Digital Biomarkers and Digital Phenotyping

Articles published in 2026 in this theme: 34 (scroll down to load remaining articles)

2026

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Targeted Real-Time Assessment of Chronic Pain (TRAC-Pain) in Youth: Protocol for a Digital Biosignature Development Through a Prospective Observational Cohort Study

Anna H Bailes, Chi-Hung Shu, Alan Chang, Sahrish Masood, Nicole Jehl, Aliyah Davis, Jeremy Giberson, Casey Cashman, Allison Hill, Javed Gill, Ryan S McGinnis, Ellen W McGinnis, Nima Aghaeepour, Laura E Simons

JMIR Res Protoc 2026 (Apr 06); 15:e84781

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Validity of Smartphone-Based Measurement for Assessing Lower Limb Power for Sarcopenia and Frailty Discrimination: Cross-Sectional Study

Shuichi P Obuchi, Hisashi Kawai, Takeshi Kera, Keigo Imamura, Manami Ejiri, Hirohiko Hirano, Kazushige Ihara, Hiroyuki Sasai, Yoshinori Fujiwara

JMIR Form Res 2026 (Apr 06); 10:e83805

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The Role of Digital Biomarkers in Physiological Signal-Based Depression Assessment: Systematic Review and Meta-Analysis

Hyeongsuk Lee, Seung-Gul Kang, SeonHeui Lee

J Med Internet Res 2026 (Apr 02); 28:e76432

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Development and Validation of Machine Learning Models for Predicting Early Cognitive Decline Using Home Sensor–Derived Behavioral Data: Sensors in-Home for Elder Wellbeing (SINEW) Cohort Study

James Patrick Moon, Khalid Abdul Jabbar, Tony Chin Ian Tay, Laura Tay, Rathi Mahendran, Tze Pin Ng, Shian Ming Tan, Wilbur Zhi Hao Koh, Weng Yan Ying, Ah-Hwee Tan, Tih-Shih Lee, Iris Rawtaer

JMIR Res Protoc 2026 (Apr 01); 15:e79490

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Video-Based Gait Assessment Using Machine Learning to Classify Age and Sex in Low-Resource Settings: Cross-Sectional Study

Chanchanok Aramrat, Poppy Alice Carson Mallinson, Papangkorn Inkaew, Pusit Seepheung, Nutchar Wiwatkunupakarn, Nida Buawangpong, Nick Birk, Judith Lieber, Santhi Bhogadi, Hemant Mahajan, Santosh Kumar Banjara, Bharati Kulkarni, Sanjay Kinra, Chaisiri Angkurawaranon

JMIR Form Res 2026 (Mar 30); 10:e76755

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Identifying Hemophagocytic Lymphohistiocytosis and Describing Outcomes Using Computable Phenotypes: Retrospective Cohort Study

Suheyla Ocak, Martin Yi, Agata Wolochacz, Ida Mehrdadi, Ahmed Naqvi, Sumit Gupta, Lillian Sung, Adam P Yan

JMIR Cancer 2026 (Mar 26); 12:e87347

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Smartphone-Based Digital Phenotyping Across Health Conditions: Scoping Review

Arlen Dumas, Joanne Hokayem, Georgia Goodman, Krishna Venkatasubramanian, Peter Chai

J Med Internet Res 2026 (Mar 24); 28:e84146

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Long Short-Term Memory–GPT-4 Integration for Interpretable Biomedical Signal Classification: Proof-of-Concept Study

Kapil Kumar Reddy Poreddy, Ajit Sahu, Sanjoy Mukherjee, Bhavan Kumar Basavaraju

JMIR Form Res 2026 (Mar 20); 10:e87962

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Assessing Mental Health and Emotional States by Using Smartphone Photoplethysmography–Based Digital Pulse Waveform Analysis: Cross-Sectional Observational Study

Ivan Liu, Luming Hu, Jing Luo, Chang Liu, Qi Zhong, Shiguang Ni

JMIR Mhealth Uhealth 2026 (Mar 16); 14:e81301

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Clinical and Behavioral Outcomes During 4 Weeks of Home-Based Self-Administered Transcranial Direct Current Stimulation in Perinatal Women With Depressive Symptoms: Open-Label Exploratory Pilot Study

Sehwan Park, Gangho Do, Jaesub Park, Min-Kyoung Kim, Sra Jung, Hyun-Ju Kim, Hee Young Cho

JMIR Form Res 2026 (Mar 12); 10:e56454

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Association Between Digital Biomarkers of Health and Anxiety: Systematic Review and Meta-Analysis

