This paper is in the following e-collection/theme issue:

mHealth for Symptom and Disease Monitoring, Chronic Disease Management (1565) Mobile Health (mhealth) (3147) Prescribable Digital Interventions (Digital Therapeutics) (32) mHealth for Wellness, Behavior Change and Prevention (3093)

Published on in Vol 9, No 5 (2021): May

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/26152, first published .
Efficacy of Zemedy, a Mobile Digital Therapeutic for the Self-management of Irritable Bowel Syndrome: Crossover Randomized Controlled Trial

Efficacy of Zemedy, a Mobile Digital Therapeutic for the Self-management of Irritable Bowel Syndrome: Crossover Randomized Controlled Trial

Efficacy of Zemedy, a Mobile Digital Therapeutic for the Self-management of Irritable Bowel Syndrome: Crossover Randomized Controlled Trial

Authors of this article:

Melissa Hunt1 Author Orcid Image ;   Sofia Miguez1 Author Orcid Image ;   Benji Dukas1 Author Orcid Image ;   Obinna Onwude2 Author Orcid Image ;   Sarah White3 Author Orcid Image
Article Authors Cited by (61) Tweetations (6) Metrics

Journals

  1. Biesiekierski J, Manning L, Murray H, Vlaeyen J, Ljótsson B, Van Oudenhove L. Review article: exclude or expose? The paradox of conceptually opposite treatments for irritable bowel syndrome. Alimentary Pharmacology & Therapeutics 2022;56(4):592 View
  2. Gentile M, De Luca V, Patalano R, Laudisio D, Tramontano G, Lindner-Rabl S, Mercurio L, Salvatore E, Farrell J, Roller-Wirnsberger R, Kubitschke L, Triassi M, Colao A, Illario M. Innovative approaches to service integration addressing the unmet needs of irritable bowel syndrome patients and new approaches for the needs of IBS patients. Frontiers in Medicine 2022;9 View
  3. Hasan S, Ballou S, Keefer L, Vasant D. Improving access to gut‐directed hypnotherapy for irritable bowel syndrome in the digital therapeutics' era: Are mobile applications a “smart” solution?. Neurogastroenterology & Motility 2023;35(4) View
  4. Knowles S, Möller S, Stengel A, Mikocka-Walus A, Ferreira N, Trindade I, Mokrowiecka A, Burisch J, Barreiro-de Acosta M, Bernstein C, Lo B, Skvarc D. Exploring the Impact of Covid-19-Related Perceptions on Psychological Distress and Quality of Life in an International Gastrointestinal Cohort Over Time Guided by the Common Sense Model. Journal of Clinical Psychology in Medical Settings 2023;30(4):804 View
  5. Zhang Q, Wang G, Zong X, Sun J. Performance evaluation of Hipee S2 point-of-care testing urine dipstick analyser: a cross-sectional study. BMJ Open 2022;12(10):e063781 View
  6. Lee V, Vijayakumar S, Lau N, Blasiak A, Siah K, Ho D. Understanding the user: Patients’ perception, needs, and concerns of health apps for chronic constipation. DIGITAL HEALTH 2022;8:205520762211046 View
  7. Knouse L, Hu X, Sachs G, Isaacs S, König L. Usability and feasibility of a cognitive-behavioral mobile app for ADHD in adults. PLOS Digital Health 2022;1(8):e0000083 View
  8. Martinengo L, Jabir A, Goh W, Lo N, Ho M, Kowatsch T, Atun R, Michie S, Tudor Car L. Conversational Agents in Health Care: Scoping Review of Their Behavior Change Techniques and Underpinning Theory. Journal of Medical Internet Research 2022;24(10):e39243 View
  9. Moreno-Ligero M, Moral-Munoz J, Salazar A, Failde I. mHealth Intervention for Improving Pain, Quality of Life, and Functional Disability in Patients With Chronic Pain: Systematic Review. JMIR mHealth and uHealth 2023;11:e40844 View
  10. Salwen-Deremer J, Sun M. Management of Sleep and Fatigue in Gastrointestinal Patients. Gastroenterology Clinics of North America 2022;51(4):829 View
  11. Sugaya N, Shirotsuki K, Nakao M. Cognitive behavioral treatment for irritable bowel syndrome: a recent literature review. BioPsychoSocial Medicine 2021;15(1) View
