<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "journalpublishing.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="2.0" xml:lang="en" article-type="letter"><front><journal-meta><journal-id journal-id-type="nlm-ta">JMIR Mhealth Uhealth</journal-id><journal-id journal-id-type="publisher-id">mhealth</journal-id><journal-id journal-id-type="index">13</journal-id><journal-title>JMIR mHealth and uHealth</journal-title><abbrev-journal-title>JMIR Mhealth Uhealth</abbrev-journal-title><issn pub-type="epub">2291-5222</issn><publisher><publisher-name>JMIR Publications</publisher-name><publisher-loc>Toronto, Canada</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">v13i1e46047</article-id><article-id pub-id-type="doi">10.2196/46047</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Letter</subject></subj-group></article-categories><title-group><article-title>Smartphone-Based Care Platform Versus Traditional Care in Primary Knee Arthroplasty in the United States: Cost Analysis</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name name-style="western"><surname>Lonner</surname><given-names>Jess H</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Naidu-Helm</surname><given-names>Ashwini</given-names></name><degrees>MBA</degrees><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Van Andel</surname><given-names>David</given-names></name><degrees>MS, PT</degrees><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Anderson</surname><given-names>Mike B</given-names></name><degrees>MSc</degrees><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Ditto</surname><given-names>Richard</given-names></name><degrees>MS</degrees><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Redfern</surname><given-names>Roberta E</given-names></name><degrees>MPH, PhD</degrees><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Foran</surname><given-names>Jared</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff4">4</xref></contrib></contrib-group><aff id="aff1"><institution>Rothman Orthopaedics, Rothman Orthopaedic Institute</institution><addr-line>825 Old Lancaster Rd, Suite 100, 140</addr-line><addr-line>Philadelphia</addr-line><addr-line>PA</addr-line><country>United States</country></aff><aff id="aff2"><institution>Health Economic and Market Access, Zimmer Biomet</institution><addr-line>Warsaw</addr-line><addr-line>IN</addr-line><country>United States</country></aff><aff id="aff3"><institution>Clinical Affairs, Zimmer Biomet</institution><addr-line>Warsaw</addr-line><addr-line>IN</addr-line><country>United States</country></aff><aff id="aff4"><institution>Panorama Orthopedics and Spine Center</institution><addr-line>Golden</addr-line><addr-line>CO</addr-line><country>United States</country></aff><contrib-group><contrib contrib-type="editor"><name name-style="western"><surname>Buis</surname><given-names>Lorraine</given-names></name></contrib></contrib-group><contrib-group><contrib contrib-type="reviewer"><name name-style="western"><surname>Nin</surname><given-names>Darren Z</given-names></name></contrib><contrib contrib-type="reviewer"><name name-style="western"><surname>Woon</surname><given-names>Ee-Lin</given-names></name></contrib></contrib-group><author-notes><corresp>Correspondence to Jess H Lonner, MD, Rothman Orthopaedics, Rothman Orthopaedic Institute, 825 Old Lancaster Rd, Suite 100, 140, Philadelphia, PA, 19010, United States, 1 8003219999; <email>jess.lonner@rothmanortho.com</email></corresp></author-notes><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>3</day><month>2</month><year>2025</year></pub-date><volume>13</volume><elocation-id>e46047</elocation-id><history><date date-type="received"><day>05</day><month>06</month><year>2023</year></date><date date-type="rev-recd"><day>06</day><month>12</month><year>2024</year></date><date date-type="accepted"><day>20</day><month>12</month><year>2024</year></date></history><copyright-statement>&#x00A9; Jess H Lonner, Ashwini Naidu-Helm, David Van Andel, Mike B Anderson, Richard Ditto, Roberta E Redfern, Jared Foran. Originally published in JMIR mHealth and uHealth (<ext-link ext-link-type="uri" xlink:href="https://mhealth.jmir.org">https://mhealth.jmir.org</ext-link>), 3.2.2025. </copyright-statement><copyright-year>2025</copyright-year><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR mHealth and uHealth, is properly cited. The complete bibliographic information, a link to the original publication on <ext-link ext-link-type="uri" xlink:href="https://mhealth.jmir.org/">https://mhealth.jmir.org/</ext-link>, as well as this copyright and license information must be included.