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Prevalence of Multiple Chronic Conditions Among Adults in the All of Us Research Program: Exploratory Analysis

Prevalence of Multiple Chronic Conditions Among Adults in the All of Us Research Program: Exploratory Analysis

We conducted an exploratory cross-sectional analysis using the Ao U Controlled Tier version 7 data release in the secure, cloud-based Ao U Researcher Workbench platform (date of first access for research purposes: September 1, 2023; date of last access: June 16, 2024). Registered researchers can access the data through the Ao U Research Hub [7]. This study was exempt from ethical approval for human subjects research as only deidentified data were analyzed.

Xintong Li, Caitlin Dreisbach, Carolina M Gustafson, Komal Patel Murali, Theresa A Koleck

JMIR Form Res 2025;9:e69138

Machine Learning Model for Predicting Coronary Heart Disease Risk: Development and Validation Using Insights From a Japanese Population–Based Study

Machine Learning Model for Predicting Coronary Heart Disease Risk: Development and Validation Using Insights From a Japanese Population–Based Study

Therefore, this dataset is adequate to answer the research questions. Missing data analysis was conducted, and variables with more than 30% missing values were excluded to enhance model robustness. Missing data were imputed using Multivariate Imputation by Chained Equations. See Multimedia Appendix 1 for details on the percentage of missing data for each variable before imputation.

Thien Vu, Yoshihiro Kokubo, Mai Inoue, Masaki Yamamoto, Attayeb Mohsen, Agustin Martin-Morales, Research Dawadi, Takao Inoue, Jie Ting Tay, Mari Yoshizaki, Naoki Watanabe, Yuki Kuriya, Chisa Matsumoto, Ahmed Arafa, Yoko M Nakao, Yuka Kato, Masayuki Teramoto, Michihiro Araki

JMIR Cardio 2025;9:e68066

Digital Mental Health Interventions for Young People Aged 16-25 Years: Scoping Review

Digital Mental Health Interventions for Young People Aged 16-25 Years: Scoping Review

The approaches were as follows: some sessions were delivered in person or via telehealth communication (18/65, 27.7%); participants were able to speak to a professional or someone from the research team if needed (16/65, 24.6%); weekly check-ins were held with participants (12/65, 18.5%); the mental health of participants was monitored, and they were directed to professional help if needed (11/65, 16.9%); participants had peer group support (11/65, 16.9%); participants were already attending a mental health

Courtney Potts, Carmen Kealy, Jamie M McNulty, Alba Madrid-Cagigal, Thomas Wilson, Maurice D Mulvenna, Siobhan O'Neill, Gary Donohoe, Margaret M Barry

J Med Internet Res 2025;27:e72892

Effect of Early Treatment of Spasticity After Stroke on Motor Recovery: Protocol for the Baclotox Multicenter, Double-Blind, Double-Dummy Randomized Controlled Trial

Effect of Early Treatment of Spasticity After Stroke on Motor Recovery: Protocol for the Baclotox Multicenter, Double-Blind, Double-Dummy Randomized Controlled Trial

Because of the different modes of administration of these treatments, each group receives both an injection and oral tablets. The study therefore comprises three arms: (1) a “toxin” group treated with an injection of botulinum toxin and placebo oral baclofen; (2) a “baclofen” group treated with oral baclofen and an injection of placebo botulinum toxin; and (3) a double “placebo” group treated with placebo oral baclofen and an injection of placebo botulinum toxin.