  12. Paine P. Review article: current and future treatment approaches for pain in IBS. Alimentary Pharmacology & Therapeutics 2021;54(S1) View
  13. Hunt M, Dalvie A, Ipek S, Wasman B. Acceptability and efficacy of the Zemedy app versus a relaxation training and meditation app for IBS: protocol for a randomised controlled trial. BMJ Open 2022;12(1):e055014 View
  14. Denecke K, May R. Investigating conversational agents in healthcare: Application of a technical-oriented taxonomy. Procedia Computer Science 2023;219:1289 View
  15. He Y, Yang L, Qian C, Li T, Su Z, Zhang Q, Hou X. Conversational Agent Interventions for Mental Health Problems: Systematic Review and Meta-analysis of Randomized Controlled Trials. Journal of Medical Internet Research 2023;25:e43862 View
  16. Jabir A, Martinengo L, Lin X, Torous J, Subramaniam M, Tudor Car L. Evaluating Conversational Agents for Mental Health: Scoping Review of Outcomes and Outcome Measurement Instruments. Journal of Medical Internet Research 2023;25:e44548 View
  17. Li Y, Liang S, Zhu B, Liu X, Li J, Chen D, Qin J, Bressington D. Feasibility and effectiveness of artificial intelligence-driven conversational agents in healthcare interventions: A systematic review of randomized controlled trials. International Journal of Nursing Studies 2023;143:104494 View
  18. Phan P, Mitragotri S, Zhao Z. Digital therapeutics in the clinic. Bioengineering & Translational Medicine 2023;8(4) View
  19. Boggiss A, Consedine N, Hopkins S, Silvester C, Jefferies C, Hofman P, Serlachius A. Improving the Well-being of Adolescents With Type 1 Diabetes During the COVID-19 Pandemic: Qualitative Study Exploring Acceptability and Clinical Usability of a Self-compassion Chatbot. JMIR Diabetes 2023;8:e40641 View
  20. Morello K, Schäfer S, Kunzler A, Priesterroth L, Tüscher O, Kubiak T. Cognitive reappraisal in mHealth interventions to foster mental health in adults: a systematic review and meta-analysis. Frontiers in Digital Health 2023;5 View
  21. Hunter R, Beattie M, O'Malley C, Gorely T. Mobile apps to self-manage chronic low back pain: A realist synthesis exploring what works, for whom and in what circumstances. PEC Innovation 2023;3:100175 View
  22. Brenner D, Ladewski A, Kinsinger S. Development and Current State of Digital Therapeutics for Irritable Bowel Syndrome. Clinical Gastroenterology and Hepatology 2024;22(2):222 View
  23. Vilalta-Abella F, Porras-Garcia B, Ghiţă A, Vacas-Moreira M, Prat-Galbany M, Gutiérrez-Maldonado J. VirtualPain. Preliminary findings from a group-based digital therapeutics intervention for fibromyalgia. British Journal of Pain 2024;18(2):155 View
  24. Jin W, Mohan S, Adams M, Hoffe S, Robinson E. The Emerging Role of Digital Therapeutics in Medical, Surgical and Radiation Oncology. Applied Radiation Oncology 2022 View
  25. Law M, Pickering I, Bartlett E, Sebaratnam G, Varghese C, Gharibans A, O'Grady G, Andrews C, Calder S. Cognitive behavioural therapy-based interventions for gastroduodenal disorders of gut-brain interaction: A systematic review. Journal of Psychosomatic Research 2023;175:111516 View
  26. Jabir A, Lin X, Martinengo L, Sharp G, Theng Y, Tudor Car L. Attrition in Conversational Agent–Delivered Mental Health Interventions: Systematic Review and Meta-Analysis. Journal of Medical Internet Research 2024;26:e48168 View
  27. Yang J, Yan J, Xiong C, Zhang X, Shen L, Zhi J, Ma S, Dong H, Yang Y. Development and validation of a scoring system to predict esophagogastroduodenoscopy necessity. Journal of Digestive Diseases 2023;24(12):671 View
  28. Slouha E, Patel B, Mohamed A, Razeq Z, Clunes L, Kollias T. Psychotherapy for Irritable Bowel Syndrome: A Systematic Review. Cureus 2023 View
