <degrees>MSc</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-7054-3209</ext-link>
        </contrib>
        <contrib id="contrib6" contrib-type="author">
          <name name-style="western">
            <surname>Niemczyk</surname>
            <given-names>Veronika</given-names>
          </name>
          <degrees>MScOT</degrees>
          <xref rid="aff5" ref-type="aff">5</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0009-0003-4244-1322</ext-link>
        </contrib>
        <contrib id="contrib7" contrib-type="author">
          <name name-style="western">
            <surname>Rashkovan</surname>
            <given-names>Jillian</given-names>
          </name>
          <xref rid="aff3" ref-type="aff">3</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0009-0006-0423-7613</ext-link>
        </contrib>
        <contrib id="contrib8" contrib-type="author">
          <name name-style="western">
            <surname>Jeyakumar</surname>
            <given-names>Saisa</given-names>
          </name>
          <degrees>HBSc</degrees>
          <xref rid="aff3" ref-type="aff">3</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0009-0000-4451-6429</ext-link>
        </contrib>
        <contrib id="contrib9" contrib-type="author">
          <name name-style="western">
            <surname>Wang</surname>
            <given-names>Rosalie H</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <xref rid="aff3" ref-type="aff">3</xref>
          <xref rid="aff6" ref-type="aff">6</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-7777-9989</ext-link>
        </contrib>
        <contrib id="contrib10" contrib-type="author">
          <name name-style="western">
            <surname>Cameron</surname>
            <given-names>Jill I</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <xref rid="aff3" ref-type="aff">3</xref>
          <xref rid="aff6" ref-type="aff">6</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-4161-1572</ext-link>
        </contrib>
        <contrib id="contrib11" contrib-type="author" corresp="yes">
          <name name-style="western">
            <surname>Nalder</surname>
            <given-names>Emily</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <address>
            <institution>Rehabilitation Sciences Institute</institution>
            <institution>Temerty Faculty of Medicine</institution>
            <institution>University of Toronto</institution>
            <addr-line>Suite 160</addr-line>
            <addr-line>500 University Avenue</addr-line>
            <addr-line>Toronto, ON, M5G 1V7</addr-line>
            <country>Canada</country>
            <phone>1 416 978 5937</phone>
            <email>emily.nalder@utoronto.ca</email>
          </address>
          <xref rid="aff3" ref-type="aff">3</xref>
          <xref rid="aff6" ref-type="aff">6</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-9612-9420</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution>Rehabilitation Sciences Institute</institution>
        <institution>Temerty Faculty of Medicine</institution>
        <institution>University of Toronto</institution>
        <addr-line>Toronto, ON</addr-line>
        <country>Canada</country>
      </aff>
      <aff id="aff2">
        <label>2</label>
        <institution>Rotman Research Institute</institution>
        <institution>Baycrest Health Sciences</institution>
        <addr-line>Toronto, ON</addr-line>
        <country>Canada</country>
      </aff>
      <aff id="aff3">
        <label>3</label>
        <institution>Department of Occupational Science and Occupational Therapy</institution>
        <institution>Temerty Faculty of Medicine</institution>
        <institution>University of Toronto</institution>
        <addr-line>Toronto, ON</addr-line>
        <country>Canada</country>
      </aff>
      <aff id="aff4">
        <label>4</label>
        <institution>Department of Physical Therapy</institution>
        <institution>Temerty Faculty of Medicine</institution>
        <institution>University of Toronto</institution>
        <addr-line>Toronto, ON</addr-line>
        <country>Canada</country>
      </aff>
      <aff id="aff5">
        <label>5</label>
        <institution>School of Rehabilitation Science</institution>
        <institution>Faculty of Health Sciences</institution>
        <institution>McMaster University</institution>
        <addr-line>Hamilton, ON</addr-line>
        <country>Canada</country>
      </aff>
      <aff id="aff6">
        <label>6</label>
        <institution>KITE Research Institute</institution>
        <institution>Toronto Rehabilitation Institute</institution>
        <institution>University Health Network</institution>
        <addr-line>Toronto, ON</addr-line>
        <country>Canada</country>
      </aff>
      <author-notes>
        <corresp>Corresponding Author: Emily Nalder <email>emily.nalder@utoronto.ca</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <year>2023</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>6</day>
        <month>12</month>
        <year>2023</year>
      </pub-date>
      <volume>11</volume>
      <elocation-id>e46558</elocation-id>
      <history>
        <date date-type="received">
          <day>16</day>
          <month>2</month>
          <year>2023</year>
        </date>
        <date date-type="rev-request">
          <day>3</day>
          <month>7</month>
          <year>2023</year>
        </date>
        <date date-type="rev-recd">
          <day>3</day>
          <month>10</month>
          <year>2023</year>
        </date>
        <date date-type="accepted">
          <day>18</day>
          <month>10</month>
          <year>2023</year>
        </date>
      </history>
      <copyright-statement>©Alexandra N Thompson, Deirdre R Dawson, Jean Michelle Legasto-Mulvale, Nivetha Chandran, Chelsea Tanchip, Veronika Niemczyk, Jillian Rashkovan, Saisa Jeyakumar, Rosalie H Wang, Jill I Cameron, Emily Nalder. Originally published in JMIR mHealth and uHealth (https://mhealth.jmir.org), 06.12.2023.</copyright-statement>
      <copyright-year>2023</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR mHealth and uHealth, is properly cited. The complete bibliographic information, a link to the original publication on https://mhealth.jmir.org/, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://mhealth.jmir.org/2023/1/e46558" xlink:type="simple"/>
      <abstract>
        <sec sec-type="background">
          <title>Background</title>
          <p>There is growing interest in enhancing stroke self-management support using mobile health (mHealth) technology (eg, smartphones and apps). Despite this growing interest, “self-management support” is inconsistently defined and applied in the poststroke mHealth intervention literature, which limits efforts to synthesize and compare evidence. To address this gap in conceptual clarity, a scoping review was conducted.</p>
        </sec>
        <sec sec-type="objective">
          <title>Objective</title>
          <p>The objectives were to (1) identify and describe the types of poststroke mHealth interventions evaluated using a randomized controlled trial design, (2) determine whether (and how) such interventions align with well-accepted conceptualizations of self-management support (the theory by Lorig and Holman and the Practical Reviews in Self-Management Support [PRISMS] taxonomy by Pearce and colleagues), and (3) identify the mHealth functions that facilitate self-management.</p>
        </sec>
        <sec sec-type="methods">
          <title>Methods</title>
          <p>A scoping review was conducted according to the methodology by Arksey and O’Malley and Levac et al. In total, 7 databases were searched. Article screening and data extraction were performed by 2 reviewers. The data were analyzed using descriptive statistics and content analysis.</p>
        </sec>
        <sec sec-type="results">
          <title>Results</title>
          <p>A total of 29 studies (26 interventions) were included. The interventions addressed 7 focal areas (physical exercise, risk factor management, linguistic exercise, activities of daily living training, medication adherence, stroke education, and weight management), 5 types of mobile devices (mobile phones or smartphones, tablets, wearable sensors, wireless monitoring devices, and laptops), and 7 mHealth functions (educating, communicating, goal setting, monitoring, providing feedback, reminding, and motivating). Collectively, the interventions aligned well with the concept of self-management support. However, on an individual basis (per intervention), the alignment was less strong.</p>
        </sec>
        <sec sec-type="conclusions">
          <title>Conclusions</title>
          <p>On the basis of the results, it is recommended that future research on poststroke mHealth interventions be more theoretically driven, more multidisciplinary, and larger in scale.</p>
        </sec>
      </abstract>
      <kwd-group>
        <kwd>stroke</kwd>
        <kwd>chronic disease</kwd>
        <kwd>self-management</kwd>
        <kwd>rehabilitation</kwd>
        <kwd>mobile health</kwd>
        <kwd>mHealth</kwd>
        <kwd>eHealth</kwd>
        <kwd>telehealth</kwd>
        <kwd>telemedicine</kwd>
        <kwd>digital health</kwd>
        <kwd>mobile phone</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <sec>
        <title>Background</title>
        <p>Managing the chronic effects of stroke (eg, mobility problems, cognitive impairment, and depression) has become a global health priority because of its enormous burden on health care systems [<xref ref-type="bibr" rid="ref1">1</xref>,<xref ref-type="bibr" rid="ref2">2</xref>]. In Canada, &#62;400,000 people live with the effects of stroke, and by 2038, this number is expected to increase to nearly 700,000 [<xref ref-type="bibr" rid="ref3">3</xref>]. To meet the needs of this growing population and address international priorities, self-management support interventions for stroke are of growing interest to researchers and health care professionals. Broadly defined, self-management support is a complex intervention that provides people with knowledge, confidence, and skills to manage their chronic condition [<xref ref-type="bibr" rid="ref4">4</xref>]. Self-management support interventions have been shown to improve a variety of health outcomes after stroke, including risk factor control [<xref ref-type="bibr" rid="ref5">5</xref>], functional ability [<xref ref-type="bibr" rid="ref6">6</xref>], participation [<xref ref-type="bibr" rid="ref6">6</xref>], and quality of life [<xref ref-type="bibr" rid="ref7">7</xref>]. They have also been recommended in recent clinical practice guidelines [<xref ref-type="bibr" rid="ref8">8</xref>]. Unfortunately, however, because of limited health care budgets and unequal access to rehabilitation, few Canadians have the opportunity to participate in self-management support interventions following stroke [<xref ref-type="bibr" rid="ref8">8</xref>,<xref ref-type="bibr" rid="ref9">9</xref>]. Increased access to timely, effective, and low-cost stroke self-management support could be provided through mobile health (mHealth) technology–based (eg, smartphone app–based) interventions.</p>
