The global prevalence of adult overweight and obesity has risen in recent decades and now represents one of the most significant public health challenges worldwide [1]. As of 2022, a total of 2.5 billion adults were living with overweight or obesity globally [2]. Obesity substantially increases the risk of chronic diseases, including type 2 diabetes, cardiovascular disease, and certain cancers [3], and contributes to an estimated 4 million deaths annually [4]. The associated economic burden was estimated to reach US $2.5 trillion in 2025 [5,6], highlighting the urgent need for scalable and sustainable solutions to weight management.

Multiple strategies have been used to support weight loss, including bariatric surgery, prescription medication (ie, appetite suppressants), and lifestyle interventions [7]. Recently, pharmacotherapy, particularly glucagon-like peptide-1 (GLP-1) receptor agonists, has gained significant attention due to its demonstrated effectiveness in reducing body weight [8]. However, long-term use of these drugs has not yet been well studied, and there are potential concerns related to loss of muscle mass and other health effects that warrant ongoing monitoring [9]. Lifestyle interventions that combine dietary modification with physical activity remain a cornerstone of obesity management and are particularly effective when delivered with guidance from health care professionals, such as registered dietitians (RDs) [10,11].

Despite their effectiveness, lifestyle interventions delivered through in-person counseling are difficult to scale to large populations. The emergence of digital health and nutrition platforms offers an alternative scalable approach to supporting weight management. These platforms typically combine individualized nutrition counseling with tools for dietary self-monitoring, educational resources, and behavioral prompts designed to encourage sustained lifestyle change. Although these platforms vary in their specific content and features, initial evidence suggests that mobile and web-based health technologies can effectively support improved diet quality and weight loss among adults with overweight or obesity [12-14].

However, digital nutrition platforms differ substantially in their design, level of professional involvement, and behavioral support mechanisms [15]. Evaluations of digital nutrition platforms consistently identify motivation, education, and support features as core user needs [16,17]. User engagement with specific digital intervention features is an important component of achieving weight loss outcomes. Use of self-regulation techniques has been identified as a predictor of successful weight loss among users of digital nutrition platforms [18,19]. A recent meta-analysis of digital food-focused interventions found positive effects on food consumption, particularly if the intervention used prompts or cues [20]. Positive cues that reinforce healthful behaviors can help to combat the “food noise” (persistent thoughts about food) many individuals report as a barrier to successful weight management [21]. Indeed, many GLP-1 users attribute the reduction in “food noise” to their weight loss [22]. However, the specific types and intensity of engagement associated with optimal weight outcomes remain unclear, particularly in dietitian-led platforms.

Inclusion of tailored feedback or individualized counseling has been demonstrated to enhance participant success in digital interventions focused on changing eating behavior [23-25]. An evaluation of a web platform in Brazil concluded that use of the platform in combination with coaching from a dietitian led to greater weight loss and significant changes in eating behavior (more fruits and vegetables, less ultraprocessed food) compared with users who only accessed the platform on their own [26]. Although limited in scope, these results suggest a high level of effectiveness when digital nutrition platforms include access to a dietitian. While the overall utility of digital nutrition platforms is generally positive, the heterogeneity in features, including the level of dietitian support, underscores the need for platform-specific evaluations. This allows for identification of individual components that best enhance weight management outcomes.

Nutrium is a digital health platform designed to facilitate hybrid nutrition interventions through integrated asynchronous and synchronous communication between users and RDs. Unlike automated or self-guided nutrition applications, which rely on algorithmic feedback [27], this model centers on practitioner-led care. The platform integrates scheduled teleconsultations with continuous in-app messaging, allowing RDs to develop personalized nutritional interventions, monitor real-time dietary intake, and provide iterative feedback throughout the care continuum. By digitizing the dietitian user interface while maintaining professional oversight (Figure 1), the Nutrium platform aligns with behavioral frameworks that prioritize engagement and therapeutic adherence as primary drivers of long-term health outcomes, such as weight management [28].

