Digital Biomarkers and Digital Phenotyping

Association of Daily Step Count With Depressive Symptoms in Patients With Major Depressive Disorder Using a Smartphone App (ReMAP): Longitudinal Study

Alexander Refisch, Lara Gutfleisch, Daniel Emden, Vincent Holstein, Marius Gruber, Janik Goltermann, Maike Richter, Janette Ratzsch, Anna Fleuchhaus, Elisabeth Leehr, Susanne Meinert, Tiana Borgers, Kira Flinkenfügel, Frederike Stein, Florian Thomas-Odenthal, Paula Usemann, Lea Teutenberg, Nina Alexander, Ronny Redlich, Igor Nenadić, Tilo Kircher, Udo Dannlowski, Tim Hahn, Nils Opel

JMIR Ment Health 2026 (Feb 10); 13:e81120

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Screen Time and Chronic Pain Health: Mendelian Randomization Study

Jiahui Jiang, Chunyan Pu, Jiarui Cai, Chuan Yu, Zhenmi Liu, Chenghan Xiao

J Med Internet Res 2026 (Feb 09); 28:e78233

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Using Smartphone-Based Digital Phenotyping to Predict Relapse in Serious Mental Disorders Among Slum Residents in Dhaka, Bangladesh: Protocol for a Machine Learning Study

Nadia Alam, Chayon Kumar Das, Neelabja Roy, Domenico Giacco, Swaran P Singh, Sagar Jilka

JMIR Res Protoc 2026 (Feb 04); 15:e79826

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Digital Phenotyping for Adolescent Mental Health: Feasibility Study Using Machine Learning to Predict Mental Health Risk From Active and Passive Smartphone Data

Balasundaram Kadirvelu, Teresa Bellido Bel, Aglaia Freccero, Martina Di Simplico, Dasha Nicholls, A Aldo Faisal

J Med Internet Res 2026 (Feb 04); 28:e72501

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The Effect of Evening Technology Use on Objective Sleep in Older Adults: Protocol for a Crossover Randomized Controlled Trial

Sarah Nauman Ghazi, Anders Behrens, Joakim Niklasson, Johan Sanmartin Berglund, Peter Anderberg

JMIR Res Protoc 2026 (Jan 30); 15:e84512

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Using Smartphone-Tracked Behavioral Markers to Recognize Depression and Anxiety Symptoms: Cross-Sectional Digital Phenotyping Study

George Aalbers, Andrea Costanzo, Raj Jagesar, Femke Lamers, Martien J H Kas, Brenda W J H Penninx

JMIR Ment Health 2026 (Jan 26); 13:e80765

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Nomograms Based on X-Ray Radiomics for Predicting Pain Progression in Knee Osteoarthritis Using Data From the Foundation for the National Institutes of Health: Development and Validation Study

Yingwei Sun, Jing Liu, Chunbo Deng, Chengbao Peng, Shinong Pan, Xueyong Liu

JMIR Med Inform 2026 (Jan 14); 14:e78338

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Assessment of Blood Glucose Measurement Using New Noninvasive Technology: Protocol and Methodology

Eka Widrian Suradji, Satvinder Singh Dhaliwal, Zhang Li-Feng, Entong Zhou, Amos Lim, Hui Hern Wong, Yao Du, Fredicia Fredicia, Amanda Dianky, Puspasari Pasaribu, Ernest Gamaliel Masayoshi Takashi, Justin Yong An Tan, Mardi Santoso, Seng Bin Ang

JMIR Res Protoc 2026 (Jan 08); 15:e76558

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Assessing Associations Between Environmental, Sleep, and Physical Activity Factors and Metabolic Syndrome Risk: Protocol for the FEASible Study

Tania Ramos-Santiago, Elise Huglo, Yanrong Li, Christian Corral, Congyu Wu, Kerry Kinney, Darla Castelli, Andreana Haley

JMIR Res Protoc 2026 (Jan 06); 15:e82034

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Personalized Machine Learning Intervention to Improve Sleep Quality Using Wearable Technology in Healthy Middle-Aged Adults From Mexico City: Protocol for a Pilot Randomized Controlled Trial

