<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "journalpublishing.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="2.0" xml:lang="en" article-type="research-article"><front><journal-meta><journal-id journal-id-type="nlm-ta">JMIR Mhealth Uhealth</journal-id><journal-id journal-id-type="publisher-id">mhealth</journal-id><journal-id journal-id-type="index">13</journal-id><journal-title>JMIR mHealth and uHealth</journal-title><abbrev-journal-title>JMIR Mhealth Uhealth</abbrev-journal-title><issn pub-type="epub">2291-5222</issn></journal-meta><article-meta><article-id pub-id-type="publisher-id">50663</article-id><article-id pub-id-type="doi">10.2196/50663</article-id><title-group><article-title>Physical Activity Pattern of Adults With Metabolic Syndrome Risk Factors: Time-Series Cluster Analysis</article-title></title-group><contrib-group><contrib contrib-type="author"><name name-style="western"><surname>Kim</surname><given-names>Junhyoung</given-names></name><degrees>MPH</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Choi</surname><given-names>Jin-Young</given-names></name><degrees>MPH</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Kim</surname><given-names>Hana</given-names></name><degrees>MPH</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Lee</surname><given-names>Taeksang</given-names></name><degrees>MPH</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Ha</surname><given-names>Jaeyoung</given-names></name><degrees>MPH</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Lee</surname><given-names>Sangyi</given-names></name><degrees>MPH</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Park</surname><given-names>Jungmi</given-names></name><degrees>MPH</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Jeon</surname><given-names>Gyeong-Suk</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author" corresp="yes"><name name-style="western"><surname>Cho</surname><given-names>Sung-il</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff3">3</xref></contrib></contrib-group><aff id="aff1"><institution>Department of Public Health Science, Graduate School of Public Health, Seoul National University</institution>, <addr-line>Seoul</addr-line>, <country>Republic of Korea</country></aff><aff id="aff2"><institution>Department of Nursing, Mokpo National University</institution>, <addr-line>Muan</addr-line>, <country>Republic of Korea</country></aff><aff id="aff3"><institution>Institute of Health and Environment, Seoul National University</institution>, <addr-line>Seoul</addr-line>, <country>Republic of Korea</country></aff><contrib-group><contrib contrib-type="editor"><name name-style="western"><surname>Buis</surname><given-names>Lorraine</given-names></name></contrib></contrib-group><contrib-group><contrib contrib-type="reviewer"><name name-style="western"><surname>Gartner</surname><given-names>Daniel</given-names></name></contrib><contrib contrib-type="reviewer"><name name-style="western"><surname>Wah</surname><given-names>Tey</given-names></name></contrib></contrib-group><author-notes><corresp>Correspondence to Sung-il Cho, PhD<email>persontime@hotmail.com</email></corresp></author-notes><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>1</day><month>12</month><year>2023</year></pub-date><volume>11</volume><elocation-id>e50663</elocation-id><history><date date-type="received"><day>08</day><month>07</month><year>2023</year></date><date date-type="rev-recd"><day>18</day><month>10</month><year>2023</year></date><date date-type="accepted"><day>19</day><month>10</month><year>2023</year></date></history><copyright-statement>&#x00A9; Junhyoung Kim, Jin-Young Choi, Hana Kim, Taeksang Lee, Jaeyoung Ha, Sangyi Lee, Jungmi Park, Gyeong-Suk Jeon, Sung-il Cho. Originally published in JMIR mHealth and uHealth (<ext-link ext-link-type="uri" xlink:href="https://mhealth.jmir.org">https://mhealth.jmir.org</ext-link>), 1.12.2023. </copyright-statement><copyright-year>2023</copyright-year><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR mHealth and uHealth, is properly cited. The complete bibliographic information, a link to the original publication on <ext-link ext-link-type="uri" xlink:href="https://mhealth.jmir.org/">https://mhealth.jmir.org/</ext-link>, as well as this copyright and license information must be included.</p></license><self-uri xlink:type="simple" xlink:href="https://mhealth.jmir.org/2023/1/e50663"/><abstract><sec><title>Background</title><p>Physical activity plays a crucial role in maintaining a healthy lifestyle, and wrist-worn wearables, such as smartwatches and smart bands, have become popular tools for measuring activity levels in daily life. However, studies on physical activity using wearable devices have limitations; for example, these studies often rely on a single device model or use improper clustering methods to analyze the wearable data that are extracted from wearable devices.</p></sec><sec><title>Objective</title><p>This study aimed to identify methods suitable for analyzing wearable data and determining daily physical activity patterns. This study also explored the association between these physical activity patterns and health risk factors.</p></sec><sec sec-type="methods"><title>Methods</title><p>People aged &#x003E;30 years who had metabolic syndrome risk factors and were using their own wrist-worn devices were included in this study. We collected personal health data through a web-based survey and measured physical activity levels using wrist-worn wearables over the course of 1 week. The Time-Series Anytime Density Peak (TADPole) clustering method, which is a novel time-series method proposed recently, was used to identify the physical activity patterns of study participants. Additionally, we defined physical activity pattern groups based on the similarity of physical activity patterns between weekdays and weekends. We used the <italic>&#x03C7;</italic><sup>2</sup> or Fisher exact test for categorical variables and the 2-tailed <italic>t</italic> test for numerical variables to find significant differences between physical activity pattern groups. Logistic regression models were used to analyze the relationship between activity patterns and health risk factors.