        <p>Despite the growing potential, need, and interest in enhancing stroke self-management support interventions with mHealth, the evidence for its effectiveness remains unclear. In previous reviews of poststroke mHealth interventions, connections were drawn to “self-management support”; however, the concept was never explicitly defined or operationalized [<xref ref-type="bibr" rid="ref10">10</xref>-<xref ref-type="bibr" rid="ref14">14</xref>]. In these previous reviews, self-management support was discussed in a way that suggests that it is a newly emerging concept in the literature on poststroke mHealth interventions. Specifically, in the abstract and introduction of 3 reviews, self-management was framed as a key concept in the rationale for the review [<xref ref-type="bibr" rid="ref10">10</xref>,<xref ref-type="bibr" rid="ref12">12</xref>,<xref ref-type="bibr" rid="ref14">14</xref>]. For example, in 1 review, mHealth for self-management was described as a “new strategy for stroke rehabilitation” [<xref ref-type="bibr" rid="ref10">10</xref>]. In the discussion of 2 reviews, improved self-management was highlighted as an important outcome of mHealth use [<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref13">13</xref>]. In the conclusion of 1 review, identifying literature on mHealth interventions to support self-management was stated as the purpose of the study [<xref ref-type="bibr" rid="ref11">11</xref>]. Although clearly emphasizing an interest in the concept, without explicit definitions or operationalizations, the literature remains challenging to synthesize and compare, which may lead future reviews to draw incorrect conclusions about intervention effectiveness [<xref ref-type="bibr" rid="ref15">15</xref>]. To our knowledge, no review has addressed this lack of conceptual clarity; that is, no review has aimed to map the literature on poststroke mHealth interventions according to well-accepted conceptualizations of self-management support.</p>
      </sec>
      <sec>
        <title>Objectives</title>
        <p>To address this gap in the literature, we conducted a scoping review. This method was selected for its utility in clarifying key concepts in the literature, identifying key characteristics related to a concept, and identifying and analyzing knowledge gaps in an emerging field [<xref ref-type="bibr" rid="ref16">16</xref>]. The objectives were to (1) identify and describe the types of poststroke mHealth interventions evaluated using a randomized controlled trial (RCT) design, (2) determine whether (and how) such interventions align with well-accepted conceptualizations (theory [<xref ref-type="bibr" rid="ref17">17</xref>] and taxonomy [<xref ref-type="bibr" rid="ref18">18</xref>]) of self-management support, and (3) identify the mHealth functions that facilitate self-management. The purpose of this study was to identify gaps in the literature and recommendations for future research related to mHealth-enhanced stroke self-management support.</p>
      </sec>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <sec>
        <title>Design</title>
        <p>Using well-established methods [<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref20">20</xref>], a scoping review was conducted. The protocol was not registered. A critical appraisal of the included studies was not conducted as the aim of this review was to map the breadth and depth of conceptualizations, not to draw conclusions about intervention effectiveness [<xref ref-type="bibr" rid="ref16">16</xref>]. The PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) checklist is provided in <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref> [<xref ref-type="bibr" rid="ref21">21</xref>].</p>
      </sec>
      <sec>
        <title>Identifying Relevant Studies</title>
        <p>In consultation with 2 librarians, ANT searched MEDLINE, Embase, PsycINFO, CINAHL, AMED, Scopus, and ProQuest Dissertations and Theses Global 3 times (October 2-3, 2020, February 28, 2022, and July 10, 2023). The second and third searches were conducted to identify new literature published between 2020 and 2022 and between 2022 and 2023. The search terms captured 2 search concepts: stroke and mHealth (see <xref ref-type="supplementary-material" rid="app2">Multimedia Appendix 2</xref> for the full Ovid search strategy).</p>
      </sec>
      <sec>
        <title>Selecting Studies</title>
        <p>ANT, JML-M, NC, CT, VN, JR, and SJ conducted level-1 (title and abstract) and level-2 (full-text) screening in duplicate using Covidence (Veritas Health Innovation). Disagreements were resolved through consensus-based discussion. Studies were included if the article reported original research, the study included human participants with stroke or transient ischemic attack, the study evaluated an mHealth intervention (mHealth defined using 2 definitions: those of the World Health Organization—“[the] medical and public health practice supported by mobile devices, such as mobile phones, patient monitoring devices, personal digital assistants [PDAs], and other wireless devices” [<xref ref-type="bibr" rid="ref22">22</xref>]—and Akter et al [<xref ref-type="bibr" rid="ref23">23</xref>]—“focusing on any wireless technologies [e.g., Bluetooth, GSM, GPRS/3G, Wi-Fi, WiMAX] to transmit various health-related data content and services through mobile devices, including mobile phones, smartphones, PDAs, laptops and Tablet PCs”), and the study was an RCT. The search was limited to RCTs as a preliminary search identified a large number of studies using an RCT design. In addition, as RCTs are typically regarded as the highest in quality and presumably are the farthest along in the technology development process, their influence on research and practice was thought to be the most significant. Studies were excluded if the sample was mixed (eg, acquired brain injury), the intervention included client (person with stroke)–facing technology or equipment that was not clearly mobile and wireless, the article did not report any outcome measures related to intervention effectiveness, and the article was not written in English.</p>
      </sec>
      <sec>
        <title>Charting the Data</title>
        <p>ANT developed the data-charting form in collaboration with DRD and EN. ANT charted the data verbatim and then JML-M, NC, CT, VN, JR, and SJ verified the data. Data were charted from the included articles as well as from supplementary materials and protocol papers when referenced. The data-charting form included study characteristics (eg, study aims and outcome measures), participant characteristics (eg, time since stroke and sex or gender), and intervention characteristics (based on the Template for Intervention Description and Replication checklist [<xref ref-type="bibr" rid="ref24">24</xref>]). Visual information related to the intervention characteristics was also charted (eg, screenshots of apps).</p>
      </sec>
      <sec>
        <title>Collating, Summarizing, and Reporting the Results</title>
        <p>ANT completed the data analysis in collaboration with DRD, EN, RHW, and JIC. Quantitative data were analyzed using descriptive statistics, and qualitative data were analyzed using conventional content analysis (objective 1) and directed content analysis (objectives 2 and 3) [<xref ref-type="bibr" rid="ref25">25</xref>]. Directed content analysis for objective 2 was guided by the theory by Lorig and Holman [<xref ref-type="bibr" rid="ref17">17</xref>] and the Practical Reviews in Self-Management Support (PRISMS) taxonomy by Pearce et al [<xref ref-type="bibr" rid="ref18">18</xref>] as they are widely cited, slightly different conceptualizations of self-management support (see <xref ref-type="supplementary-material" rid="app3">Multimedia Appendix 3</xref> [<xref ref-type="bibr" rid="ref17">17</xref>,<xref ref-type="bibr" rid="ref18">18</xref>] for the operational definitions of codes). Directed content analysis for objective 3 was guided by the definition of mHealth functions by Cameron et al [<xref ref-type="bibr" rid="ref26">26</xref>] (“the verbs describing the behavior of the system”), examples from previous research on mHealth functions [<xref ref-type="bibr" rid="ref27">27</xref>-<xref ref-type="bibr" rid="ref31">31</xref>], and dictionary definitions [<xref ref-type="bibr" rid="ref32">32</xref>-<xref ref-type="bibr" rid="ref38">38</xref>] (see <xref ref-type="supplementary-material" rid="app4">Multimedia Appendix 4</xref> [<xref ref-type="bibr" rid="ref29">29</xref>-<xref ref-type="bibr" rid="ref38">38</xref>] for the operational definitions of codes).</p>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <sec>
        <title>Study Characteristics</title>
        <p>A total of 29 studies describing 26 interventions were included (see <xref rid="figure1" ref-type="fig">Figure 1</xref> for the PRISMA [Preferred Reporting Items for Systematic Reviews and Meta-Analyses] flow diagram [<xref ref-type="bibr" rid="ref39">39</xref>]). The studies were published between 2007 and 2023 and were from Asia (13/29, 45%), Europe (8/29, 28%), North America (4/29, 14%), Africa (2/29, 7%), and Australia (2/29, 7%). Of the 29 studies, 1 (3%) was a doctoral dissertation [<xref ref-type="bibr" rid="ref40">40</xref>] and the remaining 28 (97%) were peer-reviewed journal articles. A total of 34% (10/29) of the studies were considered pilot, proof-of-concept, or feasibility studies. The sample sizes ranged from 11 to 4298. <xref ref-type="table" rid="table1">Table 1</xref> presents the study and participant characteristics.</p>
        <fig id="figure1" position="float">
          <label>Figure 1</label>
          <caption>