Yolanda Lau, Natalia Chemas, Heema Ajeet Gokani, Rachel Morrell, Harisd Phannarus, Claudia Cooper, Zuzana Walker, Harriet Demnitz-King, Natalie L Marchant

J Med Internet Res 2026 (Mar 09); 28:e73812

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Leveraging Naturalistic Driving Digital Biomarkers for Early Mild Cognitive Impairment Detection: Deep Learning Strategies

Firas Al-Hindawi, Teresa Wu, Yutong Wen, Peter Serhan, Erica Forzani, Francis Tsow, Yonas E Geda

JMIR Med Inform 2026 (Mar 06); 14:e83622

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Standardized Methods for Evaluating Physical and Eating Behaviors: The WEALTH Cross-Sectional Study Protocol

Grainne Hayes, Christoph Buck, Greet Cardon, Richard Cimler, Steriani Elavsky, Leopold Fezeu K, Janas M Harrington, Jitka Kühnová, Jean-Michel Oppert, Luis Sigcha, Pepijn Van de Ven, Tomas Vetrovsky, Catherine B Woods, Antje Hebestreit, Alan E Donnelly

JMIR Res Protoc 2026 (Mar 06); 15:e70186

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Assessment of Emerging Technologies to Support Individuals With At-Risk Alcohol Consumption: Pilot Controlled Investigation Study

Karl Andersson, Linda Handlin, Sanela Huskic Beslic, Rajna Knez, Afrouz Behboudi, Marie Wilhsson

JMIR Form Res 2026 (Mar 06); 10:e83592

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Tracking Cognitive Health With Wearables in Telerehabilitation Female Participants: Could Nighttime Sleep Measures Be Used as Sex-Specific Digital Endpoints?

Stephanie J Zawada, Louis Faust, Emma Fortune

JMIR Neurotech 2026 (Mar 05); 5:e81318

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Prediction of Aspiration Risk by Using Vocal Biomarkers: Machine Learning Development and Validation Study

Cyril Varghese, Jianwei Zhang, Sara Charney, Abdelmohaymin A Abdalla, Elizabeth Reeves, Stacy Holyfield, Adam E Brown, Michelle K Higgins, Hunter Stearns, Julie Liss, Nan Zhang, Diana Orbelo, Rebecca L Pittelko, Lindsay Rigelman, Victor Ortega, David G Lott, Visar Berisha

JMIR Form Res 2026 (Mar 04); 10:e86069

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Real-Time Type 1 Diabetes Self-Management Decision-Making in Adolescents: Protocol for a Longitudinal Mixed Methods Study Using Text Messaging and Continuous Glucose Monitoring

Melissa DeJonckheere, Samantha A Chuisano, Juniar Lucien, Fouzaan Amjad, Oorvi Duvvuri, Hasan Khan, Maryam Khan, Rafee Mirza, Maya Joy Ollivierre, Timothy Guetterman, Yu Kuei Lin, Lorraine R Buis, James E Aikens, Caroline Richardson, Joyce M Lee

JMIR Res Protoc 2026 (Mar 04); 15:e83218

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Machine Learning–Based Audiovisual Phenotyping for Measuring Communication, Shared Decision-Making, and Trust

Shely Khaikin, Vineet Tiruvadi, Jeffrey Brooks, Alice Baird, Anne-Catherine Grela-Mpoko, Lindsey Hoffman, Jadyn Crossley, Menachem Leasy, Jaime Fineman, Margot Savoy, Laura Igarabuza, Anuradha Paranjape, Cheryl YS Foo, Michael L Birnbaum, Yaara Zisman-Ilani

JMIR Form Res 2026 (Mar 03); 10:e85906

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Distinguishing Common Digital Phenotyping and Self-Report Parameters for Monitoring and Predicting Depression: Scoping Review

Lisa Busshart, Milica Petrovic, Rebeka Amin, Ulrich Hegerl

JMIR Mhealth Uhealth 2026 (Mar 02); 14:e70840

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Implementation of a Personalized Medicine Approach in Patients With Type 2 Diabetes Mellitus Receiving Multiple Daily Insulin Injections (POMA Project): Protocol for a Before-and-After Intervention Study

Rosa Giné-Balcells, Bogdan Vlacho, Olga Carmen Vidal-Pérez, Albert Lecube, Josep Franch-Nadal, Dídac Mauricio, Àngels Molló-Iniesta, Marta Hernández, POMA Study Group

JMIR Res Protoc 2026 (Feb 24); 15:e85375

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