</p></sec><sec sec-type="results"><title>Results</title><p>A total of 47 participants were included in the analysis, generating a total of 329 person-days of data. We identified 2 different types of physical activity patterns (early bird pattern and night owl pattern) for weekdays and weekends. The physical activity levels of early birds were less than that of night owls on both weekdays and weekends. Additionally, participants were categorized into stable and shifting groups based on the similarity of physical activity patterns between weekdays and weekends. The physical activity pattern groups showed significant differences depending on age (<italic>P</italic>=.004) and daily energy expenditure (<italic>P</italic>&#x003C;.001 for weekdays; <italic>P</italic>=.003 for weekends). Logistic regression analysis revealed a significant association between older age (&#x2265;40 y) and shifting physical activity patterns (odds ratio 8.68, 95% CI 1.95-48.85; <italic>P</italic>=.007).</p></sec><sec sec-type="conclusions"><title>Conclusions</title><p>This study overcomes the limitations of previous studies by using various models of wrist-worn wearables and a novel time-series clustering method. Our findings suggested that age significantly influenced physical activity patterns. It also suggests a potential role of the TADPole clustering method in the analysis of large and multidimensional data, such as wearable data.</p></sec></abstract><kwd-group><kwd>wrist-worn wearable</kwd><kwd>wearable data</kwd><kwd>physical activity pattern</kwd><kwd>TADPole clustering</kwd><kwd>TADPole</kwd><kwd>cluster</kwd><kwd>clustering</kwd><kwd>wearable</kwd><kwd>wearables</kwd><kwd>wrist-worn</kwd><kwd>physical activity</kwd><kwd>pattern</kwd><kwd>patterns</kwd><kwd>data analysis</kwd><kwd>data analytics</kwd><kwd>regression</kwd><kwd>risk</kwd><kwd>risks</kwd><kwd>time series</kwd><kwd>Time-Series Anytime Density Peak</kwd></kwd-group></article-meta></front><body><sec id="s1" sec-type="intro"><title>Introduction</title><p>Physical activity has been linked to numerous health benefits. A cross-sectional study conducted in Japan reported that inactive individuals with &#x003C;23 metabolic equivalent (MET) hours per week had more than double the risk of metabolic syndrome compared to active individuals (&#x2265;23 MET h/wk) [<xref ref-type="bibr" rid="ref1">1</xref>]. Another study used X-means clustering to identify intensity and temporal activity patterns and demonstrated that inactive individuals had a 3-fold higher risk of cardiovascular disease compared to active individuals [<xref ref-type="bibr" rid="ref2">2</xref>]. A systematic review also suggested that increased physical activity correlates with improved health status [<xref ref-type="bibr" rid="ref3">3</xref>]. Additionally, a meta-analysis by Pearce et al [<xref ref-type="bibr" rid="ref4">4</xref>] found that adults who achieved the recommended physical activity level (4.4 marginal MET h/wk) had a 25% lower risk of depression compared to inactive adults.</p><p>Wrist-worn wearables, such as smartwatches and smart bands equipped with computers and sensors, have become popular tools for measuring physical activity [<xref ref-type="bibr" rid="ref5">5</xref>,<xref ref-type="bibr" rid="ref6">6</xref>]. Most individuals opt to wear wrist-worn wearables for several reasons, including affordability, functionality, and stylish design [<xref ref-type="bibr" rid="ref7">7</xref>]. This has enabled the measurement of physical activity in daily life rather than being limited to the laboratory setting. There have also been notable improvements in the accuracy of measurements obtained from wrist-worn wearables [<xref ref-type="bibr" rid="ref8">8</xref>,<xref ref-type="bibr" rid="ref9">9</xref>]. As a result, an increasing number of studies are focusing on measuring and analyzing physical activity using wrist-worn devices [<xref ref-type="bibr" rid="ref7">7</xref>].</p><p>Several studies are currently exploring different aspects of physical activity using wrist-worn devices. These include investigations of the accuracy of these devices [<xref ref-type="bibr" rid="ref8">8</xref>,<xref ref-type="bibr" rid="ref9">9</xref>], the relationship between physical activity and personal characteristics [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref10">10</xref>], the impact of interventions using wrist-worn wearables [<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref12">12</xref>], and behavior prediction [<xref ref-type="bibr" rid="ref13">13</xref>-<xref ref-type="bibr" rid="ref15">15</xref>]. Some studies have also sought to identify physical activity patterns using data collected from wrist-worn wearables [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref16">16</xref>-<xref ref-type="bibr" rid="ref20">20</xref>]. However, it is important to note that these studies have certain limitations.</p><p>The diversity of wearable device models poses a challenge for observational studies using wearables within a population. Most previous studies either provided the participants with a specific device model or restricted participation to individuals using a particular model [<xref ref-type="bibr" rid="ref21">21</xref>-<xref ref-type="bibr" rid="ref23">23</xref>]. However, wearable device models are continuously evolving to cater to individual preferences. Furthermore, each model has its own app, which extracts data in a specific format. Consequently, there is a need for flexible methods that can effectively analyze essential information derived from diverse forms of wearable data.</p><p>Grouping methods, such as principal component analysis [<xref ref-type="bibr" rid="ref16">16</xref>-<xref ref-type="bibr" rid="ref18">18</xref>] and <italic>k</italic>-means clustering [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref20">20</xref>], have commonly been used to identify similarities among participants and summarize activity patterns within groups. Time-series analysis methods can also be used to classify daily activity patterns. However, previous studies using popular clustering methods have shown sensitivity to minor variations in data formats, resulting in inconsistent outcomes.