Background: The development of a surgical site infection (SSI) after cesarean section (c-section) is a significant cause of morbidity and mortality in low- and middle-income countries, including Rwanda. Rwanda relies on a robust community health worker (CHW)–led, home-based paradigm for delivering follow-up care for women after childbirth. However, this program does not currently include postoperative care for women after c-section, such as SSI screenings.
Objective: This trial assesses whether CHW’s use of a mobile health (mHealth)–facilitated checklist administered in person or via phone call improved rates of return to care among women who develop an SSI following c-section at a rural Rwandan district hospital. A secondary objective was to assess the feasibility of implementing the CHW-led mHealth intervention in this rural district.
Methods: A total of 1025 women aged ≥18 years who underwent a c-section between November 2017 and September 2018 at Kirehe District Hospital were randomized into the three following postoperative care arms: (1) home visit intervention (n=335, 32.7%), (2) phone call intervention (n=334, 32.6%), and (3) standard of care (n=356, 34.7%). A CHW-led, mHealth-supported SSI diagnostic protocol was delivered in the two intervention arms, while patients in the standard of care arm were instructed to adhere to routine health center follow-up. We assessed intervention completion in each intervention arm and used logistic regression to assess the odds of returning to care.
Results: The majority of women in Arm 1 (n=295, 88.1%) and Arm 2 (n=226, 67.7%) returned to care and were assessed for an SSI at their local health clinic. There were no significant differences in the rates of returning to clinic within 30 days (P=.21), with high rates found consistently across all three arms (Arm 1: 99.7%, Arm 2: 98.4%, and Arm 3: 99.7%, respectively).
Conclusions: Home-based post–c-section follow-up is feasible in rural Africa when performed by mHealth-supported CHWs. In this study, we found no difference in return to care rates between the intervention arms and standard of care. However, given our previous study findings describing the significant patient-incurred financial burden posed by traveling to a health center, we believe this intervention has the potential to reduce this burden by limiting patient travel to the health center when an SSI is ruled out at home. Further studies are needed (1) to determine the acceptability of this intervention by CHWs and patients as a new standard of care after c-section and (2) to assess whether an app supplementing the mHealth screening checklist with image-based machine learning could improve CHW diagnostic accuracy.
Trial Registration: ClinicalTrials.gov NCT03311399; https://clinicaltrials.gov/ct2/show/NCT03311399
Rates of cesarean section (c-section) births are increasing in low- and middle-income countries (LMIC), including in sub-Saharan Africa (SSA) . Increased access to timely c-section can prevent maternal and neonatal mortality, but also carries risk of perioperative complications [ ]. Surgical site infections (SSIs) are a significant cause of morbidity and mortality globally, but the magnitude of the risk is significantly higher in LMIC. In SSA, post–c-section SSI rates range from 7% to 48% [ - ], in part due to geographic and infrastructural barriers that delay or prevent patients from accessing care postoperatively [ , ].
In much of SSA, networks of community health workers (CHWs) provide home-based prenatal care to pregnant women, postpartum care for women after vaginal delivery only, and follow-up care for children under the age of 5 years . However, women delivering via c-section can only access follow-up care at their local health center because CHWs are not currently trained to conduct home-based postoperative follow-up or wound care. In complementary work from our team, we found that geographical and financial barriers can lead to delays in return to care after discharge [ , ]. This delayed or lack of access to care may contribute to post–c-section SSI rates, which our group reported to be 10.9% in the district where this study took place [ ]. Strengthening the CHW workforce to provide SSI screening and home-based care to women who deliver via c-section could reduce barriers to care and lead to earlier detection and treatment of SSIs. However, it is not known if home-based care by CHWs is feasible or improves access to care in this context. In LMIC, previous studies have demonstrated the feasibility of phone-based surveillance of postdischarge SSI, including in women who had undergone c-section surgery [ - ]. In our study, we explored the feasibility and impact of return to care of CHW-led SSI surveillance in patient homes using a mobile health (mHealth) checklist administered via REDCap (Research Electronic Data Capture; Vanderbilt University) either in person or via phone call to facilitate remote diagnoses. This mHealth screening protocol is a battery of questions about the presence or absence of clinical findings highly associated with SSI (eg, pain, swelling, discharge, and wound gaping), which we described in previous work [ ].
In this paper, we describe two CHW-led mHealth interventions to diagnose SSIs following c-section in rural Rwanda, which are (1) administering a mobile phone–based SSI screening protocol to a patient via phone call; and (2) administering the same screening protocol, carried on an electronic tablet, in person during a home visit along with collecting wound photo images on the same tablet for remote diagnosis. Here, we compare these two interventions to the standard of care via a 3-arm randomized controlled trial (ClinicalTrials.gov NCT03311399) and describe the feasibility of the two interventions in this context.
