Published on 05.08.19 in Vol 7, No 8 (2019): August
Preprints (earlier versions) of this paper are available at http://preprints.jmir.org/preprint/14991, first published Jun 10, 2019.
German Mobile Apps in Rheumatology: Review and Analysis Using the Mobile Application Rating Scale (MARS)
Background: Chronic rheumatic diseases need long-term treatment and professional supervision. Mobile apps promise to improve the lives of patients and physicians. In routine practice, however, rheumatology apps are largely unknown and little is known about their quality and safety.
Objective: The aim of this study was to provide an overview of mobile rheumatology apps currently available in German app stores, evaluate app quality using the Mobile Application Rating Scale (MARS), and compile brief, ready-to-use descriptions for patients and rheumatologists.
Methods: The German App Store and Google Play store were systematically searched to identify German rheumatology mobile apps for patient and physician use. MARS was used to independently assess app quality by 8 physicians, 4 using Android and 4 using iOS smartphones. Apps were randomly assigned so that 4 apps were rated by all raters and the remaining apps were rated by two Android and two iOS users. Furthermore, brief app descriptions including app developers, app categories, and features were compiled to inform potential users and developers.
Results: In total, 128 and 63 apps were identified in the German Google Play and App Store, respectively. After removing duplicates and only including apps that were available in both stores, 28 apps remained. Sixteen apps met the inclusion criteria, which were (1) German language, (2) availability in both app stores, (3) targeting patients or physicians as users, and (4) clearly including rheumatology or rheumatic diseases as subject matter. Exclusion criteria were (1) congress apps and (2) company apps with advertisements. Nine apps addressed patients and 7 apps addressed physicians. No clinical studies to support the effectiveness and safety of apps could be found. Pharmaceutical companies were the main developers of two apps. Rheuma Auszeit was the only app mainly developed by a patient organization. This app had the highest overall MARS score (4.19/5). Three out of 9 patient apps featured validated questionnaires. The median overall MARS score was 3.85/5, ranging from 2.81/5 to 4.19/5. One patient-targeted and one physician-targeted app had MARS scores >4/5. No significant rater gender or platform (iOS/Android) differences could be observed. The overall correlation between app store ratings and MARS scores was low and inconsistent between platforms.
Conclusions: To our knowledge, this is the first study that systematically identified and evaluated mobile apps in rheumatology for patients and physicians available in German app stores. We found a lack of supporting clinical studies, use of validated questionnaires, and involvement of academic developers. Overall app quality was heterogeneous. To create high-quality apps, closer cooperation led by patients and physicians is vital.
JMIR Mhealth Uhealth 2019;7(8):e14991
There is great potential in using eHealth tools, especially in chronic rheumatic diseases . In the anticipated reality of Rheumatology 4.0 computer-aided diagnostic systems allowing precise and quick diagnosis [ ], mobile apps and other eHealth tools could improve the positions of all stakeholders, including patients, physicians, health insurance companies, and the pharmaceutical industry.
The use of diagnostic decision support systems could shorten the time to correct diagnosis, even for rare diseases . Once a correct diagnosis is established, patients and physicians need to maintain disease control, which necessitates continuous monitoring of treatment adherence, accurate symptom tracking, and surveillance of adverse treatment effects. eHealth is promising to increase the quantity, quality, and availability of medical data, thus allowing a more precise and personalized treatment. A recent study showed that remote monitoring of disease activity using physical activity trackers precisely detects flareups in patients with rheumatoid arthritis [ ]. This is a good example in which an accurate clinical assessment is accomplished using an eHealth tool without necessitating a direct patient-physician encounter. Such tools could drastically increase the efficiency of health care delivery.
The development of apps is becoming easier and less expensive thanks to the lack of restrictions on interventions in app stores. These low market barriers attract various businesses that seek to seize the opportunity of entering the profitable health care market . This leads to considerable heterogeneity regarding security and quality in general.
Quality indicators for health care–related apps beyond the app store star ratings, comments, and number of downloads are largely unavailable. Trust marks and certification labels (like CE marking indicating conformity with health, safety, and environmental protection standards for products sold within the European Economic Area) for apps are rarely found , making quality assessment of an app a challenge for the end user. A number of tools have been proposed to this end [ , ]. Among the relatively established tools to rate app quality is the validated Mobile Application Rating Scale (MARS) [ ]. Since its publication in 2015, it has been used to rate various medical mobile apps [ , ]. The MARS score is based on a 5-point Likert scale in four sections with multiple items: engagement (5 items), functionality (4 items), aesthetics (3 items), and information quality (7 items). In addition, there is a subjective section consisting of 4 items.