</p></license><self-uri xlink:type="simple" xlink:href="https://mhealth.jmir.org/2025/1/e46047"/><abstract><p>Cost savings were achieved with the use of a smartphone-based care management platform, considering several health care resources following knee arthroplasty procedures without negatively impacting clinical outcomes.</p><sec><title>Trial registration</title><p>ClinicalTrials.gov NCT03737149; https://clinicaltrials.gov/study/NCT03737149</p></sec></abstract><kwd-group><kwd>telerehabilitation</kwd><kwd>telehealth</kwd><kwd>telemedicine</kwd><kwd>rehabilitation</kwd><kwd>physiotherapy</kwd><kwd>mobile health</kwd><kwd>knee arthroplasty</kwd></kwd-group></article-meta></front><body><sec id="s1" sec-type="intro"><title>Introduction</title><p>The number of knee arthroplasty procedures performed in the United States has increased annually, accompanied by rises in health care resource use and costs [<xref ref-type="bibr" rid="ref1">1</xref>]. Risk-sharing and bundled payment plans have been implemented with the goal of improving care and controlling costs through the sharing of financial responsibility for a 90-day joint replacement episode-of-care (EOC) [<xref ref-type="bibr" rid="ref2">2</xref>]. Approximately 36% of the EOC cost has been attributed to postdischarge services [<xref ref-type="bibr" rid="ref3">3</xref>]. In-person outpatient physiotherapy (PT) has been the standard of care (SoC) postoperatively but is associated with significant cost and may be overused following uncomplicated knee arthroplasty [<xref ref-type="bibr" rid="ref4">4</xref>]. Telerehabilitation and mobile health delivery of PT has gained popularity in recent years [<xref ref-type="bibr" rid="ref5">5</xref>]. The aim of this study was to compare costs of a smartphone-based care management platform (sbCMP) with traditional care in adult patients undergoing knee arthroplasty.</p></sec><sec id="s2" sec-type="methods"><title>Methods</title><sec id="s2-1"><title>Study Design and Analysis</title><p>Patients undergoing primary total or partial knee arthroplasty were randomized (block randomization, block size of 4) to receive institutional SoC (control group) or sbCMP (treatment group) using the mymobility app (Zimmer Biomet), as previously described [<xref ref-type="bibr" rid="ref6">6</xref>]. The 90-day health care intervention collected information on PT visits, manipulations under anesthesia, non-SoC physician visits, all-cause readmissions, emergency department (ED) visits, and urgent care visits.</p><p>Costs associated with the use of each resource were estimated from multiple sources [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref7">7</xref>,<xref ref-type="bibr" rid="ref8">8</xref>]. The cost of the sbCMP was estimated based on the maximum cost per patient. Costs were multiplied across number of uses; the average cost per patient was calculated using the entire cohort as the denominator and compared between groups by a 2-tailed student <italic>t</italic> test. Costs in the noncrossover treatment group (patients who did not receive traditional PT in the original study) were also calculated. One-way and two-way deterministic sensitivity analyses were performed.</p></sec><sec id="s2-2"><title>Ethical Considerations</title><p>The multicenter randomized controlled trial (ClinicalTrials.gov NCT03737149) received central Institutional Review Board approval (20182103). All patients voluntarily provided written informed consent upon enrollment, with the opportunity to withdraw at any time. Smartwatches were provided (approximately US $329 in value). Data were deidentified prior to analyses.