This study was conducted in the Eastern Province of Rwanda at Kirehe District Hospital (KDH), a 233-bed facility operated by the Rwanda Ministry of Health and supported by Partners In Health, an international NGO. KDH serves a catchment area of 364,000 people including patients from Mahama Refugee Camp, which comprises over 50,000 people . In Rwanda, over 91% of women deliver in health facilities [ ]. Women in labor first present to their local health center where most vaginal deliveries take place. Complex cases and cases requiring surgical intervention are transferred to the district hospital to be assessed and managed by a general practitioner, who performs the c-section procedure, if indicated. After surgery, the woman is admitted to the postoperative ward for an average of 3 days for monitoring, medication administration, and wound checks. Before leaving the hospital, she receives postdischarge instructions directing her to the health center nearest to her home for follow-up and wound dressing changes.
This study included women aged ≥18 years who received a c-section at KDH between November 2, 2017, and September 4, 2018, and were residents of Kirehe District. Women who developed an SSI while being an inpatient or who remained inpatient at KDH past postoperative day (POD) 10 were excluded as they were not able to participate in a POD 10 home visit. Women who resided in Mahama Refugee Camp and were therefore not covered by the CHW network were also excluded.
We hired 4 study CHWs (sCHWs) using the Rwanda Ministry of Health criteria though a community-led process. The sCHWs received a 4-week training on implementation procedures, including the following: education on the Rwandan health sector; post–c-section follow-up; operating mHealth tools; best practices in wound photography; basic SSI physiopathology (including signs and symptoms of an infection); and how to examine surgical wounds and change wound dressings. Previously, we led a 7-month SSI protocol development study at KDH to identify a simple screening protocol with high accuracy to diagnose SSIs. In that study, three questions were found to have sufficient sensitivity and specificity for SSI diagnosis, which comprised the following: (1) fever since discharge from the hospital, (2) increasing pain since discharge, and (3) the presence of discolored wound discharge .
This randomized study included three arms—Arm 1, where the sCHW visited a participant’s home on POD 10 (SD 3 days) and administered the SSI screening protocol; Arm 2, where the sCHW called the participant and administered the SSI screening protocol over the phone on POD 10 (SD 3 days); and Arm 3, where the participant received the standard of care instructions to return to the health center for follow-up. In Arm 2, the sCHW attempted phone calls while sitting in the study office and made 3 call attempts before deeming a patient to be inaccessible. If a patient was deemed inaccessible, they were included in the evaluation of the feasibility of the intervention and classified as “not successfully assessed for SSI.” However, these individuals were not included in the evaluation of the presence of an SSI. If a participant in Arm 1 or 2 was suspected of having an SSI by the responses to the screening protocol, the sCHW was prompted to refer her to a nearby health center for additional medical care.
Enrollment, Randomization, Follow-up, and Data Collection
All data collected were entered and stored using REDCap (v8.10.20), a secure web application certified for medical research studies . The study staff enrolled and randomized eligible participants at discharge, independent of any patient factors, to one of the three study arms. The study staff prepared study packets in sealed envelopes numbered consecutively. REDCap was then used to randomly generate arm assignments to each packet using simple randomization in a 1:1:1 ratio [ ]. All consenting participants’ demographic and socioeconomic data were collected using a self-reported questionnaire administered by a trained study data collector. In addition, the study staff extracted clinical data from the patients’ medical files. Upon discharge, the patients received a packet with arm-specific follow-up and general discharge instructions.
Each health center in the catchment area and KDH had a study-specific patient registry to document return to care. Study staff entered the following details into REDCap: return to care status, SSI diagnosis (by nurse), treatment received, hospitalization, patient referral, and need for surgical procedures, if any. Data collectors contacted each woman on POD 30 to validate what was captured in the registry and to ensure that no follow-up visits were missed.
Data were analyzed using Stata (14.0 version, Stata Corp) statistical software. We characterized study participant demographics and clinical characteristics using descriptive statistics. For the primary outcome, a patient was classified as having returned to care if the return visit was documented in the health center registry or if the patient reported returning to the health center during the POD 30 follow-up call. In this primary analysis, we excluded anyone without information on return to care by POD 30 from analyses. Feasibility assessments across Arms 1 and 2 were reported as the percentage of visits where that specific task was completed. We used a Fisher exact test at α=.05 significance level to assess the association between patients’ return to care and interventions implemented in Arms 1 and 2 as compared to Arm 3 (standard of care). We used a logistic regression model to assess the impact of study interventions on return to care, controlling for potential confounders that were unbalanced at baseline. In this primary analysis, we excluded anyone without information on return to care by POD 30 from analyses. We used chi-squared tests to assess for differences in having information about return to care by study arm and by patient demographics. We also conducted a sensitivity analysis, whereby any individual missing information on return to care was presumed to have not returned to care.