            <p>PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flow diagram.</p>
          </caption>
          <graphic xlink:href="mhealth_v11i1e46558_fig1.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
        <table-wrap position="float" id="table1">
          <label>Table 1</label>
          <caption>
            <p>Study and participant characteristics.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="90"/>
            <col width="90"/>
            <col width="130"/>
            <col width="200"/>
            <col width="70"/>
            <col width="120"/>
            <col width="110"/>
            <col width="110"/>
            <col width="80"/>
            <thead>
              <tr valign="top">
                <td>Study</td>
                <td>Country</td>
                <td>Study aims</td>
                <td>Outcome measures</td>
                <td>Sample size</td>
                <td>Stroke type</td>
                <td>Time since stroke or stroke stage</td>
                <td>Age (y)</td>
                <td>Sex or gender (male or men; %)</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Asano et al [<xref ref-type="bibr" rid="ref41">41</xref>]</td>
                <td>Singapore</td>
                <td>Effectiveness</td>
                <td>Late-Life Function and Disability Instrument; timed 5-Meter Walk Test; 2-minute walk test; Modified Barthel Index; Activities-Specific Balance Confidence Scale; EQ-5D</td>
                <td>98 (IG<sup>a</sup>: 50; CG<sup>b</sup>: 48)</td>
                <td>78% ischemic; 22% hemorrhagic</td>
                <td>Within 4 wk</td>
                <td>Mean 64.1 (range 40.5-89.6)</td>
                <td>52</td>
              </tr>
              <tr valign="top">
                <td>Emmerson et al [<xref ref-type="bibr" rid="ref42">42</xref>]</td>
                <td>Australia</td>
                <td>Effectiveness</td>
                <td>Self-report logbook; Wolf Motor Function Test; customized questionnaire</td>
                <td>58 (IG: 28; CG: 30)</td>
                <td>86% ischemic; 15% hemorrhagic</td>
                <td>Median 120 (range 58-226) d</td>
                <td>Mean 66 (SD 16)</td>
                <td>63</td>
              </tr>
              <tr valign="top">
                <td>Ferrete Ruíz et al [<xref ref-type="bibr" rid="ref43">43</xref>]</td>
                <td>Spain</td>
                <td>Effectiveness</td>
                <td>Mississippi Aphasia Screening Test; minutes of device use</td>
                <td>30 (IG: 23; CG: 7)</td>
                <td>100% ischemic</td>
                <td>Within 7 d</td>
                <td>IG: mean 73.20 (SD 9.53); CG: mean 72.40 (SD 2.79)</td>
                <td>50</td>
              </tr>
              <tr valign="top">
                <td>Grau-Pellicer et al [<xref ref-type="bibr" rid="ref44">44</xref>]</td>
                <td>Spain</td>
                <td>Effectiveness</td>
                <td>Participant reports of community ambulation and sedentary behavior; 10-Meter Walk Test; 6-Minute Walk Test; Timed Up and Go test; Barthel Index; EQ-5D; satisfaction questionnaire</td>
                <td>34 (IG: 21; CG: 13)</td>
                <td>Not reported</td>
                <td>IG: mean 18.92 (SD 27.6; range 1-96) mo; CG: mean 20.85 (SD 59.74; range 1-252) mo</td>
                <td>IG: mean 62.96 (SD 11.87; range 33-89); CG: mean 68.53 (SD 11.53; range 41-83)</td>
                <td>51</td>
              </tr>
              <tr valign="top">
                <td>Hankinson et al [<xref ref-type="bibr" rid="ref45">45</xref>]</td>
                <td>Australia</td>
                <td>Pilot study; feasibility; effectiveness</td>
                <td>Adherence to intervention; Fugl-Meyer Assessment</td>
                <td>15 (IG: 6; CG: 9)</td>
                <td>Not reported</td>
                <td>0-180 d</td>
                <td>Not reported</td>
                <td>59</td>
              </tr>
              <tr valign="top">
                <td>Ifejika et al [<xref ref-type="bibr" rid="ref46">46</xref>]</td>
                <td>United States</td>
                <td>Pilot; feasibility; preliminary effectiveness</td>
                <td>Reduction in total body weight; compliance with the weight loss intervention; Patient Health Questionnaire–9; systolic blood pressure; serum low-density lipoprotein value; proportion of total hemoglobin; proportion of serum coagulation factor VIII</td>
                <td>25 (IG: 13; CG: 12)</td>
                <td>Not reported</td>
                <td>Acutely hospitalized</td>
                <td>Mean 54.1 (SD 9.4)</td>
                <td>56</td>
              </tr>
              <tr valign="top">
                <td>Jang and Jang [<xref ref-type="bibr" rid="ref47">47</xref>]</td>
                <td>South Korea</td>
                <td>Effectiveness</td>
                <td>Manual Muscle Test; Manual Function Test; Purdue Pegboard Test</td>
                <td>21 (IG: 10; CG: 11)</td>
                <td>19% ischemic; 81% hemorrhagic</td>
                <td>Mean 963 (SD 799) d</td>
                <td>Mean 44.5 (SD 16.5)</td>
                <td>71</td>
              </tr>
              <tr valign="top">
                <td>Kamal et al [<xref ref-type="bibr" rid="ref48">48</xref>]</td>
                <td>Pakistan</td>
                <td>Effectiveness</td>
                <td>Morisky Medication Adherence Scale; systolic and diastolic blood pressure; satisfaction questionnaires</td>
                <td>162 (IG: 83; CG: 79)</td>
                <td>84% ischemic; 17% hemorrhagic</td>
                <td>IG: median 2 (range 1-5) mo; CG: median 2 (range 1-4) mo</td>
                <td>IG: mean 56.07 (SD 1.5); CG: mean 57.62 (SD 1.3)</td>
                <td>68</td>
              </tr>
              <tr valign="top">
                <td>Kamal et al [<xref ref-type="bibr" rid="ref49">49</xref>]</td>
                <td>Pakistan</td>
                <td>Effectiveness; safety</td>
                <td>Systolic and diastolic blood pressure; blood sugar (HbA<sub>1c</sub><sup>c</sup>); blood cholesterol (low-density lipoprotein level); mortality; modified Rankin Scale; National Institutes of Health Stroke Scale; Barthel Index</td>
                <td>277 (IG: 141; CG: 136)</td>
                <td>Not reported</td>
                <td>Not reported</td>
                <td>IG: mean 60.6 (SD 12); CG: mean 59.7 (SD 14.3)</td>
                <td>67</td>
              </tr>
              <tr valign="top">
                <td>Kamwesiga et al [<xref ref-type="bibr" rid="ref50">50</xref>]</td>
                <td>Sweden</td>
                <td>Feasibility study; preliminary effectiveness</td>
                <td>Logbook to record adherence; Canadian Occupational Performance Measure; self-efficacy scale; Stroke Impact Scale 3.0 Uganda version; Barthel Index; Occupational Gaps Questionnaire, Ugandan version</td>
                <td>28 (IG: 13; CG: 15)</td>
                <td>75% ischemic; 21% hemorrhagic; 4% unspecified</td>
                <td>3-6 mo—IG: 10 (76.9%) and CG: 10 (66.7%); 7-11 mo—IG: 3 (23.1%) and CG: 3 (20%); 1-2 y—IG: 0 and CG: 2 (13.3%)</td>
                <td>IG: mean 61.2 (SD 15); CG: mean 58.5 (SD 14)</td>
                <td>25</td>
              </tr>
              <tr valign="top">
                <td>Kang et al [<xref ref-type="bibr" rid="ref51">51</xref>]</td>
                <td>South Korea</td>
                <td>Effectiveness</td>
                <td>Regional House-Brackmann Facial Nerve Grading System; length between the corner of the mouth and the earlobe</td>
                <td>21 (IG: 10; CG: 11)</td>
                <td>95% ischemic; 5% hemorrhagic</td>
                <td>Within 12 wk</td>
                <td>IG: mean 63.1 (SD 10.3); CG: mean 55.6 (SD 16)</td>
                <td>62</td>
              </tr>
              <tr valign="top">
                <td>Kang et al [<xref ref-type="bibr" rid="ref52">52</xref>]</td>
                <td>Taiwan</td>
                <td>Effectiveness</td>
                <td>Stroke knowledge questionnaire; EQ-5D</td>
                <td>63 (IG: 30; CG: 33)</td>
                <td>43% ischemic; 57% hemorrhagic</td>
                <td>Not reported</td>
                <td>IG: mean 50.47 (SD 10.82); CG: mean 52.33 (SD 11.03)</td>
                <td>68</td>
              </tr>
              <tr valign="top">
                <td>Kenny et al [<xref ref-type="bibr" rid="ref53">53</xref>]</td>
                <td>United Kingdom</td>
                <td>Feasibility; acceptability; preliminary effectiveness</td>
                <td>Motor Status Scale; Leeds Movement Performance Index; General Self-Efficacy Scale; diary to record time spent exercising</td>
                <td>11 (IG: 5; CG: 6)</td>
                <td>77% ischemic; 8% hemorrhagic; 15% unspecified</td>
                <td>Not reported</td>
                <td>Mean 73.46 (range 41-88)</td>
                <td>46</td>
              </tr>
              <tr valign="top">
                <td>Kim et al [<xref ref-type="bibr" rid="ref54">54</xref>]</td>
                <td>South Korea</td>
                <td>Effectiveness</td>
                <td>Activities-Specific Balance Confidence Scale; Dynamic Gait Index; Four Square Step Test; Functional Ambulation Categories; Timed Up and Go test; up-stair and down-stair times; spatiotemporal parameters of gait (velocity and cadence)</td>
                <td>18 (IG: 9; CG: 9)</td>
                <td>40% ischemic; 60% hemorrhagic</td>
                <td>IG: mean 5.68 (SD 1.04) mo; CG: mean 4.76 (SD 2.65) mo</td>
                <td>IG: mean 58.3 (SD 11.8); CG: mean 51.8 (SD 13.7)</td>
                <td>65</td>
              </tr>
              <tr valign="top">
                <td>Labovitz et al [<xref ref-type="bibr" rid="ref55">55</xref>]</td>
                <td>United States</td>
                <td>Effectiveness</td>
                <td>Pill count; plasma sampling; data from artificial intelligence platform</td>
                <td>27 (IG: 15; CG: 12)</td>
                <td>100% ischemic</td>
                <td>Not reported</td>
                <td>Mean 57 (SD 13.17); median 59 (range 30-79)</td>
                <td>46</td>
              </tr>
              <tr valign="top">
                <td>Lakshminarayan et al [<xref ref-type="bibr" rid="ref56">56</xref>]</td>
                <td>United States</td>
