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Ayurvedic Management of Presbycusis (Project TOPMAC): Protocol for an Exploratory Randomized Controlled Trial

Ayurvedic Management of Presbycusis (Project TOPMAC): Protocol for an Exploratory Randomized Controlled Trial

The administration of the water extract from Ashwagandha (100 mg/kg/d) with drinking water for 8 months has shown to be safe and showed no toxicity in rats [21]. Ashwagandha may operate as a gamma-aminobutyric acid mimetic, cholinomimetic, and agonist for α-7 nicotinic receptors for cognitive function protection [22]. However, no clinical trials or documented data are available on the efficacy of these drugs for presbycusis treatment, despite being widely used in clinics.

Krishna Kumar V, Sanjeev V Thomas, Murugan C Nair, Parvathy G Nair, Nisha M L, Anuradha S, Arunabh Tripathi, Pallavi Mundada, Babita Yadav, B C S Rao, Sudhakar D, Srikanth N

JMIR Res Protoc 2024;13:e55089

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