A New Zealand study recently reported the results of a MARS assessment evaluating patient apps for rheumatoid arthritis and found a lack of high-quality apps . Such systematic quality assessments are scarce and represent an unmet need. A recent survey conducted by the Working Group Young Rheumatology of the German Society for Rheumatology (Arbeitsgemeinschaft Junge Rheumatologie, or rheumadocs) showed that medical app use among German rheumatologists increased by 12% during two years, yet rheumatologists were aware of only two recommendable apps specific to rheumatology (RheumaHelper, RheumaLive) [ ].
To our knowledge, no systematic quality assessment of rheumatology apps available in German app stores has yet been carried out. Therefore, the aim of this study was to identify and evaluate rheumatology-specific German mobile apps targeting patients or physicians.
Selection of Mobile Apps
An extensive German App Store and Google Play search was performed from May 1-31, 2018. This search included the following search terms: “Rheuma” OR “Rheumatologie” OR “Arthritis” OR “Psoriasisarthritis” OR “PsA” OR “PsoA” OR “Rheumatoide Arthritis” OR “RA” OR “Morbus Bechterew” OR “Spondylarthritis” OR “Spondylitis ankylosans” OR “Spondylopathie” OR “axSpa” OR “Spondylarthropathie” OR “Spa” OR “Spondylitis ankylosans” OR “ankylosierende Spondylarthritis” OR “Kollagenose” OR “SLE” OR “Systemischer Lupus Erythematodes” OR “Sklerodermie” OR “Lupus” OR “Sjögren” OR “APS” OR “Antiphospholipidsyndrom” OR “systemische Sklerose” OR “SSc” OR “Polymyositis” OR “Dermatomyositis” OR “RZA” OR “Riesenzellarteriitis” OR “Riesenzellarteritis” OR “EGPA” OR “GPA” OR “eosinophile Granulomatose mit Polyangiitis” OR “Granulomatose mit Polyangiitis” OR “PAN” OR “panarteriitis nodosa” OR “polyarteriitis nodosa” OR “mikroskopische Polyangiitis” OR “Morbus Behcet” OR ”Takayasu Arteriitis” OR “Kawasaki Syndrom” OR “Arteriitis temporalis” OR “PMR” OR “Polymyalgie” OR “Polymyalgia rheumatica” OR “reaktive Arthritis” OR “enteropathische Arthritis” OR “Vaskulitis” OR “FMF” OR “familiäres Mittelmeerfieber” OR “Autoinflammation” OR “AOSD.”
All 8 raters () were physicians currently completing their rheumatology fellowships. Four physicians were using Android phones and four physicians were using iPhones to individually search for the terms in the associated app stores. Raters stated no conflict of interest regarding the industry surrounding the apps being rated. Searches were performed from May 1-31, 2018.
App inclusion criteria were (1) German language, (2) availability in both app stores, (3) targeting patients or physicians as users, and (4) clearly including rheumatology or rheumatic diseases as subject matter. Exclusion criteria were (1) congress apps and (2) company apps with advertisements.
As recommended by the MARS developers, all raters viewed the training video by Stoyanov et al , and each app was tested for at least 10 minutes. The raters agreed on the relevance of all MARS items to this project. Before rating their assigned apps, all raters evaluated two apps selected for training purposes (previously excluded from the analysis) and discussed their results to ensure a similar understanding of the MARS items and process.