                <td>Pilot, proof-of-concept study; feasibility; usability; acceptability; preliminary effectiveness</td>
                <td>Number of days blood pressure data were transmitted; systolic blood pressure; Morisky Medication Adherence Scale</td>
                <td>50 (IG: 28; CG: 22)</td>
                <td>Not reported</td>
                <td>Acute</td>
                <td>IG: mean 63.1 (SD 9.7; range 42-81); CG: mean 68.3 (SD 10.0; range 46-85); withdrawn: mean 60.33 (SD 13.7; range 47-84)</td>
                <td>68</td>
              </tr>
              <tr valign="top">
                <td>Maresca et al [<xref ref-type="bibr" rid="ref57">57</xref>]</td>
                <td>Italy</td>
                <td>Pilot study; effectiveness</td>
                <td>Token Test; Esame Neuropsicologico Per l’Afasia; Aphasic Depression Rating Scale; EQ-5D; Psychosocial Impact of Assistive Devices Scale</td>
                <td>30 (IG: 15; CG: 15)</td>
                <td>63% ischemic; 37% hemorrhagic</td>
                <td>Not reported</td>
                <td>Mean 51.2 (SD 11.3)</td>
                <td>47</td>
              </tr>
              <tr valign="top">
                <td>Moon et al [<xref ref-type="bibr" rid="ref58">58</xref>]</td>
                <td>South Korea</td>
                <td>Effectiveness</td>
                <td>Functional Dysphagia Scale; penetration-aspiration scale; visual analog satisfaction scale</td>
                <td>16 (IG: 8; CG: 8)</td>
                <td>88% ischemic; 13% hemorrhagic</td>
                <td>IG: mean 22.75 (SD 9.21) d; CG: mean 21 (SD 9.02) d</td>
                <td>IG: mean 54.13 (SD 5.41); CG: mean 55.38 (SD 14.88)</td>
                <td>56</td>
              </tr>
              <tr valign="top">
                <td>Øra et al [<xref ref-type="bibr" rid="ref59">59</xref>]</td>
                <td>Norway</td>
                <td>Pilot study; preliminary effectiveness</td>
                <td>Norwegian Basic Aphasia Assessment; Verb and Sentence Test; Communicative Effectiveness Index</td>
                <td>62 (IG: 32; CG: 30)</td>
                <td>69% ischemic; 18% hemorrhagic; 13% both</td>
                <td>≤3 mo—IG: 16 (50%) and CG: 12 (40%); 3-12 mo—IG: 5 (15.6%) and CG: 4 (13.3%); &#62;12 mo—IG: 11 (34.4%) and CG: 14 (46.7%)</td>
                <td>IG: mean 64.7 (SD 11.7); CG: mean 65 (SD 12.2)</td>
                <td>66</td>
              </tr>
              <tr valign="top">
                <td>Pandian et al [<xref ref-type="bibr" rid="ref60">60</xref>]</td>
                <td>India</td>
                <td>Effectiveness</td>
                <td>Composite end point of recurrent stroke, high-risk transient ischemic attack, acute coronary syndrome, and all-cause mortality; change in BMI; physical activity total metabolic equivalent (min/wk); current smoking; current alcohol intake; modified Rankin Scale; medication noncompliance; systolic and diastolic blood pressure (mm Hg); fasting blood sugar (mg/dL); low-density lipoprotein cholesterol (mg/dL); triglycerides (mg/dL)</td>
                <td>4298 (IG: 2148; CG: 2150)</td>
                <td>83% ischemic; 17% hemorrhagic</td>
                <td>2 d to 3 mo</td>
                <td>IG: median 56 (range 18-88); CG: median 56 (range 18-89)</td>
                <td>73</td>
              </tr>
              <tr valign="top">
                <td>Radomski [<xref ref-type="bibr" rid="ref40">40</xref>]</td>
                <td>United States</td>
                <td>Effectiveness</td>
                <td>Everyday habit questionnaire; self-reported adherence to self-care checklist; Functional Independence Measure; Frenchay Activities Index; Caregiver’s Burden Scale; performance time for self-care task (seconds)</td>
                <td>15 (IG: 5; CG 1: 5; CG 2: 5)</td>
                <td>Not reported</td>
                <td>Not reported</td>
                <td>Mean 59 (SD 14)</td>
                <td>80</td>
              </tr>
              <tr valign="top">
                <td>Sarfo et al [<xref ref-type="bibr" rid="ref61">61</xref>]</td>
                <td>Ghana</td>
                <td>Pilot; feasibility; preliminary effectiveness</td>
                <td>Systolic and diastolic blood pressure; medication possession ratio; perceived confidence scale; Treatment Self-Regulation Questionnaire</td>
                <td>56 (IG: 29; CG: 27)</td>
                <td>77% ischemic; 23% hemorrhagic</td>
                <td>&#60;1 mo</td>
                <td>IG: mean 54.3 (SD 11.9); CG: mean 55.9 (SD 13.7)</td>
                <td>65</td>
              </tr>
              <tr valign="top">
                <td>Sarfo et al [<xref ref-type="bibr" rid="ref62">62</xref>]</td>
                <td>Ghana</td>
                <td>Pilot study; preliminary effectiveness</td>
                <td>Systolic and diastolic blood pressure; medication possession ratio score; Morisky Medication Adherence Scale; perceived confidence scale; Treatment Self-Regulation Questionnaire; Telemedicine Satisfaction and Usefulness Questionnaire; hypertension and stroke knowledge 14-item questionnaire</td>
                <td>55 (IG: 28; CG: 27)</td>
                <td>77% ischemic; 23% hemorrhagic</td>
                <td>&#60;1 mo</td>
                <td>IG: mean 54.3 (SD 11.9); CG: mean 55.9 (SD 13.7)</td>
                <td>65</td>
              </tr>
              <tr valign="top">
                <td>Tomori et al [<xref ref-type="bibr" rid="ref63">63</xref>]</td>
                <td>Japan</td>
                <td>Pilot study; feasibility; preliminary effectiveness</td>
                <td>36-Item Short Form Health Survey; Brunnstrom recovery stages; Functional Independence Measure; Client Satisfaction Questionnaire; duration of stay</td>
                <td>37 (IG: 16; CG: 21)</td>
                <td>Not reported</td>
                <td>≥30 d; subacute</td>
                <td>Mean 66.22 (SD 10.64)</td>
                <td>67</td>
              </tr>
              <tr valign="top">
                <td>Vahlberg et al [<xref ref-type="bibr" rid="ref64">64</xref>]</td>
                <td>Sweden</td>
                <td>Effectiveness</td>
                <td>6-Minute Walk Test (m); chair stand test (s); 10-Meter Walk Test (m/s); Short Physical Performance Battery</td>
                <td>79 (IG: 40; CG: 39)</td>
                <td>72% ischemic; 11% hemorrhagic; 17% transient ischemic attack</td>
                <td>Mean 6 (SD 4.4) d</td>
                <td>IG: mean 63.9 (SD 10.1); CG: mean 63.9 (SD 10.8)</td>
                <td>63</td>
              </tr>
              <tr valign="top">
                <td>Vahlberg et al [<xref ref-type="bibr" rid="ref65">65</xref>]</td>
                <td>Sweden</td>
                <td>Effectiveness</td>
                <td>Fat-free mass (kg); fat mass (kg); BMI; body weight (kg); HbA<sub>1c</sub>; serum insulin-like growth factor; low- and high-density lipoprotein cholesterol; self-reported health; mortality</td>
                <td>71 (IG: 36; CG: 35)</td>
                <td>72% ischemic; 11% hemorrhagic; 17% transient ischemic attack</td>
                <td>Median 5 d</td>
                <td>IG: mean 63.9 (SD 10); CG: mean 63.9 (SD 10)</td>
                <td>63</td>
              </tr>
              <tr valign="top">
                <td>Wan et al [<xref ref-type="bibr" rid="ref66">66</xref>]</td>
                <td>China</td>
                <td>Effectiveness</td>
                <td>Systolic and diastolic blood pressure; Health-Promoting Lifestyle Profile II</td>
                <td>158 (IG: 80; CG: 78)</td>
                <td>100% ischemic</td>
                <td>Within 1 mo</td>
                <td>Median 63.81</td>
                <td>65</td>
              </tr>
              <tr valign="top">
                <td>Wang et al [<xref ref-type="bibr" rid="ref67">67</xref>]</td>
                <td>China</td>
                <td>Effectiveness</td>
                <td>Health-Promoting Lifestyle Profile II; systolic and diastolic blood pressure; modified Rankin Scale; stroke recurrence</td>
                <td>151 (IG: 76; CG: 75)</td>
                <td>100% ischemic</td>
                <td>Within 1 mo</td>
                <td>Median 63.80</td>
                <td>66</td>
              </tr>
              <tr valign="top">
                <td>Wang et al [<xref ref-type="bibr" rid="ref68">68</xref>]</td>
                <td>China</td>
                <td>Effectiveness</td>
                <td>Systolic blood pressure; Self-Management Ability Scale; Morisky Medication Adherence Scale; BMI; blood low-density lipoprotein</td>
                <td>193 (IG: 98; CG: 95)</td>
                <td>67% ischemic; 33% hemorrhagic</td>
                <td>Not reported</td>
                <td>IG: mean 42.75 (SD 0.16); CG: mean 41.32 (SD 2.16)</td>
                <td>61</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table1fn1">
              <p><sup>a</sup>IG: intervention group.</p>
            </fn>
            <fn id="table1fn2">
              <p><sup>b</sup>CG: control group.</p>
            </fn>
            <fn id="table1fn3">
              <p><sup>c</sup>HbA<sub>1c</sub>: glycated hemoglobin.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
      </sec>
      <sec>
        <title>Participant Characteristics</title>
        <p>In total, 62% (18/29) of the studies included participants with both ischemic and hemorrhagic stroke, and 7% (2/29) also included transient ischemic attack. Of the 23 studies that reported participants’ stroke stage or time since stroke, 16 (70%) focused on the subacute stage (7 d to 6 mo after stroke). The average age of the participants ranged from 42 to 74 years (weighted average 57, weighted SD 4.46). No studies differentiated between sex and gender. A total of 83% (24/29) of the studies included more male participants or men than female participants or women, ranging from 25% to 80% of male participants or men. Some studies reported on participants’ education (15/29, 52%), marital status (8/29, 28%), employment status (6/29, 21%), and geographic location (5/29, 17%), and fewer studies reported on race (3/29, 10%), ethnicity (1/29, 3%), and income (2/29, 7%).</p>
      </sec>
      <sec>
        <title>Objective 1: Types of Poststroke mHealth Interventions</title>