</p><p>The <italic>k</italic>-means clustering method is a kind of partitional clustering method [<xref ref-type="bibr" rid="ref24">24</xref>]. This clustering method is easy to implement and successfully distinguishes clusters using data from all participants, with low computational cost [<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref24">24</xref>]. Therefore, it can be applied to large and multidimensional data. However, the number of clusters (parameter <italic>k</italic>) had to be predefined, because the parameter <italic>k</italic> is not commonly known; therefore, iterative analysis is required to get the optimal number of clusters. The X-means clustering mentioned above is also a type of <italic>k</italic>-means clustering and is a clustering method that automatically finds the number of clusters by taking the disadvantage of <italic>k</italic>-means into consideration [<xref ref-type="bibr" rid="ref2">2</xref>]. In addition, the <italic>k</italic>-means clustering method provides unstable results due to its random selection of the initial centroid [<xref ref-type="bibr" rid="ref24">24</xref>].</p><p>The hierarchical clustering method and Density-Based Spatial Clustering of Applications With Noise (DBSCAN) are also popular time-series clustering methods [<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref20">20</xref>]. The hierarchical clustering method is a method of classifying clusters based on the hierarchical structure of data and basically considers 1 time series as 1 cluster [<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref24">24</xref>]. The hierarchical clustering method has the advantage of visualizing the hierarchical structure of data, because it shows the hierarchical structure as a tree (ie, a dendrogram). However, its computational cost is high, and a significant number of data points must be excluded from the analysis to obtain the desired number of clusters, raising uncertainties about the accuracy of the resulting clusters [<xref ref-type="bibr" rid="ref24">24</xref>]. DBSCAN is a density-based clustering method that calculates the density of data based on the Euclidean distance calculation method and excludes data considered as noise from clustering. However, as shown in a study by Dobbins and Rawassizadeh [<xref ref-type="bibr" rid="ref20">20</xref>], DBSCAN has the highest computational cost, and the Euclidean method applied to DBSCAN is not suitable for multidimensional data. Thus, the hierarchical clustering method and DBSCAN are not feasible for large or multidimensional data.</p><p>A more flexible time-series clustering method called Time-Series Anytime Density Peak (TADPole) clustering has recently been proposed [<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref25">25</xref>]. This is an algorithm that can perform fast clustering by reducing the distance calculation process in the Density Peak clustering method. This method uses dynamic time warping to calculate distances between series. Unlike the Euclidean method, which matches data at the same points across a series, this method identifies optimal warping paths between series to identify better point-to-point matches except for the first and last points. The prototype for TADPole clustering is partition around medoid clustering, which creates clusters by minimizing the sum of distances calculated based on an arbitrary series (ie, medoid) [<xref ref-type="bibr" rid="ref24">24</xref>]. TADPole clustering classifies series as neighbors if the distance between them is below a certain cutoff value [<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref25">25</xref>]. Theoretical and technical details are readily accessible in the previous literature [<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref25">25</xref>] and thus are not repeated here.</p><p>The TADPole clustering algorithm can cluster multidimensional data measured by wearable devices as well as large data [<xref ref-type="bibr" rid="ref25">25</xref>]. In this study, we chose the TADPole clustering method to test whether it can be effectively applied to wearable data, which was not addressed in its published paper [<xref ref-type="bibr" rid="ref25">25</xref>]. To the best of our knowledge, this novel approach has not yet been applied to the study of health indicators measured using wearable devices. Therefore, this study assessed the feasibility of using a time-series clustering method to analyze wearable data for daily physical activity patterns and explored the association between these patterns and health risk factors.</p></sec><sec id="s2" sec-type="methods"><title>Methods</title><sec id="s2-1"><title>Study Participants</title><p>This study examined physical activity patterns among at-risk individuals using wrist-worn wearables. Step counts, distances, and energy expenditure (EE) were measured over 1 week in a real-life setting between November 22, 2021, and December 2, 2021. Participants aged &#x003E;30 years who had risk factors based on metabolic syndrome diagnostic criteria and were currently using wrist-worn devices (eg, smartwatches and smart bands) were included. The risk factors included blood pressure &#x2265;130/85 mm Hg, fasting blood sugar &#x2265;100 mg/dL, triglyceride levels &#x2265;150 mg/dL, high-density lipoprotein level &#x003C;40 or &#x003C;50 mg/dL (for male and female individuals, respectively), and waist circumference &#x2265;90 or &#x2265;85 cm (for male and female individuals, respectively). The number of study participants was selected based on the analysis results using G*Power (Heinrich Heine Universit&#x00E4;t D&#x00FC;sseldorf) and previous similar research cases. First, we used G*Power to perform an ANOVA because the data of the study participants would be measured repeatedly. The effect size (Cohen <italic>f</italic>) was set to be 0.25, and the significance level (&#x03B1;) and power (1 &#x2013; &#x03B2;) were assumed to be 5% and 95%, respectively. As a result, a total sample size of 36 was calculated. Next, we considered the previous work by Huh et al [<xref ref-type="bibr" rid="ref26">26</xref>], which applied wearable technology to patients with metabolic syndrome and recruited a total of 53 people. However, 33 patients dropped out during the 12-week study period due to the withdrawal of consent, device malfunction, and the loss of follow-up. We finally decided to recruit 60 study participants to achieve a sufficient effect. We used the Seoul National University mailing system to recruit research participants. Starting on November 3, 2021, we sent 2 emails to all members of the university; this lasted until November 19, 2021, when the recruitment was completed. The purpose of the study, eligibility criteria for study participants, and research procedures were provided via email. A detailed explanation of the study was provided in a web-based meeting after all written informed consent was obtained. Before physical activity measurements, all participants completed a web-based questionnaire through Google Forms, which collected personal health data and details about their physical activity (including type, intensity, and duration). The participants wore their own wrist-worn wearables for &#x2265;10 hours per day with the physical activity measurement function activated for 1 week.