MARS section scores were calculated by taking the arithmetic mean of each item score in the section, while the overall score was the arithmetic mean of the section scores (excluding subjective quality). Overall scores and section scores were summarized as median and range for each app, and apps were ranked based on the median overall MARS score. We analyzed item score deviations by section and rater using a random intercept–only mixed-effects linear regression model including the individual item scores as the dependent variable, a random effects term for the rater, and nested random effects terms for the MARS section and app. Using random intercepts from this model, we estimated how the item scores in each section in each app deviated from the overall mean item score to rank and plot the importance of the sections within each app. Similarly, we plotted the random effect intercepts and respective 95% confidence intervals for raters to rank the raters by their deviation from the overall mean item score as a measure of rater bias. We analyzed the effect of rater gender and operating system on ratings by adding respective fixed effect terms to the model and reported their coefficients and 95% confidence intervals. Random intercept and fixed effect term confidence intervals spanning both sides of 0 were considered insignificant. We constructed scatter plots of MARS scores for each app and platform against their respective store ratings and calculated Pearson correlation coefficients both across platforms and separately. Finally, we analyzed interrater agreement at item, section, and overall score levels for raters from a rater sample, namely ICC2k (two-way random, average measures, absolute agreement) . All data analysis was performed using the open source R software v3.5.3 (The R Foundation).
Selection of Mobile Apps
In total 128 and 63 apps were identified in the German App Store and Google Play, respectively. After removing duplicates and only including apps that were available in both stores, 28 apps remained. Three previously included apps were no longer available for download in July 2018 and were excluded; 9 apps were removed—6 were not available in German, one was a congress app, one a specific app for a clinical study, and one an ergo therapy advertisement app—so there remained 16 final apps for analysis (). During the analysis, Psoriapp was no longer available in Google Play and could only be rated by iOS raters. Android rater 2 downloaded Rheumatologie Visuell but the log-in repeatedly failed. The same rater was unable to successfully download Rheuma Edu although it was available in Google Play. iOS rater 2 had the same problem with the Rheumatologie Visuell app.
Characteristics of Mobile Apps
and display the characteristics of the analyzed apps. Nine apps were designed for patient use, and 7 for physician use. The following rheumatologic diseases were targeted: rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis (SpA), juvenile idiopathic arthritis (JIA), systemic lupus erythematosus (SLE), vasculitis, and giant cell arteritis. Thirteen apps were rheumatology specific, and 3 apps were nonspecific. All physician-targeted apps focused on education. Most of these apps were text and graphic based, focusing on guidelines. Other physician apps incorporated videos (Rheuma Edu), audio files (Meditorium), and case images (Rheumatologie Visuell). Three apps consisted of a score calculator. Eight out of 9 patient apps had a diary function of some sort. Rheuma Auszeit, the only patient app without a diary function, provided video and audio instructions for mental and physical exercises. Only 3 out of 8 diary patient apps consisted of validated disease activity questionnaires. Most apps provided a reminder function. Two out of 9 patient apps provided a service to exchange experiences via private or group messages.
|App||Target group||Target disease||Developer||Category|
|Rheuma Auszeit||Patient||RAa||Deutsche Rheuma-Liga Bundesverband eV||Education|
|Meditorium||Physician||Nonspecific||SchiLu Media UG||Education|
|RheumaGuide||Physician||RAa, PsAb, SpAc||MedMedia Verlag und Mediaservice GmbH||Education|
|ASAS App||Physician||SpAc||Assessment of SpondyloArthritis International Society||Education, calculator|
|RheumaLive||Patient||RAa||STAR Healthcare Management GmbH||Diary, reminder|
|Pain Companion||Patient||Nonspecific||Sanovation AG||Diary, exchange|
|MyTherapy||Patient||Nonspecific||Smartpatient GmbH||Diary, reminder|
|Psoriapp||Patient||PsAb||Novartis Pharma GmbH||Diary, reminder|
|Rheumatologie Visuell||Physician||Rheumatic||Georg Thieme Verlag KG||Education|
|PsALive||Patient||PsAb||STAR Healthcare Management GmbH||Diary, reminder|
|AxSpaLive||Patient||SpAc||STAR Healthcare Management GmbH||Diary, reminder|
|Lupuslog||Patient||SLEd||GlaxoSmithKline PLC||Diary, reminder|
|Rheuma Edu||Physician||Rheumatic||Pomcanys Marketing AG||Education|
|ANCA–Assoziierte Vaskulitiden||Physician||ANCAe–associated vasculitis||Börm Bruckmeier Verlag GmbH||Education|
|RheumaBuddy||Patient||RAa, JIAf||DAMAN P/S||Diary, exchange|
|Rheumatologie App||Physician||RAa, vasculitis||Börm Bruckmeier Verlag GmbH||Education|
aRA: rheumatoid arthritis.
bPsA: psoriatic arthritis.
