%0 Journal Article
%@ 2291-5222
%I JMIR Publications
%V 5
%N 5
%P e64
%T Assessing the Impact of a Novel Smartphone Application Compared With Standard Follow-Up on Mobility of Patients With Knee Osteoarthritis Following Treatment With Hylan G-F 20: A Randomized Controlled Trial
%A Skrepnik,Nebojsa
%A Spitzer,Andrew
%A Altman,Roy
%A Hoekstra,John
%A Stewart,John
%A Toselli,Richard
%+ Tucson Orthopaedic Institute, 5301 E. Grant Road, Tucson, AZ,, United States, 1 520 784 6140, NSkrepnik@tucsonortho.com
%K mobile health
%K mHealth
%K mobile apps
%K osteoarthritis
%K osteoarthritis, knee
%K hylan G-F 20
%K Synvisc
%D 2017
%7 09.05.2017
%9 Original Paper
%J JMIR Mhealth Uhealth
%G English
%X Background: Osteoarthritis (OA) is a leading cause of disability in the United States. Although no disease-modifying therapies exist, patients with knee OA who increase walking may reduce risk of functional limitations. Objective: The objective of the study is to evaluate the impact of a mobile app (OA GO) plus wearable activity monitor/pedometer (Jawbone UP 24) used for 90 days on the mobility of patients with knee OA treated with hylan G-F 20. Methods: Patients with knee OA aged 30 to 80 years who were eligible to receive hylan G-F 20 and were familiar with smartphone technology were enrolled in this randomized, multicenter, open-label study. Patients who had a body mass index above 35 kg/m2 were excluded. All patients received a single 6-mL injection of hylan G-F 20 and wore the Jawbone monitor. The patients were then randomized 1:1 to Jawbone and OA GO (Group A; n=107) with visible feedback (unblinded) or Jawbone only (Group B; n=104) with no visible feedback (blinded). The primary endpoint was mean change from baseline in steps per day at day 90 between Groups A and B. Results: Baseline characteristics were similar between groups. There were significant differences between the increases in least squares (LS) mean number of steps per day (1199 vs 467, P=.03) and the mean percentage change (35.8% vs 11.5%, P=.02) from baseline in favor of Group A over Group B. There was a greater reduction in pain from baseline during the 6-minute walk test in Group A versus Group B. (LS mean change: −55.3 vs −33.8, P=.007). Most patients (65.4%) and surveys of physicians (67.3%) reported they would be likely or very likely to use/recommend the devices. Patient Activity Measure-13 scores improved from baseline (LS mean change for Groups A and B: 5.0 vs 6.9), with no significant differences between groups. The occurrence of adverse events was similar in the 2 groups. Conclusions: Use of a novel smartphone app in conjunction with a wearable activity monitor provided additional improvement on mobility parameters such as steps per day and pain with walking in the 6-minute walk test in patients with knee OA who were treated with hylan G-F 20. Results also highlight the amenability of patients and physicians to using mobile health technology in the treatment of OA and suggest further study is warranted. 
%M 28487266
%R 10.2196/mhealth.7179
%U http://mhealth.jmir.org/2017/5/e64/
%U https://doi.org/10.2196/mhealth.7179
%U http://www.ncbi.nlm.nih.gov/pubmed/28487266