TY  - JOUR
AU  - Delrieu, Lidia
AU  - Pialoux, Vincent
AU  - Pérol, Olivia
AU  - Morelle, Magali
AU  - Martin, Agnès
AU  - Friedenreich, Christine
AU  - Febvey-Combes, Olivia
AU  - Pérol, David
AU  - Belladame, Elodie
AU  - Clémençon, Michel
AU  - Roitmann, Eva
AU  - Dufresne, Armelle
AU  - Bachelot, Thomas
AU  - Heudel, Pierre Etienne
AU  - Touillaud, Marina
AU  - Trédan, Olivier
AU  - Fervers, Béatrice
PY  - 2020
DA  - 2020/1/28
TI  - Feasibility and Health Benefits of an Individualized Physical Activity Intervention in Women With Metastatic Breast Cancer: Intervention Study
JO  - JMIR Mhealth Uhealth
SP  - e12306
VL  - 8
IS  - 1
KW  - metastatic breast cancer
KW  - physical activity
KW  - activity trackers
KW  - feasibility
KW  - tumor progression
AB  - Background: There is limited knowledge regarding the potential benefits of physical activity in patients with metastatic breast cancer. Objective: The Advanced stage Breast cancer and Lifestyle Exercise (ABLE) Trial aimed to assess the feasibility of a physical activity intervention in women with metastatic breast cancer and to explore the effects of physical activity on functional, psychological, and clinical parameters. Methods: The ABLE Trial was a single-arm, 6-month intervention study with a home-based, unsupervised, and personalized walking program using an activity tracker. At baseline and 6 months, we assessed anthropometrics, functional fitness, physical activity level, sedentary behavior, quality of life, fatigue, and tumor progression. Paired proportions were compared using the McNemar test and changes of parameters during the intervention were analyzed using the Wilcoxon signed-rank test, the Mann-Whitney test, and Spearman rank correlations. Results: Overall, 49 participants (mean age 55 years; recruitment rate 94%) were enrolled and 96% adhered to the exercise prescription (attrition rate 2%). Statistically significant improvements in the 6-minute walking distance test (+7%, P<.001) and isometric quadriceps strength (+22%, P<.001), as well as decreases in body mass index (-2.5%, P=.03) and hip circumference (-4.0%, P<.001) were observed at 6 months. Quality of life remained stable and a nonstatistically significant decrease (-16%, P=.07) in fatigue was observed. Conclusions: The high recruitment and adherence rates suggest the willingness of patients with metastatic breast cancer to participate in a physical activity program. The beneficial outcomes regarding physical fitness and anthropometry of this unsupervised physical activity program may encourage these patients to maintain a physically active lifestyle. Future randomized controlled trials with larger sample sizes are warranted. Trial Registration: ClinicalTrials.gov NCT03148886; https://clinicaltrials.gov/ct2/show/NCT03148886 
SN  - 2291-5222
UR  - https://mhealth.jmir.org/2020/1/e12306
UR  - https://doi.org/10.2196/12306
DO  - 10.2196/12306
ID  - info:doi/10.2196/12306
ER  -