Published on in Vol 6 , No 11 (2018) :November

Preprints (earlier versions) of this paper are available at, first published .
An Empathy-Driven, Conversational Artificial Intelligence Agent (Wysa) for Digital Mental Well-Being: Real-World Data Evaluation Mixed-Methods Study

An Empathy-Driven, Conversational Artificial Intelligence Agent (Wysa) for Digital Mental Well-Being: Real-World Data Evaluation Mixed-Methods Study

An Empathy-Driven, Conversational Artificial Intelligence Agent (Wysa) for Digital Mental Well-Being: Real-World Data Evaluation Mixed-Methods Study


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  127. Dosovitsky G, Bunge E. Bonding With Bot: User Feedback on a Chatbot for Social Isolation. Frontiers in Digital Health 2021;3 View
  128. Chew H. The Use of Artificial Intelligence–Based Conversational Agents (Chatbots) for Weight Loss: Scoping Review and Practical Recommendations. JMIR Medical Informatics 2022;10(4):e32578 View
  129. Kettle L, Lee Y. User Experiences of Well-Being Chatbots. Human Factors: The Journal of the Human Factors and Ergonomics Society 2023:001872082311624 View
  130. Molloy A, Anderson P. Engagement with mobile health interventions for depression: A systematic review. Internet Interventions 2021;26:100454 View
  131. HANABUSA R, ARAKI K. Trouble Sentence and Emotional Sentence Extraction System for Problem Recognition in Psychotherapy Dialogue. Journal of Japan Society for Fuzzy Theory and Intelligent Informatics 2021;33(4):860 View
  132. Zakharchuk M, Basyuk T. Designing and Implementation of the Information System for Providing Recommendations to People with Mental Disorders. Vìsnik Nacìonalʹnogo unìversitetu "Lʹvìvsʹka polìtehnìka". Serìâ Ìnformacìjnì sistemi ta merežì 2021;9:44 View
  133. Belda-Medina J, Calvo-Ferrer J. Using Chatbots as AI Conversational Partners in Language Learning. Applied Sciences 2022;12(17):8427 View
  134. Pauw L, Sauter D, van Kleef G, Lucas G, Gratch J, Fischer A. The avatar will see you now: Support from a virtual human provides socio-emotional benefits. Computers in Human Behavior 2022;136:107368 View
  135. Beatty C, Malik T, Meheli S, Sinha C. Evaluating the Therapeutic Alliance With a Free-Text CBT Conversational Agent (Wysa): A Mixed-Methods Study. Frontiers in Digital Health 2022;4 View
  136. Chen T, Chen L, Li S, Du J, Su H, Jiang H, Wu Q, Zhang L, Bao J, Zhao M. Virtual Digital Psychotherapist App–Based Treatment in Patients With Methamphetamine Use Disorder (Echo-APP): Single-Arm Pilot Feasibility and Efficacy Study. JMIR mHealth and uHealth 2023;11:e40373 View
  137. Gual-Montolio P, Jaén I, Martínez-Borba V, Castilla D, Suso-Ribera C. Using Artificial Intelligence to Enhance Ongoing Psychological Interventions for Emotional Problems in Real- or Close to Real-Time: A Systematic Review. International Journal of Environmental Research and Public Health 2022;19(13):7737 View
  138. Morrow E, Zidaru T, Ross F, Mason C, Patel K, Ream M, Stockley R. Artificial intelligence technologies and compassion in healthcare: A systematic scoping review. Frontiers in Psychology 2023;13 View
  139. Gifu D, Pop E. Smart Solutions to Keep Your Mental Balance. Procedia Computer Science 2022;214:503 View
  140. Balaskas A, Schueller S, Cox A, Rashleigh C, Doherty G, Tizzoni M. Examining young adults daily perspectives on usage of anxiety apps: A user study. PLOS Digital Health 2023;2(1):e0000185 View
  141. Şahin E, Berk H. Orthopedic surgeons’ attitudes and expectations toward artificial intelligence: A national survey study. Journal of Surgery and Medicine 2023;7(2):151 View
  142. Merkouris S, Loram G, Abdelrazek M, Rodda S, Ibrahim A, Bonti A, Dowling N. Improving the user experience of a gambling support and education website using a chatbot. Universal Access in the Information Society 2022 View
  143. Sinha C, Meheli S, Kadaba M. Understanding Digital Mental Health Needs and Usage With an Artificial Intelligence–Led Mental Health App (Wysa) During the COVID-19 Pandemic: Retrospective Analysis. JMIR Formative Research 2023;7:e41913 View
  144. Maharjan R, Doherty K, Rohani D, Bækgaard P, Bardram J. Experiences of a Speech-enabled Conversational Agent for the Self-report of Well-being among People Living with Affective Disorders: An In-the-Wild Study. ACM Transactions on Interactive Intelligent Systems 2022;12(2):1 View
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  146. Eagle T, Blau C, Bales S, Desai N, Li V, Whittaker S. “I don’t know what you mean by `I am anxious'”: A New Method for Evaluating Conversational Agent Responses to Standardized Mental Health Inputs for Anxiety and Depression. ACM Transactions on Interactive Intelligent Systems 2022;12(2):1 View
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Books/Policy Documents

