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Incidence, Prognostic Factors, and Treatment Impact on Survival in Natural Killer/T-Cell Lymphoma: Population-Based Study in the United States

Incidence, Prognostic Factors, and Treatment Impact on Survival in Natural Killer/T-Cell Lymphoma: Population-Based Study in the United States

When grouped by year of diagnosis, there was a significant improvement in survival over the years (P Survival was significantly better in patients diagnosed with NKTL as their initial tumor compared to those who had other types of tumors previously.

Yi Zhao, Yi Zhong, Mengqi Xiong, Linlin Huang, Xiujin Ye, Jingsong He

JMIR Form Res 2025;9:e70129

Effectiveness of AI-Driven Conversational Agents in Improving Mental Health Among Young People: Systematic Review and Meta-Analysis

Effectiveness of AI-Driven Conversational Agents in Improving Mental Health Among Young People: Systematic Review and Meta-Analysis

Results revealed that sample type significantly moderated the ESs at posttest (Qb=8.46, P.10). Results of meta-regression analyses were presented in Table 3. β coefficients represent the estimated change in the effect size (Hedges g) associated with a one-unit increase in the predictor variable. P value represents the significance of the z test. Results indicated that none of the variables (ie, mean age, publication year, sex, and quality criteria) were significant moderators (P>.05).

Yi Feng, Yaming Hang, Wenzhi Wu, Xiaohang Song, Xiyao Xiao, Fangbai Dong, Zhihong Qiao

J Med Internet Res 2025;27:e69639

Developing the MyCancerGene Digital Health Portal to Improve Patients’ Understanding of Germline Cancer Genetic Test Results: Development, User, and Usability Testing Study

Developing the MyCancerGene Digital Health Portal to Improve Patients’ Understanding of Germline Cancer Genetic Test Results: Development, User, and Usability Testing Study

Those with a positive result were significantly more likely to report that a GHP would be helpful (odds ratio [OR] 10.9, 95% CI 2.2-54.0, P=.003) and that they would use a GHP (compared to true negatives: OR 7.2, 95% CI 2.1-25.0, P=.002). Nonetheless, over 75% (25/33) of those with a VUS or uninformative negative results reported a GHP would be helpful. Another factor associated with likely GHP use was history of prior health care portal use (OR 2.5, 95% CI 1.4-4.4, P=.001).

Phillip Trieu, Dominique Fetzer, Briana McLeod, Kathryn Schweickert, Lauren Gutstein, Brian Egleston, Susan Domchek, Linda Fleisher, Lynne Wagner, Kuang-Yi Wen, Cara Cacioppo, Jessica E Ebrahimzadeh, Dana Falcone, Claire Langer, Elisabeth Wood, Kelsey Karpink, Shelby Posen, Enida Selmani, Angela R Bradbury

JMIR Form Res 2025;9:e56282

Effects of Digital Sleep Interventions on Sleep Among College Students and Young Adults: Systematic Review and Meta-Analysis

Effects of Digital Sleep Interventions on Sleep Among College Students and Young Adults: Systematic Review and Meta-Analysis

Digital sleep interventions demonstrated a significant medium effect on sleep efficiency (Hedges g=0.62, 95% CI 0.18-1.05; P=.005; I2=60%), with substantial heterogeneity among studies. However, nonsignificant effects were observed for NWAK (P=.27), TST (P=.07), and WASO (P=.18). The detailed results are provided in Figure 4 [42,45,49,50]. Although sleep parameters are crucial outcomes, the certainty of the evidence ranged from “very low” to “low” (Table S1 in Multimedia Appendix 4).

Yi-An Lu, Hui-Chen Lin, Pei-Shan Tsai

J Med Internet Res 2025;27:e69657

Large Language Models and Artificial Neural Networks for Assessing 1-Year Mortality in Patients With Myocardial Infarction: Analysis From the Medical Information Mart for Intensive Care IV (MIMIC-IV) Database

Large Language Models and Artificial Neural Networks for Assessing 1-Year Mortality in Patients With Myocardial Infarction: Analysis From the Medical Information Mart for Intensive Care IV (MIMIC-IV) Database

Calibration was considered optimal when the calibration curve was close to the diagonal line, reflected by an observed-to-expected ratio near 1 [14], and the Hosmer-Lemeshow test showed a P value greater than .05. The precision-recall curve was also used to compare different models in the highly skewed data set, addressing the optimism of the ROC curve [15].

Boqun Shi, Liangguo Chen, Shuo Pang, Yue Wang, Shen Wang, Fadong Li, Wenxin Zhao, Pengrong Guo, Leli Zhang, Chu Fan, Yi Zou, Xiaofan Wu

J Med Internet Res 2025;27:e67253

Population-Wide Depression Incidence Forecasting Comparing Autoregressive Integrated Moving Average and Vector Autoregressive Integrated Moving Average to Temporal Fusion Transformers: Longitudinal Observational Study

Population-Wide Depression Incidence Forecasting Comparing Autoregressive Integrated Moving Average and Vector Autoregressive Integrated Moving Average to Temporal Fusion Transformers: Longitudinal Observational Study

Among stable periods, t tests comparing the SMAPE of these 4 models (Figure 3) showed that the average SMAPE at 11.6% for multivariate TFT was significantly lower than the SMAPE for univariate TFT at 13.2% (P=.01), for VARIMA at 16.4% (P=.002), and for ARIMA at 14.8% (P=.003) of the same data. Univariate TFT also outperformed VARIMA (P=.03), while there was no significant difference between VARIMA and ARIMA.

Deliang Yang, Yiyi Tang, Vivien Kin Yi Chan, Qiwen Fang, Sandra Sau Man Chan, Hao Luo, Ian Chi Kei Wong, Huang-Tz Ou, Esther Wai Yin Chan, David Makram Bishai, Yingyao Chen, Martin Knapp, Mark Jit, Dawn Craig, Xue Li

J Med Internet Res 2025;27:e67156