        <p><xref ref-type="supplementary-material" rid="app5">Multimedia Appendix 5</xref> [<xref ref-type="bibr" rid="ref40">40</xref>-<xref ref-type="bibr" rid="ref68">68</xref>] summarizes the interventions individually and the following sections summarize the interventions collectively, according to selected items from the Template for Intervention Description and Replication checklist [<xref ref-type="bibr" rid="ref24">24</xref>].</p>
        <sec>
          <title>Why: Describe Any Rationale, Theory, or Goal of the Elements Essential to the Intervention</title>
          <p>mHealth technology was rationalized as a strategy to improve intervention effectiveness (18/26, 69%), access (13/26, 50%), convenience (6/26, 23%), and cost-effectiveness (5/26, 19%). A total of 5 interventions were explicitly based on a theory, model, framework, or taxonomy: self-determination theory (n=2, 40%); Health Belief Model (n=2, 40%); social cognitive theory (n=1, 20%); the International Classification of Functioning, Disability, and Health framework (n=1, 20%); the Coventry, Aberdeen, and London–Refined taxonomy of behavior change techniques (n=1, 20%); and a proposed ecological model of adherence to rehabilitation treatment recommendations (n=1, 20%). Common goals of the interventions were to improve outcomes related to treatment or medication adherence (10/26, 38%), motor or physical activity (8/26, 31%), functional ability or independence (5/26, 19%), speech, language, or swallowing (5/26, 19%), hypertension or blood pressure control (5/26, 19%), risk factor control (5/26, 19%), and quality of life (3/26, 12%).</p>
        </sec>
        <sec>
          <title>What: Describe Any Physical or Informational Materials Used and Each of the Procedures, Activities, or Processes Used in the Intervention</title>
          <p>A total of 7 focal areas were identified: physical exercise (10/26, 38%), risk factor management (5/26, 19%), linguistic exercise (3/26, 12%), activities of daily living (ADLs) training (3/26, 12%), medication adherence (2/26, 8%), stroke education (2/26, 8%), and weight management (1/26, 4%). In total, 5 types of mobile devices were used: mobile phones or smartphones (17/26, 65%), tablets (9/26, 35%), wearable sensors (5/26, 19%; eg, pedometers or wearable bracelets), wireless monitoring devices (4/26, 15%; eg, Bluetooth sphygmomanometers or Bluetooth blood glucose meters), and laptops (1/26, 4%). Within devices, the features used included: apps (15/26, 58%), messaging (12/26, 46%; eg, via an app or SMS text messaging), phone calling (7/26, 27%), videos (6/26, 23%), videoconferencing (3/26, 12%), and email (2/26, 8%). All but 4 interventions (22/26, 85%) were self-directed, and 8% (2/26) were gamified.</p>
        </sec>
        <sec>
          <title>Who Provided: For Each Category of Intervention Provider, Describe Their Background</title>
          <p>The interventions were provided by researchers (9/26, 35%), occupational therapists (7/26, 27%), physical therapists (4/26, 15%), nurses (4/26, 15%), speech-language pathologists (2/26, 8%), physicians (2/26, 8%), pharmacists (1/26, 4%), neuropsychologists (1/26, 4%), brain and heart health managers (1/26, 4%), allied health professionals (1/26, 4%), clinicians (1/26, 4%), and clinic staff (1/26, 4%). In total, 12% (3/26) were provided by a multidisciplinary team of health care professionals.</p>
        </sec>
        <sec>
          <title>How: Describe the Modes of Delivery of the Intervention and Whether It Was Provided Individually or in a Group</title>
          <p>A total of 85% (22/26) of the interventions were delivered both virtually (eg, via videoconferencing or SMS text messaging) and in-person (eg, in-person orientation or clinic visits). In total, 77% (20/26) were individual based (delivered to the individual with stroke), 38% (10/26) were dyad based (delivered to the individual with stroke and their caregiver or family member), and 8% (2/26) were group based (delivered to groups of people with stroke).</p>
        </sec>
        <sec>
          <title>Where: Describe the Types of Locations Where the Intervention Occurred</title>
          <p>In total, 58% (15/26) of the interventions occurred both at the hospital or clinic (in-person component) and the participants’ home (virtual component).</p>
        </sec>
        <sec>
          <title>When and How Much: Describe the Number of Times the Intervention Was Delivered and Over What Period</title>
          <p>Intervention delivery time ranged from 14 days to 1 year, with the most common being 4 weeks (5/26, 19%) and 6 months (5/26, 19%). Session frequency varied (twice/d to once every 2-3 mo), as did session length (5 min to 1 h). This variability reflects a wide range of session types (eg, exercise sessions, education sessions, blood pressure self-monitoring, and clinic visits). There was also variability in the dosage of technology used, such as the schedule for sending and receiving messages (twice/d to once/wk) and the amount of time connected to the devices (eg, 1 intervention required participants to wear a pedometer at all times except when sleeping, bathing, or swimming).</p>
        </sec>
        <sec>
          <title>Tailoring: If the Intervention Was Planned to be Personalized, Titrated, or Adapted, Describe What, Why, When, and How</title>
          <p>A total of 69% (18/26) of the interventions involved tailoring to the person with stroke (eg, abilities, goals, or preferred music). In total, 8% (2/26) of the interventions involved tailoring to the caregiver or family member (eg, preferred ADLs) [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref50">50</xref>]. A total of 12% (3/26) of the interventions involved self-tailoring by the person with stroke (eg, education topics [<xref ref-type="bibr" rid="ref52">52</xref>] or exercises [<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref65">65</xref>]).</p>
        </sec>
      </sec>
      <sec>
        <title>Objective 2: Alignment With Self-Management Support Theory and Taxonomy</title>
        <p>Of the 29 conceptual variables, 26 (90%) were coded at least once. The number of interventions coded per variable ranged from 0 to 25 (mean 8.55). The number of variables coded per intervention ranged from 2 to 15 (mean 9.54). <xref rid="figure2" ref-type="fig">Figure 2</xref> [<xref ref-type="bibr" rid="ref17">17</xref>,<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref40">40</xref>-<xref ref-type="bibr" rid="ref68">68</xref>] presents the extent and range of alignment, and <xref ref-type="table" rid="table2">Table 2</xref> presents the nature of alignment.</p>
        <fig id="figure2" position="float">
          <label>Figure 2</label>
          <caption>
            <p>Extent and range of alignment between poststroke mobile technology–based interventions and self-management support theory and taxonomy. Please see <xref ref-type="supplementary-material" rid="app6">Multimedia Appendix 6</xref> for a larger version.</p>
          </caption>
          <graphic xlink:href="mhealth_v11i1e46558_fig2.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
        <table-wrap position="float" id="table2">
          <label>Table 2</label>
          <caption>
            <p>Nature of alignment between poststroke mobile technology–based interventions and self-management support theory and taxonomy.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="30"/>
            <col width="30"/>
            <col width="30"/>
            <col width="130"/>
            <col width="0"/>
            <col width="0"/>
            <col width="780"/>
            <thead>
              <tr valign="top">
                <td colspan="6">Conceptual variable</td>
                <td>Intervention examples</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td colspan="7">
                  <bold>Self-management support theory [<xref ref-type="bibr" rid="ref17">17</xref>]</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="6">
                  <bold>Core self-management skills</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td colspan="3">Problem-solving</td>
                <td colspan="2">Clients developed skills in problem-solving through training focused on the Target-Plan-Perform-Prove strategy [<xref ref-type="bibr" rid="ref50">50</xref>].</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td colspan="3">Decision-making</td>
                <td colspan="2">Clients developed skills in decision-making through learning information about stroke, rehabilitation, medications, lifestyle, and risk factors (eg, stroke history, heart disease, atrial fibrillation, obesity, age, sleep patterns, diet, exercise, and blood pressure [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref48">48</xref>-<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref60">60</xref>-<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref66">66</xref>-<xref ref-type="bibr" rid="ref68">68</xref>]), as well as by learning how to perform exercises [<xref ref-type="bibr" rid="ref41">41</xref>-<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref65">65</xref>], take medications [<xref ref-type="bibr" rid="ref55">55</xref>], measure blood pressure [<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref66">66</xref>-<xref ref-type="bibr" rid="ref68">68</xref>], and measure blood glucose [<xref ref-type="bibr" rid="ref68">68</xref>].</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td colspan="3">Resource utilization</td>
                <td colspan="2">Not reported</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td colspan="3">Forming a patient-professional relationship</td>
                <td colspan="2">Clients developed skills in forming a relationship with a professional through participating in virtual (eg, videoconference or phone call) and in-person sessions [<xref ref-type="bibr" rid="ref40">40</xref>-<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref48">48</xref>-<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref66">66</xref>-<xref ref-type="bibr" rid="ref68">68</xref>], as well as by sending and receiving messages (eg, via an app or SMS text messaging [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref60">60</xref>-<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref64">64</xref>-<xref ref-type="bibr" rid="ref68">68</xref>]).</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td colspan="3">Taking action</td>