Nutrium Care is one delivery model for the Nutrium platform, implemented via employer-sponsored health and wellness programs. Through this model, employees gain access to professional dietetic consultations and sustained nutritional support through the Nutrium platform. This study aimed to provide the first evaluation of the Nutrium Care delivery model by quantifying longitudinal weight loss outcomes among program users and assessing the relationship between weight loss and user engagement with the program. Specifically, the study aimed to (1) characterize absolute weight loss among active Nutrium Care users after 3 and 6 months; (2) describe the proportion of active users achieving weight loss thresholds of 3%, 5%, and 10% of baseline body weight in the action phase; and (3) estimate the association between user engagement with the program and weight loss across multiple engagement metrics, including dietitian appointments, days of active platform use, and logging of food, water intake, and physical exercise.

This study evaluated real-world longitudinal data among more than 10,000 users with overweight and obesity enrolled in the Nutrium Care program who progressed to the action phase, reflecting active commitment to achieving their weight goals. Active users lost, on average, 2.0 kg and 2.3 kg after 3 and 6 months, respectively. Among active users with a weight recorded near the 3-month time point, 74.5% (4200/5637) weighed less than at baseline, 43.7% (2464/5637) lost at least 3% of their baseline weight, 22.9% (1293/5637) lost at least 5% of their baseline weight, and 2.9% (166/5637) lost at least 10% of their baseline weight. Greater program engagement was associated with more weight loss across the included engagement metrics, with bimonthly dietitian appointments showing the strongest association with improved weight loss outcomes.

The findings reported in this study are consistent with the growing evidence supporting digital nutrition platforms [35]. The weight loss observed is comparable to outcomes reported for digital interventions and is consistent with losses reported in meta-analyses of smartphone-based apps [36]. Among active users with a weight recorded near the 3-month time point, 23% (1293/5637) reached at least 5% weight loss. The 5% threshold is the benchmark most commonly used to define clinically significant weight loss [37]. Some evidence indicates benefits for cardiovascular risk factors at more modest losses [38], although this is not the established standard. While current guidelines indicate that individuals with obesity will see the biggest health benefits when weight loss exceeds 10% of body weight, most experts agree that these amounts are more likely to result from surgical or pharmaceutical interventions rather than lifestyle changes [39-41].

Behavior change and lifestyle modification have been identified as integral components of successful weight management, including external support from health care providers such as dietitians [42]. Incorporation of techniques that encourage self-regulation, such as tracking hunger levels, mood, and other common cues associated with eating habits, can support increased awareness of an individual’s environmental triggers that either facilitate or derail weight loss attempts [43]. However, simple tracking activities such as recording weight have been shown to be effective, particularly when paired with goal setting within a digital platform [44,45]. In this context, the engagement metrics assessed in the present study may reflect not only platform use but also behaviors associated with sustained participation in weight management.

The association between engagement and weight loss further contextualizes these results within the broader literature [46,47]. Active users attending bimonthly dietitian appointments lost 0.8 kg more than matched users without this level of contact, suggesting a relationship between professional interaction and weight loss [48,49]. These findings are consistent with evidence suggesting that digital interventions that include a component of actual human contact are more effective than fully automated programs [35] and that nutrition coaching, including medical nutrition therapy, delivered via telehealth can be as effective as traditional clinical nutrition care [11,48]. Within the TTM framework, behavioral processes of change such as helping relationships and reinforcement management are most prominent during the action phase, so forms of professional support that provide reinforcement may be particularly relevant for users working to sustain new routines [29]. Dietitian contact showed a stronger association with weight loss than self-directed platform engagement, although the design cannot establish why. However, in the absence of established benchmarks, the thresholds applied to engagement metrics were exploratory, so the estimated differences between more and less engaged users should be limited to hypothesis-generating interpretation. Further, statistical significance does not indicate clinical importance. The differences observed here, ranging from 0.3 kg to 0.8 kg at 3 months, may not be clinically meaningful for individual users.