The estimated sample size was 364 patients per arm, for a total of 1092 patients. We anticipated an SSI rate of 15%, which would result in 55 SSIs per arm. Assuming an 80% return to care rate in the two intervention arms and a 40% return to care rate in the standard of care arm, we would have 81% power to detect a difference between the two intervention arms as compared to the routine care arm. The trial was halted when 1166 patients were enrolled (in excess of the targeted sample size of 1092).
Eligible women gave informed consent prior to participation. The study team members provided information in Kinyarwanda, including details of the three study arms and the right to withdraw from the study or refrain from giving information at any stage. Deidentified data were collected and managed using REDCap. This study was approved by the Rwanda National Ethics Committee (848/RNEC/2016) and Partners Human Research Committee (2016P001943/MGH). Seven months into the study, a Data and Safety Monitoring Board reviewed the study participants’ safety, data quality, and midterm outcomes, and deemed it appropriate to continue to study completion.
In total, 1166 women were enrolled, of which 107 (9.1%) were excluded—95 residents of Mahama Refugee Camp and 12 patients who developed an SSI while at the hospital. Of the enrolled patients who were randomized at discharge, 34 participants were removed from analysis—30 participants who remained in hospital after discharge to attend to their admitted neonates and 4 participants who were assigned to one arm but inadvertently received the follow-up of another arm. Of the remaining 1025 women, 335 (32.7%) were randomized to Arm 1, 334 (32.6%) to Arm 2, and 356 (34.7%) to Arm 3 ().
There were no significant differences between the three groups for most demographic variables (), including age (P=.29), marital status (P=.2), occupation (P=.496), or type of insurance (P=.15). The only statically significant differences found were regarding education and income. Women in Arm 3 were more likely to report having only a primary education (P=.006). Women in Arm 2 were significantly more likely to report higher income (P=.03). There was no significant difference between the three groups in terms of their access to health care, measured by the cost of transportation from the woman’s home to the nearest health center (P=.93) and the travel time from a woman’s home to the nearest health center (P=.25; ).
|Characteristics||Total, n (%)||Arm 1: home visit (n=335), n (%)||Arm 2: phone call (n=334), n (%)||Arm 3: standard of care (n=356), n (%)||P value|
|18-21||174 (17.0)||52 (15.5)||50 (15.0)||72 (20.2)|
|22-30||549 (53.6)||182 (54.3)||178 (53.3)||189 (53.1)|
|>30||302 (29.5)||101 (30.2)||106 (31.7)||95 (26.7)|
|No education||90 (8.8)||29 (8.7)||39 (11.7)||22 (6.2)|
|Primary education||696 (67.9)||225 (67.2)||205 (61.4)||266 (74.7)|
|Secondary education||214 (20.9)||75 (22.4)||82 (24.6)||57 (16.0)|
|University education||25 (2.4)||6 (1.8)||8 (2.4)||11 (3.1)|
|Single||95 (9.3)||28 (8.4)||26 (7.8)||41 (11.5)|
|Married||446 (43.5)||156 (46.6)||148 (44.3)||142 (39.9)|
|Living with a partner||480 (46.8)||150 (44.8)||160 (47.9)||170 (47.8)|
|Separated (divorced or widowed)||4 (0.4)||1 (0.3)||0 (0)||3 (0.8)|
|Student||10 (1.0)||2 (0.6)||5 (1.5)||3 (0.8)|
|Farmer||874 (85.3)||289 (86.3)||280 (83.8)||305 (85.7)|
|Employed||38 (3.7)||8 (2.4)||15 (4.5)||15 (4.2)|
|Self-employed||69 (6.7)||28 (8.4)||21 (6.3)||20 (5.6)|
|Housewife||34 (3.3)||8 (2.4)||13 (3.9)||13 (3.7)|
|Incomea (US $)||.03|
|>33.70||854 (83.3)||290 (86.6)||264 (79.0)||300 (84.3)|
|<33.70||171 (15.7)||45 (13.4)||70 (21.0)||56 (15.7)|
|Type of insurance||.15|
|No insurance||24 (2.3)||5 (1.5)||10 (3.0)||9 (2.5)|
|Community-based insurance||941 (91.8)||316 (94.3)||297 (88.9)||328 (92.1)|
|Private insurance||60 (5.9)||14 (4.2)||27 (8.1)||19 (5.3)|
|Cost of transportation from home to health centera (US $; n=969)||.93|
|≤1.12||586 (60.5)||192 (60.0)||192 (61.3)||202 (60.1)|
|>1.12||383 (39.5)||128 (40.0)||121 (38.7)||134 (39.9)|
|Time from home to health center (n=964)||.25|
|≤1 hour||881 (91.4)||288 (90.0)||281 (90.7)||312 (93.4)|
|>1 hour||83 (8.6)||32 (10.0)||29 (9.4)||22 (6.7)|
aCalculated using an exchange rate of US $1 to 890 Rwandan Francs.
