Efficacy and Safety of Mobile App–Based Metamemory Cognitive Training for Mild Cognitive Impairment: Multicenter Randomized Clinical Trial

Sunyoung Kang   ¹ , MD ;   Jung-In Lim   ² , MA ;   Lukas Stenzel   ³ , PhD ;   Keun You Kim   ¹ , MD, PhD ;   Eosu Kim   ^{1, 4, 5} , MD, PhD ;   Hong Jun Jeon   ⁶ , MD ;   Doo-Heum Park   ⁶ , MD, PhD ;   Hyun Kook Lim   ^{7, 8} , MD, PhD ;   YongSoo Shim   ⁹ , MD, PhD ;   Jae-Won Jang   ¹⁰ , MD, PhD ;   Yeshin Kim   ¹⁰ , MD, PhD ;   Sanghoon Lee   ¹¹ , BS ;   Kee Hyung Park   ¹² , MD, PhD

¹ Department of Psychiatry & Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea

² Interdisciplinary Program in Cognitive Science, Seoul National University, Seoul, Republic of Korea

³ Cogthera GmbH, Munich, Germany

⁴ Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Republic of Korea

⁵ Metabolism-Dementia Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea

⁶ Department of Psychiatry, Konkuk University Medical Center, Seoul, Republic of Korea

⁷ Department of Psychiatry, Yeouido St. Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea

⁸ Catholic Medical Center Institute for Basic Medical Science, The Catholic University of Korea Catholic Medical Center, Seoul, Republic of Korea

⁹ Department of Neurology, St. Vincent's Hospital, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea

¹⁰ Department of Neurology, Kangwon National University Hospital, College of Medicine, Kangwon National University, Chuncheon, Gangwon-do, Republic of Korea

¹¹ Emocog Inc., Seoul, Republic of Korea

¹² Department of Neurology, College of Medicine, Gachon University Gil Medical Center, Incheon, Republic of Korea