</p></sec></sec><sec id="s3" sec-type="results"><title>Results</title><p>Preoperative patient characteristics as well as baseline and postsurgical clinical outcomes were similar between the two groups [<xref ref-type="bibr" rid="ref6">6</xref>]. The estimated costs associated with health care resources are presented in <xref ref-type="table" rid="table1">Table 1</xref>. The number of events was lower in the treatment group in each category except for non-SoC physician office visits. Patients using the sbCMP had significantly fewer ED visits and readmissions. The average cost per patient was approximately US $732 lower in the treatment group after including the cost of the sbCMP. The reduction in the number of in-person PT visits accounted for the bulk of the potential savings in the cohort, with costs approximately US $400 less in the treatment group. The average number of PT visits in the control and sbCMP groups were 9.75 (SD 3.98) and 5.40 (SD 5.51), respectively. Considering only noncrossovers, average costs were further reduced to approximately US $186 per patient through 90 days (<xref ref-type="table" rid="table2">Table 2</xref>). Sensitivity analyses demonstrated cost savings across all scenarios (<xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>).</p><table-wrap id="t1" position="float"><label>Table 1.</label><caption><p>Estimated costs associated with resource use as a function of treatment group.</p></caption><table id="table1" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom">Variable</td><td align="left" valign="bottom">Cost per unit (US $)<sup><xref ref-type="table-fn" rid="table1fn1">a</xref></sup></td><td align="left" valign="bottom" colspan="3">Control arm (n=244)</td><td align="left" valign="bottom" colspan="3">Treatment arm (n=208)</td><td align="left" valign="bottom"><italic>P</italic> value</td></tr><tr><td align="left" valign="bottom"/><td align="left" valign="bottom"/><td align="left" valign="bottom">Frequency, n</td><td align="left" valign="bottom">Total cost per group (US $)</td><td align="left" valign="bottom">Average cost per patient (US $)</td><td align="left" valign="bottom">Frequency, n</td><td align="left" valign="bottom">Total cost per group (US $)</td><td align="left" valign="bottom">Average cost per patient (US $)</td><td align="left" valign="bottom"/></tr></thead><tbody><tr><td align="left" valign="top">Physiotherapy<sup><xref ref-type="table-fn" rid="table1fn2">b</xref></sup></td><td align="left" valign="top">126<sup><xref ref-type="table-fn" rid="table1fn3">c</xref></sup> [<xref ref-type="bibr" rid="ref4">4</xref>]</td><td align="left" valign="top">1736</td><td align="left" valign="top">218,736</td><td align="left" valign="top">896.46</td><td align="left" valign="top">799</td><td align="left" valign="top">100,674</td><td align="left" valign="top">484.01</td><td align="left" valign="top">&#x003C;.001</td></tr><tr><td align="left" valign="top">Readmission</td><td align="left" valign="top">9723 [<xref ref-type="bibr" rid="ref7">7</xref>]</td><td align="left" valign="top">16</td><td align="left" valign="top">155,568</td><td align="left" valign="top">637.57</td><td align="left" valign="top">5</td><td align="left" valign="top">48,615</td><td align="left" valign="top">233.73</td><td align="left" valign="top">.055</td></tr><tr><td align="left" valign="top">ED visit<sup><xref ref-type="table-fn" rid="table1fn4">d</xref></sup></td><td align="left" valign="top">519 [<xref ref-type="bibr" rid="ref8">8</xref>]</td><td align="left" valign="top">16</td><td align="left" valign="top">8304</td><td align="left" valign="top">34.03</td><td align="left" valign="top">5</td><td align="left" valign="top">2595</td><td align="left" valign="top">12.48</td><td align="left" valign="top">.03</td></tr><tr><td align="left" valign="top">MUA</td><td align="left" valign="top">1549</td><td align="left" valign="top">10</td><td align="left" valign="top">15,490</td><td align="left" valign="top">63.48</td><td align="left" valign="top">4</td><td align="left" valign="top">6196</td><td align="left" valign="top">29.79</td><td align="left" valign="top">.20</td></tr><tr><td align="left" valign="top">Physician