Of the 335 women in Arm 1, 295 (88.1%) were successfully visited in their homes and had the full SSI assessment completed by the sCHW (). The primary reasons for noncompletion in Arm 1 were prolonged hospitalization of either mother or baby or an inability to contact the mother to confirm the home visit appointment. Of the 334 women in Arm 2, 67.7% (n=226) were successfully called and assessed over the phone by a sCHW for an SSI. The primary reasons for noncompletion in Arm 2 were as follows: lack of mobile phone ownership, poor network coverage, or the phone belonging to another person (eg, husband or neighbor). Women in Arm 1 had slightly higher rates of reporting SSI symptoms as compared to women in Arm 2 ( ). As Arm 3 was the standard of care arm, there was no attempt to contact patients either via phone call or home visit.
|Interventions and call attempts||Values, n (%)|
|Home visit intervention (n=335)|
|Number of patients who were visited and assessed for SSIa by CHWb at patient’s home||295 (88.1)|
|Home visits attempted by study CHW||295 (88.1)|
|Completion of steps to conduct home visit|
|Study CHW was able to find local CHW in patient’s village||281 (95.3)|
|Study CHW was able to locate patient’s home||295 (100)|
|Study CHW was allowed into patient’s home||295 (100)|
|Patient was at home when study CHW arrived||287 (97.3)|
|Patient allowed study CHW to ask SSI screening questions||295 (100)|
|Patient allowed study CHW to physically examine her||295 (100)|
|Phone call intervention (n=334)|
|Phone call to patient attempted by study CHW||319 (95.5)|
|Number of patients who were called and assessed for SSI by CHW over phone||226 (67.7)|
|Phone call attempt #1|
|Phone number went through, or phone rang (n=319)||268 (84)|
|Phone call resulted in talking with the patient (n=268)||167 (62.3)|
|Outcomes of talking with patient (n=167)|
|Patient answered SSI screening questions at time of call||163 (97.6)|
|Patient was busy||3 (1.8)|
|Patient did not respond, reason not recorded||1 (0.6)|
|Reason for not talking with patient (n=101)|
|Wrong number||7 (6.9)|
|Patient did not pick up the phone||6 (5.9)|
|Another person picked up the phone, patient was not available||87 (86.1)|
|Not reported||1 (1.0)|
|Patients requiring a second attempt (n=319)||156 (48.9)|
|Phone call attempt #2|
|Number of patients who were called a second time (n=156)||133 (85.3)|
|Phone number went through, or phone rang (n=133)||89 (66.9)|
|Phone call resulted in talking with the patient (n=89)||51 (57.3)|
|Outcomes of talking with patient (n=51)|
|Patient answered SSI screening questions at time of call||50 (98)|
|Patient did not respond, reason not recorded||1 (2)|
|Reason for not talking with patient (n=38)|
|Patient did not pick up the phone||4 (11)|
|Another person picked up the phone, patient was not available||33 (89)|
|Not reported||1 (3)|
|Patients requiring a third attempt (n=156)||106 (67.9)|
|Phone call attempt #3|
|Number of patients who were called a second time (n=106)||83 (78.3)|
|Phone number went through/phone rang (n=83)||36 (43)|
|Phone call resulted in talking with the patient (n=36)||13 (36)|
|Outcomes of talking with patient (n=13)|
|Patient answered SSI screening questions at time of call||13 (100)|
|Reason for not talking with patient (n=23)|
|Wrong number||1 (4)|
|Patient did not pick up the phone||2 (9)|
|Another person picked up the phone, patient was not available||20 (87)|
aSSI: surgical site infection.
bCHW: community health worker.
|Responses to CHW screening||Arm 1: home visit (n=295), n (%)||Arm 2: phone call (n=228), n (%)|
|Fever since discharge (n=522)||35c (11.9)||22 (9.7)|
|Pain since discharge||51 (17.3)||32 (14.0)|
|Discolored drainage since discharge||46 (15.6)||20 (8.8)|
|CHW suspected wound infection||52 (17.6)||29 (12.7)|
|CHW advised patient to return to care (n=482)d||56e (20.3)||30f (14.6)|
aCHW: community health worker.
bArm 3 not included because no CHW screenings occurred in the standard of care arm.
cMissing data for 1 patient, n=294.
dAmong those for whom CHW suspected wound infection in the home visit arm, 1 patient was not advised to return to care.
eMissing data for 19 patients, n=276.
fMissing data for 22 patients, n=206.