</p><p>Following the 1-week period of physical activity measurements, the participants were asked to complete another web-based questionnaire to assess user experience, including cognition, context, applicability, and behavioral changes. Of the 60 participants initially included in the study, 13 were excluded due to missing or limited baseline data (n=3) or the unavailability of physical activity data from the database (n=10). Consequently, the analysis involved 47 participants who met the inclusion criteria and had data available for analysis.</p></sec><sec id="s2-2"><title>Data Collection</title><p>During the 7-day measurement period, the participants activated the measurement function on their wrist-worn wearables, generating a total of 329 person-days of data. The study included wrist-worn wearables from the Apple Watch, Samsung Galaxy Watch, and Xiaomi Mi Band series (<xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>). Data were collected continuously throughout the measurement period, with each device automatically storing individual data and synchronizing it with the participants&#x2019; cell phones.</p><p>Upon the completion of the measurement period, each participant exported their individual data through the official data export system and submitted the data via email. We provided the participants with detailed instructions specific to the manufacturer, version, and brand of their wrist-worn wearables. We then decompressed the data files and preprocessed the data to extract the selected variables, including step count, distance, EE, and duration with the start and end points. These variables were then merged into a unified data format for analysis.</p></sec><sec id="s2-3"><title>Time-Series Clustering</title><p>The time-series clustering method was applied in 3 steps to identify clusters representing the physical activity patterns of the study participants. First, due to variations in data recording formats among the different wrist-worn device brands, the data were edited to ensure consistency. Data from different brands were standardized into the same format. For instance, the Samsung Galaxy Watch series record EE as &#x201C;kcal per minute&#x201D; during wearing, whereas the Apple Watch and Xiaomi Mi Band series record EE as &#x201C;cal&#x201D; and &#x201C;kcal,&#x201D; respectively, for each distinct activity. We converted these data into 10-minute &#x201C;kcal&#x201D; EE values. For activities performed for &#x003E;10 minutes while wearing the Apple Watch or Xiaomi Mi Band series, the activity duration was divided into 10-minute intervals, assuming that a consistent amount of energy was expended during each interval.</p><p>Second, the data were divided into weekdays (Monday to Friday; 235 person-days) and weekends (Saturday and Sunday; 94 person-days), with the clustering method applied separately to each group. We calculated the average EE for weekdays and weekends based on the daily 10-minute EE values. It was assumed that the EE was 0 when the participant was not wearing the device. <xref ref-type="fig" rid="figure1">Figure 1</xref> illustrates an example of physical activity measurements for 7 person-days, with each data point representing the EE in kcal per 10 minutes over the course of 1 week.</p><fig position="float" id="figure1"><label>Figure 1.</label><caption><p>Physical activity measurement for 1 of the participants (7 person-days).</p></caption><graphic alt-version="no" mimetype="image" position="float" xlink:type="simple" xlink:href="mhealth_v11i1e50663_fig01.png"/></fig><p>Third, time-series clustering was conducted through TADPole clustering, a recently developed technique that allows faster clustering by implementing a cutoff value to determine clusters [<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref25">25</xref>]. To determine the optimal clustering model, we analyzed the expected number of clusters (parameter <italic>k</italic>) and the cutoff value. For the third step, we used the <italic>dtwclust</italic> package in RStudio [<xref ref-type="bibr" rid="ref27">27</xref>]. This package offers a range of functions for conducting time-series clustering, including the TADPole clustering method. We had to specify certain parameters, including the cluster type, the number of clusters, the cutoff value, and the window size. Since we chose TADPole as the cluster type, we did not need to specify the distance parameter. As for the cutoff value and window size, we adjusted them based on the volume of data. Given that our study used 144 data points, we selected values that fell below this threshold. As the optimal number of clusters and cutoff values were unknown, cluster evaluation was performed using the silhouette index, which is a popular cluster validity index. Based on the cluster evaluation, the model with the highest silhouette index was selected as the optimal clustering model.</p></sec><sec id="s2-4"><title>Statistical Analysis</title><p>The demographic characteristics of the participants, including sex, age, work type (sitting, standing, etc), daily EE (weekdays and weekends), physical activity changes after using wrist-worn wearables, weekly physical activity patterns, and number of risk factors (1 or &#x003E;1), were recorded. For categorical variables, the number and proportion for each category were presented, along with the <italic>P</italic> value calculated using the <italic>&#x03C7;</italic><sup>2</sup> or Fisher exact test for variables with counts &#x003C;5. For numerical variables, mean and SD with <italic>P</italic> values were calculated using the 2-tailed <italic>t</italic> test.</p><p>The association between weekly physical activity patterns and participant characteristics was analyzed using a logistic regression model. The regression model was evaluated in terms of pseudo-<italic>R</italic><sup>2</sup>, accuracy, Hosmer-Lemeshow goodness of fit, and the receiver operating characteristic curve. The results of the logistic regression were presented as odds ratios with 95% CIs and the corresponding <italic>P</italic> values. Statistical significance was taken as <italic>P</italic>&#x2264;.05. The statistical analyses were performed using RStudio (version 2022.07.2+576; Posit) [<xref ref-type="bibr" rid="ref28">28</xref>].