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Uncovering Social States in Healthy and Clinical Populations Using Digital Phenotyping and Hidden Markov Models: Observational Study

Uncovering Social States in Healthy and Clinical Populations Using Digital Phenotyping and Hidden Markov Models: Observational Study

(E) The total dwell time was compared to clinical measures. (F) Lower socially active dwell time in AD versus HCs, and an interaction between socially active dwell time and AD when predicting social functioning, were observed. AD: Alzheimer disease; HC: healthy control; SCC: subjective cognitive complaints; SZ: schizophrenia; S1: state 1; S2: state 2; zt: hidden state at time point, t.

Imogen E Leaning, Andrea Costanzo, Raj Jagesar, Lianne M Reus, Pieter Jelle Visser, Martien J H Kas, Christian F Beckmann, Henricus G Ruhé, Andre F Marquand

J Med Internet Res 2025;27:e64007

Sex Differences in the Variability of Physical Activity Measurements Across Multiple Timescales Recorded by a Wearable Device: Observational Retrospective Cohort Study

Sex Differences in the Variability of Physical Activity Measurements Across Multiple Timescales Recorded by a Wearable Device: Observational Retrospective Cohort Study

The results from these tests and the distributions compared with these tests are shown in most of the figures and tables (Figures 1 C-E, 2 A-D, 3 D, and 4 A and 4 B; Figures S2-S5 in Multimedia Appendix 1). Population SDs of the subpopulations described were calculated for their relevance to power analysis (Tables S1 and S2 in Multimedia Appendix 1).

Kristin J Varner, Lauryn Keeler Bruce, Severine Soltani, Wendy Hartogensis, Stephan Dilchert, Frederick M Hecht, Anoushka Chowdhary, Leena Pandya, Subhasis Dasgupta, Ilkay Altintas, Amarnath Gupta, Ashley E Mason, Benjamin L Smarr

J Med Internet Res 2025;27:e66231

Moderators’ Experiences of the Safety and Effectiveness of Patient Engagement in an Asthma Online Health Community: Exploratory Qualitative Interview Study

Moderators’ Experiences of the Safety and Effectiveness of Patient Engagement in an Asthma Online Health Community: Exploratory Qualitative Interview Study

private message (ie, a message sent between users, not published on the OHC and only seen by moderators if reported by a user) was against the rules and when contacting users, the moderators mentioned that they often referred to a published set of community guidelines, which users agreed to abide by when they signed up to the OHC: If I get an inappropriate post, I review it to make sure what part of the terms and conditions it’s breaking, then I’ll delete the post and then I’ll send a warning to the member, via e-mail

Helen E Wood, Georgios Dimitrios Karampatakis, Neil S Coulson, Nishanth Sastry, Xiancheng Li, Stephanie J C Taylor, Chris J Griffiths, Anna De Simoni

J Med Internet Res 2025;27:e58167

Relationship Between Within-Session Digital Motor Skill Acquisition and Alzheimer Disease Risk Factors Among the MindCrowd Cohort: Cross-Sectional Descriptive Study

Relationship Between Within-Session Digital Motor Skill Acquisition and Alzheimer Disease Risk Factors Among the MindCrowd Cohort: Cross-Sectional Descriptive Study

However, these examples have overall low sensitivity to risk factors of AD, such as age [10], sex [11], apolipoprotein-E (APOE) ε4 carrier status [12,13], and brain amyloid [9]. Considering this, another potential digital biomarker of AD could be motor skill. Motor skill acquisition is the within-session improvement in a motor skill as a function of practice [14].

Andrew Hooyman, Matt J Huentelman, Matt De Both, Lee Ryan, Kevin Duff, Sydney Y Schaefer

JMIR Aging 2025;8:e67298