We had information on return to care for 896/1025 (87.4%) women, as described in. Women in Arm 2 were marginally, but nonsignificantly, more likely to have this information recorded (P=.06). There were no differences in having this documented among key demographics; though women with higher monthly incomes were more likely to have information on return to care recorded (P=.03). In the primary analyses, there was no difference in care-seeking behavior between the three arms. Women across all three arms had high rates of returning to clinic by POD 30 (99.7% in Arm 1, 98.4% in Arm 2, and 99.7% in Arm 3), with no significant statistical difference between them (P=.21 crude; P=.19 adjusted). Reasons for returning to care were not significantly different between the groups, with similar percentages of women returning for either routine wound care (n=253, 89.4% in Arm 1; n=264, 88.6% in Arm 2; and n=278, 90.3% in Arm 3; P=.08) or for a specific concern related to their c-section (n=30, 10.6% in Arm 1; n=34, 11.4% in Arm 2; and n=30, 9.7% in Arm 3; P=.08). There were similar rates of nurse-diagnosed SSIs in each group (n=33, 11.9% in Arm 1; n=34, 11.6% in Arm 2; and n=28, 9.3% in Arm 3; P=.54). In the sensitivity analysis, difference in return to care rates by study arm remained insignificant (P=.19 crude; P=.26 adjusted).
|Outcomes||Total, n (%)||Arm 1: home visit, n (%)||Arm 2: phone call, n (%)||Arm 3: standard of care, n (%)||P value|
|Patients randomized||1025 (100)||335 (32.7)||334 (32.6)||356 (34.7)||N/Ab|
|Patientsc with 30-day follow-up data||896 (87.4)||284 (84.8)||303 (90.7)||309 (68.8)||N/A|
|Source of 30-day follow-up datad|
|Phone call with patient||555 (61.9)||180 (63.4)||188 (62.1)||187 (60.5)||.77|
|Health center registry||635 (70.9)||194e (68.6)||215 (71.0)||226 (73.1)||.47|
|District hospital medical records||18 (2.0)||11 (3.9)||2 (0.7)||5 (1.6)||.02|
|Patientsf who returned to care (n=896)||889 (99.2)||283 (99.7)||298 (98.4)||308 (99.7)||.21g|
|Among those with 30-day follow-up data (n=889)|
|Reason for returning to care||.8|
|Routine wound care (wound check and removal of stitches)||795 (89.4)||253 (89.4)||264 (88.6)||278 (90.3)|
|Concern related to c-section (fever, pain, and concern about wound)||94 (10.6)||30 (10.6)||34 (11.4)||30 (9.7)|
|Patient returned to care with nurse-diagnosed SSIh (n=871)||95 (10.7)||33i (11.9)||34j (11.6)||28k (9.3)||.54|
ac-section: cesarean section.
bN/A: not applicable.
cThose who were randomized.
dInformation could have been collected from more than one source.
eMissing data for 1 patient (n=283).
fThose with 30-day follow-up data.
gP=.19 from likelihood ratio test (from logistic regression models controlling for education and income).
hSSI: surgical site infection.
iMissing data for 5 patients (n=278).
jMissing data for 6 patients (n=292).
kMissing data for 7 patients (n=301).
Surprisingly, nearly all patients in our study returned to care at least once by POD 30, with no significant difference in follow-up between arms. This contrasts with the findings in the Central African Republic, where a study reported that only 25% of surgical patients returned for a POD 30 follow-up visit . A possible reason for this is that Rwanda, a small country with a strong functional decentralized public health system [ ], offers greater access to follow-up care.
In this study, we observed that home-based follow-up care of participants allows the sCHW to enter the women’s homes, physically examine them, and take a photo of their wound. As close to 90% of participants in Arm 1 successfully visited and were assessed for SSI, we found that home visits are a feasible way to conduct post–c-section care. In rural Rwanda and many other low-resource settings, CHWs already provide in-home screening for child health , maternal health [ ], and HIV care [ ] referrals. The high feasibility of in-home screening could be due to the familiarity women have with the CHW system and how they value support from CHWs [ , ].
On the other hand, SSI screening by phone excluded close to 30% of women. Other studies in Tanzania  and Sudan [ ] also demonstrated gaps in using telephone calls for postdischarge surveillance of SSIs. Currently, only 54% of households in Rwanda own a mobile phone [ ]. Telephone-based interventions may be more feasible as phone access and network coverage expand. Two recent systematic review articles assessing the use of smartphones to identify SSI found that there are few articles in the literature, the majority are in high income settings, and they require smartphone ownership by patients. We have not found any other experience of CWH home follow-up for SSI identification and care [ , ]. Currently in the rural Rwandan setting, in-person sCHW visitation at the patient’s home provides greater follow-up coverage than phone calls alone.