  29. Johnson E, Corrick S, Isley S, Vandermeer B, Dolgoy N, Bates J, Godfrey E, Soltys C, Muir C, Vohra S, Tandon P, Ayatollahi H. Mind-body internet and mobile-based interventions for depression and anxiety in adults with chronic physical conditions: A systematic review of RCTs. PLOS Digital Health 2024;3(1):e0000435 View
  30. Pala D, Petrini G, Bosoni P, Larizza C, Quaglini S, Lanzola G. Smartphone applications for nutrition Support: A systematic review of the target outcomes and main functionalities. International Journal of Medical Informatics 2024;184:105351 View
  31. Kurniawan M, Handiyani H, Nuraini T, Hariyati R, Sutrisno S. A systematic review of artificial intelligence-powered (AI-powered) chatbot intervention for managing chronic illness. Annals of Medicine 2024;56(1) View
  32. MacNeill A, MacNeill L, Yi S, Goudreau A, Luke A, Doucet S. Depiction of conversational agents as health professionals: a scoping review. JBI Evidence Synthesis 2024;22(5):831 View
  33. Laymouna M, Ma Y, Lessard D, Schuster T, Engler K, Lebouché B. Roles, Users, Benefits, and Limitations of Chatbots in Health Care: Rapid Review. Journal of Medical Internet Research 2024;26:e56930 View
  34. Zhong W, Luo J, Zhang H. The therapeutic effectiveness of artificial intelligence-based chatbots in alleviation of depressive and anxiety symptoms in short-course treatments: A systematic review and meta-analysis. Journal of Affective Disorders 2024;356:459 View
  35. Pathipati M, Scott L, Griser A, Staller K. Real‐world outcomes for a digital prescription mobile application for adults with irritable bowel syndrome. Neurogastroenterology & Motility 2024;36(7) View
  36. Burgell R, Hoey L, Norton K, Fitzpatrick J. Treating disorders of brain–gut interaction with multidisciplinary integrated care. Moving towards a new standard of care. JGH Open 2024;8(5) View
  37. Limpanopparat S, Gibson E, Harris D. User engagement, attitudes, and the effectiveness of chatbots as a mental health intervention: A systematic review. Computers in Human Behavior: Artificial Humans 2024;2(2):100081 View
  38. Villarreal-Zegarra D, Reategui-Rivera C, García-Serna J, Quispe-Callo G, Lázaro-Cruz G, Centeno-Terrazas G, Galvez-Arevalo R, Escobar-Agreda S, Dominguez-Rodriguez A, Finkelstein J. Self-Administered Interventions Based on Natural Language Processing Models for Reducing Depressive and Anxiety Symptoms: Systematic Review and Meta-Analysis. JMIR Mental Health 2024;11:e59560 View
  39. Corrick S, Johnson E, Isley S, Vandermeer B, Dolgoy N, Bates J, Godfrey E, Soltys C, Muir C, Tegg N, Norris C, Tandon P, Dale R. Sex and gender reporting in RCTs of internet and mobile-based interventions for depression and anxiety in chronic conditions: A secondary analysis of a systematic review. PLOS Mental Health 2024;1(2):e0000048 View
  40. Chen P, Li Y, Zhang X, Feng X, Sun X. The acceptability and effectiveness of artificial intelligence-based chatbot for hypertensive patients in community: protocol for a mixed-methods study. BMC Public Health 2024;24(1) View
  41. Armeni P, Polat I, De Rossi L, Diaferia L, Meregalli S, Gatti A. Exploring the potential of digital therapeutics: An assessment of progress and promise. DIGITAL HEALTH 2024;10 View
  42. Eaton C, Vallejo N, McDonald X, Wu J, Rodríguez R, Muthusamy N, Mathioudakis N, Riekert K. User Engagement With mHealth Interventions to Promote Treatment Adherence and Self-Management in People With Chronic Health Conditions: Systematic Review. Journal of Medical Internet Research 2024;26:e50508 View
  43. Doğan T, Koçtürk N, Akın E, Kurnaz M, Öztürk C, Şen A, Yalçın M. Science‐Based Mobile Apps for Reducing Anxiety: A Systematic Review and Meta‐Analysis. Clinical Psychology & Psychotherapy 2024;31(5) View