                <td colspan="2">Clients developed skills in taking action through goal-setting training focused on weight loss [<xref ref-type="bibr" rid="ref46">46</xref>], ADLs<sup>a</sup> [<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref63">63</xref>], and self-management (eg, medication adherence [<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref67">67</xref>]).</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="6">
                  <bold>Self-management tasks or behaviors</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td colspan="3">Medical self-management</td>
                <td colspan="2">Clients practiced the medical tasks of performing self-directed physical or linguistic exercises [<xref ref-type="bibr" rid="ref41">41</xref>-<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref65">65</xref>], taking medications [<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref55">55</xref>], and self-monitoring physical health data (weight, diet, and exercise [<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref68">68</xref>]; sleep [<xref ref-type="bibr" rid="ref68">68</xref>]; fatigue [<xref ref-type="bibr" rid="ref44">44</xref>]; blood pressure [<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref66">66</xref>-<xref ref-type="bibr" rid="ref68">68</xref>]; and blood glucose [<xref ref-type="bibr" rid="ref68">68</xref>]).</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td colspan="3">Emotional self-management</td>
                <td colspan="2">Clients practiced the emotional task of self-monitoring mood through app-based questionnaires [<xref ref-type="bibr" rid="ref44">44</xref>].</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td colspan="3">Role self-management</td>
                <td colspan="2">Clients practiced maintaining or changing behaviors related to ADLs or life roles (eg, dressing or cooking) in the context of their home environment [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref50">50</xref>].</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="6">
                  <bold>Mechanism of change</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td colspan="3">Enhanced self-efficacy</td>
                <td colspan="2">Self-efficacy was used as an outcome measure [<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref53">53</xref>].</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="6">
                  <bold>Characteristics of self-management support</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td colspan="3">Patient-perceived problems</td>
                <td colspan="2">Interventions were based on client-identified problems, concerns, or goals [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref59">59</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref67">67</xref>].</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td colspan="3">Self-tailoring</td>
                <td colspan="2">Self-tailoring was encouraged by instructing clients to select their own educational content based on their time and needs [<xref ref-type="bibr" rid="ref52">52</xref>], practice the exercises as often as they wished [<xref ref-type="bibr" rid="ref53">53</xref>], and gradually modify the exercises based on preference and perceived strenuous intensity [<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref65">65</xref>].</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td colspan="5">
                  <bold>Efficacy enhancement</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Performance mastery</td>
                <td colspan="3">Performance mastery was promoted through feedback (eg, via an app or wearable sensor, through SMS text messaging, or from a therapist [<xref ref-type="bibr" rid="ref40">40</xref>-<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref54">54</xref>-<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref68">68</xref>]) and self-reflection (eg, through checklists or diaries or from reminder messages prompting a response [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref47">47</xref>-<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref64">64</xref>-<xref ref-type="bibr" rid="ref67">67</xref>]).</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Modeling</td>
                <td colspan="3">Modeling was offered through group-based formats [<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref59">59</xref>]; demonstration videos (eg, of the therapist or client performing the exercises or of animated characters taking medications [<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref58">58</xref>]); fictional and nonfictional stories about people with stroke that are age appropriate, country specific, and culturally relevant (eg, Mahatma Gandhi was a character in a story created for an Indian audience [<xref ref-type="bibr" rid="ref60">60</xref>]); distorted mirror reflections via an app that allowed clients to watch the reflection of the unaffected half of their face as if it were the affected half [<xref ref-type="bibr" rid="ref51">51</xref>]; and culturally competent counseling by clinicians of clients’ ethnic groups [<xref ref-type="bibr" rid="ref46">46</xref>].</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Interpretation of symptoms</td>
                <td colspan="3">Not reported</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>
                  <break/>
                </td>
                <td>Social persuasion</td>
                <td colspan="3">Social persuasion was promoted through group-based (eg, a WhatsApp group was created for clients to motivate each other to maintain an active lifestyle [<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref59">59</xref>]) and dyad (client-caregiver or family member)-based (eg, caregivers were instructed to support the client at home in using the technology and adhering to the program [<xref ref-type="bibr" rid="ref40">40</xref>-<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref48">48</xref>-<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref60">60</xref>]) formats.</td>
              </tr>
              <tr valign="top">
                <td colspan="7">
                  <bold>Self-management support taxonomy [<xref ref-type="bibr" rid="ref18">18</xref>]</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">Information about condition and/or its management</td>
                <td colspan="2">Clients were provided with general information about stroke, rehabilitation, medications, lifestyle, and risk factors (eg, stroke history, heart disease, atrial fibrillation, obesity, age, sleep patterns, diet, exercise, and blood pressure [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref48">48</xref>-<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref60">60</xref>-<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref66">66</xref>-<xref ref-type="bibr" rid="ref68">68</xref>]) as well as general instruction on how to perform exercises [<xref ref-type="bibr" rid="ref41">41</xref>-<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref65">65</xref>], take medications [<xref ref-type="bibr" rid="ref55">55</xref>], measure blood pressure [<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref66">66</xref>-<xref ref-type="bibr" rid="ref68">68</xref>], and measure blood glucose [<xref ref-type="bibr" rid="ref68">68</xref>].</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">Information about available resources</td>
                <td colspan="2">Not reported</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">Provision of or agreement on specific clinical action plans and/or rescue medication</td>
                <td colspan="2">Clients were provided with specific, tailored instruction on how to perform physical or linguistic exercises [<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref57">57</xref>].</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">Regular clinical review</td>
                <td colspan="2">Clients connected with health care professionals on a regular basis for a scheduled review of their condition and self-management (eg, via videoconference, phone call, messaging, or in-person sessions [<xref ref-type="bibr" rid="ref40">40</xref>-<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref55">55</xref>-<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref66">66</xref>-<xref ref-type="bibr" rid="ref68">68</xref>]).</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">Monitoring of condition with feedback</td>
                <td colspan="2">Clients monitored symptoms, behaviors, or objective measures related to their condition (eg, exercise adherence data from wearable sensors, weight management data through tracking calories consumed, medication adherence data via app-based artificial intelligence, and blood pressure data from wireless monitoring devices [<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref43">43</xref>-<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref55">55</xref>-<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref64">64</xref>-<xref ref-type="bibr" rid="ref68">68</xref>]). Professionals also reviewed the monitored data and provided clients with feedback [<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref55">55</xref>-<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref68">68</xref>].</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">Practical support with adherence (medication or behavioral)</td>
                <td colspan="2">Practical support with adherence was provided to clients in the form of reminder alarms [<xref ref-type="bibr" rid="ref42">42</xref>], reminder messages (eg, via push notifications within an app or through SMS text messaging [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref48">48</xref>-<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref64">64</xref>-<xref ref-type="bibr" rid="ref68">68</xref>]), reminder phone calls [<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref60">60</xref>], and reminder sheets (eg, checklists, diaries, and calendars [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref64">64</xref>-<xref ref-type="bibr" rid="ref67">67</xref>]).</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">Provision of equipment</td>