cSpA: ankylosing spondylitis.
dSLE: systemic lupus erythematosus.
eANCA: antineutrophil cytoplasmic antibody.
fJIA: juvenile idiopathic arthritis.
|Rheuma Auszeit||Videos and audio files||No||Yes||No||Free|
|Meditorium||Audio files||No||Yes||No||2.99 € to 47.99 € (US $3 to $54)|
|RheumaGuide||Diagnostic and therapeutic guidelines, score calculator||No||Yes||No||Free|
|ASAS App||Diagnostic and therapeutic guidelines, score calculator||No||No||No||Free|
|RheumaLive||Diarya, medication reminder, export function||No||Yes||Yes||Free|
|Pain Companion||Diary, group discussion, private messages, export function||No||Yes||No||Free|
|MyTherapy||Tracking, medication/task reminder||Nob||Yes||No||Free|
|Psoriapp||Diary, medication reminder, export function||No||Yes||No||Free|
|Rheumatologie Visuell||Rheumatology images||No||Yes||No||Free|
|AxSpaLive||Diarya, medication reminder, export function||No||Yes||Yes||Free|
|PsALive||Diarya, medication reminder, export function||No||Yes||Yes||Free|
|Lupuslog||Diary, reminder, pictures, export function, local weather||No||Yes||No||Free|
|Rheuma Edu||Videos||No||Yes||No||6.49 € (US $7)|
|ANCA–Assoziierte Vaskulitiden||Diagnostic and therapeutic guidelines||No||Yes||No||Free|
|RheumaBuddy||Diary, group discussion, private messages, reminder, export function||No||Yes||No||Free|
|Rheumatologie App||Diagnostic and therapeutic guidelines, score calculator||No||Yes||No||Free|
aThis allowed tracking of validated rheumatology-specific questionnaires.
bDeveloper website states clinical study, yet no details could be identified using Google Scholar or Pubmed.
The overall MARS scores ranged from 2.81 to 4.19. The apps were ranked by median overall score. The individual MARS score ratings by each rater and their range are presented in. The individual MARS section scores by each rater and their ranges are displayed in .
Random intercepts and 95% confidence intervals from the mixed-effects linear regression analysis are presented in, summarizing the mean deviation of item scores and their 95% confidence intervals by section and their ranking within each app. This figure shows that subjective quality was the section in which item scores were most often significantly lower compared to the overall mean (Pain Companion, Psoriapp, RheumaBuddy, and Rheumatologie App). Information was the section in which item scores were most often significantly higher compared to the overall mean (Rheuma Auszeit, ASAS App, and Rheumatologie Visuell). For the aesthetics, functionality, and engagement sections there was no app with significantly lower item score deviations.
Rater agreement on overall MARS score at app level was poor and imprecise (ICC2k 0.53, 95% CI 0.08 to 0.81) whereas the interrater agreement for section scores (ICC2k 0.82, 95% CI 0.76 to 0.88) and individual item scores (ICC2k 0.84, 95% CI 0.81 to 0.86) were good. Random intercepts for observers from the mixed-effects model are presented in.
The point estimates and confidence intervals show that 3 of the 4 iOS raters were significantly biased with respect to mean item scores either in the positive or negative direction, whereas the random intercepts for the Android raters were similar. However, adding the operating system as a fixed effect in the regression model did not seem to be associated with an overall significant difference in item scores (β=–0.10, 95% CI –0.44 to 0.24; P=.57 for iOS, compared to Android). Finally, the mixed-effects model with rater gender as a fixed effect also shows that the adjusted difference between item scores between male and female raters was small and imprecise (β=0.08, 95% CI –0.27 to 0.44; P=.64 for male gender) and does not suggest a gender effect on item scores.
MARS and app store ratings, including the range and number of ratings, are shown in. App store ratings were retrieved on April 21, 2019. At the time, Psoriapp was not available in both app stores. For all apps, Google Play had more ratings than App Store. MyTherapy had by far the most ratings (24,408).
Correlation analysis between overall MARS scores of the apps and their respective store ratings was limited by the availability of store ratings. We did not find a significant correlation between MARS scores and store ratings, whether overall or grouped by operating system.