  44. D’Silva A, Hua N, Modayil M, Seidel J, Marshall D. Digital Health Interventions Are Effective for Irritable Bowel Syndrome Self-Management: A Systematic Review. Digestive Diseases and Sciences 2024 View
  45. González-Pérez A, Diaz-Sanahuja L, Matey-Sanz M, Osma J, Granell C, Bretón-López J, Casteleyn S. Towards a self-applied, mobile-based geolocated exposure therapy software for anxiety disorders: SyMptOMS-ET app. DIGITAL HEALTH 2024;10 View
  46. Uetova E, Hederman L, Ross R, O’Sullivan D. Exploring the characteristics of conversational agents in chronic disease management interventions: A scoping review. DIGITAL HEALTH 2024;10 View
  47. Nogueira-Rio N, Varela Vazquez L, Lopez-Santamarina A, Mondragon-Portocarrero A, Karav S, Miranda J. Mobile Applications and Artificial Intelligence for Nutrition Education: A Narrative Review. Dietetics 2024;3(4):483 View
  48. Barandouzi Z, Chen J, Henderson W, Starkweather A, Cong X. Nurse-led self-management support to improve symptom management and self-reported outcomes in people with irritable bowel syndrome. Interdisciplinary Nursing Research 2024;3(3):163 View
  49. Wang X, Thakur E, Shapiro J. Non-pharmaceutical treatments for irritable bowel syndrome. BMJ 2024:e075777 View
  50. Macedo P, Madeira R, Santos P, Mota P, Alves B, Pereira C. A Conversational Agent for Empowering People with Parkinson’s Disease in Exercising Through Motivation and Support. Applied Sciences 2024;15(1):223 View
  51. Yang Q, Cheung K, Zhang Y, Zhang Y, Qin J, Xie Y. Conversational agents in physical and psychological symptom management: A systematic review of randomized controlled trials. International Journal of Nursing Studies 2025;163:104991 View
  52. Warner M, Soliman O, Crichton M, Marshall S, Staudacher H, Kelly J. Systematic Review: Integrated Models of Care for Managing Irritable Bowel Syndrome. Neurogastroenterology & Motility 2025;37(2) View
  53. Lau Y, Ang W, Ang W, Pang P, Wong S, Chan K, Lamela D. Artificial Intelligence–Based Psychotherapeutic Intervention on Psychological Outcomes: A Meta‐Analysis and Meta‐Regression. Depression and Anxiety 2025;2025(1) View
  54. Pickering I, Law M, Calder S, O’Grady G, Broadbent E. Perspectives of digital cognitive behavioural therapy for functional dyspepsia: qualitative interviews using thematic analysis. Psychology & Health 2025:1 View
  55. Yang L, Zhang M, Jia L, Yan Z, Yin Q. Understanding digital therapeutics in disease self-management: A systematic literature review. Technology in Society 2025;81:102831 View
  56. Ryan A, Ferreira N, Moffat H, Eugenicos M, Howson W, Casburn-Jones A, Moroni F, Stevens P, Wolters M, Gillanders D. Investigating the delivery of an acceptance and commitment therapy (ACT) smartphone app intervention on symptomology in adult IBS patients: A feasibility study. Journal of Contextual Behavioral Science 2025;36:100887 View
  57. Hunt M, Dalvie A, Ipek S, Glinski S, Macks R. Efficacy of a CBT Self-Help App (Zemedy) Versus an Education, Relaxation, and Mindfulness App for IBS. Journal of Clinical Gastroenterology 2025 View
  58. Souza F, Bowman H, Yang F, Hesam‐Shariati N, Linke J, Gilanyi Y, Jones M, Z‐Pinto R, McAuley J, Rizzo R. Conversational Agents to Support Pain Management: A Scoping Review. European Journal of Pain 2025;29(5) View
  59. Zickgraf H, Murray H, Rigby A. Avoidant/Restrictive Food Intake Disorder Symptoms are Common and Impairing in Adults With Specific Phobia of Vomiting: An Exploratory Study in an Understudied Population. Psychological Reports 2025 View

Books/Policy Documents

  1. van Tilburg M, Taft T. Encyclopedia of Mental Health. View
  2. Hennemann S, Böhme K, Witthöft M. Digitale Gesundheitsinterventionen. View