Emmeline Montane, Nabila Brihmat, Camille Cormier, Claire Thalamas, Vanessa Rousseau, Gerard Tap, Xavier De Boissezon, Evelyne Castel-Lacanal, Baclotox Group, Philippe Marque

JMIR Res Protoc 2025;14:e62951

Machine Learning Clinical Decision Support for Interdisciplinary Multimodal Chronic Musculoskeletal Pain Treatment: Prospective Pilot Study of Patient Assessment and Prognostic Profile Validation

Machine Learning Clinical Decision Support for Interdisciplinary Multimodal Chronic Musculoskeletal Pain Treatment: Prospective Pilot Study of Patient Assessment and Prognostic Profile Validation

The Medical Research Ethics Committee Isala Zwolle, the Netherlands, previously reviewed the initial study (case number assigned: 200510), and as all patients have consented to the use of their data for research, further ethics approval was not required. This satisfies that the study was conducted in accordance with the principles outlined in the Declaration of Helsinki.

Fredrick Zmudzki, Rob J E M Smeets, Jan S Groenewegen, Erik van der Graaff

JMIR Rehabil Assist Technol 2025;12:e65890

Mono-Professional Simulation-Based Obstetric Training in a Low-Resource Setting: Stepped-Wedge Cluster Randomized Trial

Mono-Professional Simulation-Based Obstetric Training in a Low-Resource Setting: Stepped-Wedge Cluster Randomized Trial

The effect of the intervention was reported as an odds ratio, and the performance per treatment group was reported as a percentage or as an incidence rate ratio with 95% CI. Ethical approval was obtained from the Mulago Research and Ethics Committee (Protocol MREC: 674), and the Uganda National Council for Science and Technology (UNCST, SS 3927).

Anne A C van Tetering, Ella L de Vries, Peter Ntuyo, E R van den Heuvel, Annemarie F Fransen, M Beatrijs van der Hout-van der Jagt, Imelda Namagembe, Josaphat Byamugisha, S Guid Oei

JMIR Med Educ 2025;11:e54911

Telenursing Health Education and Lifestyle Modification Among Patients With Diabetes in Bangladesh: Protocol for a Pilot Study With a Quasi-experimental Pre- and Postintervention Design

Telenursing Health Education and Lifestyle Modification Among Patients With Diabetes in Bangladesh: Protocol for a Pilot Study With a Quasi-experimental Pre- and Postintervention Design

Group education (1 group of less than 20 patients) will be provided at the PHC by the nurses on the scheduled date (1 group education is set for 2 hours). One week after the group session, telephone calls from the nurses (telenursing education) will be provided weekly on the first month, then biweekly from the second month to the six month.

Michiko Moriyama, K A T M Ehsanul Huq, Lucy Mondol, Akhi Roy Mita, Niru Shamsun Nahar

JMIR Res Protoc 2025;14:e71849

Use and Acceptance of Innovative Digital Health Solutions Among Patients and Professionals: Survey Study

Use and Acceptance of Innovative Digital Health Solutions Among Patients and Professionals: Survey Study

Every nonmedical professional from the general population is considered a patient for research purposes. An anonymous web-based survey, adopted from some of the authors’ [FS, VF, GME, DP] earlier research in 2018 [8], was conducted between April and September 2023 via the scientific survey platform So Sci Survey [9] hosted on German servers complying with European data protection laws.

Fritz Seidl, Florian Hinterwimmer, Ferdinand Vogt, Günther M Edenharter, Karl F Braun, Rüdiger von Eisenhart-Rothe, AG Digitalisierung der DGOU, Peter Biberthaler, Dominik Pförringer

JMIR Hum Factors 2025;12:e60779

Real-World Effectiveness of Glucose-Guided Eating Using the Data-Driven Fasting App Among Adults Interested in Weight and Glucose Management: Observational Study

Real-World Effectiveness of Glucose-Guided Eating Using the Data-Driven Fasting App Among Adults Interested in Weight and Glucose Management: Observational Study

In addition, self-monitoring of glucose in research settings has historically been done with paper-and-pen logs, whereas DDF uses a mobile app that features progress tracking and educational resources. The increasing availability of glucose monitoring technology enhances the relevance and potential impact of DDF.

Michelle R Jospe, Martin Kendall, Susan M Schembre, Melyssa Roy

JMIR Form Res 2025;9:e65368