</p></sec><sec id="s2-5"><title>Ethical Considerations</title><p>The study was approved by the Institutional Review Board of Mokpo National University (approval MNUIRB-210625-SB-014-01). All participants provided informed consent before study participation. The submitted data were anonymized before analysis. Participants who provided data and finished the web-based survey received a compensation of &#x20A9;100,000 (US $77.65).</p></sec></sec><sec id="s3" sec-type="results"><title>Results</title><sec id="s3-1"><title>General Participant Characteristics</title><p>Among the 47 participants, 23 (49%) were male and 24 (51%) were female (<xref ref-type="table" rid="table1">Table 1</xref>). In terms of age, 30 (64%) participants were aged &#x003C;40 years, whereas 17 (36%) were aged &#x2265;40 years. The majority (n=42, 89%) of the participants had a sedentary job. The average EE during weekdays was 223 (SD 175) kcal, whereas that on weekends was 191 (SD 164) kcal. After using wrist-worn wearables, 29 (62%) participants reported a decrease or no change in physical activity, whereas 18 (38%) participants reported an increase. In terms of health risk factors, 25 (53%) participants had only 1 risk factor, whereas 22 (47%) had &#x003E;1 risk factors.</p><table-wrap id="t1" position="float"><label>Table 1.</label><caption><p>General participant characteristics.</p></caption><table id="table1" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom" colspan="2">Variable and level</td><td align="left" valign="bottom">Value (N=47)</td></tr></thead><tbody><tr><td align="left" valign="top" colspan="3"><bold>Sex, n (%)</bold></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top">Male</td><td align="left" valign="top">23 (49)</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top">Female</td><td align="left" valign="top">24 (51)</td></tr><tr><td align="left" valign="top" colspan="3"><bold>Age group (y), n (%)</bold></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top">&#x003C;40</td><td align="left" valign="top">30 (64)</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top">&#x2265;40</td><td align="left" valign="top">17 (36)</td></tr><tr><td align="left" valign="top" colspan="3"><bold>Work type, n (%)</bold></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top">Sitting</td><td align="left" valign="top">42 (89)</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top">Other</td><td align="left" valign="top">5 (11)</td></tr><tr><td align="left" valign="top" colspan="3"><bold>Daily EE</bold><sup><xref ref-type="table-fn" rid="table1fn1"><bold>a</bold></xref></sup> <bold>(kcal), mean (SD)</bold></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top">Weekdays</td><td align="left" valign="top">223 (175)</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top">Weekends</td><td align="left" valign="top">191 (164)</td></tr><tr><td align="left" valign="top" colspan="3"><bold>Change in PA</bold><sup><xref ref-type="table-fn" rid="table1fn2"><bold>b</bold></xref></sup><bold>, n (%)</bold></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top">No change or decrease</td><td align="left" valign="top">29 (62)</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top">Increase</td><td align="left" valign="top">18 (38)</td></tr><tr><td align="left" valign="top" colspan="3"><bold>PA pattern group, n (%)</bold></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top">Stable</td><td align="left" valign="top">35 (75)</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top">Shifting</td><td align="left" valign="top">12 (25)</td></tr><tr><td align="left" valign="top" colspan="3"><bold>Number of health risk factors, n (%)</bold></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top">1</td><td align="left" valign="top">25 (53)</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top">&#x003E;1</td><td align="left" valign="top">22 (47)</td></tr></tbody></table><table-wrap-foot><fn id="table1fn1"><p><sup>a</sup>EE: energy expenditure.</p></fn><fn id="table1fn2"><p><sup>b</sup>PA: physical activity.</p></fn></table-wrap-foot></table-wrap></sec><sec id="s3-2"><title>Physical Activity Patterns</title><p>The time-series cluster analysis resulted in the highest silhouette index when there were 2 clusters (<italic>k</italic>=2) for both weekdays and weekends. Therefore, 2 clusters each were distinguished for weekdays and weekends (<xref ref-type="fig" rid="figure2">Figure 2</xref>). The left and right columns of <xref ref-type="fig" rid="figure2">Figure 2</xref> represent the weekday and weekend clusters, respectively. Each cluster included data from at least 2 participants, and 2 distinct cluster types were distinguished with different starting times for physical activity. The &#x201C;early bird&#x201D; type (represented by blue dots in <xref ref-type="fig" rid="figure2">Figure 2</xref>) initiated physical activity after 6 AM, whereas the &#x201C;night owl&#x201D; type (represented by orange dots in <xref ref-type="fig" rid="figure2">Figure 2</xref>) began physical activity before 6 AM.</p><fig position="float" id="figure2"><label>Figure 2.</label><caption><p>Physical activity clusters on weekdays and weekends: (A) cluster 1: &#x201C;early birds&#x201D; on weekdays, (B) cluster 2: &#x201C;night owls&#x201D; on weekdays, (C) cluster 3: &#x201C;early birds&#x201D; on weekends, and (D) cluster 4: &#x201C;night owls&#x201D; on weekends.</p></caption><graphic alt-version="no" mimetype="image" position="float" xlink:type="simple" xlink:href="mhealth_v11i1e50663_fig02.png"/></fig><p>Among the 37 early birds on weekdays, 57% (n=21) were female and 76% (n=28) were in their 30s, with female participants in their 30s accounting for the highest proportion (n=18, 48%). Among the 10 night owls on weekdays, 70% (n=7) were male and 80% (n=8) were in their aged &#x2265;40 years, and 40% (n=4) were male individuals aged &#x2265;40 years. Weekend physical activity patterns were mostly from early birds (n=45, 96%) regardless of sex or age. Out of the 45 early birds on weekends, 51% (n=23) were female and 64% (n=29) were in their 30s, and 40% (n=18) were female individuals aged &#x003C;40 years. There was 1 participant per sex and age group who was a night owl on weekends, and there was no one who was a night owl on both weekdays and weekends.