This analysis of German rheumatology-specific apps showed that most apps were patient focused (9 out of 16), and only a minority of rheumatic diseases were specifically targeted. For several rheumatic diseases, such as systemic sclerosis, Sjogren syndrome, Behcet disease, and familial Mediterranean fever, there were no apps available. The three apps with the highest overall MARS score included videos, audio files, and images. The inclusion of multimedia content therefore seems to be advisable.
The MARS rating itself is quite subjective, shown by the great interrater differences despite the tutorial video and test phase with discussion of the results. The poor rater agreement is likely also due to a low number of apps and a high number of raters. This result is in line with other app rating studies including more than two raters . We chose not to discuss and adapt conflicting results like others [ , ] because we believe this results in a falsification of data. Studies using MARS and including only two raters often showed good interrater reliability [ ]. We used MARS because it is one of the most established app rating tools; however, several tools with different weaknesses and strengths exist [ ]. Interestingly, one developer created patient apps that were all certified as CE-labeled medical products for three common rheumatic diseases (RA, PsA, SpA). No other apps were found to be CE certified. However, being CE certified did not guarantee a top ranking. In order to harmonize research and increase trust and transparency, an international task force is needed to create guidelines and accepted quality criteria. These guidelines are desperately needed, as easily available quality indicators such as app store ratings only poorly reflect their true quality.
In order to increase acceptance and use among patients and health care professionals, clinical studies are also urgently needed. Only one app referred to a clinical study; however, these results could not be clearly identified using Google Scholar or PubMed. We believe that it is necessary to shift the current developer status from commercial developers toward universities and independent research institutions including patients as well as physicians. The importance of including patients is highlighted by the fact that the only app mainly developed by a patient organization had the highest MARS score (4.19/5). These findings illustrate current unmet needs hindering the use of eHealth tools despite their great potential.
Patient self-assessments via smartphone strongly correlate with rheumatologist assessments  and could cost effectively enhance current tight control strategies. An official, highly customizable app developed by a trusted and independent organization based on a common minimal data set would allow the creation of a holistic repository. This app would ensure maximally efficient use of resources. Due to its large user base, it would provide a powerful passive dataset for research. A role model could be the Swiss Web app, mySCQM [ ], developed by Swiss Clinical Quality Management in Rheumatic Diseases. This app allows patients to enter data in between visits and share these data with their doctor and the national Swiss registry. To increase acceptance of such an app among patients, it seems advisable to also allow safe communication and file exchange between patients and their physicians. Further research to identify key components [ , ] and stakeholder preferences [ , - ] is needed.
This study has some limitations. First, we only looked at app stores, and no systematic literature search was performed. For future projects, it would be time saving to use an automated process to identify and filter apps as proposed by Albrecht et al ; however, this process is restricted to native mobile apps. Web-based apps that are not featured in app stores are therefore not included. Due to the growing popularity of Web-based apps [ ], we believe it is crucial to include these apps in future research projects.
Due to the app store approach using a limited amount of German search terms, useful rheumatology apps may have been overlooked. To facilitate app evaluation, app randomization, and data analysis, we only included apps that were available in both app stores. Another limitation is the fact that only physicians performed the app rating, although most of the apps were created for patient use. As already suggested by others [, ], future research should include patients.
Due to lack of expertise and resources, we only checked the data security very briefly in terms of presence of a data policy statement, password protection, and log-in requirement. A professional in-depth security check should be applied to identify any risks, as mobile apps often do not follow data protection laws  and could be potentially harmful for the end user [ ]. Finally, it should be mentioned that due to the rapid speed of mobile app development, this review might already be out of date once published. A main limitation of the MARS score itself is that to our knowledge there is no clear definition of a high-quality app, and its meaning often varies [ , ].
Comparison With Prior Work
A major strength of this study lies in its ability to guide recommendations of apps by rheumatologists for their patients. To our knowledge, no review and analysis of mobile apps in rheumatology available in German app stores has been carried out yet. In contrast to other studies [, ] using MARS, we identified apps targeting patients as well as physicians. Furthermore, apps were tested on iOS and Android platforms to identify usability differences. To our knowledge, no previous study using MARS had as many raters as this study did. We tried to include many raters to better represent different subjective perspectives and pick up any interrater rating weaknesses of the MARS.
