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<article xmlns:xlink="http://www.w3.org/1999/xlink" article-type="letter" dtd-version="2.0">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMU</journal-id>
      <journal-id journal-id-type="nlm-ta">JMIR Mhealth Uhealth</journal-id>
      <journal-title>JMIR mHealth and uHealth</journal-title>
      <issn pub-type="epub">2291-5222</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v11i1e52204</article-id>
      <article-id pub-id-type="pmid">37721796</article-id>
      <article-id pub-id-type="doi">10.2196/52204</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Letter to the Editor</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Letter to the Editor</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Authors’ Reply: Methodological Considerations for a Diabetes Family-Based eHealth Intervention</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Leung</surname>
            <given-names>Tiffany</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author">
          <name name-style="western">
            <surname>Feng</surname>
            <given-names>Yuheng</given-names>
          </name>
          <degrees>BA</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0009-0005-4134-3223</ext-link>
        </contrib>
        <contrib id="contrib2" contrib-type="author" corresp="yes">
          <name name-style="western">
            <surname>Li</surname>
            <given-names>Xiaohong</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <address>
            <institution>Department of Health Policy and Management</institution>
            <institution>School of Public Health</institution>
            <institution>Fudan University</institution>
            <addr-line>PO Box 177, 130 Dong’ an Road</addr-line>
            <addr-line>Shanghai</addr-line>
            <country>China</country>
            <phone>86 13918213586</phone>
            <email>lixh@fudan.edu.cn</email>
          </address>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-8618-5549</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution>Department of Health Policy and Management</institution>
        <institution>School of Public Health</institution>
        <institution>Fudan University</institution>
        <addr-line>Shanghai</addr-line>
        <country>China</country>
      </aff>
      <author-notes>
        <corresp>Corresponding Author: Xiaohong Li <email>lixh@fudan.edu.cn</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <year>2023</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>18</day>
        <month>9</month>
        <year>2023</year>
      </pub-date>
      <volume>11</volume>
      <elocation-id>e52204</elocation-id>
      <history>
        <date date-type="received">
          <day>25</day>
          <month>8</month>
          <year>2023</year>
        </date>
        <date date-type="rev-request">
          <day>28</day>
          <month>8</month>
          <year>2023</year>
        </date>
        <date date-type="rev-recd">
          <day>29</day>
          <month>8</month>
          <year>2023</year>
        </date>
        <date date-type="accepted">
          <day>30</day>
          <month>8</month>
          <year>2023</year>
        </date>
      </history>
      <copyright-statement>©Yuheng Feng, Xiaohong Li. Originally published in JMIR mHealth and uHealth (https://mhealth.jmir.org), 18.09.2023.</copyright-statement>
      <copyright-year>2023</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR mHealth and uHealth, is properly cited. The complete bibliographic information, a link to the original publication on https://mhealth.jmir.org/, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://mhealth.jmir.org/2023/1/e52204" xlink:type="simple"/>
      <related-article related-article-type="commentary-article" id="v11i1e48652" ext-link-type="doi" xlink:href="10.2196/48652" vol="11" page="e48652" xlink:type="simple">http://www.jmir.org/2023/1/e48652/</related-article>
      <related-article related-article-type="commentary-article" id="v11i1e40420" ext-link-type="doi" xlink:href="10.2196/40420" vol="11" page="e40420" xlink:type="simple">http://www.jmir.org/2023/1/e40420/</related-article>
      <kwd-group>
        <kwd>public health</kwd>
        <kwd>type 2 diabetes mellitus</kwd>
        <kwd>intervention</kwd>
        <kwd>randomized controlled trial</kwd>
        <kwd>community health center</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec>
      <title/>
      <p>We greatly appreciate the authors’ interest and comments [<xref ref-type="bibr" rid="ref1">1</xref>] on our eHealth family-based intervention program [<xref ref-type="bibr" rid="ref2">2</xref>]. We hope that our responses are beneficial to the article’s readership.</p>
    </sec>
    <sec>
      <title>Intervention Program Development</title>
      <p>It is a common phenomenon that patients with type 2 diabetes mellitus (T2DM) have poor glucose control [<xref ref-type="bibr" rid="ref3">3</xref>]. Clinical inertia, including physician related, health care system related, and patient related, is the main reason [<xref ref-type="bibr" rid="ref4">4</xref>]. Our study developed an eHealth family-based intervention program, which decreased patient-related inertia. We interviewed endocrinologists and community physicians and found that physician and health care inertia existed. Some patients with T2DM with very poor glucose control failed to visit tertiary or secondary hospitals to adjust their medication.</p>
    </sec>
    <sec>
      <title>Changes in Self-Care Activities</title>
      <p>Changes in self-care activities were not substantial. There are two possible reasons. First, most patients with a long disease course had baseline self-care activities that were better than patients with a short disease course. So it was difficult to substantially enhance self-care activities. Second, the intervention intensity was not very high because we aimed to develop a generalizable labor-saving intervention model. Although differences were not substantial, it indicates that the eHealth family-based intervention program is effective.</p>
      <p>The general diet and blood sugar test had the most significant effect on changes in hemoglobin A<sub>1c</sub> (HbA<sub>1c</sub>). During the intervention implementation, family members mainly concentrated on how to help patients with T2DM maintain a healthy diet. Regarding glucose self-monitoring, family members can help them test regularly for the glucose status and prompt them to follow the physician’s suggestion.</p>
    </sec>
    <sec>
      <title>Frequency of Doctor Visits in Control Group</title>
      <p>According to the <italic>National Standard for Basic Public Health Services</italic>, community physicians need to follow up with patients registered in the community system once every 3 months. Our patients were recruited from this system. The frequency of doctor visits in the control group was the same as in the intervention group.</p>
    </sec>
    <sec>
      <title>Monitoring of Treatment Changes</title>
      <p>Due to workforce deficiencies in community health centers caused by the COVID-19 outbreak, we did not adjust oral medication or insulin. However, treatment changes should be monitored carefully. More detailed information could better explain how the intervention influenced the patients’ glucose control.</p>
    </sec>
    <sec>
      <title>Subanalysis of HbA1c Changes in Correlation With Their Baseline Levels</title>
      <p>We considered baseline HbA<sub>1c</sub> levels as a covariable. The covariance analysis indicated that patients with T2DM with worse baseline HbA<sub>1c</sub> levels get better intervention effectiveness, similar to Brož et al’s [<xref ref-type="bibr" rid="ref5">5</xref>] study, which indicates that priorities should be given to patients with T2DM and poorer glucose control.</p>
    </sec>
    <sec>
      <title>Future Studies</title>
      <p>To reduce the physician-based and health care–based inertia, measures targeted toward the health care system and physicians should be implemented. Future studies could be focused on physician-based and health care–based factors. More attention could be paid to the mechanism of improving the referral system and community physicians’ skills based on the medical alliance modes [<xref ref-type="bibr" rid="ref6">6</xref>]. The feedback mechanism of two-way referral also should be improved, which will help the community physicians know whether patients with T2DM follow suggestions and provide targeted health education to those who do not follow suggestions.</p>
    </sec>
  </body>
  <back>
    <app-group/>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">HbA<sub>1c</sub></term>
          <def>
            <p>hemoglobin A<sub>1c</sub></p>
          </def>
        </def-item>
        <def-item>
          <term id="abb2">T2DM</term>
          <def>
            <p>type 2 diabetes mellitus</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <fn-group>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
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