</p><p><xref ref-type="fig" rid="figure2">Figure 2</xref>A shows the physical activity patterns of the 37 (79%) out of 47 participants belonging to cluster 1 (early birds) on weekdays. Physical activity occurred between 6 AM and 8 PM, with most activities being &#x003C;10 kcal (mean 2.98 kcal). Meanwhile, cluster 2 included 10 (21%) &#x201C;night owls&#x201D; on weekdays (<xref ref-type="fig" rid="figure2">Figure 2</xref>B). Physical activity for cluster 2 typically started at midnight and ended before 4 PM. Cluster 2 also exhibited greater EE, with an average of 9.51 kcal.</p><p>During the weekends, the majority (45/47, 96%) of participants were early birds (cluster 3; <xref ref-type="fig" rid="figure2">Figure 2</xref>C). Cluster 3 had an average EE of 2.94 kcal. Cluster 4 (night owls) included only 2 (4%) participants on weekends (<xref ref-type="fig" rid="figure2">Figure 2</xref>D) and demonstrated a higher EE (average 8.60 kcal).</p><p>Although the average EE was similar between early birds and night owls, their physical activity patterns differed on weekdays and weekends. Regardless of the cluster type, physical activity tended to be shorter in duration on weekdays (<xref ref-type="fig" rid="figure2">Figure 2</xref>A and B), becoming longer and more continuous on weekends. Cluster 3, representing early birds on weekends, exhibited up to 10 consecutive physical activity periods, which is equivalent to 100 minutes (4-8 AM; <xref ref-type="fig" rid="figure2">Figure 2</xref>C). Cluster 4, representing the night owls on weekends, had the highest total EE of 507.59 kcal and up to 16 consecutive physical activity periods, which is equivalent to 160 minutes (4-8 AM; <xref ref-type="fig" rid="figure2">Figure 2</xref>D).</p><p>Based on the analysis of physical activity patterns, 2 groups were identified: the stable group and the shifting group. The stable group included individuals who maintained the same physical activity pattern on weekdays and weekends, regardless of whether they were classified as early birds or night owls. Among the 47 participants, 35 (74%) belonged to the stable group, exhibiting early bird physical activity patterns consistently throughout the week. There were no participants belonging to both clusters 2 and 4. On the other hand, the shifting group included individuals whose physical activity patterns differed between weekdays and weekends. There were 12 (26%) participants in the shifting group; 10 (21%) participants displayed an early bird pattern during weekdays (cluster 1) but changed to the night owl pattern on weekends (cluster 4). The remaining 2 (4%) participants exhibited the opposite pattern, that is, a night owl pattern during weekdays (cluster 4) and an early bird pattern on weekends (cluster 1).</p><p>Demographic descriptive statistics for the physical activity pattern groups, including the results of the <italic>&#x03C7;</italic><sup>2</sup> test for categorical variables and the <italic>t</italic> test for continuous variables, are presented in <xref ref-type="table" rid="table2">Table 2</xref>. There were no significant differences between the physical activity pattern groups except in age (<italic>P</italic>=.001) and EE (<italic>P</italic>&#x003C;.001 for weekdays; <italic>P</italic>=.003 for weekends).</p><table-wrap id="t2" position="float"><label>Table 2.</label><caption><p>Weekly physical activity (PA) group characteristics.</p></caption><table id="table2" frame="hsides" rules="groups"><thead><tr><td align="left" valign="top" colspan="2">Variable and level</td><td align="left" valign="top" colspan="2">PA pattern group</td><td align="left" valign="top"><italic>P</italic> value</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Stable (n=35)</td><td align="left" valign="top">Shifting (n=12)</td><td align="left" valign="top"/></tr></thead><tbody><tr><td align="left" valign="top" colspan="4"><bold>Sex, n (%)</bold></td><td align="left" valign="top">.19<sup><xref ref-type="table-fn" rid="table2fn1">a</xref></sup></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top">Male</td><td align="left" valign="top">15 (43)</td><td align="left" valign="top">8 (67)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top"/><td align="left" valign="top">Female</td><td align="left" valign="top">20 (57)</td><td align="left" valign="top">4 (33)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top" colspan="4"><bold>Age group (y), n (%)</bold></td><td align="left" valign="top">.004<sup><xref ref-type="table-fn" rid="table2fn1">a</xref></sup></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top">&#x003C;40</td><td align="left" valign="top">27 (77)</td><td align="left" valign="top">3 (25)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top" colspan="4"><bold>Work type, n (%)</bold></td><td align="left" valign="top">&#x003E;.99<sup><xref ref-type="table-fn" rid="table2fn1">a</xref></sup></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top">Sitting</td><td align="left" valign="top">31 (89)</td><td align="left" valign="top">11 (92)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top"/><td align="left" valign="top">Other</td><td align="left" valign="top">4 (11)</td><td align="left" valign="top">1 (8)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top" colspan="5"><bold>Daily EE</bold><sup><xref ref-type="table-fn" rid="table2fn2"><bold>b</bold></xref></sup> <bold>(kcal), mean (SD)</bold></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top">Weekdays</td><td align="left" valign="top">169 (130)</td><td align="left" valign="top">383 (194)</td><td align="left" valign="top">&#x003C;.001<sup><xref ref-type="table-fn" rid="table2fn3">c</xref></sup></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top">Weekends</td><td align="left" valign="top">145 (100)</td><td align="left" valign="top">327 (230)</td><td align="left" valign="top">.003<sup><xref ref-type="table-fn" rid="table2fn3">c</xref></sup></td></tr><tr><td align="left" valign="top" colspan="4"><bold>PA changes, n (%)</bold></td><td align="left" valign="top">.74<sup><xref ref-type="table-fn" rid="table2fn1">a</xref></sup></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top">No change or decrease</td><td align="left" valign="top">21 (60)</td><td align="left" valign="top">8 (67)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top"/><td align="left" valign="top">Increase</td><td align="left" valign="top">14 (40)</td><td align="left" valign="top">4 (33)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top" colspan="4"><bold>Number of health risk factors, n (%)</bold></td><td align="left" valign="top">.18<sup><xref ref-type="table-fn" rid="table2fn1">a</xref></sup></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top">1</td><td align="left" valign="top">21 (60)</td><td align="left" valign="top">4 (33)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top"/><td align="left" valign="top">&#x003E;1</td><td align="left" valign="top">14 (40)</td><td align="left" valign="top">8 (67)</td><td align="left" valign="top"/></tr></tbody></table><table-wrap-foot><fn id="table2fn1"><p><sup>a</sup>Fisher exact test.