Despite the null results in the difference between rates of return to care, this study has important implications linked to our understanding of the financial risks associated with health care seeking in this population. Undergoing a c-section is a financial burden for women in rural Rwanda . This is true even for women covered by community-based health insurance. Our group has previously reported that the median out-of-pocket cost of transport for a single visit to the health center for women who received a c-section at KDH is up to 10% of their monthly income and that those who spent more money had increased risk of SSI [ ]. Transportation cost was also self-reported by patients from Arm 3 of the study to be a barrier to health care seeking in the postoperative period [ ]. These costs of transport were uniform across the arms of the study, as all three arms had equal rates of return to clinic.
In this setting, approximately 90% of patients do not develop an SSI. Treatment of an SSI is a principal reason for return to health center for care that cannot be provided by a CHW. Thus, accurate home rule-out of a post–c-section SSI can eliminate the need for 90% of women undergoing c-section to make the return journey and incur the out-of-pocket expense of transport to the health center. Given the financial burden of transport to the health center and the feasibility of in-person CHW SSI screening, leveraging the existing CHW system in Rwanda to bring postcesarean care to women’s homes could reduce both financial barriers to care and medical impoverishment. Further analysis is needed to determine the effect that home-based surgical wound monitoring would have on reducing unnecessary visits to the health center, health system cost savings, and workload on clinicians, though promising results have been shown in other settings [, ]. This study’s findings will also be used to develop a supporting app to facilitate in-person SSI screening by CHWs.
This study had several limitations. Health center data may not have been consistent in quality due to variations in study patient tracking and data collection processes across sites. Targeted interventions, including calling health centers weekly with a list of expected enrolled patients and monthly in-person audits of each health center’s registry, were implemented to improve patient tracking. We also called all patients on POD 30 regarding their follow-up activities and SSI diagnoses. There was 100% agreement between data from registries and phone calls for the 228 patients from Arms 1 and 2 . Secondly, we could not accurately or consistently capture dates of health center visits. As a result, we do not know when within-POD-30 women returned to care and whether there were differences between the intervention arms and the control arm. Additional research is needed to assess how CHW interventions affect the timeliness of return to care for post–c-section SSI evaluation.
We did not observe a difference in the rate of return to the health center between women who were visited at home, who called at home, and who asked to continue with standard of care visits. In fact, women in all groups demonstrated high levels of health seeking behavior. However, our study found that home-based post–c-section follow-up by CHWs facilitated by an mHealth app to identify and refer SSIs is feasible. Our previous studies have shown that health center visits can pose a significant financial burden on women following c-section. Therefore, use of home visits for postoperative care could greatly reduce the nonmedical costs related to transport for routine follow-up for women who do not develop SSIs. Home, mHealth-enhanced, visits were also found to be more effective than phone-based follow-up for connecting CHWs with patients. Thus, home visits have the potential to greatly reduce the patient’s economic burden of post–c-section care. Future studies to understand the acceptability of CHW home visits for patients and health care workers are needed before this can be adopted as a standard care protocol.
This work was supported by National Institutes of Health grant 1R21EB022369.
FK, RR, and BHG are the primary investigators for the National Institute of Health grant that provided funding for this research. FK, RR, and BHG led the design and planning of this study, supervised the conduct and data analysis, and were involved in all steps of manuscript drafting and revising. AG led the drafting and revising of the manuscript. TN, TC, LB, EN, CH, GN, AM, EG, LG, BP, KS, RK, and JN were involved in study design, planning, conduct, and data analysis, and were involved in manuscript drafting and editing.
Conflicts of Interest
None to declare.