The low number of recommendable rheumatology-specific apps found in the previous survey  can now largely be explained by the lack of German rheumatology-specific apps in general (16 identified apps in total) and their heterogeneous quality. However, in contrast to a previous rheumatology app review [ ], we identified one patient and one physician app with promising overall MARS scores (>4/5).
This study exposes the lack of reliable studies for mobile apps in general  and specifically in rheumatology [ ]. Similarly, in this work we observed a wide range of MARS scores reflecting heterogeneous quality. Grainger et al [ ] reported that 6 out of 11 patient-targeted apps allowed data sharing. In our analysis, this was the case for 8 out of 9 patient-targeted apps.
The lack of academic app developers reported by Salazar et al  is supported by our work. In accordance with prior publications [ , ], there was no strong correlation of app store ratings and MARS ratings. App store ratings therefore seem to be a poor quality indicator. In our analysis, 89% (8/9) of the patient apps had a symptom tracking function. In a previous publication [ ] focusing on rheumatoid arthritis, this was only the case for 50% of the apps.
Noticeably, Rheuma Auszeit, the only app mainly developed by a patient organization, had the best MARS score and lowest rater standard deviation. This highlights the importance and success of including patients in the app development process, as stressed by Grainger et al . Interestingly, this was the only patient app not containing a diary function. The name of the app is translated as rheuma timeout, implying that the goal of this app is exactly the opposite of tracking pain. This could be a main cause of adherence problems with patient apps, as patients are constantly reminded of their disease and limitations.
Based on our study findings, we established 10 recommendations () that might direct developers to create better apps that maximize patient and physician satisfaction.
To our knowledge, this is the first study to systematically identify and evaluate mobile apps in rheumatology for patients and physicians available in German app stores. App quality, origin, and amount of evidence was heterogeneous. Brief descriptions and recommendations were compiled to provide ready-to-use, useful information for potential users and developers.
We recommend continual evaluation of mobile apps based on automatic crawling techniques; quality evaluations by users (patients and physicians); and supporting cost-effectiveness studies to enhance awareness, use, and potential benefit. Furthermore, we would like to emphasize the importance of research institutes and academics as data recipients and partners in app development. Only then can truly powerful data analysis and insights be collected and used for scientific research.
To maximize the great eHealth potential in rheumatology, a close collaboration of patients, rheumatologists, developers, and industry is needed. To avoid redundant work and save time, international and national eHealth consortiums and collaborations are needed to create guidelines and recommendations.
The authors thank the German Society for Rheumatology (Working Group Young Rheumatology) for their support of this project. Thanks to Antoine Murray for proofreading the manuscript. External funding was obtained by Pfizer GmbH, Germany, to conduct the presented work.
J Knitza1, KT, MK, and ER wrote the draft manuscript. J Knitza1, MM, DV, AP, PB, J Kittler, DS, and MK rated apps. KT did the statistical analysis. All authors reviewed the draft and provided comments for changes. All authors approved the final manuscript.
Conflicts of Interest
Multimedia Appendix 1
Rater gender, hardware and software.PDF File (Adobe PDF File), 20KB
Multimedia Appendix 2
Individual Mobile Application Rating Scale section ratings of included apps.PNG File, 233KB
Multimedia Appendix 3
Mobile Application Rating Scale and app store ratings of included apps.PDF File (Adobe PDF File), 24KB
Multimedia Appendix 4
Recommendations for developers of mobile rheumatology apps.PNG File, 133KB
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|ANCA: antineutrophil cytoplasmic antibodies|
|ICC2k: two-way random, average measures, absolute agreement|
|JIA: juvenile idiopathic arthritis|
|MARS: Mobile Application Rating Scale|
|PsA: psoriatic arthritis|
|RA: rheumatoid arthritis|
|SLE: systemic lupus erythematosus|
|SpA: ankylosing spondylitis|
Edited by G Eysenbach; submitted 10.06.19; peer-reviewed by H de Sola, G Peters, A Salazar; comments to author 12.07.19; revised version received 17.07.19; accepted 19.07.19; published 05.08.19
©Johannes Knitza, Koray Tascilar, Eva-Maria Messner, Marco Meyer, Diana Vossen, Almut Pulla, Philipp Bosch, Julia Kittler, Arnd Kleyer, Philipp Sewerin, Johanna Mucke, Isabell Haase, David Simon, Martin Krusche. Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org), 05.08.2019.
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