</p></fn><fn id="table2fn2"><p><sup>b</sup>EE: energy expenditure.</p></fn><fn id="table2fn3"><p><sup>c</sup><italic>t</italic> test.</p></fn></table-wrap-foot></table-wrap></sec><sec id="s3-3"><title>Association Between Physical Activity Patterns and Health Risk Factors</title><p>A logistic regression model was used to examine the associations of sex, age, and the number of health risk factors with weekly physical activity patterns (<xref ref-type="table" rid="table3">Table 3</xref>). Logistic regression model accuracy and diagnostic results are presented in <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>. Sex (<italic>P</italic>=.45) and the number of health risk factors (<italic>P</italic>=.33) were not significantly associated with the physical activity pattern. In contrast, age showed a statistically significant association with physical activity patterns; the higher age group had higher odds of differences between weekday and weekend physical activity patterns (odds ratio 8.68, 95% CI 1.95-48.85; <italic>P</italic>=.007).</p><table-wrap id="t3" position="float"><label>Table 3.</label><caption><p>Associations between physical activity patterns and health risk factors.</p></caption><table id="table3" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom">Variable and level (reference)</td><td align="left" valign="bottom" colspan="2">OR<sup><xref ref-type="table-fn" rid="table3fn1">a</xref></sup> (95% CI)</td><td align="left" valign="bottom"><italic>P</italic> value</td></tr></thead><tbody><tr><td align="left" valign="top">Sex: female (vs male)</td><td align="left" valign="top" colspan="2">0.69 (0.13-3.64)</td><td align="left" valign="top">.45</td></tr><tr><td align="left" valign="top">Age group: &#x2265;40 y (vs &#x003C;40 y)</td><td align="left" valign="top" colspan="2">8.68 (1.95-48.85)</td><td align="left" valign="top">.007</td></tr><tr><td align="left" valign="top">Number of health risk factors: &#x003E;1 (vs 1)</td><td align="left" valign="top" colspan="2">2.21 (0.45-11.92)</td><td align="left" valign="top">.33</td></tr></tbody></table><table-wrap-foot><fn id="table3fn1"><p><sup>a</sup>OR: odds ratio.</p></fn></table-wrap-foot></table-wrap><p>To account for the possibility of reverse causality, we conducted another logistic regression analysis with the number of health risk factors as the outcome variable. Despite this adjustment, there were no significant associations between physical activity patterns and health risk factors (<italic>P</italic>&#x003E;.99; <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>).</p></sec></sec><sec id="s4" sec-type="discussion"><title>Discussion</title><sec id="s4-1"><title>Principal Findings</title><p>In this study, we assessed the effectiveness of the TADPole clustering method for identifying physical activity patterns from wearable data. We also explored the association between these patterns and health risk factors. We found that physical activity patterns on weekdays and weekends were categorized as either daytime (early bird) or nighttime (night owl) patterns. Furthermore, 2 groups were distinguished: 1 with consistent physical activity patterns on weekdays and weekends (stable group) and the other with different patterns between weekdays and weekends (shifting group). Age significantly influenced physical activity patterns.</p></sec><sec id="s4-2"><title>Comparison to Prior Works</title><p>We found that physical activity patterns on weekdays and weekends differed as age increased. Our findings shed light on previously unaddressed or overlooked associations between physical activity patterns and health risk factors. Many previous studies did not report the association between age and physical activity patterns [<xref ref-type="bibr" rid="ref17">17</xref>,<xref ref-type="bibr" rid="ref18">18</xref>], and this association was reported only in a few studies [<xref ref-type="bibr" rid="ref29">29</xref>-<xref ref-type="bibr" rid="ref32">32</xref>]. Some of these studies reported results consistent with our findings. A study by Caspersen et al [<xref ref-type="bibr" rid="ref29">29</xref>], which analyzed physical activity patterns according to sex and age, found that not only inactivity but also vigorous activity increased with age. In their study, those aged 18-29 years showed a pattern with the lowest vigorous activity and the highest sustained physical activity, whereas those aged &#x2265;75 years showed a pattern with the highest vigorous activity and the lowest sustained physical activity, indicating differences in physical activity patterns by age. Another study by Rossen et al [<xref ref-type="bibr" rid="ref32">32</xref>], which analyzed the physical activity patterns of individuals with diabetes for 2 years, found that the younger the age, the more physical activity increased 2 years later, showing that physical activity patterns can vary depending on age.