CONSORT-EHEALTH (V 1.6.1) checklist.PDF File (Adobe PDF File), 2873 KB
- Harrison MS, Goldenberg RL. Cesarean section in sub-Saharan Africa. Matern Health Neonatol Perinatol 2016;2:6 [FREE Full text] [CrossRef] [Medline]
- Statement on caesarean section rates. World Health Organization. 2015. URL: https://www.who.int/reproductivehealth/publications/maternal_perinatal_health/cs-statement/en [accessed 2020-03-01]
- Mivumbi VN, Little SE, Rulisa S, Greenberg JA. Prophylactic ampicillin versus cefazolin for the prevention of post-cesarean infectious morbidity in Rwanda. Int J Gynaecol Obstet 2014 Mar;124(3):244-247. [CrossRef] [Medline]
- De Nardo P, Gentilotti E, Nguhuni B, Vairo F, Chaula Z, Nicastri E, et al. Post-caesarean section surgical site infections at a Tanzanian tertiary hospital: a prospective observational study. J Hosp Infect 2016 Aug;93(4):355-359. [CrossRef] [Medline]
- Mpogoro FJ, Mshana SE, Mirambo MM, Kidenya BR, Gumodoka B, Imirzalioglu C. Incidence and predictors of surgical site infections following caesarean sections at Bugando Medical Centre, Mwanza, Tanzania. Antimicrob Resist Infect Control 2014;3:25 [FREE Full text] [CrossRef] [Medline]
- Chu K, Maine R, Trelles M. Cesarean section surgical site infections in sub-Saharan Africa: a multi-country study from Medecins Sans Frontieres. World J Surg 2015 Feb;39(2):350-355 [FREE Full text] [CrossRef] [Medline]
- Kaboré B, Soudouem G, Seck I, Millogo T, Evariste Yaméogo WM, Kouanda S. A case-control study of risk factors for surgical site infection after cesarean delivery in eastern Burkina Faso. Int J Gynaecol Obstet 2016 Nov;135 Suppl 1:S107-S110. [CrossRef] [Medline]
- Grimes CE, Bowman KG, Dodgion CM, Lavy CBD. Systematic review of barriers to surgical care in low-income and middle-income countries. World J Surg 2011 May 1;35(5):941-950. [CrossRef] [Medline]
- Hsia RY, Mbembati NA, Macfarlane S, Kruk ME. Access to emergency and surgical care in sub-Saharan Africa: the infrastructure gap. Health Policy Plan 2012 May;27(3):234-244. [CrossRef] [Medline]
- Mugeni C, Levine AC, Munyaneza RM, Mulindahabi E, Cockrell HC, Glavis-Bloom J, et al. Nationwide implementation of integrated community case management of childhood illness in Rwanda. Glob Health Sci Pract 2014 Aug;2(3):328-341 [FREE Full text] [CrossRef] [Medline]
- Powell B, Nkurunziza T, Kateera F. Synthesizing postpartum care pathways, facilitators, and barriers for women after cesarean section: a qualitative analysis from rural Rwanda. J Glob Health Rep 2021 Jun 18;5:e2021043. [CrossRef]
- Nguhuni B, De Nardo P, Gentilotti E, Chaula Z, Damian C, Mencarini P, et al. Reliability and validity of using telephone calls for post-discharge surveillance of surgical site infection following caesarean section at a tertiary hospital in Tanzania. Antimicrob Resist Infect Control 2017;6:43 [FREE Full text] [CrossRef] [Medline]
- Aiken AM, Wanyoro AK, Mwangi J, Mulingwa P, Wanjohi J, Njoroge J, et al. Evaluation of surveillance for surgical site infections in Thika Hospital, Kenya. J Hosp Infect 2013 Feb;83(2):140-145 [FREE Full text] [CrossRef] [Medline]
- Pathak A, Sharma S, Sharma M, Mahadik VK, Lundborg CS. Feasibility of a Mobile Phone-Based Surveillance for Surgical Site Infections in Rural India. Telemed J E Health 2015 Nov;21(11):946-949 [FREE Full text] [CrossRef] [Medline]
- Sandberg CEJ, Knight SR, Qureshi AU, Pathak S. Using Telemedicine to Diagnose Surgical Site Infections in Low- and Middle-Income Countries: Systematic Review. JMIR Mhealth Uhealth 2019 Aug 19;7(8):e13309 [FREE Full text] [CrossRef] [Medline]
- Sonderman KA, Nkurunziza T, Kateera F, Gruendl M, Koch R, Gaju E, et al. Using mobile health technology and community health workers to identify and refer caesarean-related surgical site infections in rural Rwanda: a randomised controlled trial protocol. BMJ Open 2018 May 08;8(5):e022214 [FREE Full text] [CrossRef] [Medline]
- Mahama: Now a Safe Haven for over 50,000 Burundian refugees. The UN Refugee Agency. 2016. URL: https://www.unhcr.org/rw/559-559.html [accessed 2020-03-01]
- Statistical yearbook. National Institute of Statistics of Rwanda (NISR). 2016. URL: http://www.statistics.gov.rw/publication/statistical-yearbook-2016 [accessed 2020-08-28]
