%0 Journal Article
%@ 2291-5222
%I JMIR Publications
%V 13
%N 
%P e57540
%T Effectiveness of an mHealth Intervention With Short Text Messages to Promote Treatment Adherence Among HIV-Positive Mexican Adults: Randomized Controlled Trial
%A Del Moral Trinidad,Luis Eduardo
%A Andrade Villanueva,Jaime Federico
%A Martínez Ayala,Pedro
%A Cabrera Silva,Rodolfo Ismael
%A Herrera Godina,Melva Guadalupe
%A González-Hernández,Luz Alicia
%K HIV
%K treatment adherence
%K mobile health
%K mHealth
%K mHealth intervention
%K randomized clinical trial
%K text messages
%K eHealth intervention
%K sexual health
%K randomized controlled trial
%K RCT
%D 2025
%7 28.1.2025
%9 
%J JMIR Mhealth Uhealth
%G English
%X Background: HIV continues to be a public health concern in Mexico and Latin America due to an increase in new infections, despite a decrease being observed globally. Treatment adherence is a pillar for achieving viral suppression. It prevents the spread of the disease at a community level and improves the quality and survival of people living with HIV. Thus, it is important to implement strategies to achieve sustained treatment adherence. Objective: The objective of this study is to evaluate the effectiveness of a mobile health (mHealth) intervention based on SMS text messages to increase antiretroviral therapy (ART) adherence for HIV-positive adults. Methods: A randomized controlled trial was performed at the Hospital Civil de Guadalajara – Fray Antonio Alcalde on HIV-positive adults who had initiated ART. The mHealth intervention included the use of SMS text messages as a reminder system for upcoming medical examinations and ART resupply to increase adherence. This intervention was provided to 40 participants for a 6-month period. A control group (n=40) received medical attention by the standard protocol used in the hospital. Intervention effectiveness was assessed by quantifying CD4+ T cells and viral load, as well as a self-report of adherence by the patient. Results: The intervention group had greater adherence to ART than the control group (96% vs 92%; P<.001). In addition, the intervention group had better clinical characteristics, including a lower viral load (141 copies/mL vs 2413 copies/mL; P<.001) and a trend toward higher CD4+ T cells counts (399 cells/μL vs 290 cells/μL; P=.15). Conclusions: These results show that an mHealth intervention significantly improves ART adherence. Implementing mHealth programs could enhance the commitment of HIV-positive adults to their treatment. Trial Registration: ClinicalTrials.gov NCT05187741; https://clinicaltrials.gov/study/NCT05187741 
%R 10.2196/57540
%U https://mhealth.jmir.org/2025/1/e57540
%U https://doi.org/10.2196/57540