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Ayurvedic Management of Presbycusis (Project TOPMAC): Protocol for an Exploratory Randomized Controlled Trial

Ayurvedic Management of Presbycusis (Project TOPMAC): Protocol for an Exploratory Randomized Controlled Trial

Withania somnifera (L.) Dunal (Ashwagandha) is another medicine commonly used, as it can regenerate damaged nerve cells and thereby improve nerve function [18]. Recent reviews have shown Ashwagandha as a potent medicine for cognitive function protection [19]. A randomized controlled trial has shown that Ashwagandha effectively enhanced immediate and general memory in individuals with mild cognitive impairment and improved attention, executive function, and information processing speed [20].

Krishna Kumar V, Sanjeev V Thomas, Murugan C Nair, Parvathy G Nair, Nisha M L, Anuradha S, Arunabh Tripathi, Pallavi Mundada, Babita Yadav, B C S Rao, Sudhakar D, Srikanth N

JMIR Res Protoc 2024;13:e55089

Using Laboratory Test Results for Surveillance During a New Outbreak of Acute Hepatitis in 3-Week- to 5-Year-Old Children in the United Kingdom, the Netherlands, Ireland, and Curaçao: Observational Cohort Study

Using Laboratory Test Results for Surveillance During a New Outbreak of Acute Hepatitis in 3-Week- to 5-Year-Old Children in the United Kingdom, the Netherlands, Ireland, and Curaçao: Observational Cohort Study

While there is variation by region, the upper limit of normal (ULN) for AST and ALT in children is usually around 50 U/L and 40 U/L, respectively, meaning that our cutoff is roughly 4‐5 times the ULN, and is typically considered a mild to moderate elevation [14]. These statistics were calculated for each month in our study period in the age groups of younger than 3 weeks old, 3 weeks to 5 years old, 6‐16 years old, 17‐50 years old, and older than 50 years.

Maaike C Swets, Steven R Kerr, Brian MacKenna, Louis Fisher, Merel van Wijnen, Diederik Brandwagt, Paul W Schenk, Pieter Fraaij, Leonardus G Visser, Sebastian Bacon, Amir Mehrkar, Alistair Nichol, Patrick Twomey, Philippa C Matthews, ISARIC4C Hepatitis Study Group, Malcolm G Semple, Geert H Groeneveld, Ben Goldacre, Iain Jones, J Kenneth Baillie

JMIR Public Health Surveill 2024;10:e55376

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