- Cherian T, Hedt-Gauthier B, Nkurunziza T, Sonderman K, Gruendl MA, Nihiwacu E, et al. Diagnosing Post-Cesarean Surgical Site Infections in Rural Rwanda: Development, Validation, and Field Testing of a Screening Algorithm for Use by Community Health Workers. Surg Infect (Larchmt) 2020 Sep;21(7):613-620 [FREE Full text] [CrossRef] [Medline]
- Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform 2009 Apr;42(2):377-381 [FREE Full text] [CrossRef] [Medline]
- Bercion R, Gaudeuille A, Mapouka PA, Behounde T, Guetahoun Y. [Surgical site infection survey in the orthopaedic surgery department of the "Hôpital communautaire de Bangui," Central African Republic]. Bull Soc Pathol Exot 2007 Aug;100(3):197-200. [Medline]
- Manzi A, Munyaneza F, Mujawase F, Banamwana L, Sayinzoga F, Thomson DR, et al. Assessing predictors of delayed antenatal care visits in Rwanda: a secondary analysis of Rwanda demographic and health survey 2010. BMC Pregnancy Childbirth 2014 Aug 28;14:290 [FREE Full text] [CrossRef] [Medline]
- Dao B, Ngabo F, Zoungrana J, Rawlins B, Mukarugwiro B, Musoni P, et al. Increasing Access to Prevention of Postpartum Hemorrhage Interventions for Births in Health Facilities and at Home in Four Districts of Rwanda. Afr J Reprod Health 2015 Dec;19(4):58-67. [Medline]
- Mwai GW, Mburu G, Torpey K, Frost P, Ford N, Seeley J. Role and outcomes of community health workers in HIV care in sub-Saharan Africa: a systematic review. J Int AIDS Soc 2013 Sep 10;16:18586 [FREE Full text] [CrossRef] [Medline]
- Condo J, Mugeni C, Naughton B, Hall K, Tuazon MA, Omwega A, et al. Rwanda's evolving community health worker system: a qualitative assessment of client and provider perspectives. Hum Resour Health 2014 Dec 13;12:71 [FREE Full text] [CrossRef] [Medline]
- Tuyisenge G, Crooks VA, Berry NS. Facilitating equitable community-level access to maternal health services: exploring the experiences of Rwanda's community health workers. Int J Equity Health 2019 Nov 26;18(1):181 [FREE Full text] [CrossRef] [Medline]
- Elbur AI, Ma Y, Elsayed ASA, Abdel-Rahman ME. Post-discharge surveillance of wound infections by telephone calls method in a Sudanese Teaching Hospital. J Infect Public Health 2013 Oct;6(5):339-346 [FREE Full text] [CrossRef] [Medline]
- Baniasadi T, Ghazisaeedi M, Hassaniazad M, Niakan Kalhori SR, Shahi M, Esmaeili M. Surgical Patients Follow-Up by Smartphone-Based Applications: A Systematic Literature Review. Stud Health Technol Inform 2020 Jun 23;271:85-92. [CrossRef] [Medline]
- Ng HJH, Huang D, Rajaratnam V. Diagnosing surgical site infections using telemedicine: A Systematic Review. Surgeon 2021 Jun 19:Online ahead of print. [CrossRef] [Medline]
- Nkurunziza T, Kateera F, Sonderman K, Gruendl M, Nihiwacu E, Ramadhan B, et al. Prevalence and predictors of surgical-site infection after caesarean section at a rural district hospital in Rwanda. Br J Surg 2019 Jan;106(2):e121-e128 [FREE Full text] [CrossRef] [Medline]
- Koch R, Nkurunziza T, Irasubiza HL, Shrime M, Hedt-Gauthier B, Kateera F. Financial risk protection in cesarean section patients at a rural district hospital in Rwanda. East Cent Afr J Surg 2018;23(3):152-153.
- Evans HL, Lober WB. A Pilot Use of Patient-Generated Wound Data to Improve Postdischarge Surgical Site Infection Monitoring. JAMA Surg 2017 Jun 01;152(6):595-596. [CrossRef] [Medline]
|c-section: cesarean section|
|CHW: community health worker|
|KDH: Kirehe District Hospital|
|LMIC: low- and middle-income countries|
|mHealth: mobile health|
|POD: postoperative day|
|RCT: randomized controlled trial|
|REDCap: Research Electronic Data Capture|
|sCHW: study community health worker|
|SSA: sub-Saharan Africa|
|SSI: surgical site infection|
Edited by L Buis; submitted 02.12.21; peer-reviewed by A Joseph, H Ayatollahi; comments to author 02.02.22; revised version received 30.03.22; accepted 04.05.22; published 08.06.22Copyright
©Fredrick Kateera, Robert Riviello, Andrea Goodman, Theoneste Nkurunziza, Teena Cherian, Laban Bikorimana, Jonathan Nkurunziza, Evrard Nahimana, Caste Habiyakare, Georges Ntakiyiruta, Alexi Matousek, Erick Gaju, Magdalena Gruendl, Brittany Powell, Kristin Sonderman, Rachel Koch, Bethany Hedt-Gauthier. Originally published in JMIR mHealth and uHealth (https://mhealth.jmir.org), 08.06.2022.
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