                <td colspan="2">Self-monitoring or self-management was enabled, assisted, or promoted through the provision of tablets [<xref ref-type="bibr" rid="ref41">41</xref>-<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref57">57</xref>], smartphones [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref62">62</xref>], wearable sensors (eg, pedometers or wearable bracelets [<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref65">65</xref>,<xref ref-type="bibr" rid="ref68">68</xref>]), wireless monitoring devices (eg, Bluetooth sphygmomanometers or Bluetooth blood glucose meters [<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref68">68</xref>]), apps [<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref49">49</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref52">52</xref>,<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref68">68</xref>], and measuring cups [<xref ref-type="bibr" rid="ref46">46</xref>].</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">Provision of easy access to advice or support when needed</td>
                <td colspan="2">Clients were provided with a 24/7 stroke helpline number [<xref ref-type="bibr" rid="ref49">49</xref>].</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">Training or rehearsal to communicate with health care professionals</td>
                <td colspan="2">Clients developed communication skills by using apps to communicate their needs with nursing staff [<xref ref-type="bibr" rid="ref43">43</xref>] and participate in shared decision-making with occupational therapists for goal setting [<xref ref-type="bibr" rid="ref63">63</xref>].</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">Training or rehearsal for everyday activities</td>
                <td colspan="2">Clients developed skills to support ADLs (eg, dressing, cooking, or knitting [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref63">63</xref>]).</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">Training or rehearsal for practical self-management activities</td>
                <td colspan="2">Clients developed specific, practical skills in performing self-directed physical or linguistic exercises [<xref ref-type="bibr" rid="ref41">41</xref>-<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref47">47</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref53">53</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref58">58</xref>,<xref ref-type="bibr" rid="ref60">60</xref>,<xref ref-type="bibr" rid="ref64">64</xref>,<xref ref-type="bibr" rid="ref65">65</xref>], taking medications [<xref ref-type="bibr" rid="ref48">48</xref>,<xref ref-type="bibr" rid="ref55">55</xref>], and self-monitoring health data (weight, diet, and exercise [<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref68">68</xref>]; sleep [<xref ref-type="bibr" rid="ref68">68</xref>]; fatigue [<xref ref-type="bibr" rid="ref44">44</xref>]; blood pressure [<xref ref-type="bibr" rid="ref56">56</xref>,<xref ref-type="bibr" rid="ref61">61</xref>,<xref ref-type="bibr" rid="ref62">62</xref>,<xref ref-type="bibr" rid="ref66">66</xref>-<xref ref-type="bibr" rid="ref68">68</xref>]; blood glucose [<xref ref-type="bibr" rid="ref68">68</xref>]; and mood [<xref ref-type="bibr" rid="ref44">44</xref>]).</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">Training or rehearsal for psychological strategies</td>
                <td colspan="2">Clients developed psychological skills in goal setting [<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref63">63</xref>,<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref67">67</xref>] and problem-solving [<xref ref-type="bibr" rid="ref50">50</xref>].</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">Social support</td>
                <td colspan="2">Social support was facilitated through group-based (eg, a WhatsApp group was created for clients to facilitate peer support [<xref ref-type="bibr" rid="ref44">44</xref>,<xref ref-type="bibr" rid="ref59">59</xref>]) and dyad (client-caregiver or family member)-based (eg, caregivers were encouraged to watch educational videos with the client and engage in a follow-up discussion with a professional afterward or instructed to support the client at home in using the technology and adhering to the program [<xref ref-type="bibr" rid="ref40">40</xref>-<xref ref-type="bibr" rid="ref43">43</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref48">48</xref>-<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref60">60</xref>]) formats.</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td colspan="4">Lifestyle advice and support</td>
                <td colspan="2">Lifestyle advice and support were provided to clients through a peer-based WhatsApp group [<xref ref-type="bibr" rid="ref44">44</xref>] and nurse-led education and goal-setting sessions [<xref ref-type="bibr" rid="ref66">66</xref>,<xref ref-type="bibr" rid="ref67">67</xref>].</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table2fn1">
              <p><sup>a</sup>ADL: activity of daily living.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
      </sec>
      <sec>
        <title>Objective 3: mHealth Functions That Facilitate Self-Management</title>
        <p>Across all conceptual variables and interventions, 7 mHealth functions were identified as facilitating self-management: educating, communicating, goal setting, monitoring, providing feedback, reminding, and motivating.</p>
      </sec>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Principal Findings</title>
        <sec>
          <title>Overview</title>
          <p>To our knowledge, this is the first scoping review to map the literature on poststroke mHealth interventions according to a self-management support theory and taxonomy. A total of 29 studies describing 26 interventions were included. Overall, we found that the interventions addressed 7 focal areas, 5 types of mobile devices, and 7 mHealth functions. Collectively, the interventions aligned well with the concept of self-management support. However, on an individual basis (per intervention), the alignment was less strong. The following sections further explain how this review extends previous reviews on poststroke mHealth [<xref ref-type="bibr" rid="ref10">10</xref>-<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref69">69</xref>-<xref ref-type="bibr" rid="ref72">72</xref>] and telehealth [<xref ref-type="bibr" rid="ref73">73</xref>] interventions in relation to the study objectives and interventions included.</p>
        </sec>
        <sec>
          <title>Objective 1: Types of Poststroke mHealth Interventions</title>
          <sec>
            <title>Focal Areas: Current Trends and Gaps</title>
            <p>Our first objective was to identify and describe the types of poststroke mHealth interventions evaluated using an RCT design. Speaking to such types, 7 focal areas were identified: physical exercise, risk factor management, linguistic exercise, ADLs training, medication adherence, stroke education, and weight management. These 7 focal areas have been identified in previous reviews on poststroke mHealth interventions [<xref ref-type="bibr" rid="ref10">10</xref>-<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref69">69</xref>-<xref ref-type="bibr" rid="ref72">72</xref>]; however, the included interventions varied. Compared with previous reviews, 45% (13/29) of the studies included in our review (12 interventions) had not been previously identified. Similar to previous reviews, this review found the most common focal area to be physical exercise, likely reflecting the rising trend within the general population of using mobile technology to promote physical fitness in everyday life [<xref ref-type="bibr" rid="ref74">74</xref>,<xref ref-type="bibr" rid="ref75">75</xref>]. Hence, the literature clearly supports continued research on poststroke mHealth interventions for physical exercise. Also consistent with previous reviews, this review did not identify any interventions focused on mood or fatigue. Considering the high prevalence of poststroke depression, anxiety, and fatigue, this is a serious gap that should be addressed in future research [<xref ref-type="bibr" rid="ref76">76</xref>]. Surprisingly, unlike 5 previous reviews [<xref ref-type="bibr" rid="ref10">10</xref>,<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref71">71</xref>], this review did not identify any interventions focused on cognition. This difference was due to the varying eligibility criteria (eg, study design). Given this difference across reviews as well as the high prevalence of poststroke cognitive impairment [<xref ref-type="bibr" rid="ref76">76</xref>], future research on poststroke mHealth interventions for cognition is encouraged to progress toward the level of RCTs.</p>
          </sec>
          <sec>
            <title>mHealth Technology: Positioning on the Spectrum of Definitions</title>
            <p>Regarding the types of technology used in the interventions, our review identified 5 types of mobile devices (mobile phones or smartphones, tablets, wearable sensors, wireless monitoring devices, and laptops) and 6 features within these devices (apps, messaging, phone calling, videos, videoconferencing, and email). This wide range of technologies resulted from our novel approach to defining mHealth. Previous reviews on poststroke mHealth interventions have defined mHealth either very narrowly, focusing on a few specific mobile devices or features (eg, mobile phones [<xref ref-type="bibr" rid="ref72">72</xref>], wearable activity monitors [<xref ref-type="bibr" rid="ref69">69</xref>], or mobile apps for phones [<xref ref-type="bibr" rid="ref10">10</xref>,<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref71">71</xref>] and tablets [<xref ref-type="bibr" rid="ref10">10</xref>,<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref70">70</xref>,<xref ref-type="bibr" rid="ref71">71</xref>]), or very broadly, focusing on mHealth in general and including devices and features that may not be entirely mobile and wireless (eg, computer programs [<xref ref-type="bibr" rid="ref10">10</xref>,<xref ref-type="bibr" rid="ref12">12</xref>,<xref ref-type="bibr" rid="ref71">71</xref>], telephone calls [<xref ref-type="bibr" rid="ref12">12</xref>], and web-based applications [<xref ref-type="bibr" rid="ref13">13</xref>]). Our review was interested in the literature between these 2 ends of the narrow-broad spectrum of mHealth definitions. We followed the recommendation of Cameron et al [<xref ref-type="bibr" rid="ref26">26</xref>] to define mHealth in a way that captures the “combinatorial complexity” of the mobile system and used 2 open-ended definitions of mHealth [<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref23">23</xref>]. Thus, we captured additional literature on poststroke mHealth interventions by focusing on entirely mobile <italic>systems</italic> (technology and equipment) of any type (devices and features). As the field of mHealth continues to grow, we suggest that future reviews explicitly position themselves on this narrow-broad spectrum of mHealth definitions so that the literature can be more readily interpreted and applied. In addition, future work should build on that by Cameron et al [<xref ref-type="bibr" rid="ref26">26</xref>] to further deepen our understanding of the mobile system.</p>