office visit</td><td align="left" valign="top">27</td><td align="left" valign="top">67</td><td align="left" valign="top">1809</td><td align="left" valign="top">7.41</td><td align="left" valign="top">77</td><td align="left" valign="top">2079</td><td align="left" valign="top">10.00</td><td align="left" valign="top">.18</td></tr><tr><td align="left" valign="top">Urgent care visit</td><td align="left" valign="top">100</td><td align="left" valign="top">3</td><td align="left" valign="top">300</td><td align="left" valign="top">1.23</td><td align="left" valign="top">2</td><td align="left" valign="top">200</td><td align="left" valign="top">0.96</td><td align="left" valign="top">.79</td></tr><tr><td align="left" valign="top">Smartphone-based care platform</td><td align="left" valign="top">137</td><td align="left" valign="top">0</td><td align="left" valign="top">0</td><td align="left" valign="top">0.00</td><td align="left" valign="top">208</td><td align="left" valign="top">28,496</td><td align="left" valign="top">137.00</td><td align="left" valign="top">&#x2014;</td></tr><tr><td align="left" valign="top">Total</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">400,207</td><td align="left" valign="top">1640.19</td><td align="left" valign="top"/><td align="left" valign="top">188,855</td><td align="left" valign="top">907.96</td><td align="left" valign="top">.001</td></tr><tr><td align="left" valign="top">Cost reduction</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top"/><td align="left" valign="top">211,352</td><td align="left" valign="top">732.24</td><td align="left" valign="top"/></tr></tbody></table><table-wrap-foot><fn id="table1fn1"><p><sup>a</sup>Reference citations indicated the studies from which the costs were derived.</p></fn><fn id="table1fn2"><p><sup>b</sup>Estimates based on categorical collection of physiotherapy visits used. Categories included 1&#x2010;3 visits, 4&#x2010;6 visits, 7&#x2010;9 visits, 10&#x2010;12 visits, and 13 or more visits. Given the largest category did not include an upper bound, the lowest number of visits in each category was applied, providing conservative estimates in both groups.</p></fn><fn id="table1fn3"><p><sup>c</sup>Weighted mean accounting for location (home, outpatient, or both).</p></fn><fn id="table1fn4"><p><sup>d</sup>Represents only emergency department visits that did not result in admission. Readmissions associated with an emergency department visit are categorized only as readmission, without impacting emergency department visit rate.</p></fn><fn id="table1fn5"><p><sup>e</sup>ED: emergency department.</p></fn><fn id="table1fn6"><p><sup>f</sup>MUA: manipulations under anesthesia.</p></fn></table-wrap-foot></table-wrap><table-wrap id="t2" position="float"><label>Table 2.</label><caption><p>Resource use and estimated costs within the treatment noncrossover group, where in-person physiotherapy was not used.</p></caption><table id="table2" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom">Variable</td><td align="left" valign="bottom">Treatment group noncrossover (n=61), n</td><td align="left" valign="bottom">Total cost per group (US $)</td><td align="left" valign="bottom">Average cost per patient (US $)</td></tr></thead><tbody><tr><td align="left" valign="top">Physiotherapy</td><td align="char" char="." valign="top">0</td><td align="char" char="." valign="top">0</td><td align="char" char="." valign="top">0</td></tr><tr><td align="left" valign="top">Readmission</td><td align="char" char="." valign="top">0</td><td align="char" char="." valign="top">0</td><td align="char" char="." valign="top">0</td></tr><tr><td align="left" valign="top">ED<sup><xref ref-type="table-fn" rid="table2fn1">a</xref></sup> visit</td><td align="char" char="." valign="top">1</td><td align="char" char="." valign="top">519</td><td align="char" char="." valign="top">8.51</td></tr><tr><td align="left" valign="top">MUA<sup><xref ref-type="table-fn" rid="table2fn2">b</xref></sup></td><td align="char" char="." valign="top">1</td><td align="char" char="." valign="top">1549</td><td align="char" char="." valign="top">25.39</td></tr><tr><td