TY  - JOUR
AU  - Braune, Katarina
AU  - O'Donnell, Shane
AU  - Cleal, Bryan
AU  - Lewis, Dana
AU  - Tappe, Adrian
AU  - Willaing, Ingrid
AU  - Hauck, Bastian
AU  - Raile, Klemens
PY  - 2019
DA  - 2019/07/30
TI  - Real-World Use of Do-It-Yourself Artificial Pancreas Systems in Children and Adolescents With Type 1 Diabetes: Online Survey and Analysis of Self-Reported Clinical Outcomes
JO  - JMIR Mhealth Uhealth
SP  - e14087
VL  - 7
IS  - 7
KW  - artificial pancreas
KW  - do it yourself
KW  - open source
KW  - mobile health
KW  - diabetes
KW  - type 1 diabetes
KW  - pediatric diabetes
KW  - closed loop
KW  - automated insulin delivery
AB  - Background: Patient-driven initiatives have made uptake of Do-it-Yourself Artificial Pancreas Systems (DIYAPS) increasingly popular among people with diabetes of all ages. Observational studies have shown improvements in glycemic control and quality of life among adults with diabetes. However, there is a lack of research examining outcomes of children and adolescents with DIYAPS in everyday life and their social context. Objective: This survey assesses the self-reported clinical outcomes of a pediatric population using DIYAPS in the real world. Methods: An online survey was distributed to caregivers to assess the hemoglobin A1c levels and time in range (TIR) before and after DIYAPS initiation and problems during DIYAPS use. Results: A total of 209 caregivers of children from 21 countries responded to the survey. Of the children, 47.4% were female, with a median age of 10 years, and 99.4% had type 1 diabetes, with a median duration of 4.3 years (SD 3.9). The median duration of DIYAPS use was 7.5 (SD 10.0) months. Clinical outcomes improved significantly, including the hemoglobin A1c levels (from 6.91% [SD 0.88%] to 6.27% [SD 0.67]; P<.001) and TIR (from 64.2% [SD 15.94] to 80.68% [SD 9.26]; P<.001). Conclusions: Improved glycemic outcomes were found across all pediatric age groups, including adolescents and very young children. These findings are in line with clinical trial results from commercially developed closed-loop systems. 
SN  - 2291-5222
UR  - http://mhealth.jmir.org/2019/7/e14087/
UR  - https://doi.org/10.2196/14087
UR  - http://www.ncbi.nlm.nih.gov/pubmed/31364599
DO  - 10.2196/14087
ID  - info:doi/10.2196/14087
ER  -