</p><p>The physical activity patterns identified in our study were similar to chronotypes, which categorize individuals into morning type (M-type), evening type (E-type), and intermediate type (N-type) based on their preferred timings of activities and sleep [<xref ref-type="bibr" rid="ref33">33</xref>]. M-type individuals are typically early birds, whereas E-type individuals are night owls who prefer late activity and sleep schedules. N-type individuals do not fall strictly into either category, and most adults belong to this type [<xref ref-type="bibr" rid="ref33">33</xref>]. Previous studies have suggested that E-type individuals have lower physical activity levels and a higher risk of metabolic syndrome [<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref35">35</xref>]. However, this study found that the individuals with night owl tendencies, that is, E-type individuals, exhibited higher physical activity levels compared to early birds, that is, M-type individuals. It is important to note that most participants in our study reported engaging in sedentary work, indicating that the increased physical activity levels among night owls were likely due to leisure activities rather than occupational tasks. This suggests that physical activity patterns are not determined solely by chronotype and that other factors, such as health awareness, can have a significant impact. It is worth noting that an individual&#x2019;s chronotype and activity times may vary based on age and occupation, potentially leading to health issues if not addressed [<xref ref-type="bibr" rid="ref36">36</xref>]. Therefore, it is crucial to make efforts to achieve the recommended level of physical activity regardless of the specific activity pattern or chronotype.</p><p>None of the participants in our study met the criteria for &#x201C;weekend warriors,&#x201D; which refers to individuals engaging in 1 or 2 sessions of physical activity, particularly on weekends, per week, consuming at least 1000 kcal [<xref ref-type="bibr" rid="ref37">37</xref>]. Although the combined EE for cluster 2 (weekday night owls) and cluster 4 (weekend night owls) was the closest to that of weekend warriors at 735 kcal, no participants were included in both clusters. In a study conducted by Jang et al [<xref ref-type="bibr" rid="ref38">38</xref>] in South Korea, only 2.1% of the participants were classified as weekend warriors, but there was no significant difference in metabolic risk between weekend warriors and the regularly active group. The weekend warrior physical activity pattern, which is popular in the United Kingdom, the United States, and Latin America [<xref ref-type="bibr" rid="ref39">39</xref>], is associated with several health benefits, including a lower risk of obesity [<xref ref-type="bibr" rid="ref38">38</xref>] and all-cause mortality [<xref ref-type="bibr" rid="ref37">37</xref>]. A study of Chinese adults found that the weekend warrior physical activity pattern was associated with a lower risk of metabolic syndrome, hypertension, and diabetes in both male and female individuals [<xref ref-type="bibr" rid="ref40">40</xref>]. Promoting physical activity guidelines may increase the number of weekend warriors in South Korea, where sedentary jobs are common (<xref ref-type="table" rid="table1">Table 1</xref>).</p><p>The TADPole clustering method addresses the limitations of previously popular time-series clustering techniques such as the <italic>k</italic>-means and hierarchical clustering methods in data analysis. As we mentioned in the introduction, the <italic>k</italic>-means clustering method often produced unstable results with clusters changing each time, whereas the TADPole clustering method consistently provided reliable clustering outcomes. However, similar to <italic>k</italic>-means, we iteratively performed the analysis to obtain the optimal clustering results. The TADPole clustering method stands out by providing more reliable results compared to hierarchical clustering and DBSCAN, as it uses all available data without any loss or exclusion. Additionally, our study demonstrated the feasibility of the TADPole clustering method, showing its suitability for handling large and multidimensional data such as wearable data.</p></sec><sec id="s4-3"><title>Strengths</title><p>A key advantage of our study was that we used multiple wrist-worn device models. Although wearables provide data in different formats depending on the model, we standardized the data into a single format to successfully conduct statistical analyses. Furthermore, the TADPole clustering method allowed us to overcome the limitations of hierarchical and <italic>k</italic>-means clustering, which are commonly used time-series clustering methods, resulting in robust and reliable findings.</p></sec><sec id="s4-4"><title>Limitations</title><p>This study had several limitations. It only included 47 participants, which may not have been sufficient to generate meaningful results. The measurement period for physical activity was only 7 days, which may not have been representative of the daily physical activity. Additionally, we assumed that the EE for physical activities exceeding 10 minutes was consistent across 10-minute intervals. Although these assumptions may not perfectly reflect reality, they were considered reasonable given that the participants were going about their normal daily routines.</p></sec><sec id="s4-5"><title>Conclusions</title><p>This study successfully performed time-series clustering using various wrist-worn device models and found TADPole clustering to be a suitable tool for analyzing the data. Physical activity patterns on weekdays and weekends could be categorized into &#x201C;early birds&#x201D; and &#x201C;night owls,&#x201D; and these patterns were significantly influenced by age. To address the limitations of our study, additional studies with larger sample sizes are required.</p></sec></sec></body><back><ack><p>This research was supported by the Ministry of Science and ICT (MSIT), South Korea, under the Information Technology Research Center (ITRC) support program (IITP-2020-0-01778) supervised by the Institute of Information and Communications Technology Planning and Evaluation (IITP).</p></ack><notes><sec><title>Data Availability</title><p>The data sets generated and analyzed during the current study are available from the corresponding author upon reasonable request.</p></sec></notes><fn-group><fn fn-type="conflict"><p>None declared.</p></fn></fn-group><glossary><title>Abbreviations</title><def-list><def-item><term id="abb1">DBSCAN</term><def><p>Density-Based Spatial Clustering of Applications With Noise</p></def></def-item><def-item><term id="abb2">E-type</term><def><p>evening type</p></def></def-item><def-item><term id="abb3">EE</term><def><p>energy 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1</label><p>Included wearable models and the results of the regression model.</p><media xlink:href="mhealth_v11i1e50663_app1.docx" xlink:title="DOCX File, 10165 KB"/></supplementary-material></app-group></back></article>