align="left" valign="top">Physician office visit</td><td align="char" char="." valign="top">34</td><td align="char" char="." valign="top">918</td><td align="char" char="." valign="top">15.05</td></tr><tr><td align="left" valign="top">Urgent care visit</td><td align="char" char="." valign="top">0</td><td align="char" char="." valign="top">0</td><td align="char" char="." valign="top">0</td></tr><tr><td align="left" valign="top">Smartphone-based care platform</td><td align="char" char="." valign="top">61</td><td align="char" char="." valign="top">8357</td><td align="char" char="." valign="top">137</td></tr><tr><td align="left" valign="top">Total</td><td align="left" valign="top"/><td align="char" char="." valign="top">11,343</td><td align="char" char="." valign="top">185.95</td></tr></tbody></table><table-wrap-foot><fn id="table2fn1"><p><sup>a</sup>ED: emergency department.</p></fn><fn id="table2fn2"><p><sup>b</sup>MUA: manipulations under anesthesia.</p></fn></table-wrap-foot></table-wrap></sec><sec id="s4" sec-type="discussion"><title>Discussion</title><p>This analysis demonstrated cost savings for patients using the sbCMP for self-directed rehabilitation following primary knee arthroplasty. Most savings were derived from the reduction in PT, the most common resource used. Cost savings were also achieved with the sbCMP for all health care resources except physician office visits. It is possible that this increase in office visits is the result of improved communication between patients and their care team via real-time messaging. This may have prompted additional unexpected office visits for postoperative concerns, which may have prevented more costly ED visits or readmissions. Alternately, this could be due to a patient need for feedback and assurance not received during in-person PT.</p><p>To our knowledge, this is the first cost comparison analysis of this care management platform compared with traditional care. There are few studies of other telerehabilitation programs compared with traditional care in this context. One study reported reduced outpatient PT costs with increased use of web-based PT [<xref ref-type="bibr" rid="ref9">9</xref>] and another reported overall EOC cost savings with telerehabilitation and acknowledged improved outcomes, without attributing costs to the type of event [<xref ref-type="bibr" rid="ref10">10</xref>].</p><p>A key limitation of this analysis is the uncertainty regarding the generalizability of the list price for the sbCMP used in the analysis. Additionally, the cost data may not be generalizable. Postacute care use was not accounted for given it is not expected to differ between treatment modalities.</p><p>In conclusion, the sbCMP has a potential for robust cost savings without negatively impacting postsurgical outcomes in patients undergoing knee arthroplasty.</p></sec></body><back><ack><p>The study was funded by Zimmer Biomet.</p></ack><fn-group><fn fn-type="conflict"><p>JHL receives royalties and research support from Zimmer Biomet and Smith and Nephew and is a paid consultant. JHL also receives stock or stock options and research support from Force Therapeutics and is a paid consultant. ANH, DVA, MBA, RD, and RER are employees of Zimmer Biomet. JF receives stock or stock options from Cast Orthopedics, is on the editorial or governing board of the Journal of Arthroplasty, and is a paid consultant for Zimmer Biomet.</p></fn></fn-group><glossary><title>Abbreviations</title><def-list><def-item><term id="abb1">ED</term><def><p>emergency department</p></def></def-item><def-item><term id="abb2">EOC</term><def><p>episode-of-care</p></def></def-item><def-item><term id="abb3">PT</term><def><p>physiotherapy</p></def></def-item><def-item><term id="abb4">sbCMP</term><def><p>smartphone-based care management platform</p></def></def-item><def-item><term id="abb5">SoC</term><def><p>standard of care</p></def></def-item></def-list></glossary><ref-list><title>References</title><ref id="ref1"><label>1</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Sloan</surname><given-names>M</given-names> </name><name 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