  1. McAllister P, Kerr J, McTear M, Mulvenna M, Bond R, Kirby K, Morning J, Glover D. Chatbot Research and Design. View
  2. Fiske A, Henningsen P, Buyx A. Ethics of Digital Well-Being. View
  3. Luxton D, Sirotin A. Innovations in Global Mental Health. View
  4. Cho P, Singh K, Dunn J. Artificial Intelligence in Medicine. View
  5. van Wezel M, Croes E, Antheunis M. Chatbot Research and Design. View
  6. Benítez-Guijarro A, Bond R, Booth F, Callejas Z, Ennis E, Esposito A, Kraus M, McConvey G, McTear M, Mulvenna M, Potts C, Pragst L, Turkington R, Wagner N, Zheng H. Conversational Dialogue Systems for the Next Decade. View
  7. Callejas Z, Griol D. Dialog Systems. View
  8. Galindo M, Moreno L. Graph Structures for Knowledge Representation and Reasoning. View
  9. Kara O, Kurutkan M. The Impact of Artificial Intelligence on Governance, Economics and Finance, Volume I. View
  10. Jovanović M, Jevremović A, Pejović-Milovančević M. Artificial Intelligence: Theory and Applications. View
  11. McKay G. Shame 4.0. View
  12. Davids J, Ashrafian H. Artificial Intelligence in Medicine. View
  13. Denecke K, Abd-Alrazaq A, Househ M. Multiple Perspectives on Artificial Intelligence in Healthcare. View
  14. Luxton D, Sirotin A. Innovations in Global Mental Health. View
  15. Goh N, Goh T, Lim C, Fung D. Handbook of Research on Promoting Economic and Social Development Through Serious Games. View
  16. Gundavarapu M, Saaketh Koundinya G, Bollina Devi Sai T, Kidambi Sree G. Applied Computational Technologies. View
  17. Bickmore T, O'Leary T. Digital Therapeutics for Mental Health and Addiction. View
  18. Viduani A, Cosenza V, Araújo R, Kieling C. Digital Mental Health. View
  19. Dhimolea T, Kaplan-Rakowski R, Lin L. Bridging Human Intelligence and Artificial Intelligence. View
  20. Strauss J, Zhang J, Jarrett M, Patterson B, Van Ameringen M. Mental Health in a Digital World. View
  21. Davids J, Ashrafian H. Artificial Intelligence in Medicine. View
  22. Oyeniyi O, Dhandhukia S, Sen A, Fletcher K. Service-Oriented Computing – ICSOC 2021 Workshops. View
  23. Striegl J, Gotthardt M, Loitsch C, Weber G. Computers Helping People with Special Needs. View
  24. Cuciniello M, Amorese T, Cordasco G, Marrone S, Marulli F, Cavallo F, Gordeeva O, Carrión Z, Esposito A. Applied Intelligence and Informatics. View
  25. Tang X, Upadyaya K, Toyama H, Kasanen M, Salmela-Aro K. AI in Learning: Designing the Future. View
  26. Cheng Y, Xie C, Wang Y, Jiang H. The International Encyclopedia of Health Communication. View
  27. Henkel T, Linn A, van der Goot M. Chatbot Research and Design. View
  28. Galindo M, Moreno L, Rojas-Velázquez D, Nieves J. Deceptive AI. View
  29. Kuhlmeier F, Gnewuch U, Lüttke S, Brakemeier E, Mädche A. The Transdisciplinary Reach of Design Science Research. View
  30. Zubiaga I, Justo R. Pattern Recognition and Image Analysis. View
  31. Rakib A, Rumky E, Ashraf A, Hillas M, Rahman M. Brain Informatics. View
  32. Gotthardt M, Striegl J, Loitsch C, Weber G. Computers Helping People with Special Needs. View
  33. Fiorentino M, Dastan M, Ajroudi S, Boccaccio A, Uva A. Revolutions in Product Design for Healthcare. View
  34. Chatterjee L, Sengupta R. Digital Identity in the New Era of Personalized Medicine. View
  35. Lucero Fredes A, Cano S, Cubillos C, Díaz M. HCI International 2022 – Late Breaking Papers: HCI for Health, Well-being, Universal Access and Healthy Aging. View
  36. Simões de Almeida R, da Silva T. Digital Therapies in Psychosocial Rehabilitation and Mental Health. View
  37. Pacheco-Lorenzo M, Valladares-Rodríguez S, Anido-Rifón L, Fernández-Iglesias M. Proceedings of 2nd International Conference on Artificial Intelligence: Advances and Applications. View
  38. Das A, Day T, Kulkarni V, Buchanan A, Cottrell K, John N, Chatterjee K. Augmenting Neurological Disorder Prediction and Rehabilitation Using Artificial Intelligence. View