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Peer Review of “Raw, Unadulterated African Honey for Ulcer Healing in Leprosy: Protocol for the Honey Experiment on Leprosy Ulcer (HELP) Randomized Controlled Trial”

Peer Review of “Raw, Unadulterated African Honey for Ulcer Healing in Leprosy: Protocol for the Honey Experiment on Leprosy Ulcer (HELP) Randomized Controlled Trial”

This is the peer-review report for “Raw, Unadulterated African Honey for Ulcer Healing in Leprosy: Protocol for the Honey Experiment on Leprosy Ulcer (HELP) Randomized Controlled Trial.” This is an excellent interventional protocol for a randomized controlled trial assessing honey as a potential ulcer therapeutic [1]. Careful consideration has been made to avoid bias and ensure robust results. I would suggest a few things to consider (below) prior to publishing.

Anonymous, ­ Anonymous

JMIRx Med 2024;5:e56498

Peer Review of “Raw, Unadulterated African Honey for Ulcer Healing in Leprosy: Protocol for the Honey Experiment on Leprosy Ulcer (HELP) Randomized Controlled Trial”

Peer Review of “Raw, Unadulterated African Honey for Ulcer Healing in Leprosy: Protocol for the Honey Experiment on Leprosy Ulcer (HELP) Randomized Controlled Trial”

This is the peer-review report for “Raw, Unadulterated African Honey for Ulcer Healing in Leprosy: Protocol for the Honey Experiment on Leprosy Ulcer (HELP) Randomized Controlled Trial.” This paper is a protocol description of an important study [1], especially for contexts in which advanced wound care products are often not available. It is a well-written protocol with clear steps to take. Below are some of my feedback; I also included some small textual feedback points in the text.

Anonymous, Anonymous

JMIRx Med 2024;5:e57310

Authors’ Response to Peer Reviews of “Raw, Unadulterated African Honey for Ulcer Healing in Leprosy: Protocol for the Honey Experiment on Leprosy Ulcer (HELP) Randomized Controlled Trial”

Authors’ Response to Peer Reviews of “Raw, Unadulterated African Honey for Ulcer Healing in Leprosy: Protocol for the Honey Experiment on Leprosy Ulcer (HELP) Randomized Controlled Trial”

This is the authors’ response to peer-review reports for “Raw, Unadulterated African Honey for Ulcer Healing in Leprosy: Protocol for the Honey Experiment on Leprosy Ulcer (HELP) Randomized Controlled Trial.” All the editorial comments are noted and carefully followed. This is an excellent interventional protocol for a randomized controlled trial assessing honey as a potential ulcer therapeutic. Careful consideration has been made to avoid bias and ensure robust results.

Sunday Udo, Pius Ogbu Sunday, Paul Alumbugu Tsaku, Israel Olaoluwa Oladejo, Anthony Meka, Linda Chinonso Ugwu, Motunrayo Ajisola, Joshua Akinyemi, Abiola Oladejo, Akinyinka Omigbodun, Sopna Mannan Choudhury, Jo Sartori, Onaedo Ilozumba, Sam Watson, Richard Lilford

JMIRx Med 2024;5:e56442

Raw, Unadulterated African Honey for Ulcer Healing in Leprosy: Protocol for the Honey Experiment on Leprosy Ulcer (HELP) Randomized Controlled Trial

Raw, Unadulterated African Honey for Ulcer Healing in Leprosy: Protocol for the Honey Experiment on Leprosy Ulcer (HELP) Randomized Controlled Trial

This study will evaluate the effectiveness of honey in the treatment of ulcers in leprosy in comparison with normal saline dressing. The aim of this study, Honey Experiment on Leprosy Ulcer (HELP), is to evaluate the healing properties of raw, unadulterated African honey in comparison with normal saline dressing for the treatment of leprosy ulcers. The study objectives are as follows: Recruit 90‐130 eligible, consenting people within 12 months.

