TY  - JOUR
AU  - Yu, Kaitao
AU  - Yin, Baobing
AU  - Zhu, Ying
AU  - Meng, Hongdao
AU  - Zhu, Wenwei
AU  - Lu, Lu
AU  - Wang, Junqiao
AU  - Chen, Shugeng
AU  - Ni, Jun
AU  - Lin, Yifang
AU  - Jia, Jie
PY  - 2025
DA  - 2025/4/7
TI  - Efficacy of a Digital Postoperative Rehabilitation Intervention in Patients With Primary Liver Cancer: Randomized Controlled Trial
JO  - JMIR Mhealth Uhealth
SP  - e59228
VL  - 13
KW  - digital health
KW  - surgery
KW  - exercise rehabilitation
KW  - randomized controlled trial
KW  - primary liver cancer
AB  - Background: Rehabilitation is considered a fundamental component of cancer treatment, especially for patients undergoing cancer surgery. In contrast to conventional rehabilitation education, digital rehabilitation has the potential to improve patients’ access to postoperative rehabilitation programs. While digital health has rapidly emerged to aid patients with various diseases, their clinical efficacy in the recovery of patients with primary liver cancer (PLC) undergoing hepatectomy remains inadequately investigated. Objective: This study aims to evaluate whether a digital postoperative rehabilitation intervention is efficient in improving physical fitness, enhancing exercise adherence, and alleviating fatigue among patients with PLC after hepatectomy. Methods: A randomized controlled trial was undertaken across 2 university-affiliated hospitals in Eastern China. A total of 100 participants were enrolled in this study and were allocated randomly to either the digital health (intervention group, n=50) or the rehabilitation manual-based group (control group, n=50) at a 1:1 ratio. Patients were unblinded and prospectively followed for the intervention of 3 weeks. Outcome measures included physical fitness, exercise adherence, and status of fatigue. Results: Overall, 91 out of 100 patients completed the research and were evaluated after 3 weeks of intervention. The digital health group showed better cardiopulmonary endurance than the control group. The mean difference in the change of 6-minute walk test distance from baseline between the groups was 70.21 (95% CI 0.730-82.869) m (P=.05). No statistically significant effects were found for grip strength, 5-repetition-sit-to-stand test time, and fatigue. The exercise adherence in the digital health group was higher than that in the control group (χ22=15.871, P<.001). Conclusions: The findings suggested that the implementation of digital health had a positive impact on recovery in exercise capacity after hepatectomy. In addition, rehabilitation exercise mode based on digital health has the potential to improve the exercise adherence of patients with PLC compared to conventional manual-based rehabilitation guidance. Trial Registration: Chinese Clinical Trial Registry ChiCTR2100052911; https://www.chictr.org.cn/showproj.html?proj=135351 
SN  - 2291-5222
UR  - https://mhealth.jmir.org/2025/1/e59228
UR  - https://doi.org/10.2196/59228
DO  - 10.2196/59228
ID  - info:doi/10.2196/59228
ER  -