Rodrigo Quezada Reyes, Luis A Trejo

JMIR Res Protoc 2026 (Jan 06); 15:e76415

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Using Indoor Movement Complexity in Smart Homes to Detect Frailty in Older Adults: Multiple-Methods Case Series Study

Katherine Wuestney, Diane Cook, Catherine Van Son, Roschelle Fritz

JMIR Aging 2026 (Jan 02); 9:e77322

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Predicting Ultra-High Risk Outcomes Using Linguistic and Acoustic Measures From High-Risk Social Challenge Recordings: mHealth Longitudinal Cohort Exploratory Study

Samuel Ming Xuan Tan, May Yen Lieu, Jun Kai, Zixu Yang, Luke KK, May O Lwin, Jimmy Lee, Wilson Wen Bin Goh

JMIR Form Res 2025 (Dec 30); 9:e75960

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Evaluating the Body Roundness Index as a Novel Digital Biomarker for Psoriasis Risk Prediction: Cross-Sectional Study

Pengfei Wen, Xiaoyan Wang, Xiaoxue Zhuo, Siliang Xue

JMIR Med Inform 2025 (Dec 23); 13:e75727

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Collection of Ambulatory Electrocardiogram and Behavioral Data for the Identification of Digital Biomarkers for Heart Failure (CATCH-ECG): Protocol for a Prospective Cohort Study

Jakob Eyvind Bardram, Gouthamaan Manimaran, Chloë Cammaerts, Sadasivan Puthusserypady, Helena Dominguez

JMIR Res Protoc 2025 (Dec 19); 14:e79651

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Digital Bioimpedance for Physical Activity Detection in Type-2 Diabetes: Quasi-Experimental Validation Study

Akira Kimura, Shinobu Onozawa, Takayuki Ogiwara, Marwan El Ghoch

JMIR Diabetes 2025 (Dec 16); 10:e83768

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Smartwatch-Derived Digital Phenotypes Relate to Psychopathology Dimensions in Patients With Psychotic Spectrum Disorders: Longitudinal Observational Study

Vasiliki Garyfalli, Emmanouil Kalisperakis, Alexandros Smyrnis, Marina Lazaridi, Thomas Karantinos, Asimakis Mantas, Panagiotis P Filntisis, Niki Efthymiou, Athanasia Zlatintsi, Petros Maragos, Nikolaos Smyrnis

JMIR Ment Health 2025 (Dec 12); 12:e75774

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Lumbar Acceleration Gait Estimation: “Step-by-Step” Algorithm Updates and Improvements

Lukas Adamowicz, Wenyi Lin, F Isik Karahanoglu, Xuemei Cai, Mar Santamaria, Charmaine Demanuele, Junrui Di

J Med Internet Res 2025 (Dec 12); 27:e72831

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Comparison and Validation of Actigraphy Algorithms Using a Large Community Dataset: Algorithm Validation Study

Darshan Panesar, Aashish Vichare, Jason Goncalves, Robyn Stremler

JMIR Form Res 2025 (Dec 11); 9:e70778

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Digital Biomarkers of Cytokine Release Syndrome: Scoping Review and Ontology Development of the Role and Relevance of Digital Measures Using a Mixed Methods Approach

Christopher J Medberry, Charlotte Zoe Angel, Ashita S Batavia, Sarah Bradley, Nunzio Camerlingo, Melinda Chen, Mohamed Datoo, Premal Kamdar, Erik Koenig, Lieke Kusters, Celine Marquez, Ujwani Nukala, Michael Pettinati, Ruth Phillips, Daniel P Sanchez, Nazila Shafagati, Jenifer Siegelman, Mark Stewart, Cindy Varga, Benjamin Vandendriessche, Matt Wilkes, Dana L Wolff-Hughes, David Zahavi, Sylvain Zorman, Samantha J McClenahan

J Med Internet Res 2025 (Dec 11); 27:e71956

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Efficacy and Reliability of Mobile Uroflowmetry in Patients With Benign Prostatic Hyperplasia Undergoing Transurethral Resection: Prospective Multicenter Observational Pilot Validation Study

Sang Hun Song, Younsoo Chung, Hoyoung Ryu, Jeong Woo Lee, Sangchul Lee

J Med Internet Res 2025 (Dec 05); 27:e75313

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