Sunday Udo, Pius Ogbu Sunday, Paul Alumbugu Tsaku, Israel Olaoluwa Oladejo, Anthony Meka, Linda Chinonso Ugwu, Motunrayo Ajisola, Joshua Akinyemi, Abiola Oladejo, Akinyinka Omigbodun, Sopna Mannan Choudhury, Jo Sartori, Onaedo Ilozumba, Sam Watson, Richard Lilford

JMIRx Med 2024;5:e50970

Participatory Development and Assessment of Audio-Delivered Interventions and Written Material and Their Impact on the Perception, Knowledge, and Attitudes Toward Leprosy in Nigeria: Protocol for a Cluster Randomized Controlled Trial

Participatory Development and Assessment of Audio-Delivered Interventions and Written Material and Their Impact on the Perception, Knowledge, and Attitudes Toward Leprosy in Nigeria: Protocol for a Cluster Randomized Controlled Trial

Stigma reduction (which often consists of positively influencing the perception of leprosy and increasing knowledge of leprosy) is crucial to improving the lives of people affected by leprosy and to improving leprosy services. Several interventions have successfully reduced leprosy-related stigma [21-24]. Interventions that are culture-specific and contextualized tend to be more effective [25,26]. Nigeria is among 23 global priority countries identified by the World Health Organization (WHO).

Ngozi Murphy-Okpala, Tahir Dahiru, Anna T van ’t Noordende, Carolin Gunesch, Joseph Chukwu, Charles Nwafor, Suleiman Hudu Abdullahi, Chukwuma Anyaike, Ugochinyere Angelic Okereke, Anthony Meka, Chinwe Eze, Okechukwu Ezeakile, Ngozi Ekeke

JMIR Res Protoc 2024;13:e53130

From the Cochrane Library: Interventions for Ulceration and Other Skin Changes Caused by Nerve Damage in Leprosy

From the Cochrane Library: Interventions for Ulceration and Other Skin Changes Caused by Nerve Damage in Leprosy

Leprosy (Hansen disease) is a chronic and infectious bacterial disease that was responsible for 127,558 new cases worldwide in 2020 [1]. The disease is most prevalent in developing countries, particularly in India, Indonesia, Brazil, Nigeria, and Bangladesh [2]. The pathogenic bacteria responsible for the disease, Mycobacterium leprae, infects peripheral nerves, causing nerve damage and sensory loss in up to 30% of patients [2].

Lachlan Anderson, Madeline Adelman, Liv Merete Reinar, Robert P Dellavalle

JMIR Dermatol 2023;6:e47148

A Review of Software and Mobile Apps to Support the Clinical Diagnosis of Hansen Disease

A Review of Software and Mobile Apps to Support the Clinical Diagnosis of Hansen Disease

Hansen disease, or leprosy, is a chronic infectious disease caused by Mycobacterium leprae (M leprae). It mainly affects the skin’s superficial nerves and peripheral nerve trunks and can also impact the eyes and internal organs. If untreated, leprosy becomes contagious and can lead to physical disabilities. Additionally, it imposes significant social, emotional, and economic burdens [1]. The diagnosis of leprosy is based on assessing clinical presentation, including signs and symptoms.

Wilbert Dener Lemos Costa, Alan Maicon de Oliveira, Guilherme José Aguilar, Luana Michelly Aparecida Costa dos Santos, Luiz Ricardo Albano dos Santos, Dantony de Castro Barros Donato, Felipe Foresto, Marco Andrey Cipriani Frade

JMIR Dermatol 2023;6:e47142

Leprosy Screening Based on Artificial Intelligence: Development of a Cross-Platform App

Leprosy Screening Based on Artificial Intelligence: Development of a Cross-Platform App

Therefore, there is a long way to go to achieve the following criteria for leprosy elimination: (1) confirmed absence of children with leprosy for 5 consecutive years and (2) confirmed absence of new leprosy cases for 10 years [2]. Currently, the conventional diagnosis of leprosy is typically based on clinical evaluation alone, especially when histopathological analysis is not available.

Márcio Luís Moreira De Souza, Gabriel Ayres Lopes, Alexandre Castelo Branco, Jessica K Fairley, Lucia Alves De Oliveira Fraga

JMIR Mhealth Uhealth 2021;9(4):e23718