TY  - JOUR
AU  - Del Moral Trinidad, Luis Eduardo
AU  - Andrade Villanueva, Jaime Federico
AU  - Martínez Ayala, Pedro
AU  - Cabrera Silva, Rodolfo Ismael
AU  - Herrera Godina, Melva Guadalupe
AU  - González-Hernández, Luz Alicia
PY  - 2025
DA  - 2025/1/28
TI  - Effectiveness of an mHealth Intervention With Short Text Messages to Promote Treatment Adherence Among HIV-Positive Mexican Adults: Randomized Controlled Trial
JO  - JMIR Mhealth Uhealth
SP  - e57540
VL  - 13
KW  - HIV
KW  - treatment adherence
KW  - mobile health
KW  - mHealth
KW  - mHealth intervention
KW  - randomized clinical trial
KW  - text messages
KW  - eHealth intervention
KW  - sexual health
KW  - randomized controlled trial
KW  - RCT
AB  - Background: HIV continues to be a public health concern in Mexico and Latin America due to an increase in new infections, despite a decrease being observed globally. Treatment adherence is a pillar for achieving viral suppression. It prevents the spread of the disease at a community level and improves the quality and survival of people living with HIV. Thus, it is important to implement strategies to achieve sustained treatment adherence. Objective: The objective of this study is to evaluate the effectiveness of a mobile health (mHealth) intervention based on SMS text messages to increase antiretroviral therapy (ART) adherence for HIV-positive adults. Methods: A randomized controlled trial was performed at the Hospital Civil de Guadalajara – Fray Antonio Alcalde on HIV-positive adults who had initiated ART. The mHealth intervention included the use of SMS text messages as a reminder system for upcoming medical examinations and ART resupply to increase adherence. This intervention was provided to 40 participants for a 6-month period. A control group (n=40) received medical attention by the standard protocol used in the hospital. Intervention effectiveness was assessed by quantifying CD4+ T cells and viral load, as well as a self-report of adherence by the patient. Results: The intervention group had greater adherence to ART than the control group (96% vs 92%; P<.001). In addition, the intervention group had better clinical characteristics, including a lower viral load (141 copies/mL vs 2413 copies/mL; P<.001) and a trend toward higher CD4+ T cells counts (399 cells/μL vs 290 cells/μL; P=.15). Conclusions: These results show that an mHealth intervention significantly improves ART adherence. Implementing mHealth programs could enhance the commitment of HIV-positive adults to their treatment. Trial Registration: ClinicalTrials.gov NCT05187741; https://clinicaltrials.gov/study/NCT05187741 
SN  - 2291-5222
UR  - https://mhealth.jmir.org/2025/1/e57540
UR  - https://doi.org/10.2196/57540
DO  - 10.2196/57540
ID  - info:doi/10.2196/57540
ER  -