The findings from this study should be interpreted considering its limitations. First, we relied on secondary observational data with no control group or comparison with other digital nutrition platforms. Therefore, we cannot establish causality in the weight loss results documented here, nor can we directly compare with the effectiveness of other weight loss solutions. Second, both criteria defining the action phase cohort depend on behavior after baseline. Users met the action phase definition only by attending a second dietitian appointment within 6 months, and follow-up was measured from a user’s first to last weight measurement, excluding those who stopped generating data before 3 months. Together, these criteria excluded 48.6% (11,192/23,024) of eligible users, compared with 6.7% (1544/23,024) excluded for joining too late to accrue 3 months of data. The cohort therefore represents users who remained active, and estimates should not be extrapolated to all enrolled users or to employer-sponsored digital nutrition programs more broadly. The action phase criterion is also conceptually adjacent to our strongest engagement exposure, since both are defined by continued dietitian attendance, so the engagement comparison is made within a group already selected on a related behavior. Estimates in the cohort without the action phase restriction were not smaller than our primary estimates, which offers no indication that the restriction inflated our findings, although that cohort includes many users whose values at 3 and 6 months are extrapolated from the fitted model rather than observed, so it cannot serve as a reliable counterfactual. Third, weight measurements were not recorded on a fixed schedule, so the threshold analyses depend on data availability near each time point. At 3 months, this reflects measurement timing rather than absent data, since all users recorded a weight at or beyond 3 months and those excluded had weighed in outside the 30-day window. At 6 months, approximately half the cohort had no recorded weight at or beyond that point. Users who stall or regain weight are more likely to stop recording weights, so the 6-month proportions based on measured weights alone are likely to overstate achievement of each threshold. We therefore report the lower bound of these proportions. Fourth, we were restricted in the length of follow-up. We addressed this by examining 2 time points, 3 and 6 months. However, further evidence on long-term weight loss maintenance, including after discontinuation of platform use, is needed. Fifth, this study was limited to weight loss as an outcome and does not include data on user experiences during the care they received and its impact on well-being. Sixth, the engagement analysis could not control for all possible confounders and potential reverse causality. For example, we did not have data on comorbidities experienced by users. Further, users experiencing difficulty with weight loss may be more engaged with the program, potentially biasing our estimate toward the null. Finally, we relied on data entered both by dietitians and self-reported by users, which may be subject to measurement error and reporting bias.

Our findings support the use of digital nutrition platforms as a meaningful tool to aid in weight management among users motivated and in the action phase of behavior change. Given the reality that primary care providers have limited time to incorporate behavioral change techniques during routine appointments, encouraging users with overweight or obesity to engage with a dietitian via a digital platform will increase access to the services and support needed. Having virtual access to a dietitian increases equity in care and reduces the logistical burden users experience associated with transportation and scheduling challenges that often occur with in-person appointments. Indeed, nutrition interventions using telehealth modalities are more cost-effective overall, with digital (mobile health) rated as the most cost-effective [50]. As employers (and health insurance companies) expand health benefits to include nutrition services from a dietitian, offering a digital nutrition platform provides a scalable yet evidence-based solution that can ultimately drive down medical costs as employees achieve weight management goals.

Nutrium Care’s observational findings provide motivation for pragmatic randomized evaluations to more directly test causal effects and durability of outcomes beyond 12 months. This need is increasingly recognized within the digital nutrition field, where planned randomized trials have begun to examine longer-term effectiveness and maintenance of digital programs [51]. Further work is also needed to characterize platform use patterns associated with optimal outcomes, for example, by identifying combinations of engagement behaviors that predict clinically meaningful weight loss and maintenance. Finally, given the scale of obesity-related costs, formal economic evaluation is an important next step. Modeling should consider (1) health care use offsets, (2) productivity impacts, (3) program delivery costs (including clinician time), and (4) subgroup targeting where marginal benefit is highest (eg, higher baseline BMI categories).