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Effect of Early Treatment of Spasticity After Stroke on Motor Recovery: Protocol for the Baclotox Multicenter, Double-Blind, Double-Dummy Randomized Controlled Trial

Effect of Early Treatment of Spasticity After Stroke on Motor Recovery: Protocol for the Baclotox Multicenter, Double-Blind, Double-Dummy Randomized Controlled Trial

Because of the different modes of administration of these treatments, each group receives both an injection and oral tablets. The study therefore comprises three arms: (1) a “toxin” group treated with an injection of botulinum toxin and placebo oral baclofen; (2) a “baclofen” group treated with oral baclofen and an injection of placebo botulinum toxin; and (3) a double “placebo” group treated with placebo oral baclofen and an injection of placebo botulinum toxin.

Emmeline Montane, Nabila Brihmat, Camille Cormier, Claire Thalamas, Vanessa Rousseau, Gerard Tap, Xavier De Boissezon, Evelyne Castel-Lacanal, Baclotox Group, Philippe Marque

JMIR Res Protoc 2025;14:e62951

Telehealth Initiative to Enhance Primary Care Access in Brazil (UBS+Digital Project): Multicenter Prospective Study

Telehealth Initiative to Enhance Primary Care Access in Brazil (UBS+Digital Project): Multicenter Prospective Study

In order to facilitate this process, an instant group at a messaging app was created for ESF team professionals and local managers to forward their questions. Additionally, synchronous meetings were organized to discuss telehealth experiences from the UBS+Digital project, allowing teams from different PHUs to present their successful cases, meet external speakers, and further engage in collaborative learning.

Celina de Almeida Lamas, Patrícia Gabriela Santana Alves, Luciano Nader de Araújo, Ana Beatriz de Souza Paes, Ana Claudia Cielo, Luciana Maciel de Almeida Lopes, André Longo Araújo de Melo, Thais Yokoyama, Clarice Pagani Savastano, Paula Gobi Scudeller, Carlos Carvalho, Digital Primary Health Unit HCFMUSP Study Group

J Med Internet Res 2025;27:e68434

School-Based Virtual Reality Programming for Obtaining Moderate-Intensity Exercise Among Children With Disabilities: Pre-Post Feasibility Study

School-Based Virtual Reality Programming for Obtaining Moderate-Intensity Exercise Among Children With Disabilities: Pre-Post Feasibility Study

The development phase included a 4-month preparation phase, where study staff worked with a community engagement group to modify a working VR randomized controlled trial home-based protocol to a local public high school setting. The 9-month implementation phase used a “learn-as-you-go” approach with a single group pre- to posttrial design to test the implementation of the developed VR HMD school-based protocol.

Byron Lai, Ashley Wright, Bailey Hutchinson, Larsen Bright, Raven Young, Drew Davis, Sultan Ali Malik, James H Rimmer, Pelham High Community Engagement Group

JMIR Form Res 2025;9:e65801

Assessment of Health System Readiness and Quality of Dementia Services in Peru: Protocol for a Qualitative Study With Stakeholder Interviews and Documentation Review

Assessment of Health System Readiness and Quality of Dementia Services in Peru: Protocol for a Qualitative Study With Stakeholder Interviews and Documentation Review

The 10/66 Dementia Research Group study [25] highlights the high cost of dementia for health systems and the negative mental health impacts on women in LMICs, who are often primary caregivers for people with dementia [26]. This underscores the need for further research on dementia diagnosis and care in LMICs and for directing it effectively toward impactful decision-making.

Maria Lazo-Porras, Francisco Jose Tateishi-Serruto, Christopher Butler, María Sofía Cuba-Fuentes, Daniela Rossini-Vilchez, Silvana Perez-Leon, Miriam Lúcar-Flores, J Jaime Miranda, Antonio Bernabe-Ortiz, Francisco Diez-Canseco, Graham Moore, Filipa Landeiro, Maria Kathia Cardenas, Juan Carlos Vera Tudela, Lee White, Rafael A Calvo, William Whiteley, Jemma Hawkins, IMPACT Salud Study Group

JMIR Res Protoc 2025;14:e60296

Understanding the Engagement and Interaction of Superusers and Regular Users in UK Respiratory Online Health Communities: Deep Learning–Based Sentiment Analysis

Understanding the Engagement and Interaction of Superusers and Regular Users in UK Respiratory Online Health Communities: Deep Learning–Based Sentiment Analysis

Regular users’ and superusers’ sentiments when replying to each other: To do this, we first identified threads started by regular users and superusers, denoted as TU and TS, and calculated the AVS of replies written by the other group of users. Specifically, we computed , which denotes the average sentiment of regular users in reply to superusers' initiated threads; and , which denotes the average sentiment of superusers in reply to regular users' initiated threads.

Xiancheng Li, Emanuela Vaghi, Gabriella Pasi, Neil S Coulson, Anna De Simoni, Marco Viviani, AD HOC Group

J Med Internet Res 2025;27:e56038

Status of Digital Health Technology Adoption in 5 Vietnamese Hospitals: Cross-Sectional Assessment

Status of Digital Health Technology Adoption in 5 Vietnamese Hospitals: Cross-Sectional Assessment

The selected hospitals were identified from a professional network that the study’s principal investigators (authors LT and CP) were part of. The hospitals were invited to participate in the assessment through an invitation letter explaining the purpose and scope of the study. Upon approval by the hospitals’ authorities, the hospital IT directors were provided with an information sheet, the questionnaire, and an instruction document.

Duc Minh Tran, Nguyen Thanh Dung, Chau Minh Duc, Huynh Ngoc Hon, Le Minh Khoi, Nguyen Phuc Hau, Duong Thi Thu Huyen, Huynh Thi Le Thu, Tran Van Duc, VITAL (Vietnam ICU Translational Applications Laboratory) Investigators, Lam Minh Yen, C Louise Thwaites, Chris Paton

JMIR Form Res 2025;9:e53483

Text Messaging Versus Postal Reminders to Improve Participation in a Colorectal Cancer Screening Program: Randomized Controlled Trial

Text Messaging Versus Postal Reminders to Improve Participation in a Colorectal Cancer Screening Program: Randomized Controlled Trial

The recovery strategy involved a postal reminder for all nonrespondents within the intervention group if they were still eligible to participate (SMS text message reminder received within the last 10 weeks). This strategy aimed to reduce nonparticipation in the intervention group and, therefore, mitigate the impact of the nonresponse of the intervention group and prevent ethical issues.

Nuria Vives, Gemma Binefa, Noemie Travier, Albert Farre, Jon Aritz Panera, Berta Casas, Carmen Vidal, Gemma Ibáñez-Sanz, Montse Garcia, M-TICS research group

JMIR Mhealth Uhealth 2025;13:e64243