          </sec>
        </sec>
        <sec>
          <title>Objective 2: Alignment With Self-Management Support Theory and Taxonomy</title>
          <p>Our second objective was to determine whether (and how) the included interventions aligned with well-accepted conceptualizations (theory [<xref ref-type="bibr" rid="ref17">17</xref>] and taxonomy [<xref ref-type="bibr" rid="ref18">18</xref>]) of self-management support. Collectively, the interventions addressed 90% (26/29) of the conceptual variables, whereas individual interventions only addressed an average of 33% (9.54/29) of the conceptual variables. This discrepancy speaks to the potential for improvements in the alignment between poststroke mHealth interventions and the concept of self-management support. The results also revealed key conceptual variables missing from the literature, such as “emotional self-management” and “information about available resources.” Hence, the results suggest that future research should be more closely aligned with the theory and taxonomy of self-management support. Previous reviews on poststroke mHealth interventions [<xref ref-type="bibr" rid="ref10">10</xref>-<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref69">69</xref>-<xref ref-type="bibr" rid="ref72">72</xref>] have not mapped the literature in this way. However, a review of poststroke telehealth interventions [<xref ref-type="bibr" rid="ref73">73</xref>] used the PRISMS taxonomy [<xref ref-type="bibr" rid="ref18">18</xref>] in a similar way, further validating the relevance of this approach.</p>
        </sec>
        <sec>
          <title>Objective 3: mHealth Functions That Facilitate Self-Management</title>
          <p>Our third objective was to identify the mHealth functions that facilitate self-management. A total of 7 mHealth functions were identified: educating, communicating, goal setting, monitoring, providing feedback, reminding, and motivating. These 7 functions, although together framed as facilitating self-management, are not inherently specific to self-management support interventions as they speak generally to what the intervention <italic>does</italic>, not specifically to what the intervention is <italic>about</italic>. Viewing mHealth functions in this way, as generic “verbs describing the behavior of the system” [<xref ref-type="bibr" rid="ref26">26</xref>] or as action words that link technology capabilities with intervention components, has not been done in past reviews on poststroke mHealth interventions [<xref ref-type="bibr" rid="ref10">10</xref>-<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref69">69</xref>-<xref ref-type="bibr" rid="ref72">72</xref>]. However, this approach to conceptualizing mHealth functions does align with other work in the broader field of mHealth [<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref30">30</xref>]. Future research is encouraged to build on this approach and use the identified functions to describe how specific technology capabilities are linked to specific intervention components. Specifically linking technology capabilities with intervention components is important as it would allow for more systematic examinations as to what it is about delivery through mHealth that may be superior or not to other intervention delivery modalities (eg, is educating on sensitive topics via mHealth better than via in-person groups?).</p>
        </sec>
      </sec>
      <sec>
        <title>Recommendations for Future Research</title>
        <p>The purpose of this study was to identify gaps in the literature and recommendations for future research related to mHealth-enhanced stroke self-management support. In total, 3 overarching recommendations for future research were identified. First, future research should be more explicit about the theories their interventions are based on as well as their conceptualizations of self-management support. Using theory and other conceptualizations in this way would help promote a common language of self-management support and ensure that all conceptual variables are considered, which could ultimately improve intervention adherence, effectiveness, replicability, and uptake in clinical practice. Second, future research should be more multidisciplinary so that a wider range of conceptual variables can be addressed per intervention. This multidisciplinary approach to improving alignment would likely lead to more comprehensive, holistic, and effective interventions. Third, future research should use larger sample sizes and consider using pragmatic trial designs to establish real-world effectiveness.</p>
      </sec>
      <sec>
        <title>Limitations</title>
        <p>The search was limited to the English language, so the findings may be biased toward English-speaking countries, although 15 countries were represented. Directed content analysis, as with any qualitative approach, involves subjectivity; to address this, operational definitions for codes were used and reported. Finally, this review focused on RCTs, so the findings may be biased toward more traditional or RCT-suited interventions. Given the challenges associated with conducting RCTs on technology-based interventions [<xref ref-type="bibr" rid="ref77">77</xref>], future reviews should consider including other study designs.</p>
      </sec>
      <sec>
        <title>Conclusions</title>
        <p>This scoping review clarified the concept of self-management support in the literature on poststroke mHealth interventions by mapping studies according to well-accepted conceptualizations of self-management support. On the basis of the results, it is recommended that future research on poststroke mHealth interventions be more theoretically driven, more multidisciplinary, and larger in scale.</p>
      </sec>
    </sec>
  </body>
  <back>
    <app-group>
      <supplementary-material id="app1">
        <label>Multimedia Appendix 1</label>
        <p>PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) checklist.</p>
        <media xlink:href="mhealth_v11i1e46558_app1.docx" xlink:title="DOCX File , 25 KB"/>
      </supplementary-material>
      <supplementary-material id="app2">
        <label>Multimedia Appendix 2</label>
        <p>Search strategy for the Ovid databases (MEDLINE, Embase, PsycINFO, and AMED).</p>
        <media xlink:href="mhealth_v11i1e46558_app2.docx" xlink:title="DOCX File , 15 KB"/>
      </supplementary-material>
      <supplementary-material id="app3">
        <label>Multimedia Appendix 3</label>
        <p>Operational definitions used in the directed content analysis related to self-management support theory and taxonomy (objective 2).</p>
        <media xlink:href="mhealth_v11i1e46558_app3.docx" xlink:title="DOCX File , 28 KB"/>
      </supplementary-material>
      <supplementary-material id="app4">
        <label>Multimedia Appendix 4</label>
        <p>Operational definitions used in the directed content analysis related to mobile health functions (objective 3).</p>
        <media xlink:href="mhealth_v11i1e46558_app4.docx" xlink:title="DOCX File , 17 KB"/>
      </supplementary-material>
      <supplementary-material id="app5">
        <label>Multimedia Appendix 5</label>
        <p>Intervention characteristics according to selected items from the Template for Intervention Description and Replication checklist.</p>
        <media xlink:href="mhealth_v11i1e46558_app5.docx" xlink:title="DOCX File , 51 KB"/>
      </supplementary-material>
      <supplementary-material id="app6">
        <label>Multimedia Appendix 6</label>
        <p>Extent and range of alignment between poststroke mobile technology–based interventions and self-management support theory and taxonomy.</p>
        <media xlink:href="mhealth_v11i1e46558_app6.png" xlink:title="PNG File , 540 KB"/>
      </supplementary-material>
    </app-group>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">ADL</term>
          <def>
            <p>activity of daily living</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb2">mHealth</term>
          <def>
            <p>mobile health</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb3">PRISMA</term>
          <def>
            <p>Preferred Reporting Items for Systematic Reviews and Meta-Analyses</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb4">PRISMA-ScR</term>
          <def>
            <p>Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb5">PRISMS</term>
          <def>
            <p>Practical Reviews in Self-Management Support</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb6">RCT</term>
          <def>
            <p>randomized controlled trial</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <ack>
      <p>This research is part of the doctoral work of ANT, which was funded by the Queen Elizabeth II Graduate Scholarship in Science and Technology, Ontario Graduate Scholarship, Ydessa Hendeles Graduate Scholarship at Baycrest Award, and Toronto Rehabilitation Institute Student Scholarship. EN is supported by a Canada Research Chair (Tier 2) in Resiliency and Rehabilitation funded by the Canada Research Chairs Program. The authors gratefully acknowledge Erica Nekolaichuk and Jessica Shiers-Hanley, librarians at the University of Toronto, for their assistance in developing the search strategy.</p>
    </ack>
    <fn-group>
      <fn fn-type="con">
        <p>ANT conceptualized and designed the study under the guidance of DRD and EN. ANT searched the databases. ANT, JML-M, NC, CT, VN, JR, and SJ screened the articles. ANT extracted the data. JML-M, NC, CT, VN, JR, and SJ verified the data. ANT analyzed the data and wrote the manuscript in collaboration with DRD, EN, RHW, and JIC. All authors have reviewed the final manuscript.</p>
      </fn>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
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